Developmental cell最新文献_第7页

Sealing and healing: A two-step model for plasma membrane repair. 封闭与愈合：质膜修复的两步模型。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-07-08 DOI: 10.1016/j.devcel.2026.06.011

Athanasios Kournoutis, Harald Stenmark

引用次数: 0

Genetic interrogation reveals mechanisms regulating nexus glia development and shaping heart physiology. 基因询问揭示了调节联结神经胶质发育和塑造心脏生理的机制。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-07-08 Epub Date: 2026-06-15 DOI: 10.1016/j.devcel.2026.05.010

Sarah E W Light, John Dennen, Anna Barry-Wolbers, Natália Araújo do Carmo, Antonio Dolojan, O Amandhi Mathews, Grace Waddell, Khang Chau, Cara Cavanaugh, Quinn Deitch, Cody J Smith

{"title":"Genetic interrogation reveals mechanisms regulating nexus glia development and shaping heart physiology.","authors":"Sarah E W Light, John Dennen, Anna Barry-Wolbers, Natália Araújo do Carmo, Antonio Dolojan, O Amandhi Mathews, Grace Waddell, Khang Chau, Cara Cavanaugh, Quinn Deitch, Cody J Smith","doi":"10.1016/j.devcel.2026.05.010","DOIUrl":"10.1016/j.devcel.2026.05.010","url":null,"abstract":"Functional organs require precise cellular organization to engage in bidirectional communication with the nervous system. However, the cellular specialization underlying this vital communication remains incompletely understood. Here, we investigated zebrafish cardiac nexus glia and found that they are post-mitotic and exhibit dynamic Ca2+ transients that mature throughout development and coordinate with cardiomyocyte activity. We demonstrate that mechanical cues are dispensable for nexus glia abundance. Using a large-scale CRISPR screen of genes identified from single-cell RNA sequencing (scRNA-seq) analysis of embryonic human cardiac cells, we identify nexus glia genetic modifiers. Specifically, perturbation of cdh6 expands the nexus glia population, enhances glial calcium activity, and disrupts cardiomyocyte calcium handling. Crucially, this glial overexpansion protects against cardiac exhaustion via a potassium channel-dependent mechanism. These findings reveal the genetic architecture of neuro-cardiac communication and highlight the role of nexus glia in cardiac resilience.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":" ","pages":"1555-1571.e7"},"PeriodicalIF":9.2,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13360737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148257847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glia orchestrate neural circuit development. 神经胶质协调神经回路的发育。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-07-08 DOI: 10.1016/j.devcel.2026.06.008

Kristina Sakers, Patrick W Sheehan, Wendy Xin, Dorothy P Schafer, Cagla Eroglu

{"title":"Glia orchestrate neural circuit development.","authors":"Kristina Sakers, Patrick W Sheehan, Wendy Xin, Dorothy P Schafer, Cagla Eroglu","doi":"10.1016/j.devcel.2026.06.008","DOIUrl":"https://doi.org/10.1016/j.devcel.2026.06.008","url":null,"abstract":"Over the past ∼25 years, our understanding of neural circuit development in the central nervous system has shifted. Once considered passive supporters, glial cells, namely, astrocytes, oligodendrocyte lineage cells, and microglia, are increasingly recognized as active regulators of developmental circuit formation and maturation. In this review, we synthesize evidence for the multifaceted functions by which glial cells instruct neuronal circuit establishment and maturation across developmental stages and in both vertebrate and invertebrate nervous systems. We describe the programs deployed to guide successive phases of synapse formation, refinement, plasticity, and stabilization in a circuit- and experience-dependent manner. We also highlight how an extensive glia-glia communication repertoire provides another critical layer of control over development. In summary, glia cooperatively shape circuit development by instructing, stabilizing, or eliminating specific wiring programs. Disruption of this coordinated logic, beyond dysfunction of any single glial or neuronal process, underlies vulnerability to neurodevelopmental and neuropsychiatric disease.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"61 7","pages":"1407-1430"},"PeriodicalIF":9.2,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant stem cell systems: Robust by design. 植物干细胞系统：强健的设计。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-07-08 DOI: 10.1016/j.devcel.2026.06.005

Thomas Greb, Jan U Lohmann

引用次数: 0

Noncanonical caps, m⁶A, and Ψ RNA modifications in plant and animal development. 植物和动物发育中的非规范帽，m6A和Ψ RNA修饰。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-07-08 DOI: 10.1016/j.devcel.2026.05.013

Xuemei Chen, Hao Hu, Guifang Jia, Chengqi Yi, Danmeng Zhu

{"title":"Noncanonical caps, m6A, and Ψ RNA modifications in plant and animal development.","authors":"Xuemei Chen, Hao Hu, Guifang Jia, Chengqi Yi, Danmeng Zhu","doi":"10.1016/j.devcel.2026.05.013","DOIUrl":"https://doi.org/10.1016/j.devcel.2026.05.013","url":null,"abstract":"RNA modifications constitute a dynamic layer of gene regulation during development. Among them, noncanonical caps, N6-methyladenosine (m6A), and pseudouridine (Ψ) represent three major classes of chemical marks. Noncanonical caps diversify the 5' end of RNA, whereas m6A and Ψ act as internal modifications that modulate RNA structure and RNA-protein interactions. Through these molecular effects, noncanonical caps, m6A, and Ψ influence RNA processing, localization, and function, thereby governing RNA fate in response to developmental and environmental cues. Advances in detection, quantification, and transcriptome-wide profiling have greatly expanded our understanding of these modifications, while revealing important technical challenges. In this review, we discuss how these three major RNA modifications regulate developmental programs in plants and animals, with emphasis on their molecular mechanisms and biological functions. We further highlight their potential relevance for therapeutic strategies in human diseases and agricultural approaches for crop improvement under climate change.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"61 7","pages":"1446-1470"},"PeriodicalIF":9.2,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Menstruation: Once unspoken but now uncovered, one cell type at a time. 月经：曾经说不出口，但现在发现了，一次一种细胞类型。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-07-08 Epub Date: 2026-06-25 DOI: 10.1016/j.devcel.2026.06.010

Harriet C Fitzgerald, Caroline E Gargett

引用次数: 0

From regeneration to tumorigenesis: ARID1A as an epigenetic guardian of gastric identity. 从再生到肿瘤发生：ARID1A作为胃身份的表观遗传监护人。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-07-08 DOI: 10.1016/j.devcel.2026.06.007

Jee-Eun Choi, Helen H N Yan, Suet Yi Leung

引用次数: 0

P5CS represses tumor progression via inhibiting assembly of 48S pre-translation initiation complex. P5CS通过抑制48S翻译前起始复合物的组装来抑制肿瘤进展。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-07-08 Epub Date: 2026-06-16 DOI: 10.1016/j.devcel.2026.05.011

Qingqing Zhang, Shuwen Cheng, Yinmin Gu, Yongbo Pan, Xiaofeng Zhu, Jinghan Sun, Ya Wen, Shan Gao

{"title":"P5CS represses tumor progression via inhibiting assembly of 48S pre-translation initiation complex.","authors":"Qingqing Zhang, Shuwen Cheng, Yinmin Gu, Yongbo Pan, Xiaofeng Zhu, Jinghan Sun, Ya Wen, Shan Gao","doi":"10.1016/j.devcel.2026.05.011","DOIUrl":"10.1016/j.devcel.2026.05.011","url":null,"abstract":"Δ1-Pyrroline-5-carboxylate synthase (P5CS), therate-limiting enzyme in the proline biosynthesis, has been implicated in diverse physiology and pathology, including cancer. However, whether P5CS exerts functions beyond its enzymatic activity has remained unclear. Here, we identify P5CS as a non-canonical RNA-binding protein that inhibits cancer cell growth and metastasis by inhibiting translation initiation in an enzyme-activity-independent manner in human cancer cells and cell-derived xenograft mouse models. Mechanistically, P5CS binds to the 5' untranslated region (UTR) of oncogenic mRNAs and disrupts the recruitment of eukaryotic translation initiation factor (eIF) 3a/3d-containing 43S preinitiation complex to cap-binding complex eIF4F, thereby blocking 48S assembly and subsequent global protein synthesis. Loss of P5CS accelerates the translational efficiency of IGF1R and promotes tumor progression. Collectively, our study highlights a non-canonical function of P5CS in translational regulation and the emerging non-metabolic functions of metabolic enzymes in tumorigenesis.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":" ","pages":"1521-1534.e7"},"PeriodicalIF":9.2,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A moonlighting metabolic enzyme shines light on translation initiation. 一种兼职代谢酶在翻译起始过程中发挥作用。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-07-08 DOI: 10.1016/j.devcel.2026.06.012

Vivian Lobo, Kathrin Leppek

引用次数: 0

Organoid modeling of lung branching morphogenesis and epithelial lineage specification. 肺分支形态发生的类器官模型和上皮谱系规范。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-07-08 Epub Date: 2026-06-18 DOI: 10.1016/j.devcel.2026.05.012

Mengjie Pan, Baomei Cai, Guanlie Li, Ruifang Zhang, Chuncao Deng, Huan Chen, Yingxiu Chen, Sihao Chen, Ziyu Feng, Xiongzhi Quan, Yunjing Du, Wei He, Yiyi Cheng, Chunhua Zhou, Yudong Fu, Shujuan Liu, Dafeng Tao, Yangqing Tian, Jiajun Hou, Yongchang Huang, Yiwei Li, Shengyong Yu, Dajiang Qin, An Gong, Duanqing Pei, Jiekai Chen, Man Zhang, Mingwei Min, Shangtao Cao

{"title":"Organoid modeling of lung branching morphogenesis and epithelial lineage specification.","authors":"Mengjie Pan, Baomei Cai, Guanlie Li, Ruifang Zhang, Chuncao Deng, Huan Chen, Yingxiu Chen, Sihao Chen, Ziyu Feng, Xiongzhi Quan, Yunjing Du, Wei He, Yiyi Cheng, Chunhua Zhou, Yudong Fu, Shujuan Liu, Dafeng Tao, Yangqing Tian, Jiajun Hou, Yongchang Huang, Yiwei Li, Shengyong Yu, Dajiang Qin, An Gong, Duanqing Pei, Jiekai Chen, Man Zhang, Mingwei Min, Shangtao Cao","doi":"10.1016/j.devcel.2026.05.012","DOIUrl":"10.1016/j.devcel.2026.05.012","url":null,"abstract":"Branching morphogenesis is a fundamental process governing pulmonary development, epithelial differentiation, and functional maturation. Here, we report a multilevel branching lung organoid (BLO) model generated from primary tip epithelial cells using a robust, chemically defined protocol. These BLOs exhibit characteristic dendritic architectures with proximodistal patterning and alveolar-sac-like structures. Time-resolved single-cell RNA sequencing reveals that BLOs comprise both proximal airway and distal alveolar epithelial populations and recapitulate the developmental trajectories of lung epithelial lineages in vitro. Live-cell imaging further demonstrates that the spatial organization and branching dynamics of BLOs closely resemble those of native murine pulmonary epithelium in vivo. Upon transplantation into bleomycin-injured murine models, BLO-derived cells further mature and ameliorate pulmonary fibrosis. Together, these findings establish BLOs as a powerful platform for investigating lung branching morphogenesis, epithelial lineage specification and regeneration.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":" ","pages":"1504-1520.e8"},"PeriodicalIF":9.2,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0