Ebba Wennberg, Rudy Bittar, Helena Svensson, John Paoli
{"title":"薄黑色素瘤中微卫星转移、卫星转移和残留肿瘤的频率:一项回顾性队列研究。","authors":"Ebba Wennberg, Rudy Bittar, Helena Svensson, John Paoli","doi":"10.5826/dpc.1502a5157","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Thin invasive melanomas (Breslow thickness ≤1.0 mm) are increasing in incidence in Sweden, but notably also have a favorable prognosis. Treatment typically involves complete diagnostic excision followed by wide local excision (WLE) to eliminate potential microsatellite and satellite metastases along with residual melanoma.</p><p><strong>Objectives: </strong>This study aimed to investigate the frequency of microsatellite and satellite metastases in diagnostic excision specimens and residual melanoma in WLE specimens from thin melanomas.</p><p><strong>Methods: </strong>This was a retrospective cohort study including consecutively collected primary thin melanomas excised at Sahlgrenska University Hospital (Gothenburg, Sweden) between January 2014 and December 2020.</p><p><strong>Results: </strong>Among 1,012 cases, no microsatellites were observed in the diagnostic excisions. Meanwhile, macroscopic satellite metastases were only present in 0.2% of the cases (N=2). Among 887 melanomas undergoing WLE with available data (87.6%), no microsatellites or satellite metastases were found in the extra tissue removed. Of the completely excised melanomas (N=936, 92.5%), only 0.2% (N=2) exhibited residual melanoma in the WLE.</p><p><strong>Conclusions: </strong>Our findings align with previous studies suggesting that WLE may result in excessive and unnecessary treatment for completely excised thin melanomas. The requirement of performing WLEs following complete excision of thin melanomas needs to be reevaluated.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 2","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090915/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Frequency of Microsatellite Metastases, Satellite Metastases, and Residual Tumor in Thin Melanomas: A Retrospective Cohort Study.\",\"authors\":\"Ebba Wennberg, Rudy Bittar, Helena Svensson, John Paoli\",\"doi\":\"10.5826/dpc.1502a5157\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Thin invasive melanomas (Breslow thickness ≤1.0 mm) are increasing in incidence in Sweden, but notably also have a favorable prognosis. Treatment typically involves complete diagnostic excision followed by wide local excision (WLE) to eliminate potential microsatellite and satellite metastases along with residual melanoma.</p><p><strong>Objectives: </strong>This study aimed to investigate the frequency of microsatellite and satellite metastases in diagnostic excision specimens and residual melanoma in WLE specimens from thin melanomas.</p><p><strong>Methods: </strong>This was a retrospective cohort study including consecutively collected primary thin melanomas excised at Sahlgrenska University Hospital (Gothenburg, Sweden) between January 2014 and December 2020.</p><p><strong>Results: </strong>Among 1,012 cases, no microsatellites were observed in the diagnostic excisions. Meanwhile, macroscopic satellite metastases were only present in 0.2% of the cases (N=2). Among 887 melanomas undergoing WLE with available data (87.6%), no microsatellites or satellite metastases were found in the extra tissue removed. Of the completely excised melanomas (N=936, 92.5%), only 0.2% (N=2) exhibited residual melanoma in the WLE.</p><p><strong>Conclusions: </strong>Our findings align with previous studies suggesting that WLE may result in excessive and unnecessary treatment for completely excised thin melanomas. The requirement of performing WLEs following complete excision of thin melanomas needs to be reevaluated.</p>\",\"PeriodicalId\":11168,\"journal\":{\"name\":\"Dermatology practical & conceptual\",\"volume\":\"15 2\",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090915/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dermatology practical & conceptual\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5826/dpc.1502a5157\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dermatology practical & conceptual","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5826/dpc.1502a5157","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}
The Frequency of Microsatellite Metastases, Satellite Metastases, and Residual Tumor in Thin Melanomas: A Retrospective Cohort Study.
Introduction: Thin invasive melanomas (Breslow thickness ≤1.0 mm) are increasing in incidence in Sweden, but notably also have a favorable prognosis. Treatment typically involves complete diagnostic excision followed by wide local excision (WLE) to eliminate potential microsatellite and satellite metastases along with residual melanoma.
Objectives: This study aimed to investigate the frequency of microsatellite and satellite metastases in diagnostic excision specimens and residual melanoma in WLE specimens from thin melanomas.
Methods: This was a retrospective cohort study including consecutively collected primary thin melanomas excised at Sahlgrenska University Hospital (Gothenburg, Sweden) between January 2014 and December 2020.
Results: Among 1,012 cases, no microsatellites were observed in the diagnostic excisions. Meanwhile, macroscopic satellite metastases were only present in 0.2% of the cases (N=2). Among 887 melanomas undergoing WLE with available data (87.6%), no microsatellites or satellite metastases were found in the extra tissue removed. Of the completely excised melanomas (N=936, 92.5%), only 0.2% (N=2) exhibited residual melanoma in the WLE.
Conclusions: Our findings align with previous studies suggesting that WLE may result in excessive and unnecessary treatment for completely excised thin melanomas. The requirement of performing WLEs following complete excision of thin melanomas needs to be reevaluated.