单细胞时代乳腺上皮细胞类型的界定

IF 8.7 1区生物学 Q1 CELL BIOLOGY

Developmental cell Pub Date : 2025-09-08 DOI:10.1016/j.devcel.2025.06.032

G. Kenneth Gray, Eric G. Carlson, Tatyana Lev, Bailey Marshall, Austin D. Reed, Alex P. Sánchez-Covarrubias, Alecia-Jane Twigger, Aleix Puig-Barbe, Aatish Thennavan, Ayodele Omotoso, Lyndsay M. Murrow, Deeptiman Chatterjee, Siyuan He, Sara Pensa, Brian Aevermann, Norbert K. Tavares, Natalie Chen, Jason A. Hilton, Kerrigan Blake, Yunlong Liu, Walid T. Khaled

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引用次数: 0

摘要

乳腺组织的单细胞研究有助于改变我们对乳腺上皮多样性的理解，而这反过来又导致了对乳腺细胞类型缺乏共识。围绕这一问题的困惑凸显了推进乳房地图集工作可能面临的挑战。从这个角度来看，我们提出了我们对乳腺上皮细胞类型的身份、性质和命名惯例的共识，并提出了未来图谱工作的目标。我们的建议及其潜在的思考过程旨在促进这种组织的共享模型的采用，并为面临类似挑战的其他研究人员提供指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Defining breast epithelial cell types in the single-cell era

Single-cell studies on breast tissue have contributed to a change in our understanding of breast epithelial diversity that has, in turn, precipitated a lack of consensus on breast cell types. The confusion surrounding this issue highlights a possible challenge for advancing breast atlas efforts. In this perspective, we present our consensus on the identities, properties, and naming conventions for breast epithelial cell types and propose goals for future atlas endeavors. Our proposals and their underlying thought processes aim to catalyze the adoption of a shared model for this tissue and to serve as guidance for other investigators facing similar challenges.

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来源期刊

Developmental cell 生物-发育生物学

CiteScore

18.90

自引率

1.70%

发文量

203

审稿时长

3-6 weeks

期刊介绍： Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.