Common mechanisms regulate stem cell self-organization and symmetry breaking across various glandular epithelia

IF 8.7 1区生物学 Q1 CELL BIOLOGY

Developmental cell Pub Date : 2025-10-06 DOI:10.1016/j.devcel.2025.07.009

Brigida Novello, Cédric Blanpain

引用次数: 0

Abstract

In this issue of Developmental Cell, Journot et al. identify a conserved mechanism promoting the development and lineage segregation of multipotent stem cells across different glandular epithelia. p63, YAP, and Notch control symmetry breaking, cell positioning, and cell-fate decision during development and regeneration, illustrating how spatial cues orchestrate tissue self-organization.

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共同机制调节干细胞自组织和对称打破在各种腺上皮

在本期的《发育细胞》中，Journot等人发现了一种保守的机制，可以促进多能干细胞在不同腺上皮中的发育和谱系分离。p63， YAP和Notch控制发育和再生过程中的对称性破坏，细胞定位和细胞命运决定，说明空间线索如何协调组织自组织。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental cell 生物-发育生物学

CiteScore

18.90

自引率

1.70%

发文量

203

审稿时长

3-6 weeks

期刊介绍： Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.