Dual threat: VSIG4⁺ macrophages use IL-11 and VSIG4 to silence T cells

IF 8.7 1区生物学 Q1 CELL BIOLOGY

Developmental cell Pub Date : 2025-10-06 DOI:10.1016/j.devcel.2025.08.006

Darya Khantakova, Marco Colonna

引用次数: 0

Abstract

In this issue of Developmental Cell, Ma et al. show that embryonically derived VSIG4⁺ macrophages suppress CD8⁺ T cell responses across cancers. They identify IL-11 as a key effector and MEF2C as a transcriptional regulator of VSIG4⁺ macrophages, highlighting new therapeutic avenues for targeting immunosuppressive tumor-associated macrophages to improve immunotherapy outcomes.

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双重威胁：VSIG4 +巨噬细胞利用IL-11和VSIG4沉默T细胞

在本期的《发育细胞》杂志上，Ma等人表明，胚胎来源的VSIG4 +巨噬细胞抑制了CD8 + T细胞对癌症的反应。他们确定IL-11是VSIG4 +巨噬细胞的关键效应物，MEF2C是VSIG4 +巨噬细胞的转录调节剂，这突出了靶向免疫抑制性肿瘤相关巨噬细胞以改善免疫治疗结果的新治疗途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental cell 生物-发育生物学

CiteScore

18.90

自引率

1.70%

发文量

203

审稿时长

3-6 weeks

期刊介绍： Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.