Developmental cell最新文献_第6页

Nodal/Smad2 signaling sustains developmental pausing by repressing Pparg-mediated lipid metabolism Nodal/Smad2信号通过抑制pparg介导的脂质代谢来维持发育暂停

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-08-04 DOI: 10.1016/j.devcel.2026.07.006

Giacomo Furlan,S. Bryn Martin,Brandon Cho,Ying Yu Ng,Sarah A. McClymont,Abdul Rahman,Elizabeth J. Robertson,Evelyne Collignon,Miguel Ramalho-Santos

{"title":"Nodal/Smad2 signaling sustains developmental pausing by repressing Pparg-mediated lipid metabolism","authors":"Giacomo Furlan,S. Bryn Martin,Brandon Cho,Ying Yu Ng,Sarah A. McClymont,Abdul Rahman,Elizabeth J. Robertson,Evelyne Collignon,Miguel Ramalho-Santos","doi":"10.1016/j.devcel.2026.07.006","DOIUrl":"https://doi.org/10.1016/j.devcel.2026.07.006","url":null,"abstract":"Mammalian embryonic diapause is a reversible state of pre-implantation dormancy characterized by metabolic rewiring toward lipid usage as energy source. Whether active signaling sustains this dormant state remained unclear. Here, we show that the transforming growth factor- β (TGF-β) pathway, previously thought to only be required post-implantation, is essential for diapause. Nodal signaling is activated and its downstream effector SMAD family member 2 (Smad2) is required during diapause in vivo. Using ex vivo blastocyst and embryonic stem cells models of diapause, we show that Smad2 represses peroxisome proliferator-activated receptor gamma (Pparg), a master regulator of lipid storage. Loss of Smad2-mediated Pparg repression leads to lipid accumulation and is incompatible with pausing. Our findings establish a Nodal-Smad2-Pparg axis that is pivotal for sustaining the transcriptional and metabolic programs of embryonic diapause. This axis may be redeployed in other contexts, including cancer dormancy and metabolic disorders.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"9 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148666049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The ARLA1A-NAC089 module coordinates ER phagy with the unfolded protein response to maintain cellular homeostasis in plants ARLA1A-NAC089模块协调内质网吞噬和未折叠蛋白反应，维持植物细胞内稳态

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-08-04 DOI: 10.1016/j.devcel.2026.07.007

Lianming Yang,Weixin Luo,Tingting Huang,Shuo Wang,Zhiran Cao,Dong Jiang,Lei Pang,Jian-Xiang Liu,Sicong He,Ruixi Li

引用次数: 0

Myc sustains sex-biased organ zonation in the Drosophila intestine. Myc在果蝇肠道中维持性别偏向的器官区分。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-07-08 Epub Date: 2026-06-30 DOI: 10.1016/j.devcel.2026.06.003

Christopher Amourda, Laura Blackie, Pedro Gaspar, Laura Martin-Coll, Anadika R Prasad, Andrew H House, Minna Holopainen, Hanna Ruhanen, Nicole Lamichane, Dafni Hadjieconomou, Tomotsune Ameku, Alessandro Mineo, Milly Coxhead, Irene Soler-Sáez, Cristina Galiana-Roselló, Francisco García-Garcia, Yi-Fang Wang, Cyrille Alexandre, Ville Hietakangas, Reijo Käkelä, Santiago Vernia, Irene Miguel-Aliaga

{"title":"Myc sustains sex-biased organ zonation in the Drosophila intestine.","authors":"Christopher Amourda, Laura Blackie, Pedro Gaspar, Laura Martin-Coll, Anadika R Prasad, Andrew H House, Minna Holopainen, Hanna Ruhanen, Nicole Lamichane, Dafni Hadjieconomou, Tomotsune Ameku, Alessandro Mineo, Milly Coxhead, Irene Soler-Sáez, Cristina Galiana-Roselló, Francisco García-Garcia, Yi-Fang Wang, Cyrille Alexandre, Ville Hietakangas, Reijo Käkelä, Santiago Vernia, Irene Miguel-Aliaga","doi":"10.1016/j.devcel.2026.06.003","DOIUrl":"10.1016/j.devcel.2026.06.003","url":null,"abstract":"Organs exhibit distinct transcriptional and metabolic territories; how and why such organ zonation differs between the sexes is unclear. Using adult Drosophila intestines, we combine whole-organ 3D cellular mapping with metabolic profiling to uncover regional differences in gene expression and metabolism that vary by sex and genotype. Zonation emerges from opposing, region-specific, and sex-biased actions of the sex determinant doublesex (Dsx) and the transcription factor Myc. In enterocytes, male-specific Dsx represses Myc, resulting in female-biased Myc expression. Myc acts in specific gut regions to increase enterocyte ploidy in females. Myc also sustains a female-specific lipid profile, marked by sex-biased expression of a cluster of lipases and selective triacylglycerol storage in the anterior midgut. Myc activity in female enterocytes sustains peripheral lipid reserves and fecundity. These findings identify relevant roles for Myc in sex differentiation and the intestine as a key, previously overlooked contributor to sex differences in lipid metabolism.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":" ","pages":"1535-1554.e6"},"PeriodicalIF":9.2,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148359799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Celebrating 25 years of Developmental Cell. 庆祝25年的发育细胞。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-07-08 DOI: 10.1016/j.devcel.2026.06.013

Yuli Ding, Andrea Halsey, Akshaya Keerthi Saikumar Jayalatha, Christine Weber

引用次数: 0

Embryo models as experiments in self-organization: The logic of productive failure. 胚胎模型作为自组织的实验：生产失败的逻辑。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-07-08 DOI: 10.1016/j.devcel.2026.06.009

Magdalena Zernicka-Goetz, Sergio de la Rosa

引用次数: 0

Dissecting human organ development using spatial technologies. 利用空间技术解剖人体器官发育。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-07-08 DOI: 10.1016/j.devcel.2026.05.004

Xiaoshan Zhang, J Jeya Vandana, Benjamin Greenspun, Shuibing Chen

{"title":"Dissecting human organ development using spatial technologies.","authors":"Xiaoshan Zhang, J Jeya Vandana, Benjamin Greenspun, Shuibing Chen","doi":"10.1016/j.devcel.2026.05.004","DOIUrl":"10.1016/j.devcel.2026.05.004","url":null,"abstract":"Spatial technologies have revolutionized the study of human development by enabling molecular profiling within intact tissue architecture. Advances in spatial transcriptomics, epigenomics, proteomics, metabolomics, and multiomics have generated high-resolution atlases of embryonic and fetal organs, which have revealed how gene regulatory programs, cell-cell interactions, and tissue patterning are organized in space and time during organogenesis. However, limited access to human developmental tissues and ethical constraints restrict experimental validation and mechanistic studies. Stem cell-derived organoids offer tractable, human-relevant models that recapitulate key structural and cellular features of developing organs while allowing controlled perturbation and longitudinal analysis. Integrating spatial profiling with organoids constitutes a sophisticated methodology for systematic analysis of lineage specification, niche signaling, and metabolic maturation. This review synthesizes current spatial technologies, highlights emerging organoid-based technologies, and discusses future directions integrating spatial multiomics, machine learning, and accessible data resources to advance mechanistic and predictive developmental biology.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"61 7","pages":"1363-1391"},"PeriodicalIF":9.2,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13353200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AXIN1 and AXIN2 regulate the WNT-signaling landscape to promote distinct mesoderm programs. AXIN1和AXIN2调节wnt信号景观，促进不同的中胚层程序。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-07-08 Epub Date: 2026-07-01 DOI: 10.1016/j.devcel.2026.06.004

Rocío Hernández-Martínez, Sonja Nowotschin, Luke T G Harland, Ying-Yi Kuo, Bart Theeuwes, Berthold Göttgens, Elizabeth Lacy, Anna-Katerina Hadjantonakis, Kathryn V Anderson

{"title":"AXIN1 and AXIN2 regulate the WNT-signaling landscape to promote distinct mesoderm programs.","authors":"Rocío Hernández-Martínez, Sonja Nowotschin, Luke T G Harland, Ying-Yi Kuo, Bart Theeuwes, Berthold Göttgens, Elizabeth Lacy, Anna-Katerina Hadjantonakis, Kathryn V Anderson","doi":"10.1016/j.devcel.2026.06.004","DOIUrl":"10.1016/j.devcel.2026.06.004","url":null,"abstract":"How distinct lineage identities are specified from pluripotent epiblast cells during gastrulation is a longstanding open question. By investigating AXIN, a negative regulator of the WNT/β-catenin pathway, we have uncovered previously unrecognized roles for WNT signaling in the specification of distinct mesoderm identities. Using complementary approaches, including a detailed analysis of Axin1;Axin2 mutant mouse embryos involving single-cell and single-embryo transcriptomics and in vitro pluripotent stem cell differentiation assays, our data revealed two critical layers of regulation. First, WNT initiates differentiation of primitive streak cells into mesoderm progenitors. Next, WNT amplifies and cooperates with bone morphogenetic protein (BMP)/pSMAD1/5/9 or NODAL/pSMAD2/3 to propel differentiating mesoderm progenitors into either posterior or anterior streak identities, respectively. We propose that Axin1 and Axin2 function to prevent precocious differentiation of pluripotent epiblast cells into mesoderm through the spatiotemporal regulation of WNT-signaling levels.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":" ","pages":"1572-1588.e6"},"PeriodicalIF":9.2,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148367551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The ALS- and FTD-associated proteins annexin A11 and CHMP2B act sequentially in plasma membrane repair. ALS和ftd相关蛋白annexin A11和CHMP2B在质膜修复中依次起作用。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-07-08 Epub Date: 2026-06-25 DOI: 10.1016/j.devcel.2026.05.014

Catherine M Heffner, Georgina P Starling, Lorian C Straker, Philippa C Hawes, Adrian M Isaacs, Jeremy G Carlton

{"title":"The ALS- and FTD-associated proteins annexin A11 and CHMP2B act sequentially in plasma membrane repair.","authors":"Catherine M Heffner, Georgina P Starling, Lorian C Straker, Philippa C Hawes, Adrian M Isaacs, Jeremy G Carlton","doi":"10.1016/j.devcel.2026.05.014","DOIUrl":"10.1016/j.devcel.2026.05.014","url":null,"abstract":"Maintenance of plasma membrane integrity is essential for compartmentalization of the cytosol and for cellular viability. Upon membrane damage, several factors including endosomal sorting complex required for transport-III (ESCRT-III) proteins, annexins, stress granules, lipids, and membrane fusion proteins are mobilized to orchestrate membrane repair. However, whether these factors operate independently or act together is unclear. Here, using human cell lines, we expose temporal differences and interdependencies in the recruitment of ESCRT-III and annexin proteins to sites of plasma membrane damage. We show that annexin proteins are recruited immediately and form a plug at the damage site, restricting membrane permeability. We find that ESCRT-III assembles later and acts to release plug-containing damaged membranes from the cell. Further, frontotemporal dementia (FTD)- and amyotrophic lateral sclerosis (ALS)-associated mutations in the ESCRT-III protein, CHMP2B, and the annexin protein, ANXA11, compromise plasma membrane repair, suggesting that defects in this process may contribute to these pathologies. These data present an integrated \"sealing and healing\" model of membrane repair.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":" ","pages":"1487-1503.e7"},"PeriodicalIF":9.2,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13374510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148327532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tissue mechanopathology of cancer. 癌症的组织机械病理学。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-07-08 DOI: 10.1016/j.devcel.2026.06.006

Johanna Ivaska, Sarah Sale, Alpha S Yap

引用次数: 0

ARID1A terminates gastric regeneration to prevent cancer. ARID1A终止胃再生以预防癌症。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-07-08 Epub Date: 2026-06-30 DOI: 10.1016/j.devcel.2026.06.002

Adrian K H Loe, Alyssa Ialongo, Yan Qin, Amin Afkhami-Poostchi, Shaheed W Hakim, Chiyeol Choi, Motonobu Saito, Bingxin Guan, Haiyang Guo, Ho Sung Rhee, Tae-Hee Kim

{"title":"ARID1A terminates gastric regeneration to prevent cancer.","authors":"Adrian K H Loe, Alyssa Ialongo, Yan Qin, Amin Afkhami-Poostchi, Shaheed W Hakim, Chiyeol Choi, Motonobu Saito, Bingxin Guan, Haiyang Guo, Ho Sung Rhee, Tae-Hee Kim","doi":"10.1016/j.devcel.2026.06.002","DOIUrl":"10.1016/j.devcel.2026.06.002","url":null,"abstract":"Exposed constantly to environmental challenges, the stomach undergoes highly reversible cycles of regeneration and recovery. Although abnormal activation of regeneration is known to be associated with cancer, the mechanisms underlying tissue restoration remain unclear. Our single-cell gene expression and chromatin analysis defined cell state dynamics during regeneration and recovery, identifying the Brahma-related gene 1(BRG1)/BRM-associated factor (BAF) chromatin remodeling complex during recovery. Strikingly, deletion of AT-rich interaction domain 1A (Arid1a), a subunit of the BAF complex and the second most frequently mutated gene in gastric cancer, impaired recovery across multiple murine injury models, resulting in a persistent regenerative state. Integrative analyses combining single-cell multiome and chromatin immunoprecipitation sequencing (ChIP-seq) demonstrated that the BAF complex recruits lineage-specific transcription factors such as MIST1 and estrogen related receptor gamma (ERRγ) to regulate enhancers of recovery genes. Notably, deletion of Trp53 in the unresolved regenerative state caused by Arid1a loss is sufficient to drive cancer development and invasion, revealing the epigenetic mechanisms bridging gastric regeneration, recovery, and cancer.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":" ","pages":"1471-1486.e6"},"PeriodicalIF":9.2,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148359773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0