Developmental cell最新文献_第4页

Tumors exploit interclonal Hedgehog-Wnt crosstalk to drive tumor-promoting cell competition 肿瘤利用克隆间Hedgehog-Wnt串扰来驱动肿瘤促进细胞竞争

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-08-18 DOI: 10.1016/j.devcel.2026.07.018

Du Kong, Peng Lin, Yifan Guo, Kai Lin, Sihua Zhao, Shuai Yang, Xianping Wang, Guangzhao Zhu, Lesi Xie, Shotaro Tatekawa, Jiadong Zheng, Wenyan Xu, Li He, Hideshi Ishii, Bin Jin, Kangwen Cheng, Qi Xie, Xianjue Ma

引用次数: 0

A VHL-HIF signaling axis orchestrates invariant natural killer T cell development and fate decisions VHL-HIF信号轴协调不变的自然杀伤T细胞发育和命运决定

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-08-17 DOI: 10.1016/j.devcel.2026.07.017

Qian Li, Chao Zhang, Anshu Tang, Jia Li, Yun-Cai Liu

引用次数: 0

Proteasome-dependent protein degradation shapes developmental tempo in mouse and human neural progenitors 蛋白酶体依赖的蛋白质降解影响小鼠和人类神经祖细胞的发育速度

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-08-13 DOI: 10.1016/j.devcel.2026.07.014

Shota Nakanoh,Despina Stamataki,Lorena Garcia-Perez,Chiara Azzi,Hayley L. Carr,Alexandra Pokhilko,Loukik Doshi,Giulia L.M. Boezio,Hilary Knowles,Adriana Lamas Bancalari,Manuela Melchionda,Lu Yu,Steven Howell,Mark Skehel,David Oxley,Simon Andrews,James Briscoe,Teresa Rayon

{"title":"Proteasome-dependent protein degradation shapes developmental tempo in mouse and human neural progenitors","authors":"Shota Nakanoh,Despina Stamataki,Lorena Garcia-Perez,Chiara Azzi,Hayley L. Carr,Alexandra Pokhilko,Loukik Doshi,Giulia L.M. Boezio,Hilary Knowles,Adriana Lamas Bancalari,Manuela Melchionda,Lu Yu,Steven Howell,Mark Skehel,David Oxley,Simon Andrews,James Briscoe,Teresa Rayon","doi":"10.1016/j.devcel.2026.07.014","DOIUrl":"https://doi.org/10.1016/j.devcel.2026.07.014","url":null,"abstract":"The pace of embryonic development differs between mammalian species, yet the molecular basis for this remains unknown. By comparing protein dynamics in mouse and human neural progenitors (NPs), we show that protein turnover is faster in mouse NPs, driven by higher rates of protein synthesis and degradation. Human NPs exhibit longer protein half-lives, reduced proteasomal activity, and lower proteasome abundance. These differences persist in post-mitotic neurons and are also observed in the embryonic spinal cord in vivo. Pharmacological inhibition of proteasomal activity slows differentiation in mouse NPs. Conversely, enhancing proteasomal activity accelerates neuronal output in human NPs. Moreover, accelerating the degradation of the key transcriptional repressor IRX3 in mouse NPs speeds the activation of its target gene. Together, these results provide evidence that species-specific regulation of proteasome-mediated proteolysis influences the timing of neural development and suggest that evolutionary tuning of proteasomal activity contributes to differences in embryonic developmental pace.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"10 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148717822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic differences in protein stability underlie species-specific developmental tempo 蛋白质稳定性的系统差异是物种特异性发育速度的基础

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-08-13 DOI: 10.1016/j.devcel.2026.07.012

Mitsuhiro Matsuda,Henrik M. Hammarén,Jorge Lázaro,Mikhail M. Savitski,Miki Ebisuya

{"title":"Systematic differences in protein stability underlie species-specific developmental tempo","authors":"Mitsuhiro Matsuda,Henrik M. Hammarén,Jorge Lázaro,Mikhail M. Savitski,Miki Ebisuya","doi":"10.1016/j.devcel.2026.07.012","DOIUrl":"https://doi.org/10.1016/j.devcel.2026.07.012","url":null,"abstract":"Human embryonic development proceeds more slowly than in mice. The segmentation clock offers a tractable model for studying species-specific developmental tempo, as its oscillation period in human induced presomitic mesoderm (iPSM) cells is approximately twice that of mouse. While the core clock gene HES7 exhibits slower protein degradation in human cells, it remains unclear whether such cross-species differences in protein stability reflect a general principle. Here, we perform a dynamic stable isotope labeling of amino acids in cell culture (SILAC)-based proteomic analysis of ∼5,000 proteins in human and mouse iPSM, and we uncover a broad trend of slower protein degradation in human cells, regardless of subcellular localization or degradation pathways. Moreover, inhibition of glycolysis in mouse iPSM partially phenocopies the human protein stability profile, and modulation of protein stability alters the tempo of both the segmentation clock and cellular differentiation. Our findings establish protein stability, with systematic differences across species, as a key mediator linking metabolism to developmental tempo.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"18 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148717821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wiring autophagy: Neural circuits regulate lysosomal homeostasis in muscle 线路自噬：神经回路调节肌肉中的溶酶体稳态

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-08-12 DOI: 10.1016/j.devcel.2026.07.008

Min Chen, Congcong He

引用次数: 0

Uncovering mammalian fertilization dynamics 揭示哺乳动物受精动力学

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-08-12 DOI: 10.1016/j.devcel.2026.07.004

Tianyu Wu, Lei Wang

引用次数: 0

Redox signaling in development: An emerging frontier. 氧化还原信号的发展：一个新兴的前沿。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-08-12 Epub Date: 2026-07-31 DOI: 10.1016/j.devcel.2026.07.005

Agnes Ulfig, Ursula Jakob

{"title":"Redox signaling in development: An emerging frontier.","authors":"Agnes Ulfig, Ursula Jakob","doi":"10.1016/j.devcel.2026.07.005","DOIUrl":"10.1016/j.devcel.2026.07.005","url":null,"abstract":"<p><p>Oxygen availability is crucial for embryonic development, influencing cellular metabolism and signaling within the embryo. Fluctuations in oxygen tension disrupt the equilibrium between glycolysis and mitochondrial respiration, leading to localized alterations in reactive oxygen species (ROS) production. At physiological levels, ROS, particularly hydrogen peroxide (H₂O₂), act as important signaling molecules. They actively modulate cellular processes through reversible oxidation of critical cysteine residues in redox-sensitive proteins, thereby fine-tuning the activities of various signaling pathways, transcription factors, and epigenetic regulators. Despite limited studies directly investigating ROS signaling in development, substantial literature suggests that many developmental pathways are influenced by ROS. This review aims to synthesize this existing evidence, explore the molecular mechanisms of thiol-dependent regulation, and examine how disruptions in redox balance impact cell fate decisions, developmental timing, and tissue morphogenesis. Our goal is to catalyze further research in this promising yet heavily underexplored area, highlighting its significance and timeliness.</p>","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":" ","pages":"1604-1619"},"PeriodicalIF":9.2,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148648409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A TREK that activates thermogenic adipose tissue by sensing cold air in the lung 一种通过感知肺部冷空气来激活产热脂肪组织的TREK

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-08-12 DOI: 10.1016/j.devcel.2026.07.016

Andrew D.J. Tu, Deane F. Mosher, Judith A. Simcox

引用次数: 0

Prolonged cold exposure enhances regeneration potential in Arabidopsis 长时间的冷暴露提高了拟南芥的再生潜力

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-08-12 DOI: 10.1016/j.devcel.2026.07.009

Fu-Yu Hung, Yetkin Caka Ince, Ayako Kawamura, Arika Takebayashi, Yu Chen, Takuya T. Nagae, Akira Iwase, Noriko Takeda-Kamiya, Kiminori Toyooka, Dongbo Shi, Miguel Moreno-Risueno, Keqiang Wu, Keiko Sugimoto

引用次数: 0

Two parallel neuronal circuits involving electrical synapse and DAF-7/TGF-β signaling regulate muscle autophagy in C. elegans. 涉及电突触和DAF-7/TGF-β信号的两个平行神经元回路调节秀丽隐杆线虫的肌肉自噬。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-08-12 Epub Date: 2026-06-29 DOI: 10.1016/j.devcel.2026.06.001

Hui Zheng, Hongyu Zhao, Hong Zhang

引用次数: 0