Developmental cell最新文献_第2页

A plant histone H3.3-specific amino acid safeguards the deposition of H3K36 methylation for proper development and stress responses. 植物组蛋白h3.3特异性氨基酸保护H3K36甲基化沉积，以促进正常发育和应激反应。

IF 8.7 1区生物学

Developmental cell Pub Date : 2026-04-08 Epub Date: 2026-03-02 DOI: 10.1016/j.devcel.2026.02.002

Xiaoyi Li, Huairen Zhang, Lijun Ma, Mande Xue, Qian Liu, Zdravko J Lorković, Frédéric Berger, Danhua Jiang

{"title":"A plant histone H3.3-specific amino acid safeguards the deposition of H3K36 methylation for proper development and stress responses.","authors":"Xiaoyi Li, Huairen Zhang, Lijun Ma, Mande Xue, Qian Liu, Zdravko J Lorković, Frédéric Berger, Danhua Jiang","doi":"10.1016/j.devcel.2026.02.002","DOIUrl":"10.1016/j.devcel.2026.02.002","url":null,"abstract":"Histone variants are key regulators of chromatin function. The H3 variants H3.1 and H3.3 evolved independently in animals and plants and differ at amino acid position 31, where H3.1 contains alanine (A), whereas H3.3 carries serine (S) in animals or threonine (T) in plants. Although S and T can both be phosphorylated, the biological significance of plants having selectively adopted T over S remains unclear. Here, we report that H3.3T31 plays a critical role in plant development and stress responses by promoting H3K36me3 on H3.3. T31 prevents plant-specific H3K27 methyltransferases ATXR5 and ATXR6 from depositing H3K27me1, which otherwise inhibits the H3K36 methyltransferase EFS. The substitution of H3.3T31 with S or A increases ATXR5/6 activity and elevates H3K27me1, leading to reduced H3K36me3. Together, these findings suggest co-selection of the plant-specific H3.3T31 residue and ATXR5/6 to ensure the preferential accumulation of H3K27me1 on H3.1 and H3K36me3 on H3.3, thereby supporting chromatin function in plants.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":" ","pages":"871-885.e6"},"PeriodicalIF":8.7,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A sharper view: Imaging the fetal liver niche for HSCs. 一个更清晰的视图：成像胎儿肝生态位的造血干细胞。

IF 8.7 1区生物学

Developmental cell Pub Date : 2026-04-08 DOI: 10.1016/j.devcel.2026.03.003

Niveda Udaykumar, Shannon L McKinney-Freeman

引用次数: 0

Hypoxia-inducible factor signaling regulates embryonic interneuron development, GRIN2B expression and adult cortical function. 缺氧诱导因子信号调节胚胎间神经元发育、GRIN2B表达和成人皮质功能。

IF 8.7 1区生物学

Developmental cell Pub Date : 2026-04-08 Epub Date: 2026-02-05 DOI: 10.1016/j.devcel.2026.01.007

I-Ling Lu, Mengyi Song, Cinthia Rangel-Sandoval, Juan Moriano Palacios, JaeYeon Kim, Eric J Huang, Arturo Alvarez-Buylla, Arnold Kriegstein, Mercedes F Paredes, David H Rowitch

{"title":"Hypoxia-inducible factor signaling regulates embryonic interneuron development, GRIN2B expression and adult cortical function.","authors":"I-Ling Lu, Mengyi Song, Cinthia Rangel-Sandoval, Juan Moriano Palacios, JaeYeon Kim, Eric J Huang, Arturo Alvarez-Buylla, Arnold Kriegstein, Mercedes F Paredes, David H Rowitch","doi":"10.1016/j.devcel.2026.01.007","DOIUrl":"10.1016/j.devcel.2026.01.007","url":null,"abstract":"Although hypoxia-inducible factors (HIFs) are central regulators of cellular adaptation to oxygen and metabolic fluctuations in the mammalian brain, potential roles for HIF regulation during inhibitory neuron development are poorly understood. Here, we report that Nkx2.1-cre-driven conditional deletion of Hif1/2a in the medial ganglionic eminence (MGE) leads to reduced proliferation of Lhx6-positive interneuron precursors, whereas loss of von Hippel-Lindau (vHL), required for HIF degradation, drives increased precursor proliferation. Integrating single-cell transcriptomics, we identified HIF targets regulating proliferation and synaptogenesis. We also show that HIF1A directly activates glutamate ionotropic receptor NMDA type subunit 2B (GRIN2B), encoding glutamate ionotropic receptor N-methyl-D-aspartate (NMDA) subunit 2B. In the adult HIF1 conditional knockout (cKO) cortex, we observed decreased numbers of parvalbumin (PV) interneurons and fewer GABAergic synapses and GRIN2B/Bassoon puncta on layer 2/3 excitatory neurons, resulting in attenuated long-term potentiation. These findings identify non-canonical roles for HIF signaling that are essential for PV interneuron production, GRIN2B expression, and cortical circuit maturation and function.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":" ","pages":"773-786.e6"},"PeriodicalIF":8.7,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Active wetting and mechanics of collective cancer invasion. 主动湿润和癌症集体侵袭的机制。

IF 8.7 1区生物学

Developmental cell Pub Date : 2026-04-08 DOI: 10.1016/j.devcel.2026.03.007

Virangika K Wimalasena, Andrew J Ewald

引用次数: 0

Host-transposon mutualism supports regeneration in planarians 宿主-转座子共生支持涡虫的再生

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-03-30 DOI: 10.1016/j.devcel.2026.03.001

Hae-Lim Lee, Axel Poulet, Sudheesh Allikka Parambil, Josien C. van Wolfswinkel

引用次数: 0

Unleashing T cell surveillance for the eradication of quiescent persister tumor cells resistant to neoadjuvant chemotherapy 释放T细胞监视以根除对新辅助化疗有抵抗力的静止持久性肿瘤细胞

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-03-26 DOI: 10.1016/j.devcel.2026.02.020

Haigang Geng, Hongye Wang, Chuanjie Zhang, Yangyang Zhou, Yiqing Zhong, Zhenhua Zhu, Zhaorong Wu, Tangansu Zhang, Nuo Xu, Zhongyi Dong, Haoyu Zhang, Qian Li, Yan Li, Xiangyu Tang, Xifu Cheng, Xiang Xia, Zizhen Zhang, Bo Zhai, Zhigang Zheng, Qing Li, Chunchao Zhu

{"title":"Unleashing T cell surveillance for the eradication of quiescent persister tumor cells resistant to neoadjuvant chemotherapy","authors":"Haigang Geng, Hongye Wang, Chuanjie Zhang, Yangyang Zhou, Yiqing Zhong, Zhenhua Zhu, Zhaorong Wu, Tangansu Zhang, Nuo Xu, Zhongyi Dong, Haoyu Zhang, Qian Li, Yan Li, Xiangyu Tang, Xifu Cheng, Xiang Xia, Zizhen Zhang, Bo Zhai, Zhigang Zheng, Qing Li, Chunchao Zhu","doi":"10.1016/j.devcel.2026.02.020","DOIUrl":"https://doi.org/10.1016/j.devcel.2026.02.020","url":null,"abstract":"Although neoadjuvant chemotherapy (NAC) has shown efficacy in reducing tumor burden in colorectal cancer (CRC), its impact on long-term patient outcomes remains limited. Here, we identify quiescent persister tumor cells (PTCs) as a critical determinant of therapeutic failure. Elevated PTC abundance correlates with poor long-term prognosis, even in patients exhibiting an initial response to treatment. Quiescent PTCs possess aggressive stem-like traits and orchestrate an immunosuppressive microenvironment characterized by CD96+CD8+ T cell infiltration in an orthotopic CRC mouse model. CD96 depletion diverts CD8+ T cells from an exhaustion trajectory and promotes memory-like phenotypes through enhanced mitochondrial function. Consistently, anti-CD96 therapy effectively eliminates PTCs in preclinical models. We also engineered epithelial cell adhesion molecule (EpCAM)-targeted human chimeric antigen receptor (CAR)-T cells deficient in CD96 expression, which robustly target PTCs and demonstrate remarkable therapeutic potential against CRC. Overall, our study uncovers CD96 as a previously unrecognized axis of vulnerability within the PTC-driven microenvironment, offering a promising avenue to enhance CRC therapeutic outcomes.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"22 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147507365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hematopoietic stem cells activate a latent differentiation pathway to facilitate recovery after 5-fluorouracil-induced myeloablation 造血干细胞激活潜在分化途径，促进5-氟尿嘧啶诱导骨髓消融后的恢复

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-03-24 DOI: 10.1016/j.devcel.2026.03.009

Zhen Zhang, Ben Jin, Chenyu You, Ya Li, Li Lin, Jianlong Sun

引用次数: 0

Disruption of WNT/Notch signaling in pancreatic cancer reveals tumors depend on the intricate equilibrium of malignant cell states 胰腺癌中WNT/Notch信号的破坏揭示了肿瘤依赖于恶性细胞状态的复杂平衡

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-03-23 DOI: 10.1016/j.devcel.2026.02.017

Stefan R. Torborg, Jung Yun Kim, Anupriya Singhal, Olivera Grbovic-Huezo, Matilda Holm, Katherine Wu, Xuexiang Han, Yu-Jui Ho, Caj Haglund, Michael J. Mitchell, Scott W. Lowe, Lukas E. Dow, Kenneth L. Pitter, Francisco J. Sanchez-Rivera, Andre Levchenko, Tuomas Tammela

引用次数: 0

When stress signals to skin: Sympathetic nerves tune immune surveillance 当压力向皮肤发出信号：交感神经调节免疫监视

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-03-23 DOI: 10.1016/j.devcel.2026.03.006

Grecia Ortiz Flores, Sakeen Wali Kashem

引用次数: 0

Reconstructing human corticogenesis: Insights from cerebral organoids into neurodevelopment and disease modeling 重建人类皮质发生：从脑类器官到神经发育和疾病建模的见解

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-03-23 DOI: 10.1016/j.devcel.2026.02.018

Miguel F. Tenreiro, Alysson R. Muotri

引用次数: 0