利多卡因浓度对皮肤渗透麻醉镇痛效果及不良事件的影响。

IF 2.3 4区 医学 Q2 DERMATOLOGY
Thanh Le Thai Van, Thong Nguyen Tri, Hung Ta Quoc, Tuan Ngo Anh, Yen Thai Thanh, Thao Nguyen Phuong, Anh Le Vi, Nam Tran Ngoc Khanh, Vy Tran Hanh
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引用次数: 0

摘要

简介:利多卡因浸润麻醉在皮肤科手术过程中的疼痛管理中起着至关重要的作用,确保患者在整个过程中感到舒适。目的:探讨三种不同浓度利多卡因(2%利多卡因与1:10万肾上腺素按1:2、1:4和1:6的比例稀释)在皮肤外科手术中浸润麻醉的相关性及其镇痛效果和不良反应。方法:本研究采用随机设计,240例患者在7种常见的皮肤科手术中接受不同浓度的利多卡因和肾上腺素(2%利多卡因与1:10万肾上腺素以1:2、1:4或1:6的比例稀释):穿刺活检、切除活检、CO2激光活检、手术切除、CO2激光分次治疗和填充物注射。记录每位参与者的利多卡因总剂量和患者舒适度评估。结果:所有三种利多卡因浓度在手术过程中表现出相当的镇痛效果,通过视觉模拟量表评分来衡量。1:6稀释组所需的利多卡因剂量明显较低,与1:4稀释组相比减少39.3%,与1:2稀释组相比减少75.3%(结论:2%利多卡因与1:10万肾上腺素在1:2至1:6稀释范围内浸润麻醉在皮肤科手术中具有相似的镇痛效果。重要的是,1:6稀释显著降低了注射疼痛和利多卡因总剂量。需要更多的研究来证实我们的结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Impact of Lidocaine Concentration on Analgesic Efficacy and Adverse Events in Dermatologic Infiltrative Anesthesia.

Impact of Lidocaine Concentration on Analgesic Efficacy and Adverse Events in Dermatologic Infiltrative Anesthesia.

Introduction: Infiltrative anesthesia with lidocaine plays a vital role in pain management during dermatological procedures, ensuring patient comfort throughout the process.

Objective: We aimed to investigate the correlation between three different concentrations of lidocaine (2% lidocaine with 1:100,000 epinephrine diluted at ratios of 1:2, 1:4, and 1:6) used in infiltrative anesthesia and their analgesic efficacy and adverse effects in dermatological procedures.

Methods: This study employed a randomized design, with 240 patients assigned to receive varying concentrations of lidocaine with epinephrine (2% lidocaine with 1:100,000 epinephrine diluted at ratios of 1:2, 1:4, or 1:6) during seven common dermatological procedures: punch biopsy, excisional biopsy, CO2 laser biopsy, surgical excision, CO2 laser excision, fractional CO2 laser treatment, and filler injection. Total lidocaine dosage and patient comfort assessments were recorded for each participant.

Results: All three lidocaine concentrations demonstrated comparable analgesic efficacy during the procedures, as measured by visual analog scale scores. The 1:6 dilution group required a significantly lower lidocaine dose, with a 39.3% reduction compared to the 1:4 dilution group and a 75.3% reduction compared to the 1:2 dilution group (P<0.001). The 1:6 dilution group experienced significantly less pain during injection than that of the 1:4 dilution group and the 1:2 dilution group (P<0.001).

Conclusion: Lidocaine 2% with 1:100,000 epinephrine at dilutions ranging from 1:2 to 1:6 for infiltrative anesthesia in dermatological procedures provided similar analgesic efficacy. Importantly, the 1:6 dilution significantly reduced both injection pain and total lidocaine dosage. More studies are required to confirm our results.

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CiteScore
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