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Lineage tracing senescence in vivo shows not all senescent cells are created equal 在体内追踪衰老的谱系显示，并非所有的衰老细胞都是一样的
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-01-06 DOI: 10.1016/j.devcel.2024.12.008
Marcus Ruscetti
{"title":"Lineage tracing senescence in vivo shows not all senescent cells are created equal","authors":"Marcus Ruscetti","doi":"10.1016/j.devcel.2024.12.008","DOIUrl":"https://doi.org/10.1016/j.devcel.2024.12.008","url":null,"abstract":"Understanding the impact of senescence on disease is limited by the lack of tools to lineage label senescent cells. In a recent <em>Cell</em> issue, Zhao et al. create mouse models to genetically manipulate and trace p16<sup>+</sup> cells, identifying contrasting roles for senescent macrophages and endothelial cells (ECs) in liver fibrosis.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"34 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The mechanical state of pre-tumoral epithelia controls subsequent Drosophila tumor aggressiveness 肿瘤前上皮的机械状态控制果蝇肿瘤的侵袭性
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-01-06 DOI: 10.1016/j.devcel.2024.12.006
Marianne Montemurro, Bruno Monier, Magali Suzanne
{"title":"The mechanical state of pre-tumoral epithelia controls subsequent Drosophila tumor aggressiveness","authors":"Marianne Montemurro, Bruno Monier, Magali Suzanne","doi":"10.1016/j.devcel.2024.12.006","DOIUrl":"https://doi.org/10.1016/j.devcel.2024.12.006","url":null,"abstract":"Tumors evolve through the acquisition of increasingly aggressive traits associated with dysplasia. This progression is accompanied by alterations in tumor mechanical properties, especially through extracellular matrix remodeling. However, the contribution of pre-tumoral tissue mechanics to tumor aggressiveness remains poorly known <em>in vivo</em>. Here, we show that adherens junction tension in pre-tumoral tissues dictates subsequent tumor evolution in <em>Drosophila</em>. Increased cell contractility, observed in aggressive tumors before any sign of tissue overgrowth, proved sufficient to trigger dysplasia in normally hyperplastic tumors. In addition, high contractility precedes any changes in cell polarity and contributes to tumor evolution through cell death induction, which favors cell-cell junction weakening. Overall, our results highlight the need to re-evaluate the roles of tumoral cell death and identify pre-tumoral cell mechanics as an unsuspected early marker and key trigger of tumor aggressiveness.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"21 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age-associated interplay between zinc deficiency and Golgi stress hinders microtubule-dependent cellular signaling and epigenetic control 锌缺乏和高尔基应激之间年龄相关的相互作用阻碍了微管依赖的细胞信号传导和表观遗传控制
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-01-06 DOI: 10.1016/j.devcel.2024.12.024
Sofia Brito, Hyojin Heo, Jinyoung Kim, Byungsun Cha, Youngdo Jeong, Wooseon Choi, Chandani Shrestha, Gang Hyoung Lee, Sun Ju Park, Ki Bok Yoon, Kentaro Oh-Hashi, Sung Tae Kim, Sehyun Chae, Sung Kweon Cho, Byung Mook Weon, Jiyoon Kim, Bum-Ho Bin
{"title":"Age-associated interplay between zinc deficiency and Golgi stress hinders microtubule-dependent cellular signaling and epigenetic control","authors":"Sofia Brito, Hyojin Heo, Jinyoung Kim, Byungsun Cha, Youngdo Jeong, Wooseon Choi, Chandani Shrestha, Gang Hyoung Lee, Sun Ju Park, Ki Bok Yoon, Kentaro Oh-Hashi, Sung Tae Kim, Sehyun Chae, Sung Kweon Cho, Byung Mook Weon, Jiyoon Kim, Bum-Ho Bin","doi":"10.1016/j.devcel.2024.12.024","DOIUrl":"https://doi.org/10.1016/j.devcel.2024.12.024","url":null,"abstract":"Golgi abnormalities have been linked to aging and age-related diseases, yet the underlying causes and functional consequences remain poorly understood. This study identifies the interaction between age-associated zinc deficiency and Golgi stress as a critical factor in cellular aging. Senescent Golgi bodies from human fibroblasts show a fragmented Golgi structure, associated with a decreased interaction of the zinc-dependent Golgi-stacking protein complex Golgin45-GRASP55. Golgi stress is increased, and functions such as glycosylation and vesicle transport are impaired. These disturbances promote Golgi and perinuclear microtubule disassembly and subsequent mislocalization of intracellular proteins associated with cellular signaling and epigenetic control. Pharmacological induction of Golgi stress or zinc deficiency, or ablation of the Golgi-associated zinc transporter gene <em>Zip13</em> in mouse fibroblasts, replicate the characteristics of cellular senescence, emphasizing the critical role of Golgi-zinc homeostasis. These findings highlight the importance of adequate zinc intake and suggest targeting Golgi dysfunction as a therapeutic strategy for alleviating age-related cellular decline.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"19 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How structural interactions and receptor phosphorylation shape strigolactone signaling in rice 结构相互作用和受体磷酸化如何形成水稻独角麦内酯信号
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-01-06 DOI: 10.1016/j.devcel.2024.12.029
Kawthar F. Alashoor, Salim Al-Babili
{"title":"How structural interactions and receptor phosphorylation shape strigolactone signaling in rice","authors":"Kawthar F. Alashoor, Salim Al-Babili","doi":"10.1016/j.devcel.2024.12.029","DOIUrl":"https://doi.org/10.1016/j.devcel.2024.12.029","url":null,"abstract":"The phytohormone strigolactone (SL) regulates various developmental processes and plant adaptation to nutrient availability, which in turn regulates strigolactone biosynthesis. In the recent issue of <em>Cell</em>, Hu et al.<span><span><sup>1</sup></span></span> advance the understanding of the interaction of the SL receptor complex and reveal exciting insights into the nitrogen-dependent regulation of SL signaling and SL-dependent tillering in rice.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"100 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Matrix interactions regulate epithelial polarity and cohesion in the second heart field 基质相互作用调节上皮极性和内聚在第二心脏区
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-01-06 DOI: 10.1016/j.devcel.2024.12.017
Robert G. Kelly
{"title":"Matrix interactions regulate epithelial polarity and cohesion in the second heart field","authors":"Robert G. Kelly","doi":"10.1016/j.devcel.2024.12.017","DOIUrl":"https://doi.org/10.1016/j.devcel.2024.12.017","url":null,"abstract":"Addition of epithelial progenitor cells drives progressive extension of the heart tube during cardiac morphogenesis. In this issue of <em>Developmental Cell,</em> Arriagada et al. (2024) refine our understanding of how these cells condition and interact with the underlying extracellular matrix, demonstrating that autonomous fibronectin synthesis controls their apicobasal polarity and deployment to the heart.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"34 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lactate shuttling links histone lactylation to adult hippocampal neurogenesis in mice 乳酸穿梭将组蛋白乳酸化与小鼠成年海马神经发生联系起来
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-01-06 DOI: 10.1016/j.devcel.2024.12.021
Zhimin Li, Ziqi Liang, Huan Qi, Xing Luo, Min Wang, Zhuo Du, Weixiang Guo
{"title":"Lactate shuttling links histone lactylation to adult hippocampal neurogenesis in mice","authors":"Zhimin Li, Ziqi Liang, Huan Qi, Xing Luo, Min Wang, Zhuo Du, Weixiang Guo","doi":"10.1016/j.devcel.2024.12.021","DOIUrl":"https://doi.org/10.1016/j.devcel.2024.12.021","url":null,"abstract":"Lactate has emerged as a central metabolic fuel and an important signaling molecule. Its availability participates in various brain functions. Although lactate homeostasis is vital for adult hippocampal neurogenesis and cognition, it is still unknown how shuttles lactate across the plasma membrane of neural stem cells (NSCs) to control their activity and neurogenic potential. In this study, we show that monocarboxylate transporter (MCT)1 and MCT2, respectively, control efflux and influx of lactate in the murine NSCs, thereby maintaining intracellular lactate homeostasis. Mechanistically, lactate shuttling links histone lactylation to govern NSC proliferation through MDM2-p53 signaling pathway. Notably, genetic ablation of MCT2 from NSCs or pharmacological inhibition of MDM2-P53 interaction prevents voluntary running-induced NSC proliferation in the murine adult hippocampus. Taken together, our findings demonstrate that lactate shuttling controls histone lactylation, which acts as a nexus for controlling adult hippocampal neurogenesis.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"42 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut microbiota protect against colorectal tumorigenesis through lncRNA Snhg9 肠道微生物群通过lncRNA Snhg9保护结肠直肠癌的发生
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-01-03 DOI: 10.1016/j.devcel.2024.12.013
Meng Wang, Kailin Liu, Wu Bao, Bingqing Hang, Xianjiong Chen, Xinyi Zhu, Guifang Li, Lihong Liu, Haoyi Xiang, Hai Hu, Yanhui Lu, Zhangfa Song, Jiaxin Chen, Yuhao Wang
{"title":"Gut microbiota protect against colorectal tumorigenesis through lncRNA Snhg9","authors":"Meng Wang, Kailin Liu, Wu Bao, Bingqing Hang, Xianjiong Chen, Xinyi Zhu, Guifang Li, Lihong Liu, Haoyi Xiang, Hai Hu, Yanhui Lu, Zhangfa Song, Jiaxin Chen, Yuhao Wang","doi":"10.1016/j.devcel.2024.12.013","DOIUrl":"https://doi.org/10.1016/j.devcel.2024.12.013","url":null,"abstract":"The intestinal microbiota is a key environmental factor in the development of colorectal cancer (CRC). Here, we report that, in the context of mild colonic inflammation, the microbiota protects against colorectal tumorigenesis in mice. This protection is achieved by microbial suppression of the long non-coding RNA (lncRNA) <em>Snhg9</em>. <em>Snhg9</em> promotes tumor growth through inhibition of the tumor suppressor p53. <em>Snhg9</em> suppresses p53 activity by dissociating the p53 deacetylase sirtuin 1 (SIRT1) from the cell cycle and apoptosis regulator 2 (CCAR2). Consequently, the depletion of the microbiota by antibiotics causes upregulation of <em>Snhg9</em> and accelerates CRC progression. Moreover, <em>Snhg9</em> is functionally conserved. Human <em>SNHG9</em> promotes tumor growth via the same mechanism as mouse <em>Snhg9</em>, despite their low sequence similarity.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"155 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glutathione accelerates the cell cycle and cellular reprogramming in plant regeneration 谷胱甘肽加速植物再生中的细胞周期和细胞重编程
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-01-03 DOI: 10.1016/j.devcel.2024.12.019
Laura R. Lee, Bruno Guillotin, Ramin Rahni, Chanel Hutchison, Bénédicte Desvoyes, Crisanto Gutierrez, Kenneth D. Birnbaum
{"title":"Glutathione accelerates the cell cycle and cellular reprogramming in plant regeneration","authors":"Laura R. Lee, Bruno Guillotin, Ramin Rahni, Chanel Hutchison, Bénédicte Desvoyes, Crisanto Gutierrez, Kenneth D. Birnbaum","doi":"10.1016/j.devcel.2024.12.019","DOIUrl":"https://doi.org/10.1016/j.devcel.2024.12.019","url":null,"abstract":"The plasticity of plant cells underlies their wide capacity to regenerate, with increasing evidence in plants and animals implicating cell-cycle dynamics in cellular reprogramming. To investigate the cell cycle during cellular reprogramming, we developed a comprehensive set of cell-cycle-phase markers in the Arabidopsis root. Using single-cell RNA sequencing profiles and live imaging during regeneration, we found that a subset of cells near an ablation injury dramatically increases division rate by truncating G1 phase. Cells in G1 undergo a transient nuclear peak of glutathione (GSH) prior to coordinated entry into S phase, followed by rapid divisions and cellular reprogramming. A symplastic block of the ground tissue impairs regeneration, which is rescued by exogenous GSH. We propose a model in which GSH from the outer tissues is released upon injury, licensing an exit from G1 near the wound to induce rapid cell division and reprogramming.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"34 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rice extracellular vesicles send defense proteins into fungus Rhizoctonia solani to reduce disease 水稻细胞外囊泡将防御蛋白输送到真菌枯丝核菌中以减少疾病
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-01-03 DOI: 10.1016/j.devcel.2024.12.020
Yifan Huang, Wei Li, Tiangu Liu, Xiaoli Lin, Yanhui Xia, Wenjing Zhu, Hailing Jin, Qiang Cai
{"title":"Rice extracellular vesicles send defense proteins into fungus Rhizoctonia solani to reduce disease","authors":"Yifan Huang, Wei Li, Tiangu Liu, Xiaoli Lin, Yanhui Xia, Wenjing Zhu, Hailing Jin, Qiang Cai","doi":"10.1016/j.devcel.2024.12.020","DOIUrl":"https://doi.org/10.1016/j.devcel.2024.12.020","url":null,"abstract":"The exchange of molecular information across kingdoms is crucial for the survival of both plants and their pathogens. Recent research has identified that plants transfer their small RNAs and microRNAs into fungal pathogens to suppress infection. However, whether and how plants send defense proteins into pathogens remains unknown. Here, we report that rice (<em>Oryza sativa</em>) plants package defense proteins into extracellular vesicles (EVs) and deliver them to the fungal pathogen <em>Rhizoctonia solani</em>. These EVs, enriched with host defense proteins, are internalized by the fungal cells. Reducing the transfer of host defense proteins via EVs results in increased disease susceptibility. Furthermore, the overexpression of host defense proteins in either rice plants or the fungal cells reduced the infection. Therefore, plants use EVs to send defense proteins into fungal pathogens, thereby combating infection. This mechanism represents a form of protein exchange between plants and pathogens, which contributes to reducing crop diseases.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"18 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Latent epigenetic programs in Müller glia contribute to stress and disease response in the retina 潜在的表观遗传程序在突触神经胶质有助于应激和疾病反应在视网膜
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-01-02 DOI: 10.1016/j.devcel.2024.12.014
Jackie L. Norrie, Marybeth S. Lupo, Danielle R. Little, Abbas Shirinifard, Akhilesh Mishra, Qiong Zhang, Natalie Geiger, Daniel Putnam, Nadhir Djekidel, Cody Ramirez, Beisi Xu, Jacob M. Dundee, Jiang Yu, Xiang Chen, Michael A. Dyer
{"title":"Latent epigenetic programs in Müller glia contribute to stress and disease response in the retina","authors":"Jackie L. Norrie, Marybeth S. Lupo, Danielle R. Little, Abbas Shirinifard, Akhilesh Mishra, Qiong Zhang, Natalie Geiger, Daniel Putnam, Nadhir Djekidel, Cody Ramirez, Beisi Xu, Jacob M. Dundee, Jiang Yu, Xiang Chen, Michael A. Dyer","doi":"10.1016/j.devcel.2024.12.014","DOIUrl":"https://doi.org/10.1016/j.devcel.2024.12.014","url":null,"abstract":"Previous studies have demonstrated the dynamic changes in chromatin structure during retinal development correlate with changes in gene expression. However, those studies lack cellular resolution. Here, we integrate single-cell RNA sequencing (scRNA-seq) and single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq) with bulk data to identify cell-type-specific changes in chromatin structure during human and murine development. Although promoter activity is correlated with chromatin accessibility, we discovered several hundred genes that were transcriptionally silent but had accessible chromatin at their promoters. Most of those silent/accessible gene promoters were in Müller glial cells, which function to maintain retinal homeostasis and respond to stress, injury, or disease. We refer to these as “pliancy genes” because they allow the Müller glia to rapidly change their gene expression and cellular state in response to retinal insults. The Müller glial cell pliancy program is established during development, and we demonstrate that pliancy genes are important for regulating inflammation in the murine retina <em>in vivo</em>.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"32 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142912159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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