Developmental cell最新文献_第10页

Opposing polarity domains provide direction and play a role in cell division in plant growth 相反的极性结构域在植物生长过程中为细胞分裂提供方向并发挥作用

IF 11.8 1区生物学

Developmental cell Pub Date : 2024-05-06 DOI: 10.1016/j.devcel.2024.04.010

Olivia Hazelwood, M. Arif Ashraf

引用次数: 0

Villus myofibroblasts are developmental and adult progenitors of mammalian gut lymphatic musculature. 绒毛肌成纤维细胞是哺乳动物肠道淋巴肌肉的发育和成体祖细胞。

IF 11.8 1区生物学

Developmental cell Pub Date : 2024-05-06 Epub Date: 2024-03-26 DOI: 10.1016/j.devcel.2024.03.005

Bhargav D Sanketi, Madhav Mantri, Liqing Huang, Mohammad A Tavallaei, Shing Hu, Michael F Z Wang, Iwijn De Vlaminck, Natasza A Kurpios

{"title":"Villus myofibroblasts are developmental and adult progenitors of mammalian gut lymphatic musculature.","authors":"Bhargav D Sanketi, Madhav Mantri, Liqing Huang, Mohammad A Tavallaei, Shing Hu, Michael F Z Wang, Iwijn De Vlaminck, Natasza A Kurpios","doi":"10.1016/j.devcel.2024.03.005","DOIUrl":"10.1016/j.devcel.2024.03.005","url":null,"abstract":"Inside the finger-like intestinal projections called villi, strands of smooth muscle cells contract to propel absorbed dietary fats through the adjacent lymphatic capillary, the lacteal, sending fats into the systemic blood circulation for energy production. Despite this vital function, mechanisms of formation, assembly alongside lacteals, and maintenance of villus smooth muscle are unknown. By combining single-cell RNA sequencing and quantitative lineage tracing of the mouse intestine, we identified a local hierarchy of subepithelial fibroblast progenitors that differentiate into mature smooth muscle fibers via intermediate contractile myofibroblasts. This continuum persists as the major mechanism for villus musculature renewal throughout adult life. The NOTCH3-DLL4 signaling axis governs the assembly of smooth muscle fibers alongside their adjacent lacteals and is required for fat absorption. Our studies identify the ontogeny and maintenance of a poorly defined class of intestinal smooth muscle, with implications for accelerated repair and recovery of digestive function following injury.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":null,"pages":null},"PeriodicalIF":11.8,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11078612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatially resolved proteomics of the Arabidopsis stomatal lineage identifies polarity complexes for cell divisions and stomatal pores. 拟南芥气孔系的空间解析蛋白质组学确定了细胞分裂和气孔的极性复合体。

IF 11.8 1区生物学

Developmental cell Pub Date : 2024-05-06 Epub Date: 2024-03-21 DOI: 10.1016/j.devcel.2024.03.001

Eva-Sophie Wallner, Andrea Mair, Dominik Handler, Claire McWhite, Shou-Ling Xu, Liam Dolan, Dominique C Bergmann

{"title":"Spatially resolved proteomics of the Arabidopsis stomatal lineage identifies polarity complexes for cell divisions and stomatal pores.","authors":"Eva-Sophie Wallner, Andrea Mair, Dominik Handler, Claire McWhite, Shou-Ling Xu, Liam Dolan, Dominique C Bergmann","doi":"10.1016/j.devcel.2024.03.001","DOIUrl":"10.1016/j.devcel.2024.03.001","url":null,"abstract":"Cell polarity is used to guide asymmetric divisions and create morphologically diverse cells. We find that two oppositely oriented cortical polarity domains present during the asymmetric divisions in the Arabidopsis stomatal lineage are reconfigured into polar domains marking ventral (pore-forming) and outward-facing domains of maturing stomatal guard cells. Proteins that define these opposing polarity domains were used as baits in miniTurboID-based proximity labeling. Among differentially enriched proteins, we find kinases, putative microtubule-interacting proteins, and polar SOSEKIs with their effector ANGUSTIFOLIA. Using AI-facilitated protein structure prediction models, we identify potential protein-protein interaction interfaces among them. Functional and localization analyses of the polarity protein OPL2 and its putative interaction partners suggest a positive interaction with mitotic microtubules and a role in cytokinesis. This combination of proteomics and structural modeling with live-cell imaging provides insights into how polarity is rewired in different cell types and cell-cycle stages.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":null,"pages":null},"PeriodicalIF":11.8,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140189583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tracing embryonic hematopoiesis guides induction of pluripotent stem cells to hematopoietic progenitors 追踪胚胎造血过程，引导多能干细胞诱导为造血祖细胞

IF 11.8 1区生物学

Developmental cell Pub Date : 2024-05-06 DOI: 10.1016/j.devcel.2024.04.001

Xinjian Mao, Linheng Li

引用次数: 0

Metaplastic regeneration in the mouse stomach requires a reactive oxygen species pathway. 小鼠胃中的移行细胞再生需要活性氧途径。

IF 11.8 1区生物学

Developmental cell Pub Date : 2024-05-06 Epub Date: 2024-03-22 DOI: 10.1016/j.devcel.2024.03.002

Zhi-Feng Miao, Jing-Xu Sun, Xuan-Zhang Huang, Shi Bai, Min-Jiao Pang, Jia-Yi Li, Han-Yu Chen, Qi-Yue Tong, Shi-Yu Ye, Xin-Yu Wang, Xiao-Hai Hu, Jing-Ying Li, Jin-Wei Zou, Wen Xu, Jun-Hao Yang, Xi Lu, Jason C Mills, Zhen-Ning Wang

{"title":"Metaplastic regeneration in the mouse stomach requires a reactive oxygen species pathway.","authors":"Zhi-Feng Miao, Jing-Xu Sun, Xuan-Zhang Huang, Shi Bai, Min-Jiao Pang, Jia-Yi Li, Han-Yu Chen, Qi-Yue Tong, Shi-Yu Ye, Xin-Yu Wang, Xiao-Hai Hu, Jing-Ying Li, Jin-Wei Zou, Wen Xu, Jun-Hao Yang, Xi Lu, Jason C Mills, Zhen-Ning Wang","doi":"10.1016/j.devcel.2024.03.002","DOIUrl":"10.1016/j.devcel.2024.03.002","url":null,"abstract":"In pyloric metaplasia, mature gastric chief cells reprogram via an evolutionarily conserved process termed paligenosis to re-enter the cell cycle and become spasmolytic polypeptide-expressing metaplasia (SPEM) cells. Here, we use single-cell RNA sequencing (scRNA-seq) following injury to the murine stomach to analyze mechanisms governing paligenosis at high resolution. Injury causes induced reactive oxygen species (ROS) with coordinated changes in mitochondrial activity and cellular metabolism, requiring the transcriptional mitochondrial regulator Ppargc1a (Pgc1α) and ROS regulator Nf2el2 (Nrf2). Loss of the ROS and mitochondrial control in Ppargc1a-/- mice causes the death of paligenotic cells through ferroptosis. Blocking the cystine transporter SLC7A11(xCT), which is critical in lipid radical detoxification through glutathione peroxidase 4 (GPX4), also increases ferroptosis. Finally, we show that PGC1α-mediated ROS and mitochondrial changes also underlie the paligenosis of pancreatic acinar cells. Altogether, the results detail how metabolic and mitochondrial changes are necessary for injury response, regeneration, and metaplasia in the stomach.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":null,"pages":null},"PeriodicalIF":11.8,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cox7a1 controls skeletal muscle physiology and heart regeneration through complex IV dimerization Cox7a1通过复合体IV二聚化控制骨骼肌生理机能和心脏再生

IF 11.8 1区生物学

Developmental cell Pub Date : 2024-05-02 DOI: 10.1016/j.devcel.2024.04.012

Carolina García-Poyatos, Prateek Arora, Enrique Calvo, Ines J. Marques, Nick Kirschke, Maria Galardi-Castilla, Carla Lembke, Marco Meer, Paula Fernández-Montes, Alexander Ernst, David Haberthür, Ruslan Hlushchuk, Jesús Vázquez, Peter Vermathen, José Antonio Enríquez, Nadia Mercader

{"title":"Cox7a1 controls skeletal muscle physiology and heart regeneration through complex IV dimerization","authors":"Carolina García-Poyatos, Prateek Arora, Enrique Calvo, Ines J. Marques, Nick Kirschke, Maria Galardi-Castilla, Carla Lembke, Marco Meer, Paula Fernández-Montes, Alexander Ernst, David Haberthür, Ruslan Hlushchuk, Jesús Vázquez, Peter Vermathen, José Antonio Enríquez, Nadia Mercader","doi":"10.1016/j.devcel.2024.04.012","DOIUrl":"https://doi.org/10.1016/j.devcel.2024.04.012","url":null,"abstract":"The oxidative phosphorylation (OXPHOS) system is intricately organized, with respiratory complexes forming super-assembled quaternary structures whose assembly mechanisms and physiological roles remain under investigation. Cox7a2l, also known as Scaf1, facilitates complex III and complex IV (CIII-CIV) super-assembly, enhancing energetic efficiency in various species. We examined the role of Cox7a1, another Cox7a family member, in supercomplex assembly and muscle physiology. Zebrafish lacking Cox7a1 exhibited reduced CIV2 formation, metabolic alterations, and non-pathological muscle performance decline. Additionally, cox7a1−/− hearts displayed a pro-regenerative metabolic profile, impacting cardiac regenerative response. The distinct phenotypic effects of cox7a1−/− and cox7a2l−/− underscore the diverse metabolic and physiological consequences of impaired supercomplex formation, emphasizing the significance of Cox7a1 in muscle maturation within the OXPHOS system.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":null,"pages":null},"PeriodicalIF":11.8,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140819684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Notochord segmentation in zebrafish controlled by iterative mechanical signaling 斑马鱼的脊索节段受迭代机械信号控制

IF 11.8 1区生物学

Developmental cell Pub Date : 2024-05-01 DOI: 10.1016/j.devcel.2024.04.013

Susan Wopat, Priyom Adhyapok, Bijoy Daga, Janice M. Crawford, James Norman, Jennifer Bagwell, Brianna Peskin, Indrasen Magre, Stephanie M. Fogerson, Daniel S. Levic, Stefano Di Talia, Daniel P. Kiehart, Patrick Charbonneau, Michel Bagnat

{"title":"Notochord segmentation in zebrafish controlled by iterative mechanical signaling","authors":"Susan Wopat, Priyom Adhyapok, Bijoy Daga, Janice M. Crawford, James Norman, Jennifer Bagwell, Brianna Peskin, Indrasen Magre, Stephanie M. Fogerson, Daniel S. Levic, Stefano Di Talia, Daniel P. Kiehart, Patrick Charbonneau, Michel Bagnat","doi":"10.1016/j.devcel.2024.04.013","DOIUrl":"https://doi.org/10.1016/j.devcel.2024.04.013","url":null,"abstract":"In bony fishes, patterning of the vertebral column, or spine, is guided by a metameric blueprint established in the notochord sheath. Notochord segmentation begins days after somitogenesis concludes and can occur in its absence. However, somite patterning defects lead to imprecise notochord segmentation, suggesting that these processes are linked. Here, we identify that interactions between the notochord and the axial musculature ensure precise spatiotemporal segmentation of the zebrafish spine. We demonstrate that myoseptum-notochord linkages drive notochord segment initiation by locally deforming the notochord extracellular matrix and recruiting focal adhesion machinery at these contact points. Irregular somite patterning alters this mechanical signaling, causing non-sequential and dysmorphic notochord segmentation, leading to altered spine development. Using a model that captures myoseptum-notochord interactions, we find that a fixed spatial interval is critical for driving sequential segment initiation. Thus, mechanical coupling of axial tissues facilitates spatiotemporal spine patterning.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":null,"pages":null},"PeriodicalIF":11.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140817574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A cellular tilting mechanism important for dynamic tissue shape changes and cell differentiation in Drosophila 对果蝇动态组织形状变化和细胞分化非常重要的细胞倾斜机制

IF 11.8 1区生物学

Developmental cell Pub Date : 2024-04-30 DOI: 10.1016/j.devcel.2024.04.011

Liyuan Sui, Christian Dahmann

引用次数: 0

A critical suppression feedback loop determines soybean photoperiod sensitivity 决定大豆光周期敏感性的关键抑制反馈回路

IF 11.8 1区生物学

Developmental cell Pub Date : 2024-04-29 DOI: 10.1016/j.devcel.2024.04.004

Xiaohui Zhao, Haiyang Li, Lingshuang Wang, Jianhao Wang, Zerong Huang, Haiping Du, Yaru Li, Jiahui Yang, Milan He, Qun Cheng, Xiaoya Lin, Baohui Liu, Fanjiang Kong

{"title":"A critical suppression feedback loop determines soybean photoperiod sensitivity","authors":"Xiaohui Zhao, Haiyang Li, Lingshuang Wang, Jianhao Wang, Zerong Huang, Haiping Du, Yaru Li, Jiahui Yang, Milan He, Qun Cheng, Xiaoya Lin, Baohui Liu, Fanjiang Kong","doi":"10.1016/j.devcel.2024.04.004","DOIUrl":"https://doi.org/10.1016/j.devcel.2024.04.004","url":null,"abstract":"Photoperiod sensitivity is crucial for soybean flowering, adaptation, and yield. In soybean, photoperiod sensitivity centers around the evening complex (EC) that regulates the transcriptional level of the core transcription factor E1, thereby regulating flowering. However, little is known about the regulation of the activity of EC. Our study identifies how E2/GIGANTEA (GI) and its homologs modulate photoperiod sensitivity through interactions with the EC. During long days, E2 interacts with the blue-light receptor flavin-binding, kelch repeat, F box 1 (FKF1), leading to the degradation of J/ELF3, an EC component. EC also suppresses E2 expression by binding to its promoter. This interplay forms a photoperiod regulatory loop, maintaining sensitivity to photoperiod. Disruption of this loop leads to losing sensitivity, affecting soybean’s adaptability and yield. Understanding this loop’s dynamics is vital for molecular breeding to reduce soybean’s photoperiod sensitivity and develop cultivars with better adaptability and higher yields, potentially leading to the creation of photoperiod-insensitive varieties for broader agricultural applications.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":null,"pages":null},"PeriodicalIF":11.8,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140808640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photoregulatory protein kinases fine-tune plant photomorphogenesis by directing a bifunctional phospho-code on HY5 in Arabidopsis 光调节蛋白激酶通过引导拟南芥 HY5 上的双功能磷酸代码微调植物光形态发生

IF 11.8 1区生物学

Developmental cell Pub Date : 2024-04-26 DOI: 10.1016/j.devcel.2024.04.007

Nan Zhang, Chuang-Qi Wei, Da-Jin Xu, Zhi-Ping Deng, Ya-Chao Zhao, Lian-Feng Ai, Ying Sun, Zhi-Yong Wang, Sheng-Wei Zhang

{"title":"Photoregulatory protein kinases fine-tune plant photomorphogenesis by directing a bifunctional phospho-code on HY5 in Arabidopsis","authors":"Nan Zhang, Chuang-Qi Wei, Da-Jin Xu, Zhi-Ping Deng, Ya-Chao Zhao, Lian-Feng Ai, Ying Sun, Zhi-Yong Wang, Sheng-Wei Zhang","doi":"10.1016/j.devcel.2024.04.007","DOIUrl":"https://doi.org/10.1016/j.devcel.2024.04.007","url":null,"abstract":"Photomorphogenesis is a light-dependent plant growth and development program. As the core regulator of photomorphogenesis, ELONGATED HYPOCOTYL 5 (HY5) is affected by dynamic changes in its transcriptional activity and protein stability; however, little is known about the mediators of these processes. Here, we identified PHOTOREGULATORY PROTEIN KINASE 1 (PPK1), which interacts with and phosphorylates HY5 in Arabidopsis, as one such mediator. The phosphorylation of HY5 by PPK1 is essential to establish high-affinity binding with B-BOX PROTEIN 24 (BBX24) and CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1), which inhibit the transcriptional activity and promote the degradation of HY5, respectively. As such, PPKs regulate not only the binding of HY5 to its target genes under light conditions but also HY5 degradation when plants are transferred from light to dark. Our data identify a PPK-mediated phospho-code on HY5 that integrates the molecular mechanisms underlying the regulation of HY5 to precisely control plant photomorphogenesis.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":null,"pages":null},"PeriodicalIF":11.8,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140648391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0