Developmental cell最新文献

A natural brake tunes early calcium signaling and salt tolerance in rice 一个天然的刹车调节了水稻早期钙信号和耐盐性

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-10-14 DOI: 10.1016/j.devcel.2026.08.014

Yasufumi Kobayashi,Miki Fujita,Yasunari Fujita

引用次数: 0

Squeezed to death: Mechanical control of MLKL beyond RIPK3 挤压致死：机械控制MLKL超越RIPK3

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-10-14 DOI: 10.1016/j.devcel.2026.09.011

Gianmaria Liccardi

引用次数: 0

Cancer stem cells as adaptive sensors of the metastatic microenvironment 肿瘤干细胞作为转移性微环境的适应性传感器

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-10-14 DOI: 10.1016/j.devcel.2026.09.007

Stephanie Ma

引用次数: 0

Evasive encounters: Immunomodulatory CAFs interact with Tregs in the lung cancer microenvironment 逃避遭遇：免疫调节的CAFs与肺癌微环境中的treg相互作用

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-10-14 DOI: 10.1016/j.devcel.2026.09.012

Lucas Onder,Hung-Wei Cheng,Burkhard Ludewig

引用次数: 0

Mitochondria strike two hits to drive the SASP 线粒体通过两次撞击来驱动SASP

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-10-14 DOI: 10.1016/j.devcel.2026.09.010

Jun Bum Park,Zhixun Dou

引用次数: 0

Nitrate-sialin2 signaling coordinates stress granule assembly and autophagic recovery 硝酸盐-唾液素2信号协调应激颗粒组装和自噬恢复

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-10-14 DOI: 10.1016/j.devcel.2026.09.002

Huihui Li,Kefeng Lu

引用次数: 0

Cell cycle arrest of a craniofacial epithelial population shapes faces in mice and humans. 颅面上皮细胞周期阻滞形成小鼠和人类的面部。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-10-14 Epub Date: 2026-10-09 DOI: 10.1016/j.devcel.2026.09.008

T Qu, L Faure, R Hernández-Martínez, B H Chacón, M Losa, K Robinson, A Jones, S Lisgo, V Hermosilla-Aguayo, V Laub, J De Anda, R J Aho, M Risolino, G Panagiotakos, E J Leslie-Clarkson, I Adameyko, L Selleri

{"title":"Cell cycle arrest of a craniofacial epithelial population shapes faces in mice and humans.","authors":"T Qu, L Faure, R Hernández-Martínez, B H Chacón, M Losa, K Robinson, A Jones, S Lisgo, V Hermosilla-Aguayo, V Laub, J De Anda, R J Aho, M Risolino, G Panagiotakos, E J Leslie-Clarkson, I Adameyko, L Selleri","doi":"10.1016/j.devcel.2026.09.008","DOIUrl":"10.1016/j.devcel.2026.09.008","url":null,"abstract":"The mechanisms that shape human facial features and lead to abnormalities if disrupted are complex and multilayered. Orofacial clefting (OFC), the most common craniofacial disorder, results from a failed fusion of facial prominences, partly driven by persisting of cephalic epithelia. Here, we characterize an epithelial cell population, the zippering lambda (ZL), which is cell cycle-arrested and mediates facial prominence fusion in mice and humans. We find uninhibited cell cycle progression in the ZL of Pbx1/2 and p63 mutant mice with OFC. A comparison of ZL-enriched genes with human OFC whole-genome sequencing datasets identifies Zinc-finger homeobox 3 (ZFHX3) variants in affected individuals. Notably, the deletion of Zfhx3 in cephalic epithelia initiates murine OFC. Zfhx3 and Pbx1 genetically interact, and their protein products cooperatively downregulate cell cycle inhibitors in embryonic facial development. Taken together, we reveal a facial patterning mechanism that links cell cycle arrest to developmental tissue fusion.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":" ","pages":"2030-2048.e11"},"PeriodicalIF":9.2,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural variation in TOLS1 modulates salt tolerance via OsRacB-Ca²⁺ signaling pathway in rice. TOLS1的自然变异通过OsRacB-Ca2+信号通路调节水稻的耐盐性。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-10-14 Epub Date: 2026-08-28 DOI: 10.1016/j.devcel.2026.08.003

Jinglei Feng, Yu Zhang, Yibin Li, Wei Luo, Jie Cao, Fang Yin, Guohua Liang, Yunyuan Xu, Xiaoyu Guo, Kang Chong

{"title":"Natural variation in TOLS1 modulates salt tolerance via OsRacB-Ca2+ signaling pathway in rice.","authors":"Jinglei Feng, Yu Zhang, Yibin Li, Wei Luo, Jie Cao, Fang Yin, Guohua Liang, Yunyuan Xu, Xiaoyu Guo, Kang Chong","doi":"10.1016/j.devcel.2026.08.003","DOIUrl":"10.1016/j.devcel.2026.08.003","url":null,"abstract":"Salt stress severely limits rice productivity, yet the genetic basis of natural variation and the underlying mechanism remain poorly understood. Here, through genome-wide association analysis and fine-mapping, we identify a major quantitative trait locus (QTL) gene, Tolerance to Salt 1 (TOLS1), that negatively regulates salt tolerance in rice. Overexpression of TOLS1 increases salt sensitivity, whereas loss of function enhances salt tolerance. TOLS1 interacts with the small guanosine triphosphatase (GTPase) OsRacB and enhances its GTPase activity, thereby attenuating salt-induced cytosolic Ca2+ elevation. We further identify a natural coding variation, SNP9 (+1018 A/G), in TOLS1 that contributes to functional divergence, with the TOLS1A allele exerting a stronger negative effect on salt tolerance than TOLS1G. Collectively, these findings reveal that natural variation in TOLS1 modulates OsRacB-Ca2+ signaling and thereby contributes to salt tolerance divergence in rice. This study provides mechanistic insight into how TOLS1 allelic variation regulates salt signaling and offers a potential target for molecular design breeding.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":" ","pages":"1969-1983.e6"},"PeriodicalIF":9.2,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

More than fuel: Metabolic states shape cell fate in the human neocortex 不仅仅是燃料：代谢状态决定了人类新皮层细胞的命运

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-10-14 DOI: 10.1016/j.devcel.2026.09.009

Iacopo Bicci,Mina Gouti

引用次数: 0

Chromatin context shapes SPT5 regulation of promoter-proximal Pol II, fine-tuning gene expression changes during Drosophila embryogenesis. 染色质环境塑造SPT5调控启动子-近端Pol II，微调果蝇胚胎发生过程中的基因表达变化。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-10-14 Epub Date: 2026-09-04 DOI: 10.1016/j.devcel.2026.08.008

Alessandro Dulja, Marvin Mayer, Niklas Engel, Arkadiy K Golov, Katharina Bender, Mattia Forneris, Yacine Kherdjemil, Songjie Feng, Rebecca R Viales, Eileen E M Furlong

{"title":"Chromatin context shapes SPT5 regulation of promoter-proximal Pol II, fine-tuning gene expression changes during Drosophila embryogenesis.","authors":"Alessandro Dulja, Marvin Mayer, Niklas Engel, Arkadiy K Golov, Katharina Bender, Mattia Forneris, Yacine Kherdjemil, Songjie Feng, Rebecca R Viales, Eileen E M Furlong","doi":"10.1016/j.devcel.2026.08.008","DOIUrl":"10.1016/j.devcel.2026.08.008","url":null,"abstract":"Transcription involves initiation, pausing, elongation, and termination. Suppressor of Ty5 (SPT5) regulates promoter-proximal pausing and elongation, but how it orchestrates both steps during dynamic developmental changes in gene expression remains unclear. Here, using rapid optogenetic depletion in Drosophila embryos, we uncover different consequences of SPT5 removal at different developmental stages. In early embryos, SPT5 depletion causes a shift of RNA polymerase II (Pol II) from the canonical pausing site to the +1 nucleosome, which is strongly positioned. In late embryos, SPT5 depletion similarly reduces pausing at the canonical site, but the transcriptional machinery can overcome the +1 nucleosome-which appears more labile at this time point-moving into the gene body. This results in lethality and both up- and downregulation of expression, depending on the balance between Pol II entering the gene body and defective elongation. This is intensified for genes naturally increasing or decreasing their expression, indicating that SPT5 contributes to fine-tuning dynamic expression changes.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":" ","pages":"2001-2015.e9"},"PeriodicalIF":9.2,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0