Developmental cell最新文献_第8页

T cell InaDAGquacy in the TME driven by phosphoethanolamine 磷酸乙醇胺驱动的TME中T细胞缺乏

IF 11.8 1区生物学

Developmental cell Pub Date : 2025-07-21 DOI: 10.1016/j.devcel.2025.06.022

Erica G. Brown, Roddy S. O’Connor

引用次数: 0

Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila 果蝇血管生态位对肠道再生的神经内分泌调控

IF 11.8 1区生物学

Developmental cell Pub Date : 2025-07-21 DOI: 10.1016/j.devcel.2025.06.036

André B. Medina, Jessica Perochon, Yuanliangzi Tian, Cai T. Johnson, Jack Holcombe, Parvathy Ramesh, Sofia Polcowñuk, Yachuan Yu, Julia B. Cordero

{"title":"Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila","authors":"André B. Medina, Jessica Perochon, Yuanliangzi Tian, Cai T. Johnson, Jack Holcombe, Parvathy Ramesh, Sofia Polcowñuk, Yachuan Yu, Julia B. Cordero","doi":"10.1016/j.devcel.2025.06.036","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.06.036","url":null,"abstract":"Robust and controlled intestinal regeneration involves reciprocal interactions between the intestinal epithelium and its microenvironment. Here, we identify signaling between enteroendocrine (EE) cells, vasculature-like trachea, and neurons, which drives regional and global stem cell proliferation during adult intestinal regeneration in Drosophila. Reactive oxygen species (ROS) from midgut cells promote production and secretion of diuretic hormone 31 (Dh31), from anterior midgut EE cells. EE and neuronal Dh31 activate tracheal Dh31 receptor, leading to the production of the vascular endothelial growth factor (VEGF)- and platelet-derived-growth-factor (PDGF)-like ligand Pvf1. Pvf1 induces tracheal remodeling and intestinal stem cell (ISC) proliferation through autocrine and paracrine Pvr/mitogen-activated protein kinase (MAPK) signaling, respectively. While EE Dh31 exerts broad control of ISC proliferation throughout the midgut, effects of the neuronal source of the ligand appear restricted to the posterior midgut. Collectively, our work discovered an EE/neuronal/vascular signaling network, controlling global and domain-specific ISC proliferation during adult intestinal regeneration.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"282 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concerted changes in Epithelium and Stroma: a multi-scale, multi-omics analysis of progression from Barrett’s Esophagus to adenocarcinoma 上皮和间质协同变化：Barrett食管向腺癌进展的多尺度、多组学分析

IF 11.8 1区生物学

Developmental cell Pub Date : 2025-07-21 DOI: 10.1016/j.devcel.2025.06.034

Michael K. Strasser, David L. Gibbs, Philippe Gascard, Joanna Bons, John W. Hickey, Deng Pan, Joseph A. Caruso, Xianhong Wang, Chira Chen-Tanyolac, Rosemary Bai, Christian M. Schürch, Yuqi Tan, Sarah Black, Pauline Chu, Alican Ozkan, Nathan Basisty, Veena Sangwan, Jacob Rose, Samah Shah, Jordan B. Burton, Lorenzo E. Ferri

{"title":"Concerted changes in Epithelium and Stroma: a multi-scale, multi-omics analysis of progression from Barrett’s Esophagus to adenocarcinoma","authors":"Michael K. Strasser, David L. Gibbs, Philippe Gascard, Joanna Bons, John W. Hickey, Deng Pan, Joseph A. Caruso, Xianhong Wang, Chira Chen-Tanyolac, Rosemary Bai, Christian M. Schürch, Yuqi Tan, Sarah Black, Pauline Chu, Alican Ozkan, Nathan Basisty, Veena Sangwan, Jacob Rose, Samah Shah, Jordan B. Burton, Lorenzo E. Ferri","doi":"10.1016/j.devcel.2025.06.034","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.06.034","url":null,"abstract":"Esophageal adenocarcinoma arises from Barrett’s esophagus, a metaplastic condition. Multi-omics profiling, integrating single-cell transcriptomics, extracellular matrix proteomics, tissue mechanics and spatial proteomics of the paths of progression from squamous epithelium through metaplasia, dysplasia to adenocarcinoma, in 107 samples from 26 patients in two independent cohorts, defined shared and patient-specific progression characteristics. Metaplastic replacement of epithelial cell composition and architecture was paralleled by changes in stromal cells, extracellular matrix (ECM) and tissue stiffness. This change in pre-cancerous metaplasia was already accompanied by appearance of fibroblasts with the molecular characteristics of carcinoma-associated fibroblasts. These fibroblasts produced the immunosuppressive protein POSTN, whose expression shifted from vascular to stromal cells, consistent with the emergence of an immunosuppressive microenvironment evident in cell neighborhoods enriched for immunoregulatory NK and Treg cells. Thus, Barrett’s esophagus progresses as a coordinated multi-component system, supporting treatment paradigms that go beyond targeting cancerous cells to incorporate stromal reprogramming.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"84 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disruption of E-cadherin in the airway led to dysplastic stressed cells and asthma-like phenotypes e -钙粘蛋白在气道中的破坏导致发育不良的应激细胞和哮喘样表型

IF 11.8 1区生物学

Developmental cell Pub Date : 2025-07-18 DOI: 10.1016/j.devcel.2025.06.030

Randee E. Young, Sunyoung Lee, Jisun Chin, Barsha Dash, Jugraj Sahi, Leah B. Nantie, Yujuan Su, Rebecca Salamon, Jamie M. Verheyden, Justinn Barr, Jae Woo Shin, Andrew S.H. Day, Pandurangan Vijayanand, Nabora Reyes de Barboza, Xin Sun

{"title":"Disruption of E-cadherin in the airway led to dysplastic stressed cells and asthma-like phenotypes","authors":"Randee E. Young, Sunyoung Lee, Jisun Chin, Barsha Dash, Jugraj Sahi, Leah B. Nantie, Yujuan Su, Rebecca Salamon, Jamie M. Verheyden, Justinn Barr, Jae Woo Shin, Andrew S.H. Day, Pandurangan Vijayanand, Nabora Reyes de Barboza, Xin Sun","doi":"10.1016/j.devcel.2025.06.030","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.06.030","url":null,"abstract":"While E-cadherin is a known core component of the adherens junction, how it controls cell fate remains poorly understood. Here, we show that in the mouse airway, inactivation of E-cadherin in epithelial progenitor club cells, but not terminally differentiated ciliated cells, led to increased proliferation, goblet cell metaplasia, and immune infiltration, mimicking asthma phenotypes without exposure to allergen. Single-cell RNA sequencing identified a cellular stress signature in the mutant airway; a profile previously associated with dysplastic alveolar transitional cells in fibrotic lungs. Chemokine genes such as Cxcl17 are upregulated in the mutant airway both in vivo and when cultured in isolation, identifying an intrinsic ability of the epithelium to sense junction breach and launch immune defense. Inactivation of Il4ra in the mutant attenuated goblet cell metaplasia, but not immune recruitment. Together, these findings demonstrate that loss of E-cadherin leads to airway remodeling through both an epithelium-intrinsic mechanism and epithelium-immune crosstalk.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"20 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144664493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An extracellular matrix niche secreted by epithelial cells drives intestinal organoid formation 上皮细胞分泌的细胞外基质生态位驱动肠道类器官的形成

IF 11.8 1区生物学

Developmental cell Pub Date : 2025-07-17 DOI: 10.1016/j.devcel.2025.06.026

Antonius Chrisnandy, Matthias P. Lutolf

引用次数: 0

Microtubules coordinate mitochondria transport with myofibril morphogenesis during muscle development 在肌肉发育过程中，微管协调线粒体运输和肌原纤维形态发生

IF 11.8 1区生物学

Developmental cell Pub Date : 2025-07-17 DOI: 10.1016/j.devcel.2025.06.033

Jerome Avellaneda, Duarte Candeias, Ana da Rosa Soares, Edgar R. Gomes, Nuno Miguel Luis, Frank Schnorrer

{"title":"Microtubules coordinate mitochondria transport with myofibril morphogenesis during muscle development","authors":"Jerome Avellaneda, Duarte Candeias, Ana da Rosa Soares, Edgar R. Gomes, Nuno Miguel Luis, Frank Schnorrer","doi":"10.1016/j.devcel.2025.06.033","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.06.033","url":null,"abstract":"Muscle cells contain numerous energy-producing mitochondria and contractile myofibrils, whose myosin motors need ATP to generate force. Thus, myofibrils and mitochondria are in intimate contact in mature muscles. However, how their morphogenesis is coordinated during development remains largely unknown. Here, we used in vivo imaging to investigate myofibril and mitochondria network dynamics in developing Drosophila flight muscles. We found that mitochondria intercalate from the surface of actin bundles to their interior, and concomitantly, actin filaments condense to individual myofibrils. This ensures that mitochondria locate in proximity to every myofibril. Notably, antiparallel microtubules bundle with the assembling myofibrils, suggesting a key role in myofibril orientation. Indeed, microtubule severing affects myofibril orientation, whereas kinesin knockdown specifically blocks mitochondria intercalation. Importantly, mitochondria intercalation and their kinesin-dependent microtubule-based transport are conserved in mammalian muscle. Together, these data identify a key role for microtubules in coordinating mitochondria and myofibril morphogenesis to build functional muscles.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"57 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Jpx RNA controls Xist induction through spatial reorganization of the mouse X-inactivation center Jpx RNA通过小鼠x -失活中心的空间重组控制Xist的诱导

IF 11.8 1区生物学

Developmental cell Pub Date : 2025-07-17 DOI: 10.1016/j.devcel.2025.06.028

Hyun Jung Oh, Priyojit Das, Roy Blum, Andrea J. Kriz, Hun-Goo Lee, Yong-Woo Lee, Jeannie T. Lee

引用次数: 0

The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube 脊椎动物神经管中整合时空模式的顺式调控逻辑

IF 11.8 1区生物学

Developmental cell Pub Date : 2025-07-16 DOI: 10.1016/j.devcel.2025.06.029

Isabel Zhang, Giulia L.M. Boezio, Jake Cornwall-Scoones, Thomas Frith, Elizabeth Finnie, Junyi Luo, Ming Jiang, Michael Howell, Robin Lovell-Badge, Andreas Sagner, James Briscoe, M. Joaquina Delás

{"title":"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube","authors":"Isabel Zhang, Giulia L.M. Boezio, Jake Cornwall-Scoones, Thomas Frith, Elizabeth Finnie, Junyi Luo, Ming Jiang, Michael Howell, Robin Lovell-Badge, Andreas Sagner, James Briscoe, M. Joaquina Delás","doi":"10.1016/j.devcel.2025.06.029","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.06.029","url":null,"abstract":"The vertebrate neural tube generates a large diversity of molecularly and functionally distinct neurons and glia from a small progenitor pool. While the role of spatial patterning in organizing cell fate specification has been extensively studied, temporal patterning, which controls the timing of cell type generation, is equally important. Here, we define a global temporal program operating in progenitors throughout the mouse nervous systems that governs cell fate choices by controlling chromatin accessibility. Perturbation of this cis-regulatory program affects sequential cell fate transitions in neural progenitors and the identity of their progeny. The temporal program operates in parallel to spatial patterning, ensuring the timely availability of regulatory elements for spatial determinants to direct cell-type-specific gene expression. These findings identify a chronotopic spatiotemporal integration strategy in which a global temporal chromatin program determines the output of a spatial gene regulatory network resulting in the ordered allocation of cell type identity.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"24 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TAF1 is required for fetal but not adult hematopoiesis in mice TAF1是小鼠胎儿造血所必需的，而不是成年造血所必需的

IF 11.8 1区生物学

Developmental cell Pub Date : 2025-07-16 DOI: 10.1016/j.devcel.2025.06.027

Fan Liu, Jingyin Yue, Francesco Tamiro, Jun Sun, Pradeep Kumar Reddy Cingaram, Krystal Lisa Hossack, Concepcion Martinez Caja, Ye Xu, Chuan Chen, Felipe Beckedorff, Ramin Shiekhattar, Stephen D. Nimer

{"title":"TAF1 is required for fetal but not adult hematopoiesis in mice","authors":"Fan Liu, Jingyin Yue, Francesco Tamiro, Jun Sun, Pradeep Kumar Reddy Cingaram, Krystal Lisa Hossack, Concepcion Martinez Caja, Ye Xu, Chuan Chen, Felipe Beckedorff, Ramin Shiekhattar, Stephen D. Nimer","doi":"10.1016/j.devcel.2025.06.027","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.06.027","url":null,"abstract":"While many sequence-specific transcription factors (TFs) have been identified as key regulators of hematopoietic stem cell (HSC) lineage determination, the function of general TFs in HSC behavior is poorly understood. To evaluate the function of the TFIID subunit TAF1 in normal hematopoiesis, we generated Taf1 conditional knockout (cKO) mice and identified an essential role of TAF1 in fetal hematopoiesis. Surprisingly, TAF1 deletion in adult mice was not lethal to hematopoiesis; rather, we observed a marked expansion of the hematopoietic stem and progenitor cell (HSPC) compartment, with increased self-renewal and impaired differentiation capacity of these cells. TAF1-null HSPCs failed to produce mature blood cells in chimeric mice; these cells also failed to upregulate key differentiation genes when induced to differentiate in vitro. TAF1 loss not only disrupted TFIID chromatin recruitment but also reduced RNA polymerase II (RNAPII) promoter-proximal pausing. Thus, HSPCs utilize distinct transcriptional regulatory mechanisms to undergo differentiation versus maintaining self-renewal.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"14 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TaANK-TPR1 enhances wheat resistance against stripe rust via controlling gene expression and protein activity of NLR protein TaRPP13L1 TaANK-TPR1通过调控NLR蛋白TaRPP13L1的基因表达和蛋白活性增强小麦对条锈病的抗性

IF 11.8 1区生物学

Developmental cell Pub Date : 2025-07-15 DOI: 10.1016/j.devcel.2025.07.004

Shuangyuan Guo, Feng Zhang, Xiaoya Du, Xinmei Zhang, Xueling Huang, Zelong Li, Yanqin Zhang, Pengfei Gan, Huankun Li, Min Li, Xinyue Wang, Chunlei Tang, Xiaojie Wang, Zhensheng Kang, Xinmei Zhang

引用次数: 0