Developmental cell最新文献_第2页

Dual threat: VSIG4⁺ macrophages use IL-11 and VSIG4 to silence T cells 双重威胁：VSIG4 +巨噬细胞利用IL-11和VSIG4沉默T细胞

IF 11.8 1区生物学

Developmental cell Pub Date : 2025-10-06 DOI: 10.1016/j.devcel.2025.08.006

Darya Khantakova, Marco Colonna

引用次数: 0

Common mechanisms regulate stem cell self-organization and symmetry breaking across various glandular epithelia 共同机制调节干细胞自组织和对称打破在各种腺上皮

IF 11.8 1区生物学

Developmental cell Pub Date : 2025-10-06 DOI: 10.1016/j.devcel.2025.07.009

Brigida Novello, Cédric Blanpain

引用次数: 0

How glioblastoma stem cells turn inflammatory cues into tumor growth and immune suppression 胶质母细胞瘤干细胞如何将炎症信号转化为肿瘤生长和免疫抑制

IF 11.8 1区生物学

Developmental cell Pub Date : 2025-10-06 DOI: 10.1016/j.devcel.2025.06.011

Wenhui Chen, Yanjie Shen, Guangshuai Jia

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Kickstart the cell cycle with a sugar boost: mTOR brake on APC/C-CDH1 triggers a glycolytic pulse 通过糖的增加来启动细胞周期：APC/C-CDH1上的mTOR刹车触发糖酵解脉冲

IF 11.8 1区生物学

Developmental cell Pub Date : 2025-10-06 DOI: 10.1016/j.devcel.2025.09.006

Fangxia Wang, Yuu Kimata

引用次数: 0

TMK-PIN1 drives a short self-organizing circuit for auxin export and signaling in Arabidopsis TMK-PIN1驱动拟南芥中生长素输出和信号传导的短自组织电路

IF 11.8 1区生物学

Developmental cell Pub Date : 2025-10-02 DOI: 10.1016/j.devcel.2025.09.009

Rongfeng Huang, Jiacheng Wang, Mingzeng Chang, Wenxin Tang, Yongqiang Yu, Yi Zhang, Yao Peng, Yanan Wang, Yihan Guo, Ting Lu, Yang Cao, Yewei Zhou, Qinglin Zhang, Yuehong Huang, Angxiao Wu, Luyan Ren, Michelle Gallei, Juan Dong, Haodong Chen, Jun He, Tongda Xu

{"title":"TMK-PIN1 drives a short self-organizing circuit for auxin export and signaling in Arabidopsis","authors":"Rongfeng Huang, Jiacheng Wang, Mingzeng Chang, Wenxin Tang, Yongqiang Yu, Yi Zhang, Yao Peng, Yanan Wang, Yihan Guo, Ting Lu, Yang Cao, Yewei Zhou, Qinglin Zhang, Yuehong Huang, Angxiao Wu, Luyan Ren, Michelle Gallei, Juan Dong, Haodong Chen, Jun He, Tongda Xu","doi":"10.1016/j.devcel.2025.09.009","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.09.009","url":null,"abstract":"The versatile and pivotal roles of the phytohormone auxin in regulating plant growth and development are typically linked to its directional transport, relying on the polarized PIN-FORMED (PIN) auxin exporters at the plasma membrane (PM). For decades, auxin has been proposed to promote PIN polarization, generating self-regulatory feedback mediating much of plant development, but mechanistic insight into this regulation is lacking. Here, we uncover an auxin-induced protein complex at the PM, containing auxin co-receptors transmembrane kinases (TMKs) and PIN1 auxin exporter, as the core machinery that underlies this feedback regulation. Auxin promotes PIN1 phosphorylation by TMKs, modulating PIN1 polarization and transport activity. We also provide evidence that PIN1-exported extracellular auxin is crucial for TMK activation and cell elongation, thus forming the simplest two-element self-regulatory feedback circuit. Thus, these findings offer direct mechanistic insights into a potential self-organizing circuit for auxin signaling and transport to ensure proper plant development in Arabidopsis.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"214 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidermal hydrodynamics controls water homeostasis of shoot meristems for plant adaptation to terrestrial environments 表皮水动力学控制着植物芽分生组织的水分稳态，以适应陆地环境

IF 11.8 1区生物学

Developmental cell Pub Date : 2025-09-30 DOI: 10.1016/j.devcel.2025.09.007

Yimin Zhu, Xianmiao Zhu, Simin Bi, Dan Teng, Muhammad Tahir, Yangxuan Liu, Long Wang, Huanhuan Liu, Tingting Wen, Leyao Zhu, Zhenquan Li, Xing Chen, Minhua Zhang, Wenjuan Cai, Zhijun Liu, Mingyue Zheng, Yu Zhang, Ji-Ming Gong, Jia-Wei Wang, Zuhua He, Weibing Yang

{"title":"Epidermal hydrodynamics controls water homeostasis of shoot meristems for plant adaptation to terrestrial environments","authors":"Yimin Zhu, Xianmiao Zhu, Simin Bi, Dan Teng, Muhammad Tahir, Yangxuan Liu, Long Wang, Huanhuan Liu, Tingting Wen, Leyao Zhu, Zhenquan Li, Xing Chen, Minhua Zhang, Wenjuan Cai, Zhijun Liu, Mingyue Zheng, Yu Zhang, Ji-Ming Gong, Jia-Wei Wang, Zuhua He, Weibing Yang","doi":"10.1016/j.devcel.2025.09.007","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.09.007","url":null,"abstract":"Water uptake and redistribution represent a significant challenge for plant colonization of land. While vascular plants have evolved specialized structures for water transport, how water homeostasis is maintained in meristematic tissues remains elusive. Here, we show that the Arabidopsis shoot meristem develops within a high-humidity niche. The homeodomain leucine zipper (HD-ZIP) transcription factor ARABIDOPSIS THALIANA MERISTEM LAYER 1 (ATML1) and its regulatory target PIP2;5 establish a water conduit across L1 cells to facilitate hydraulic exchange with the surrounding microenvironment. The ATML1-PIP2;5 module regulates stem cell activity in response to humidity fluctuations and is associated with local adaptation to arid climates in natural populations. Transcriptional activation of water flux by class IV homeodomain-leucine zipper (C4HDZ) proteins predates the emergence of vascular systems, contributing to hydraulic response in the liverwort Marchantia polymorpha. Our results reveal an evolutionarily conserved epidermal hydraulic pathway that integrates developmental patterning with environmental sensing, highlighting a fundamental role for the shoot meristem in shaping plant adaptation in terrestrial habitats.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"11 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human pluripotent stem cell-derived fetal hepatic stellate cells promote vascularization and maturation in liver organoids 人多能干细胞衍生的胎儿肝星状细胞促进肝类器官的血管化和成熟

IF 11.8 1区生物学

Developmental cell Pub Date : 2025-09-29 DOI: 10.1016/j.devcel.2025.09.002

Xia Yang, Yun-Zhong Nie, Chun Lu, Yang Li, Yoshihito Hayashi, Riana Plummer, Na Luo, Qinglin Li, Toshiharu Kasai, Takashi Okumura, Yumiko Isobe, Kiyoshi Yamaguchi, Yoichi Furukawa, Yan Li, Hideki Taniguchi

{"title":"Human pluripotent stem cell-derived fetal hepatic stellate cells promote vascularization and maturation in liver organoids","authors":"Xia Yang, Yun-Zhong Nie, Chun Lu, Yang Li, Yoshihito Hayashi, Riana Plummer, Na Luo, Qinglin Li, Toshiharu Kasai, Takashi Okumura, Yumiko Isobe, Kiyoshi Yamaguchi, Yoichi Furukawa, Yan Li, Hideki Taniguchi","doi":"10.1016/j.devcel.2025.09.002","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.09.002","url":null,"abstract":"Human-induced pluripotent stem cell (hiPSC)-derived liver organoids (LOs) are valuable for studying human liver organogenesis but face challenges in faithfully recapitulating certain processes, like vasculogenesis, due to the lack of specific cell components. Hepatic stellate cells (HSCs), which are liver-specific pericytes and might be crucial for liver vasculogenesis, remain underutilized in developmental studies because of their disease-related status and inefficient generation process. Here, we present an efficient method for generating hiPSC-derived HSCs (hiPSC-HSCs) resembling the transcriptomic profiles of fetal human HSCs. These hiPSC-HSCs exhibit exceptional expandability (>105-fold) while maintaining essential cellular features. Additionally, in entirely hiPSC-derived LOs consisting of HSCs, hepatic endoderm, and endothelial cells, hiPSC-HSCs play a vital role in LO maturation and vascularization, both in vitro and in vivo. This work represents a significant advancement in understanding HSC roles in human liver development, and LOs containing hiPSC-HSCs hold potential in modeling congenital human liver diseases.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"4 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-cell-autonomous tumor promotion in DICER1 cancer predisposition 非细胞自主肿瘤促进DICER1癌症易感性

IF 11.8 1区生物学

Developmental cell Pub Date : 2025-09-29 DOI: 10.1016/j.devcel.2025.09.001

Randolph K. Larsen, Jason A. Hanna, Hongjian Jin, Kristin B. Reed, Darden W. Kimbrough, Kyna Vuong, Jongchan Hwang, Grace E. Adkins, Jack D. Hopkins, Bradley T. Stevens, Myron K. Evans, Casey G. Langdon, Catherine J. Drummond, Matthew R. Garcia, Kristin B. Wiggins, Amy R. Iverson, David Finkelstein, Patrick A. Schreiner, Jason W. Rosch, Jerold E. Rehg, Mark E. Hatley

{"title":"Non-cell-autonomous tumor promotion in DICER1 cancer predisposition","authors":"Randolph K. Larsen, Jason A. Hanna, Hongjian Jin, Kristin B. Reed, Darden W. Kimbrough, Kyna Vuong, Jongchan Hwang, Grace E. Adkins, Jack D. Hopkins, Bradley T. Stevens, Myron K. Evans, Casey G. Langdon, Catherine J. Drummond, Matthew R. Garcia, Kristin B. Wiggins, Amy R. Iverson, David Finkelstein, Patrick A. Schreiner, Jason W. Rosch, Jerold E. Rehg, Mark E. Hatley","doi":"10.1016/j.devcel.2025.09.001","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.09.001","url":null,"abstract":"DICER1-related tumors are characterized by germline loss-of-function mutations in one DICER1 allele (DICER1+/−) and a somatic “second hit” mutation in the remaining DICER1 allele. Whether the germline DICER1+/− mutation participates in tumorigenesis is unknown. We show that germline heterozygous loss of Dicer1 promotes tumor formation via aberrant neutrophil function in spontaneous and allograft mouse models of rhabdomyosarcoma. Germline heterozygous deletion of Dicer1 decreased tumor latency and increased tumor penetrance, while conditional heterozygous deletion in tumor cells did not, illustrating that non-cell-autonomous contributions were required for tumor promotion. We show that Dicer1+/− murine and human tumors were enriched for neutrophils and that tumor-bearing mice had abundant circulating neutrophil extracellular traps (NETs). Genetically and pharmacologically preventing NET release reduced tumor promotion in Dicer1+/− mice, suggesting NETs promote tumor growth. These findings demonstrate that germline DICER1+/− mutations promote tumor growth and suggest that targeting neutrophils/NET release may reduce cancer risk in DICER1+/− individuals.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"118 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lmo3-expressing peri-isthmus progenitor cells sustain renewal and repair of the mammalian intestinal telocyte niche 表达lmo3的峡周祖细胞维持哺乳动物肠远端细胞生态位的更新和修复

IF 11.8 1区生物学

Developmental cell Pub Date : 2025-09-26 DOI: 10.1016/j.devcel.2025.09.004

Daxin Jiang, Guoli Zhu, Yongchao Zhang, Jiawen Wang, Nannan Qian, Zhen Jin, Qingyu Sun, Haimeng Yu, Kebei Tang, Tao Cai, Fengchao Wang, Rongwen Xi

{"title":"Lmo3-expressing peri-isthmus progenitor cells sustain renewal and repair of the mammalian intestinal telocyte niche","authors":"Daxin Jiang, Guoli Zhu, Yongchao Zhang, Jiawen Wang, Nannan Qian, Zhen Jin, Qingyu Sun, Haimeng Yu, Kebei Tang, Tao Cai, Fengchao Wang, Rongwen Xi","doi":"10.1016/j.devcel.2025.09.004","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.09.004","url":null,"abstract":"Intestinal telocytes that reside immediately beneath the intestinal epithelium exert niche-supporting roles for intestinal stem cells and their progenies. They are heterogeneous cells compartmentalized along the crypt-villus axis, but the mechanisms governing the maintenance of this telocyte population remain unclear. Here, we identify a distinct population of subepithelial mesenchymal cells in the developing mouse embryo, marked by LIM Domain Only 3 (Lmo3), as the cellular origin of post-natal intestinal telocytes. The Lmo3+ cells emerge prior to villus formation at embryonic day 13.5, and after birth, they progressively acquire a spatial confinement to the intestinal isthmus region, where they persist as long-lived, slow-cycling cells, supplying both peri-villus and peri-crypt telocytes. Further, we show that Lmo3+ cells respond rapidly to tissue damage, becoming activated to promote repair of the telocyte niche. Therefore, a quiescent and damage-responsive progenitor cell population marked by Lmo3 maintains the intestinal telocyte niche.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"94 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145141185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cryo-EM structure and dynamic basis of phosphate uptake by PHT1 in rice 水稻PHT1吸收磷素的低温电镜结构和动态基础

IF 11.8 1区生物学

Developmental cell Pub Date : 2025-09-25 DOI: 10.1016/j.devcel.2025.09.003

Zhangmeng Du, Zeyuan Guan, Hai Liu, Jie Zhang, Haitao He, Zhiwen Zheng, Wenhui Zhang, Lihuan Jiang, Jiaqi Zuo, Yan Liu, Beijing Wan, Haifu Tu, Faming Dong, Xuelei Lai, Lizhong Xiong, Ping Yin, Shaowu Xue, Yanke Chen, Zhu Liu

{"title":"Cryo-EM structure and dynamic basis of phosphate uptake by PHT1 in rice","authors":"Zhangmeng Du, Zeyuan Guan, Hai Liu, Jie Zhang, Haitao He, Zhiwen Zheng, Wenhui Zhang, Lihuan Jiang, Jiaqi Zuo, Yan Liu, Beijing Wan, Haifu Tu, Faming Dong, Xuelei Lai, Lizhong Xiong, Ping Yin, Shaowu Xue, Yanke Chen, Zhu Liu","doi":"10.1016/j.devcel.2025.09.003","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.09.003","url":null,"abstract":"Phosphorus is an essential macronutrient for plants, primarily absorbed from the soil as inorganic phosphate (Pi) through root-located Pi transporters. Despite decades of research into these transporters as targets for developing Pi-efficient crops, their mechanisms for Pi import remain poorly understood. Here, we present the cryo-electron microscopy (cryo-EM) structures of the rice Pi importer OsPHT1;11 in both Pi-bound and unbound forms, characterize its conformational dynamics, and demonstrate how these dynamics contribute to its transport function. Pi is recognized through conserved residues found in plants, with its translocation facilitated by a typical alternating-access mechanism. Single-molecule fluorescence resonance energy transfer (smFRET) analyses show that this transporter undergoes dynamic conformational fluctuations, which are differentially linked to its Pi transport capability, with a predominance of extracellular open conformations favoring Pi transport, while more populated intracellular open conformations hinder it. These findings highlight key conformational determinants of transport activity and provide mechanistic insights into Pi uptake in plants.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"193 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0