Trained immunity of osteoclasts controls inflammatory arthritis

IF 8.7 1区生物学 Q1 CELL BIOLOGY

Developmental cell Pub Date : 2025-07-07 DOI:10.1016/j.devcel.2025.04.021

I.E. Adamopoulos

引用次数: 0

Abstract

In this issue of Developmental Cell, Haacke et al. demonstrate that osteoclasts undergo innate immune training, resulting in increased bone resorption and exacerbation of arthritis. These data highlight the complexity of inflammatory osteoclast precursors and costimulatory pathways in arthritis and open new research avenues in the ever-growing field of osteoimmunology.

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经过训练的破骨细胞免疫控制炎症性关节炎

在本期《发育细胞》中，Haacke等人证明破骨细胞接受先天免疫训练，导致骨吸收增加，关节炎加重。这些数据突出了关节炎中炎性破骨细胞前体和共刺激途径的复杂性，并在不断发展的骨免疫学领域开辟了新的研究途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental cell 生物-发育生物学

CiteScore

18.90

自引率

1.70%

发文量

203

审稿时长

3-6 weeks

期刊介绍： Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.