Developmental cell最新文献_第5页

Prolonged cold exposure enhances regeneration potential in Arabidopsis 长时间的冷暴露提高了拟南芥的再生潜力

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-08-12 DOI: 10.1016/j.devcel.2026.07.009

Fu-Yu Hung, Yetkin Caka Ince, Ayako Kawamura, Arika Takebayashi, Yu Chen, Takuya T. Nagae, Akira Iwase, Noriko Takeda-Kamiya, Kiminori Toyooka, Dongbo Shi, Miguel Moreno-Risueno, Keqiang Wu, Keiko Sugimoto

引用次数: 0

Two parallel neuronal circuits involving electrical synapse and DAF-7/TGF-β signaling regulate muscle autophagy in C. elegans. 涉及电突触和DAF-7/TGF-β信号的两个平行神经元回路调节秀丽隐杆线虫的肌肉自噬。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-08-12 Epub Date: 2026-06-29 DOI: 10.1016/j.devcel.2026.06.001

Hui Zheng, Hongyu Zhao, Hong Zhang

引用次数: 0

Pulmonary cold sensing through Club cells triggers adipose thermogenesis to ameliorate obesity. 肺冷感应通过俱乐部细胞触发脂肪产热，以改善肥胖。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-08-12 Epub Date: 2026-07-27 DOI: 10.1016/j.devcel.2026.07.003

Junkun Jiang, Chengrui Liang, Zelin Wang, Zhangming Lu, Wenjing Yu, Xinran Wang, Chuan Zhang, Zhen-Ning Zhang, Bing Luan

引用次数: 0

Live imaging captures the events immediately following fertilization. 实时成像捕捉到了受精后的瞬间。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-08-12 Epub Date: 2026-07-17 DOI: 10.1016/j.devcel.2026.06.015

Robin M Skory, Ana Domingo-Muelas, Sarah Declercq, Winter Vandenberghe, Piotr Tetlak, Blake Hernandez, Dominic Stoop, Colin C Conine, Maté Biro, Björn Heindryckx, Nicolas Plachta

{"title":"Live imaging captures the events immediately following fertilization.","authors":"Robin M Skory, Ana Domingo-Muelas, Sarah Declercq, Winter Vandenberghe, Piotr Tetlak, Blake Hernandez, Dominic Stoop, Colin C Conine, Maté Biro, Björn Heindryckx, Nicolas Plachta","doi":"10.1016/j.devcel.2026.06.015","DOIUrl":"10.1016/j.devcel.2026.06.015","url":null,"abstract":"Fertilization involves dynamic sperm-egg interactions, yet has been primarily studied in static samples. Here, we use high-resolution live imaging to capture fertilization from the moment of sperm binding in zona-intact mouse oocytes. We identify two phases of sperm remodeling: a static phase, during which sperm remain beneath the oocyte cortex as DNA decondensation and histone loading occur, and a mobile phase characterized by stereotyped sperm movement. Initial displacement away from the spindle is driven by cytoplasmic streaming, with manipulations in mouse indicating that sperm movement requires chromatin decondensation and oocyte polarization. Subsequently, polar body cytokinesis generates convergent cortical flows that draw sperm toward the emerging female pronucleus. Finally, we capture sperm-egg fusion in human oocytes and characterize post-fusion events including meiotic resumption and sperm movement, offering a live-imaging description of human fertilization dynamics. Together, these findings provide a continuous spatiotemporal framework for mammalian fertilization, extended by initial observations in human oocytes.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":" ","pages":"1620-1633.e4"},"PeriodicalIF":9.2,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148469484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical control of human embryonic mesoderm fate via β-catenin is conserved with other metazoans 通过β-连环蛋白对人类胚胎中胚层命运的机械控制在其他后生动物中是保守的

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-08-12 DOI: 10.1016/j.devcel.2026.07.010

Laurie Exposito, Paula Cambronera-Ghiglione, Maria Elena Fernández-Sánchez, Emmanuel Farge

引用次数: 0

Tissue tension permits β-catenin phosphorylation to drive mesoderm specification in human embryonic stem cells. 组织张力允许β-连环蛋白磷酸化驱动人类胚胎干细胞的中胚层规范。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-08-12 Epub Date: 2026-07-13 DOI: 10.1016/j.devcel.2026.06.014

Nadia M E Ayad, Aisha Almsoud, Johnathon N Lakins, Ajinkya Ghagre, Allen J Ehrlicher, Ophir D Klein, FuiBoon Kai, Valerie M Weaver

{"title":"Tissue tension permits β-catenin phosphorylation to drive mesoderm specification in human embryonic stem cells.","authors":"Nadia M E Ayad, Aisha Almsoud, Johnathon N Lakins, Ajinkya Ghagre, Allen J Ehrlicher, Ophir D Klein, FuiBoon Kai, Valerie M Weaver","doi":"10.1016/j.devcel.2026.06.014","DOIUrl":"10.1016/j.devcel.2026.06.014","url":null,"abstract":"The role of morphogenetic forces in cell fate specification is an area of intense interest. Using an ectopically expressed nonphosphorylatable mutant of β-catenin (Y654F) in human embryonic stem cell colonies, we provide evidence that impeding tension-dependent Src-mediated β-catenin phosphorylation compromises BMP4-driven Brachyury (T) expression. This impediment also disrupts the epithelial-to-mesenchymal transition essential for mesoderm specification. Mechanistically, the Y654F mutation prevents the translocation of the junctional and cytoskeletal pool of β-catenin to the nucleus. However, saturation of Wnt signaling with exogenous Wnt3a or the inhibition of GSK3β rescues mesoderm expression. These findings suggest that BMP4 initiates a force-dependent junctional β-catenin translocation upstream of both Wnt secretion and cytosolic Wnt/β-catenin stabilization to drive mesoderm specification. Ultimately, our work highlights the importance of force-dependent Wnt/β-catenin signaling in the self-organization of tissues during developmental processes, such as gastrulation, and emphasizes a role for fine-tuned molecular regulation of the Wnt signaling pathway.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":" ","pages":"1652-1666.e7"},"PeriodicalIF":9.2,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148435676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KRAS mutations take different trajectories to drive pancreatic transformation KRAS突变采取不同的轨迹来驱动胰腺转化

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-08-12 DOI: 10.1016/j.devcel.2026.07.013

Kayla C. LaRue-Nolan, Martin E. Fernandez-Zapico

引用次数: 0

Longitudinal zone- and cell type-specific pattern-triggered immune responses in Arabidopsis roots. 拟南芥根系纵向区和细胞类型特异性模式触发的免疫应答。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-08-12 Epub Date: 2026-07-24 DOI: 10.1016/j.devcel.2026.07.002

Lahong Xu, Fausto Andres Ortiz-Morea, Sung-Il Kim, Camilla Ferrari, Yan Yan, Derui Liu, Daniel Osorio Hurtado, James J Cai, Klaas Vandepoele, Libo Shan, Ping He

{"title":"Longitudinal zone- and cell type-specific pattern-triggered immune responses in Arabidopsis roots.","authors":"Lahong Xu, Fausto Andres Ortiz-Morea, Sung-Il Kim, Camilla Ferrari, Yan Yan, Derui Liu, Daniel Osorio Hurtado, James J Cai, Klaas Vandepoele, Libo Shan, Ping He","doi":"10.1016/j.devcel.2026.07.002","DOIUrl":"10.1016/j.devcel.2026.07.002","url":null,"abstract":"Roots, composed of diverse cell types across longitudinal developmental zones, are vital for plant survival against microbial challenges. Leveraging single-cell transcriptomics and live-cell imaging of Arabidopsis roots, we reveal here that plant-derived phytocytokines elicit more potent immune responses than microbe-derived patterns across root cell types and zones. The differential expression of receptors and key signaling modules in distinct cell types and zones contributes to the response intensity to specific elicitors. Phytocytokines sustain growth-defense trade-offs by suppressing the expression of receptor-like kinase genes associated with root cell division and elongation. The intensity of immune responses in different root zones is associated with fungal and bacterial pathogen invasion sites. Furthermore, motif-informed network inference highlighted key transcriptional regulators driving cell identity-specific transcriptomic immune responses. Our study provides a comprehensive landscape of transcriptional responses in plant roots in response to diverse immune elicitors, highlighting how distinct phytocytokines orchestrate stage- and cell type-dependent transcriptional reprogramming.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":" ","pages":"1730-1746.e7"},"PeriodicalIF":9.2,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148583670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The actin crosslinker Fimbrin is required for force sensing at tricellular junctions. 肌动蛋白交联剂芬布林是三细胞连接处力传感所必需的。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-08-12 Epub Date: 2026-07-24 DOI: 10.1016/j.devcel.2026.07.001

Nilay Taneja, Claire A Looney, Michael F Moubarak, Meriel J McGovern, Kenji Yeoh, Jennifer A Zallen

{"title":"The actin crosslinker Fimbrin is required for force sensing at tricellular junctions.","authors":"Nilay Taneja, Claire A Looney, Michael F Moubarak, Meriel J McGovern, Kenji Yeoh, Jennifer A Zallen","doi":"10.1016/j.devcel.2026.07.001","DOIUrl":"10.1016/j.devcel.2026.07.001","url":null,"abstract":"Epithelial cells sense and respond to mechanical forces by reinforcing connections between adherens junctions and the actin cytoskeleton. Tricellular junctions are key sites of mechanotransduction in epithelial cells, but how force responses are coordinated at these structures during epithelial remodeling is poorly understood. We show that the actin crosslinking protein Fimbrin is recruited by forces to tricellular junctions in Drosophila and promotes actin reorganization and cell adhesion during epithelial remodeling. In the absence of Fimbrin, cells fail to reorganize actin or recruit junction-stabilizing proteins to tricellular junctions under tension, disrupting cell adhesion. Conversely, increasing Fimbrin activity constitutively activates multiple force-response pathways, aberrantly stabilizing adhesion. We show that Fimbrin directs force responses by amplifying actomyosin contractility, and that force-regulated actin remodeling and Plastin3 and Afadin localization occur at tricellular junctions in the mouse embryo. These results suggest that conserved mechanisms underlie force responses at tricellular junctions in fly and mouse epithelia.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":" ","pages":"1699-1716.e12"},"PeriodicalIF":9.2,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148583737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis. 分子动力学驱动KRAS突变体在胰腺肿瘤发生中的表型差异。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-08-12 Epub Date: 2026-07-21 DOI: 10.1016/j.devcel.2026.06.016

Adrien Grimont, David J Falvo, Whitney J Sisso, Francisco Santos, Christopher W Chan, Paul Zumbo, William B Fall, Katherine Ferrick, Grace Pan, Megan Cleveland, Tomer M Yaron-Barir, Alexa Osterhoudt, Yinuo Meng, Maria Paz Zafra, Andre F Rendeiro, Erika Hissong, Rhonda K Yantiss, Doron Betel, Mark A Magnuson, Steven D Leach, Anil K Rustgi, Lukas E Dow, Rohit Chandwani

{"title":"Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis.","authors":"Adrien Grimont, David J Falvo, Whitney J Sisso, Francisco Santos, Christopher W Chan, Paul Zumbo, William B Fall, Katherine Ferrick, Grace Pan, Megan Cleveland, Tomer M Yaron-Barir, Alexa Osterhoudt, Yinuo Meng, Maria Paz Zafra, Andre F Rendeiro, Erika Hissong, Rhonda K Yantiss, Doron Betel, Mark A Magnuson, Steven D Leach, Anil K Rustgi, Lukas E Dow, Rohit Chandwani","doi":"10.1016/j.devcel.2026.06.016","DOIUrl":"10.1016/j.devcel.2026.06.016","url":null,"abstract":"Inflammation in the pancreas drives acinar-to-ductal metaplasia (ADM), a progenitor-like state that can be hijacked by mutant Kras in the formation of pancreatic ductal adenocarcinoma. How these cell fate decisions vary according to KRAS mutation remains poorly understood. To define mutation-specific lineage reversion and tumor initiation, we implement Ptf1a-tdTomato mice and multiple KRAS mutants across several genetic, pharmacologic, and inflammatory perturbations in vivo. Whereas KRASG12D co-opts injury to enable lineage reversion, enhancer reprogramming, and tumor initiation, KRASG12R/V cannot sustain dedifferentiated and neoplastic transcriptional and epigenetic programs. Specifically, KRASG12R/V mutants fail to invoke robust EGFR, AKT, and RAC1/VAV1 signaling and to license Pou2f3 and Vav1 in chromatin, such that only constitutive AKT activation is sufficient to rescue the tumorigenic potential of KRASG12Rin vivo. As the marked heterogeneity among KRAS variants begins early in tumorigenesis, these data are crucial to deciphering mutation-specific oncogenic trajectories and directing the implementation of KRAS-directed therapeutics.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":" ","pages":"1667-1684.e8"},"PeriodicalIF":9.2,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13404274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148548163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0