The Frequency of Microsatellite Metastases, Satellite Metastases, and Residual Tumor in Thin Melanomas: A Retrospective Cohort Study.

IF 2.3 4区 医学 Q2 DERMATOLOGY
Ebba Wennberg, Rudy Bittar, Helena Svensson, John Paoli
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Abstract

Introduction: Thin invasive melanomas (Breslow thickness ≤1.0 mm) are increasing in incidence in Sweden, but notably also have a favorable prognosis. Treatment typically involves complete diagnostic excision followed by wide local excision (WLE) to eliminate potential microsatellite and satellite metastases along with residual melanoma.

Objectives: This study aimed to investigate the frequency of microsatellite and satellite metastases in diagnostic excision specimens and residual melanoma in WLE specimens from thin melanomas.

Methods: This was a retrospective cohort study including consecutively collected primary thin melanomas excised at Sahlgrenska University Hospital (Gothenburg, Sweden) between January 2014 and December 2020.

Results: Among 1,012 cases, no microsatellites were observed in the diagnostic excisions. Meanwhile, macroscopic satellite metastases were only present in 0.2% of the cases (N=2). Among 887 melanomas undergoing WLE with available data (87.6%), no microsatellites or satellite metastases were found in the extra tissue removed. Of the completely excised melanomas (N=936, 92.5%), only 0.2% (N=2) exhibited residual melanoma in the WLE.

Conclusions: Our findings align with previous studies suggesting that WLE may result in excessive and unnecessary treatment for completely excised thin melanomas. The requirement of performing WLEs following complete excision of thin melanomas needs to be reevaluated.

Abstract Image

Abstract Image

薄黑色素瘤中微卫星转移、卫星转移和残留肿瘤的频率:一项回顾性队列研究。
简介:薄浸润性黑色素瘤(Breslow厚度≤1.0 mm)在瑞典的发病率正在增加,但值得注意的是其预后良好。治疗通常包括完全诊断性切除,然后广泛局部切除(WLE),以消除潜在的微卫星和卫星转移以及残留的黑色素瘤。目的:本研究旨在探讨薄黑色素瘤的诊断切除标本中微卫星和卫星转移的频率以及WLE标本中残留黑色素瘤的频率。方法:这是一项回顾性队列研究,包括连续收集2014年1月至2020年12月在瑞典哥德堡Sahlgrenska大学医院切除的原发性薄黑色素瘤。结果:1012例病例中,诊断性切除未见微卫星。同时,宏观卫星转移仅占0.2% (N=2)。在887例(87.6%)行WLE的黑色素瘤中,在切除的额外组织中未发现微卫星或卫星转移。在完全切除的黑色素瘤中(N= 936,92.5%),只有0.2% (N=2)在WLE中出现残留黑色素瘤。结论:我们的发现与先前的研究一致,表明WLE可能导致对完全切除的薄黑色素瘤进行过度和不必要的治疗。薄黑色素瘤完全切除后行WLEs的要求需要重新评估。
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来源期刊
CiteScore
1.40
自引率
0.00%
发文量
217
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