Developmental cell最新文献_第2页

Long-term confinement triggers RIPK3-independent necroptosis in amoeboid cancer cells to shape tumor evolution 长期禁闭触发变形虫癌细胞中不依赖ripk3的坏死下垂，从而影响肿瘤的进化

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-10-14 DOI: 10.1016/j.devcel.2026.09.003

Wei Zhang,Ya-Jun Wang,Chunman Zuo,Junyi He,Xuying Ma,Haoran Wu,Bao-Qiong Lan,Dehui Kong,Luonan Chen,Gang Wei,Na Yang,Yuandi Fu,Dan Liu,Yan-Jun Liu,Liming Sun

{"title":"Long-term confinement triggers RIPK3-independent necroptosis in amoeboid cancer cells to shape tumor evolution","authors":"Wei Zhang,Ya-Jun Wang,Chunman Zuo,Junyi He,Xuying Ma,Haoran Wu,Bao-Qiong Lan,Dehui Kong,Luonan Chen,Gang Wei,Na Yang,Yuandi Fu,Dan Liu,Yan-Jun Liu,Liming Sun","doi":"10.1016/j.devcel.2026.09.003","DOIUrl":"https://doi.org/10.1016/j.devcel.2026.09.003","url":null,"abstract":"The mesenchymal-amoeboid transition (MAT) enhances cancer cell migration and therapy resistance during dissemination through mechanically confined spaces. Using an in vitro MAT induction system combining physical confinement with a non-adhesive environment to mimic interstitial migration, we introduce “long-term MAT” (L-MAT) to describe cells sustaining MAT under prolonged pressure and show that L-MAT triggers receptor-interacting protein kinase 3 (RIPK3)-independent necroptosis. Mechanistically, the PIEZO1-STAT1 axis upregulates mixed lineage kinase domain-like pseudokinase (MLKL), whose membrane accumulation drives necroptosis in cells otherwise resistant to death-receptor signaling. Before membrane rupture, L-MAT cells show progressive migration restriction; MLKL-knockout cells bypass this checkpoint and persist as surviving clones. Spatial transcriptomics of patient tumors shows MLKL expression correlates with PIEZO1 activation and immunogenicity in less aggressive regions, while advanced malignant and metastatic clones show reduced MLKL. These findings establish MLKL as a conditional tumor checkpoint and identify the PIEZO1-STAT1-MLKL axis as a predictive biomarker and therapeutic target.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"27 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Illuminating NAD+ Metabolism in Live Cells and In Vivo Using a Genetically Encoded Fluorescent Sensor 利用基因编码荧光传感器照亮活细胞和体内NAD+代谢

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-10-10 DOI: 10.1016/j.devcel.2026.09.013

Yejun Zou,Aoxue Wang,Li Huang,Xudong Zhu,Qingxun Hu,Yinan Zhang,Xianjun Chen,Fengwen Li,Qiaohui Wang,Hu Wang,Renmei Liu,Fangting Zuo,Ting Li,Jing Yao,Yajie Qian,Mei Shi,Xiao Yue,Weicai Chen,Zhuo Zhang,Congrong Wang,Yong Zhou,Linyong Zhu,Zhenyu Ju,Joseph Loscalzo,Yi Yang,Yuzheng Zhao

引用次数: 0

A Ca2+ sensor-transcription factor cascade regulates cell-wall fortification and broad-spectrum disease resistance in rice Ca2+传感器转录因子级联调节水稻细胞壁强化和广谱抗病性

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-10-07 DOI: 10.1016/j.devcel.2026.09.006

Han Lu,Zian Ye,Yonglin Wu,Yuxin Fan,Yangxuan Liu,Xianmiao Zhu,Xi Zhang,Kui Li,Lingna Shangguan,Jingyi Wang,Weixuan Cui,Tianyi Ji,Shuai Tao,Xinxin Xie,Jiyun Liu,Yunjun Zhao,Weibing Yang,Ying Wang,Zuhua He,Mingjun Gao

{"title":"A Ca2+ sensor-transcription factor cascade regulates cell-wall fortification and broad-spectrum disease resistance in rice","authors":"Han Lu,Zian Ye,Yonglin Wu,Yuxin Fan,Yangxuan Liu,Xianmiao Zhu,Xi Zhang,Kui Li,Lingna Shangguan,Jingyi Wang,Weixuan Cui,Tianyi Ji,Shuai Tao,Xinxin Xie,Jiyun Liu,Yunjun Zhao,Weibing Yang,Ying Wang,Zuhua He,Mingjun Gao","doi":"10.1016/j.devcel.2026.09.006","DOIUrl":"https://doi.org/10.1016/j.devcel.2026.09.006","url":null,"abstract":"Crop production is persistently threatened by a multitude of destructive diseases. In rice, the Ca2+ sensor RESISTANCE OF RICE TO DISEASES1 (ROD1) is a key regulator of defense against major pathogens, including those causing blast, sheath blight, and bacterial blight. However, the molecular mechanisms underlying ROD1-mediated immune suppression remain largely elusive. Here, we characterize an immune signaling cascade comprising the B3-domain transcription factor OsVAL2, the DOF transcription factor OsDOF3, as well as their downstream target OsCSE encoding a caffeoyl shikimate esterase. We demonstrate that the OsVAL2-OsDOF3-OsCSE module promotes lignin deposition and cell-wall fortification to confer broad-spectrum disease resistance. ROD1 interacts with and sequesters OsVAL2 in the cytoplasm, thereby preventing its nuclear accumulation and subsequent initiation of this immune program. Our findings reveal a spatiotemporal regulatory mechanism that maintains immune homeostasis, highlighting the crucial role of cell-wall remodeling in crop disease resistance.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"53 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149090104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inducible human yolk sac myeloid progenitors model myeloid ontogeny and enable tissue-resident macrophage replacement in vivo 可诱导的人卵黄囊髓系祖细胞模拟髓系个体发生，并在体内实现组织内巨噬细胞替代

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-10-01 DOI: 10.1016/j.devcel.2026.09.005

Anna Martinez-Muriana,Nicola Fattorelli,Leen Wolfs,Lena Jutz,Emanuela Pasciuto,Heidi Denton,Maxim van Hoek,Jessie Premereur,Gaia Zen,Baukje Bijnens,Alma Mohebiany,Tim Meese,Arthi Shanmugavadivu,V. Hugh Perry,Bart De Strooper,Renzo Mancuso

引用次数: 0

Nitrate-responsive Sialin2 couples stress granule assembly and clearance to maintain neuronal homeostasis 硝酸反应唾液素2偶联应激颗粒组装和清除维持神经元稳态

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-10-01 DOI: 10.1016/j.devcel.2026.09.001

Xiaoyu Li,Zichen Cao,Ou Jiang,Songyue Wu,Bo Zhou,Yao Feng,Xinyue Chen,Jinsong Wang,Jian Zhou,Renhong Yan,Mo Chen,Songlin Wang

引用次数: 0

Spatially resolved genome architecture in mouse embryonic development 小鼠胚胎发育中的空间分辨基因组结构

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-10-01 DOI: 10.1016/j.devcel.2026.09.004

Yuang Ma,Bo Gou,Yuetong Xu,Fujun Sun,Muya Shu,Falong Lu,Ni Jiang,Xiang Li

引用次数: 0

Self-organizing human dual neural organoids model regional disease defects and teratogenicity 自组织人类双神经类器官模型区域疾病缺陷和致畸性

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-09-18 DOI: 10.1016/j.devcel.2026.08.013

Xiaoxiang Lu,Siyuan Chu,Jianfeng Wei,Jinkui Zhu,Wei Zhou,Yantong Liu,Xurui Feng,Xinrui Zhang,Mengqian Wang,Mingjuan Li,Jie Gao,Linlin Jiang,Wei Pang,Yao Yin,Ziling Chen,Yajing Cao,Qinzhi Zhang,Sisi Chen,Shaojie Ma,Yangfei Xiang

{"title":"Self-organizing human dual neural organoids model regional disease defects and teratogenicity","authors":"Xiaoxiang Lu,Siyuan Chu,Jianfeng Wei,Jinkui Zhu,Wei Zhou,Yantong Liu,Xurui Feng,Xinrui Zhang,Mengqian Wang,Mingjuan Li,Jie Gao,Linlin Jiang,Wei Pang,Yao Yin,Ziling Chen,Yajing Cao,Qinzhi Zhang,Sisi Chen,Shaojie Ma,Yangfei Xiang","doi":"10.1016/j.devcel.2026.08.013","DOIUrl":"https://doi.org/10.1016/j.devcel.2026.08.013","url":null,"abstract":"The human nervous system emerges during early embryogenesis through coordinated, self-organizing differentiation of peripheral and central lineages. A key event in this process is the emergence of neural crest from the dorsal neural tube, which gives rise to major peripheral nervous system (PNS) structures. However, current in vitro models face challenges in recapitulating this process, limiting mechanistic insights into human central-peripheral neurogenesis. Here, we report a method for generating human peripheral-central dual neural organoids (hPCOs), a self-organizing organoid system that recapitulates the co-development of peripheral sensory ganglia and dorsal spinal cord. Using hPCOs, we uncover an unexpected bidirectional role of Wnt signaling in orchestrating peripheral and central fate determination. Modeling with hPCOs reveals nociceptor defects in human congenital insensitivity to pain. Furthermore, integrating hPCOs with image analysis enables the visual assessment of teratogenic risks. Together, hPCOs provide a physiologically relevant platform for investigating human self-organized central nervous system (CNS)-PNS co-development, disease mechanisms, and drug discovery.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"22 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Slowing down on hot days: How morning PRR9 controls the pace of the plant circadian clock 热天慢下来：早晨PRR9如何控制植物生物钟的节奏

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-09-09 DOI: 10.1016/j.devcel.2026.08.007

Takato Imaizumi

引用次数: 0

Nodal/Smad2 signaling maintains diapause in the mouse embryo 节点/Smad2信号传导维持小鼠胚胎的滞育

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-09-09 DOI: 10.1016/j.devcel.2026.08.011

Bruce D. Murphy

引用次数: 0

Protein turnover rate sets the developmental clock 蛋白质周转率设定了发育时钟