Developmental cell最新文献_第9页

Molecular cues from distinct neuron classes drive differential myelination in the neocortex. 来自不同神经元类别的分子线索驱动新皮层中不同的髓鞘形成。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-06-10 Epub Date: 2026-06-02 DOI: 10.1016/j.devcel.2026.05.002

Nuria Domínguez-Iturza, Vahbiz Jokhi, Kwanho Kim, Ashwin S Shetty, Daniela J Di Bella, Milagros Pereira Luppi, Wen Yuan, Catherine Abbate, Paul Oyler-Castrillo, Nalini A Oliver, Vaishnavi Venkat, Xin Jin, Sean Simmons, Joshua Z Levin, Juliana R Brown, Paola Arlotta

{"title":"Molecular cues from distinct neuron classes drive differential myelination in the neocortex.","authors":"Nuria Domínguez-Iturza, Vahbiz Jokhi, Kwanho Kim, Ashwin S Shetty, Daniela J Di Bella, Milagros Pereira Luppi, Wen Yuan, Catherine Abbate, Paul Oyler-Castrillo, Nalini A Oliver, Vaishnavi Venkat, Xin Jin, Sean Simmons, Joshua Z Levin, Juliana R Brown, Paola Arlotta","doi":"10.1016/j.devcel.2026.05.002","DOIUrl":"10.1016/j.devcel.2026.05.002","url":null,"abstract":"Oligodendrocytes deposit different amounts of myelin in each neocortical layer, but the regulatory process remains unclear. We present a single-cell map of oligodendrocyte lineage cells purified from different layers of the neocortex across developmental stages. We find that each layer contains a similar compendium of oligodendrocyte classes and differs primarily in the proportions of maturation states, suggesting that oligodendrocyte heterogeneity cannot explain layer-specific myelination. We show that signals from different classes of pyramidal neurons can control oligodendrocyte maturation and the differential distribution of myelin across cortical layers. We generated a ligand-receptor interactome to predict interactions between projection neuron types and oligodendrocyte states, across cortical layers and time, and validated candidates in vivo. We find that neuronal expression of Fgf18, Ncam1, and Rspo3 promotes cortical myelination. This work provides a comprehensive molecular description of oligodendrocyte development in the mouse cortex, pointing to mechanisms whereby neuron-class-linked signals modulate myelin distribution in the neocortex.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":" ","pages":"1303-1318.e8"},"PeriodicalIF":9.2,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13322639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor-intrinsic FDFT1 determines coordinated macrophage anti-tumor immunity. 肿瘤内生性FDFT1决定协调巨噬细胞抗肿瘤免疫。

IF 8.7 1区生物学

Developmental cell Pub Date : 2026-06-10 Epub Date: 2026-04-29 DOI: 10.1016/j.devcel.2026.04.003

Rongchen Shi, Yulan Huang, Pengfei Zheng, Dapeng Zhang, Qing Qin, Fan Zhang, Meng Wang, Kun Zhao, Minli Yang, Xu Guan, Renchao Deng, Hongming Miao

{"title":"Tumor-intrinsic FDFT1 determines coordinated macrophage anti-tumor immunity.","authors":"Rongchen Shi, Yulan Huang, Pengfei Zheng, Dapeng Zhang, Qing Qin, Fan Zhang, Meng Wang, Kun Zhao, Minli Yang, Xu Guan, Renchao Deng, Hongming Miao","doi":"10.1016/j.devcel.2026.04.003","DOIUrl":"10.1016/j.devcel.2026.04.003","url":null,"abstract":"Macrophage anti-tumor efficacy requires coordinated inflammatory activation and phagocytic function, whether a tumor-intrinsic metabolic regulator simultaneously determines both macrophage anti-tumor mechanisms remains unclear. Here, we screened and identified that farnesyl-diphosphate farnesyltransferase 1 (FDFT1) drives the dual inhibition of macrophage activation and phagocytic function and promotes tumor progression. Mechanistically, tumor-intrinsic FDFT1 directly binds to STAT3 and facilitates the later phosphorylation, which induces PD-L1-dependent suppression of macrophage phagocytosis. Concurrently, FDFT1 binds to and stabilizes cholesterol 25-hydroxylase (CH25H) to promote the secretion of 25-hydroxycholesterol (25HC), suppressing proinflammatory activation of macrophages. Furthermore, FDFT1-mediated dual anti-tumor pathways were validated in mouse tumor models and correlated with clinical pathophysiology. Notably, a small-molecule drug FDFT1-I (2123) targeting FDFT1 inhibits both STAT3-PD-L1 and CH25H/25HC pathways and improves anti-tumor immunity. Collectively, our findings highlight FDFT1 as a tumor-intrinsic metabolic factor promoting tumor development via dual macrophage-dependent mechanisms, suggesting FDFT1 as a promising target for tumor therapy.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":" ","pages":"1238-1253.e7"},"PeriodicalIF":8.7,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient-derived models uncover developmental state shifts in appendiceal cancer metastasis. 患者衍生的模型揭示了阑尾癌转移的发育状态变化。

IF 8.7 1区生物学

Developmental cell Pub Date : 2026-06-10 DOI: 10.1016/j.devcel.2026.05.006

Heleen D Jüngen, Talya L Dayton

引用次数: 0

Targeting druggable ion channels to harness cancer cell mechanobiology for therapy. 靶向药物离子通道利用癌细胞机械生物学进行治疗。

IF 8.7 1区生物学

Developmental cell Pub Date : 2026-06-10 DOI: 10.1016/j.devcel.2026.05.008

Beatrice Angi, Ildiko Szabo

引用次数: 0

An appendiceal cancer organoid biobank identifies phenotypic evolution and druggable dependencies of peritoneal carcinomatosis. 阑尾癌类器官生物库识别腹膜癌病的表型进化和药物依赖性。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-06-10 Epub Date: 2026-05-26 DOI: 10.1016/j.devcel.2026.04.014

Ahmed Mahmoud, Christine Sukhwa, Michael Giarrizzo, Philip H Choi, Jura Pintar, Henry Walch, Nan Zhao, Jonathan Bermeo, Sebastian Chung, Manisha Raghavan, Samhita Bapat, Qingwen Jiang, Julia Meredith, Canan Firat, Andrea Cercek, Michael B Foote, Nikolaus Schultz, Walid K Chatila, Garrett M Nash, Jinru Shia, Francisco Sanchez-Vega, Steven Larson, Arvin C Dar, Neal Rosen, Georgios Karagkounis, Karuna Ganesh

{"title":"An appendiceal cancer organoid biobank identifies phenotypic evolution and druggable dependencies of peritoneal carcinomatosis.","authors":"Ahmed Mahmoud, Christine Sukhwa, Michael Giarrizzo, Philip H Choi, Jura Pintar, Henry Walch, Nan Zhao, Jonathan Bermeo, Sebastian Chung, Manisha Raghavan, Samhita Bapat, Qingwen Jiang, Julia Meredith, Canan Firat, Andrea Cercek, Michael B Foote, Nikolaus Schultz, Walid K Chatila, Garrett M Nash, Jinru Shia, Francisco Sanchez-Vega, Steven Larson, Arvin C Dar, Neal Rosen, Georgios Karagkounis, Karuna Ganesh","doi":"10.1016/j.devcel.2026.04.014","DOIUrl":"10.1016/j.devcel.2026.04.014","url":null,"abstract":"Peritoneal carcinomatosis (PC) is a common yet deadly manifestation of gastrointestinal cancers, with few effective treatments. To identify targetable determinants of peritoneal metastasis, we focused on appendiceal adenocarcinoma (AC), which metastasizes almost exclusively to the peritoneum. No stable preclinical models of AC exist, limiting drug discovery and representing an unmet clinical need. We establish a stable biobank of 16 long-term cultured AC patient-derived tumor organoids (PDTOs). We establish an organoid orthotopic intraperitoneal xenograft model that recapitulates diffuse PC and show that PC organoids retain increased metastatic capacity, decreased growth-factor dependency, and decreased sensitivity to standard-of-care chemotherapy relative to matched primary AC organoids. Single-cell profiling reveals dedifferentiation from differentiated states in primary AC into intestinal stem cell and fetal progenitor states in AC-PC, with upregulation of oncogenic signaling pathways. We identify KRASMULTI-ON inhibitor RMC-7977 and the Wnt-targeting tyrosine kinase inhibitor WNTinib as clinically actionable strategies to target AC-PC more effectively.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":" ","pages":"1289-1302.e6"},"PeriodicalIF":9.2,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13231493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148028118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA 衰老细胞通过分泌PDGF-AA在最佳伤口愈合中的重要作用

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-05-29 DOI: 10.1016/j.devcel.2026.04.004

Marco Demaria, Naoko Ohtani, Sameh A. Youssef, Francis Rodier, Wendy Toussaint, James R. Mitchell, Remi-Martin Laberge, Jan Vijg, Harry Van Steeg, Martijn E.T. Dollé, Jan H.J. Hoeijmakers, Alain de Bruin, Eiji Hara, Judith Campisi

引用次数: 0

A BAFfling link between the β cell nucleolus, islet immune microenvironment, and type 2 diabetes. β细胞核仁、胰岛免疫微环境和2型糖尿病之间令人困惑的联系。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-05-13 DOI: 10.1016/j.devcel.2026.04.006

Anna B Osipovich, Mark A Magnuson

引用次数: 0

A chromatin reader connects salicylic acid signaling to the RNA polymerase II gearbox in plants. 在植物中，染色质解读器连接水杨酸信号和RNA聚合酶II变速箱。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-05-13 DOI: 10.1016/j.devcel.2026.04.009

Eduardo Mateo-Bonmatí

引用次数: 0

Hematopoietic stem cells activate a latent differentiation pathway to facilitate recovery after 5-fluorouracil-induced myeloablation. 造血干细胞激活潜在分化途径，促进5-氟尿嘧啶诱导骨髓消融后的恢复。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-05-13 Epub Date: 2026-03-02 DOI: 10.1016/j.devcel.2026.02.003

Zhen Zhang, Ben Jin, Chenyu You, Ya Li, Li Lin, Jianlong Sun

{"title":"Hematopoietic stem cells activate a latent differentiation pathway to facilitate recovery after 5-fluorouracil-induced myeloablation.","authors":"Zhen Zhang, Ben Jin, Chenyu You, Ya Li, Li Lin, Jianlong Sun","doi":"10.1016/j.devcel.2026.02.003","DOIUrl":"10.1016/j.devcel.2026.02.003","url":null,"abstract":"Myeloablative chemotherapy induces hematopoietic regeneration, a process orchestrated by hematopoietic stem cells (HSCs). Although prior studies have documented enhanced HSC differentiation during this process, the temporal changes in HSC fate in response to such stress remain unclear. Here, we employed lineage tracing and mathematical modeling to investigate the cell-fate dynamics of Endothelial Protein C Receptor (EPCR)-high HSCs following 5-fluorouracil (5-FU)-induced myeloablation. Our analysis revealed a transient surge in HSC differentiation immediately after 5-FU treatment, generating primarily myeloid-biased multipotent progenitors (MPPs)-subsets that typically receive limited HSC input under steady-state conditions. Following this initial cell-fate switch, elevated HSC differentiation persisted but rapidly reverted to the homeostatic differentiation pattern observed in unperturbed hematopoiesis. Additionally, our data highlight a substantial contribution of MPPs to myeloid and lymphoid lineage regeneration following 5-FU challenge. Together, these findings delineate the sequential fate transitions adopted by HSCs during severe myeloablation and identify stage-specific differentiation patterns of HSCs in stress hematopoiesis.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":" ","pages":"1044-1060.e7"},"PeriodicalIF":9.2,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chromatin-associated PP1 subcomplexes: Together, but not in each other's pockets. 染色质相关的PP1亚复合物：在一起，但不在彼此的口袋里。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-05-13 DOI: 10.1016/j.devcel.2026.04.002

Sergio Moreno, Sandra Lopez-Aviles

引用次数: 0