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EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration EPLINα控制Rab21内体的整合素循环，驱动乳腺癌细胞迁移
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-07-15 DOI: 10.1016/j.devcel.2025.06.025
Niklas Z. Jäntti, Paulina Moreno-Layseca, Megan R. Chastney, Michal Dibus, James R.W. Conway, Veli-Matti Leppänen, Hellyeh Hamidi, Kathrin Eylmann, Leticia Oliveira-Ferrer, Stefan Veltel, Johanna Ivaska
{"title":"EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration","authors":"Niklas Z. Jäntti, Paulina Moreno-Layseca, Megan R. Chastney, Michal Dibus, James R.W. Conway, Veli-Matti Leppänen, Hellyeh Hamidi, Kathrin Eylmann, Leticia Oliveira-Ferrer, Stefan Veltel, Johanna Ivaska","doi":"10.1016/j.devcel.2025.06.025","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.06.025","url":null,"abstract":"Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different cancers. The roles of EPLIN isoforms (α/β) remain largely unknown and could explain these opposing views. We observed distinct EPLIN isoform localization in breast cancer cells; EPLINα is recruited to actin in plasma membrane ruffles and endosomes, while EPLINβ resides on stress fibers. EPLINα localizes to early endosomes in an actin-dependent manner, where it interacts with Rab21, an established regulator of β1-integrin endosomal trafficking. This supports β1-integrin recycling and cell migration. Using proximity biotinylation (BioID), we identified coronin 1C as an EPLIN-proximal protein, which also localizes at Rab21-containing endosomes and controls integrin recycling downstream of EPLINα. EPLINα expression was linked to increased breast cancer cell motility, and a high EPLINα-to-EPLINβ ratio correlated with a mesenchymal phenotype in patient samples. Our work identifies previously unknown EPLIN-isoform-specific functions relevant to breast cancer and beyond.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"3 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PIF4 controls autophagy during hypocotyl response to elevated ambient temperatures via ArpC5 in Arabidopsis 在拟南芥中，PIF4通过ArpC5控制下胚轴对环境温度升高的反应过程中的自噬
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-07-15 DOI: 10.1016/j.devcel.2025.06.024
Qing Pan, Liangfeng Luo, Jiajing Li, Jiejie Li
{"title":"PIF4 controls autophagy during hypocotyl response to elevated ambient temperatures via ArpC5 in Arabidopsis","authors":"Qing Pan, Liangfeng Luo, Jiajing Li, Jiejie Li","doi":"10.1016/j.devcel.2025.06.024","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.06.024","url":null,"abstract":"Increased hypocotyl elongation is a key adaptive response of plants to high ambient temperatures (HATs). However, the underlying molecular mechanisms remain to be elucidated. This study identifies the role of ArpC5, a subunit of the ACTIN-RELATED PROTEIN 2/3(Arp2/3) complex, in Arabidopsis hypocotyl response to HAT. We demonstrate that PIF4 induces ArpC5 expression upon HAT exposure to regulate autophagy. ArpC5 promotes the assembly of actin cables essential for autophagosome formation. Additionally, ArpC5 interacts with ATG8 to facilitate autophagosome association and movement along actin cables under HAT conditions. Activated autophagy is required for the degradation of the auxin transporter and regulates polar auxin transport to drive hypocotyl cell elongation in response to HAT. Collectively, these findings elucidate the PHYTOCHROME-INTERACTING FACTOR 4 (PIF4)-Arp2/3 complex-actin cytoskeleton-autophagy axis and underscore its role in plant growth adaptation to elevated temperatures.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"14 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The histone variant H3.14 is an early player in the abiotic stress response of Arabidopsis 组蛋白变体H3.14是拟南芥非生物胁迫反应的早期参与者
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-07-08 DOI: 10.1016/j.devcel.2025.06.019
Rocío Nunez-Vazquez, Sofía Madeira, Laura Rodríguez-Casillas, Diego Gomez-Martinez, Bénédicte Desvoyes, Crisanto Gutierrez
{"title":"The histone variant H3.14 is an early player in the abiotic stress response of Arabidopsis","authors":"Rocío Nunez-Vazquez, Sofía Madeira, Laura Rodríguez-Casillas, Diego Gomez-Martinez, Bénédicte Desvoyes, Crisanto Gutierrez","doi":"10.1016/j.devcel.2025.06.019","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.06.019","url":null,"abstract":"The combinatorial changes in DNA methylation, post-translational histone modifications, and histone variants underlie the complexity of chromatin structure and function. In the case of histone H3, apart from the canonical H3.1 and the variant H3.3, highly conserved in eukaryotes, there are additional members associated with unique developmental features, some of which have an unknown function. Here, we have investigated one of these, H3.14, a novel <em>Arabidopsis</em> H3 variant rapidly and transiently induced upon abiotic stress in a subset of responsive cells located in the root transition zone. Chromatin immunoprecipitation sequencing (ChIP-seq) and RNA sequencing (RNA-seq) data showed that H3.14 exhibits differential binding patterns in repressed genes involved in cell growth and in activated genes involved in the stress response. This dual role, further supported by genetic and cell biology data, led us to conclude that H3.14 is specifically tailored for the transcriptional rewiring during the early abiotic stress response.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"51 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144578074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coordinated control of calcium signaling by CPK3 and CaM2 via CNGCs in response to cold stress in Arabidopsis 拟南芥冷胁迫下CPK3和CaM2通过CNGCs协同调控钙信号
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-07-08 DOI: 10.1016/j.devcel.2025.06.020
Yuhang Ming, Yue Peng, Qiangbo Liu, Diyi Fu, Qihong Lin, Peng You, Xi Wang, Xiaoyan Zhang, Yi Wang, Zhizhong Gong, Wen Song, Shuhua Yang, Yanglin Ding
{"title":"Coordinated control of calcium signaling by CPK3 and CaM2 via CNGCs in response to cold stress in Arabidopsis","authors":"Yuhang Ming, Yue Peng, Qiangbo Liu, Diyi Fu, Qihong Lin, Peng You, Xi Wang, Xiaoyan Zhang, Yi Wang, Zhizhong Gong, Wen Song, Shuhua Yang, Yanglin Ding","doi":"10.1016/j.devcel.2025.06.020","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.06.020","url":null,"abstract":"Calcium (Ca<sup>2+</sup>) signaling plays a pivotal role in cellular responses to cold stress. Exposure of plant cells to cold water triggers cytosolic Ca<sup>2+</sup> elevations; however, this treatment may not fully recapitulate Ca<sup>2+</sup> signal dynamics observed under natural cold stress conditions. In this study, we characterize a distinct Ca<sup>2+</sup> signal triggered by gradual cooling and demonstrate that CYCLIC-NUCLEOTIDE-GATED CHANNEL 5 (CNGC5) and CNGC6 control this process in plants. Their activities are tightly controlled by CALCIUM-DEPENDENT PROTEIN KINASE 3 (CPK3) and CALMODULIN 2 (CaM2). Cold stress rapidly activates CPK3, which is essential for the activation of CNGC5 and CNGC6 during the initial phases of Ca<sup>2+</sup> signaling. In contrast, CaM2 negatively controls the activities of CNGC5 and CNGC6 in a Ca<sup>2+</sup>-dependent manner after Ca<sup>2+</sup> influx. This study demonstrates a previously unidentified mechanism by which the CPK3-CNGC-CaM2 module precisely orchestrates Ca<sup>2+</sup> signaling dynamics in response to cold stress in Arabidopsis.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"9 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144578073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Welcoming new Developmental Cell advisors 欢迎新的发育细胞顾问
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-07-07 DOI: 10.1016/j.devcel.2025.06.018
Hong Zhang, Hongmei Wang, Lanfen Chen, Qiang Gao, Yuling Jiao, Xuemei Chen, Jia-Wei Wang
{"title":"Welcoming new Developmental Cell advisors","authors":"Hong Zhang, Hongmei Wang, Lanfen Chen, Qiang Gao, Yuling Jiao, Xuemei Chen, Jia-Wei Wang","doi":"10.1016/j.devcel.2025.06.018","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.06.018","url":null,"abstract":"<em>Developmental Cell</em> is evolving as a cross-disciplinary journal and the fields represented by some of our new advisors emphasize this. In this collection of Voices, our board members provide their view on the future directions for their fields, encompassing cell biology in the context of human embryogenesis, cancer, or plants.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"21 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breaking a chromatin domain boundary by deleting a single CTCF motif impacts development 通过删除单个CTCF基序破坏染色质结构域边界会影响发育
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-07-07 DOI: 10.1016/j.devcel.2025.05.005
Xinyi Liu, Junjun Ding
{"title":"Breaking a chromatin domain boundary by deleting a single CTCF motif impacts development","authors":"Xinyi Liu, Junjun Ding","doi":"10.1016/j.devcel.2025.05.005","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.05.005","url":null,"abstract":"Chromatin domain boundaries are crucial for development by spatially constraining enhancer activity to ensure precise spatiotemporal gene regulation. In this issue of <em>Developmental Cell</em>, Chakraborty et al. demonstrate that the loss of a chromatin domain boundary caused by deletion of a single CTCF motif can lead to severe developmental defects.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"20 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolution of plant stem cells: Deep genetic conservation revealed by single-nucleus RNA-sequencing in a moss 植物干细胞的进化：苔藓单核rna测序揭示的深层遗传保护
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-07-07 DOI: 10.1016/j.devcel.2025.06.003
Yoan Coudert
{"title":"Evolution of plant stem cells: Deep genetic conservation revealed by single-nucleus RNA-sequencing in a moss","authors":"Yoan Coudert","doi":"10.1016/j.devcel.2025.06.003","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.06.003","url":null,"abstract":"Plant bodies develop through stem cells, but their genetic regulation is poorly understood outside of flowering plants. In this issue of <em>Developmental Cell</em>, Hata et al. have used single-nucleus RNA sequencing in a moss to map the transcriptional dynamics of stem cell formation, revealing an evolutionarily conserved cytokinin signaling module for promoting stem cell identity.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"122 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trained immunity of osteoclasts controls inflammatory arthritis 经过训练的破骨细胞免疫控制炎症性关节炎
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-07-07 DOI: 10.1016/j.devcel.2025.04.021
I.E. Adamopoulos
{"title":"Trained immunity of osteoclasts controls inflammatory arthritis","authors":"I.E. Adamopoulos","doi":"10.1016/j.devcel.2025.04.021","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.04.021","url":null,"abstract":"In this issue of <em>Developmental Cell</em>, Haacke et al. demonstrate that osteoclasts undergo innate immune training, resulting in increased bone resorption and exacerbation of arthritis. These data highlight the complexity of inflammatory osteoclast precursors and costimulatory pathways in arthritis and open new research avenues in the ever-growing field of osteoimmunology.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"31 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dual role for FLP1 in flowering and stem elongation under natural light conditions 在自然光条件下FLP1在开花和茎伸长中的双重作用
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-07-07 DOI: 10.1016/j.devcel.2025.06.014
Giulia Ave Bono, Fabio Fornara
{"title":"Dual role for FLP1 in flowering and stem elongation under natural light conditions","authors":"Giulia Ave Bono, Fabio Fornara","doi":"10.1016/j.devcel.2025.06.014","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.06.014","url":null,"abstract":"Plants have evolved mechanisms to measure seasonal time and flower during the most favorable period of the year. In this issue of <em>Developmental Cell</em>, Takagi et al. identify FLP1, a small protein produced in the leaf veins of <em>Arabidopsis</em>, that promotes flowering and inflorescence stem elongation under natural light conditions.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"12 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Remodeling of cadherin contacts in embryonic mesenchymal tissues during differential cell migration 细胞迁移过程中胚胎间充质组织钙粘蛋白接触的重塑
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-07-03 DOI: 10.1016/j.devcel.2025.06.009
David Rozema, Christine Fagotto-Kaufmann, Artur Ruppel, Paul Lasko, François Fagotto
{"title":"Remodeling of cadherin contacts in embryonic mesenchymal tissues during differential cell migration","authors":"David Rozema, Christine Fagotto-Kaufmann, Artur Ruppel, Paul Lasko, François Fagotto","doi":"10.1016/j.devcel.2025.06.009","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.06.009","url":null,"abstract":"A fundamental aspect of morphogenesis is the capacity of cells to actively exchange neighbors, which crucially requires remodeling of existing cadherin adhesive contacts. We investigate this process using <em>Xenopus</em> prechordal mesoderm as a model of a mesenchymal tissue, where cell-cell rearrangements are powered by differential migration. Using a reductionist approach, we unveil two concurrent mechanisms. Most cadherins are removed via “peeling,” i.e., disruption of the <em>trans</em> bonds and lateral diffusion out of the contact. In parallel, a remnant of cadherins concentrates at the contact, which is resolved by tearing the cytoplasmic link with the cytoskeleton. Myosin is recruited peripheral to the contact, facilitating contact rupture. Manipulating cortical tension indicates that the balance between peeling and condensation mechanisms is sensitive to the magnitude and orientation of forces applied on the contact. This study unravels a new modality of cell contact dynamics likely to be widely relevant for mesenchymal tissues.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"28 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144547558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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