prc2介导的PIF4抑制目标超出了基因表达的开/关开关

IF 8.7 1区生物学 Q1 CELL BIOLOGY

Developmental cell Pub Date : 2025-08-04 DOI:10.1016/j.devcel.2025.07.005

Zhe Wu

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引用次数: 0

摘要

在这一期的《发育细胞》中，Osborne等人报道了被植物特异性多栉抑制复合体2 （PRC2）亚基VERNALIZATION 2 （VRN2）通过稳定沉积H3K27me3以光依赖的方式抑制光敏色素相互作用因子（PIF）靶点来调节叶片生长这项工作扩展了PRC2的功能，不仅仅是作为基因表达的开关，揭示了植物中polycomb-group介导的抑制。

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PRC2-mediated repression of PIF4 targets beyond the on/off switch of gene expression

In this issue of Developmental Cell, Osborne et al. report that the angiosperm-specific polycomb repressive complex 2 (PRC2) subunit VERNALIZATION 2 (VRN2) regulates leaf growth by stable deposition of H3K27me3 to repress PHYTOCHROME INTERACTING FACTOR (PIF) targets in a light-dependent manner.¹ This work extends the function of PRC2 beyond serving as an on/off switch of gene expression, shedding light on polycomb-group-mediated repression in plants.

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来源期刊

Developmental cell 生物-发育生物学

CiteScore

18.90

自引率

1.70%

发文量

203

审稿时长

3-6 weeks

期刊介绍： Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.