通过删除单个CTCF基序破坏染色质结构域边界会影响发育

IF 8.7 1区生物学 Q1 CELL BIOLOGY

Developmental cell Pub Date : 2025-07-07 DOI:10.1016/j.devcel.2025.05.005

Xinyi Liu, Junjun Ding

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引用次数: 0

摘要

染色质结构域边界是至关重要的发展，通过空间限制增强子活动，以确保精确的时空基因调控。在本期《发育细胞》中，Chakraborty等人证明，单个CTCF基序的缺失导致染色质结构域边界的缺失会导致严重的发育缺陷。

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Breaking a chromatin domain boundary by deleting a single CTCF motif impacts development

Chromatin domain boundaries are crucial for development by spatially constraining enhancer activity to ensure precise spatiotemporal gene regulation. In this issue of Developmental Cell, Chakraborty et al. demonstrate that the loss of a chromatin domain boundary caused by deletion of a single CTCF motif can lead to severe developmental defects.

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来源期刊

Developmental cell 生物-发育生物学

CiteScore

18.90

自引率

1.70%

发文量

203

审稿时长

3-6 weeks

期刊介绍： Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.