Patient Burden and Impact of Moderate-to-Severe Atopic Dermatitis in the Spanish Healthcare System: The APOLO Cross-Sectional Study.

IF 2.3 4区 医学 Q2 DERMATOLOGY
Pablo De La Cueva Dobao, Laia Curto Barredo, Juan Francisco Silvestre Salvador, Esther Serra-Baldrich, Pedro Herranz Pinto, Natalia Hernández Cano, Francisco Javier Ortiz De Frutos, Gastón Roustan Gullón, Rosa María Lzu Belloso, Irene Arévalo Ortega, Alicia González Quesada, Manuel Galán Gutiérrez, Yolanda Gilaberte Calzada, Daniel Arumi Torredemer, Noelia Llevat Felius, Irene Hernández Martín, Francisco José Rebollo Laserna
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Abstract

Introduction: Atopic dermatitis (AD) is a chronic inflammatory condition associated with a significant physical, psychological, and economic burden. This study aimed to determine the multidimensional impact of AD on patients and the Spanish healthcare system.

Methods: The present multicenter descriptive cross-sectional study was conducted at 12 Spanish sites to detect clinical practice assessments and validated patient-reported measures.

Results: A total of 62 patients were included (54.8% males; mean age: 33.1 years). According to the validated Investigator Global Assessment scale for AD, 61.3% and 38.7% of patients had moderate and severe AD, respectively. AD involved a mean of 43.3% body surface area, with patients reporting a median of 4.0 flares in the past year. The mean Patient-Oriented Eczema Measure (POEM) questionnaire score was 19.8, indicating severe eczema. In addition, 57.1% of patients reported daily pain from scratching or skin inflammation. The mean Dermatology Life Quality Index (DLQI) was 14.3, showing a strong AD impact on patients' quality of life, positively correlated with severity, pruritus, and pain. AD also affected work productivity and sleep, with over 50% of patients reporting impairments in daily activities. Treatment patterns showed predominant use of topical corticosteroids (81.5%). Although no patient required hospitalization in the previous year, 25% resorted to alternative therapies/unlicensed products.

Conclusions: AD profoundly impacts patients' quality of life and entails high economic costs. This study emphasizes the need for more effective treatment strategies and an improved understanding of the AD burden to utilize public healthcare resources more efficiently.

西班牙医疗系统中重度特应性皮炎的患者负担和影响:APOLO横断面研究
特应性皮炎(AD)是一种慢性炎症性疾病,与显著的身体、心理和经济负担相关。本研究旨在确定阿尔茨海默病对患者和西班牙医疗系统的多维影响。方法:目前的多中心描述性横断面研究在西班牙12个地点进行,以检测临床实践评估和验证患者报告的措施。结果:共纳入62例患者,其中男性54.8%;平均年龄:33.1岁)。根据已验证的研究者AD全球评估量表,61.3%和38.7%的患者分别为中度和重度AD。AD平均涉及43.3%的体表面积,患者在过去一年中报告的中位数为4.0次耀斑。以患者为导向的湿疹测量(POEM)问卷平均得分为19.8分,为重度湿疹。此外,57.1%的患者报告每天因抓挠或皮肤炎症而疼痛。平均皮肤病生活质量指数(DLQI)为14.3,表明AD对患者生活质量的影响较强,与病情严重程度、瘙痒程度、疼痛程度呈正相关。阿尔茨海默病还影响工作效率和睡眠,超过50%的患者报告日常活动受损。治疗模式显示主要使用外用皮质类固醇(81.5%)。虽然前一年没有患者需要住院治疗,但25%的患者采用替代疗法/无证产品。结论:AD严重影响患者生活质量,经济成本高。本研究强调需要更有效的治疗策略和提高对阿尔茨海默病负担的理解,以更有效地利用公共医疗资源。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
1.40
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