Developmental cell最新文献_第3页

Growth factor receptor corralling fuels persistent leader-bleb dynamics 生长因子受体的聚集助长了持续的领袖气泡动力学

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-09-09 DOI: 10.1016/j.devcel.2026.08.012

Dipanwita Das,Victoria Sanz-Moreno

引用次数: 0

Between adaptation and cell death: An ER-localized transcription factor controls cell fate 在适应和细胞死亡之间：内质网定位的转录因子控制细胞命运

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-09-09 DOI: 10.1016/j.devcel.2026.08.005

Jiaqi Sun,Huanquan Zheng

引用次数: 0

Skeletal muscle stem cells keep their lineage options open 骨骼肌干细胞保持其谱系选择的开放性

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-09-09 DOI: 10.1016/j.devcel.2026.08.009

Vittorio Sartorelli

引用次数: 0

A thermoregulatory module for timekeeping in Arabidopsis. 拟南芥计时的温度调节模块。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-09-09 Epub Date: 2026-08-07 DOI: 10.1016/j.devcel.2026.07.011

Yuqing He, Xiling Wang, Chen Su, Yufan Niu, Yumei Qin, Jiashuo Zhang, Lei Wang

引用次数: 0

Senescent cells: Leaving cellular waste behind 衰老细胞：留下细胞废物

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-09-09 DOI: 10.1016/j.devcel.2026.08.004

Hélène Martini,João F. Passos

引用次数: 0

Functional versatility of synergid cells in plant reproduction. 植物生殖中协同细胞功能的多功能性。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-09-09 Epub Date: 2026-08-28 DOI: 10.1016/j.devcel.2026.08.001

Ling Li, Honghui Lin, Li-Jia Qu, Sheng Zhong

引用次数: 0

Two HIFs, two fates: VHL-HIF signaling controls iNKT cell identity 两个hif，两种命运：VHL-HIF信号控制iNKT细胞身份

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-09-09 DOI: 10.1016/j.devcel.2026.08.006

Kyung Min Yim,Jin Young Huh,Jae Bum Kim

引用次数: 0

Elongating human heart organoids recapitulate early cardiac morphogenesis and axial organization. 拉长的人类心脏类器官概括了早期心脏的形态发生和轴向组织。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-09-09 Epub Date: 2026-08-11 DOI: 10.1016/j.devcel.2026.07.015

Jinwoo Lee, Ahri Kim, Yideul Jeong, Eugene Choi, Tae Young Kim, Mariam Nabukenya, Daesik Kim, Jaecheol Lee, Gyu-Un Bae, Jong-Sun Kang

{"title":"Elongating human heart organoids recapitulate early cardiac morphogenesis and axial organization.","authors":"Jinwoo Lee, Ahri Kim, Yideul Jeong, Eugene Choi, Tae Young Kim, Mariam Nabukenya, Daesik Kim, Jaecheol Lee, Gyu-Un Bae, Jong-Sun Kang","doi":"10.1016/j.devcel.2026.07.015","DOIUrl":"10.1016/j.devcel.2026.07.015","url":null,"abstract":"Early heart development involves heart tube elongation, looping, and axial patterning, yet these processes remain difficult to study experimentally. While pluripotent stem cell-derived heart organoids model cardiomyocyte differentiation, they do not recapitulate early morphogenetic events. Here, we generate elongating heart organoids (EHOs) from human induced pluripotent stem cells that undergo coordinated elongation and looping-like curvature, resembling early cardiac morphogenesis. EHOs establish a venous-to-arterial axis with spatially organized sinus venosus-like, atrial, and ventricular cardiomyocytes, and exhibit sequential propagation of contractile activity along this axis. Single-cell transcriptomics and trajectory analyses, together with pulse-labeling, support a model in which progressive incorporation of cardiac cells from proliferative splanchnic mesodermal cells at the venous pole drives elongation of the cardiac structure. Consistent with in vivo phenotypes, TBX5 deletion results in shortened EHOs with reduced looping-like curvature and irregular contractions. Together, EHOs provide a human in vitro system that enables investigation of early cardiac morphogenesis.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":" ","pages":"1898-1914.e7"},"PeriodicalIF":9.2,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148711647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Senescent cells maintain viability through adhesion-dependent fragmentation that promotes debris deposition. 衰老细胞通过促进碎片沉积的粘附依赖碎片来维持活力。

IF 9.2 1区生物学

Developmental cell Pub Date : 2026-09-09 Epub Date: 2026-08-28 DOI: 10.1016/j.devcel.2026.08.002

Matej Durik, Mona Karout, Daniel Sampaio Gonçalves, Tania Knauer-Meyer, Coralie Spiegelhalter, Nadia Messaddeq, Marco Seehawer, Pauline Stephan, Dmitry V Bulavin, Yann Herault, Lars Zender, William M Keyes

{"title":"Senescent cells maintain viability through adhesion-dependent fragmentation that promotes debris deposition.","authors":"Matej Durik, Mona Karout, Daniel Sampaio Gonçalves, Tania Knauer-Meyer, Coralie Spiegelhalter, Nadia Messaddeq, Marco Seehawer, Pauline Stephan, Dmitry V Bulavin, Yann Herault, Lars Zender, William M Keyes","doi":"10.1016/j.devcel.2026.08.002","DOIUrl":"10.1016/j.devcel.2026.08.002","url":null,"abstract":"Cellular senescence is a state of stable arrest and secretion linked to aging and disease. Here, we identify that senescent cells dispose of large fragments through cell-to-cell adhesion, which we term \"senescent-cell adhesion fragments\" (SCAFs). Found in many senescent states, including human and mouse cells, and mouse tissues, SCAFs lack nuclear material but contain organelles, including damaged mitochondria. Disrupting adherens junctions decreases SCAF formation but induces senescent-cell death, due to an inability to shed damaged mitochondria. Live imaging and proteomics show that SCAFs ultimately rupture, releasing a complex proteome, including damage-associated molecular patterns (DAMPs) and proteins linked to neurodegenerative disease. Functionally, SCAFs activate wound-healing and cancer-related programs, promoting migration and invasion. Immunostaining also reveals amyloid-like material in senescent cells that can be externalized through fragmentation. Altogether, these findings identify a feature that facilitates senescent cell survival but also externally deposits damaged intracellular contents, with implications for cancer and neurodegeneration.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":" ","pages":"1789-1805.e8"},"PeriodicalIF":9.2,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postnatal Pax7-expressing limb cells are multipotent and generate non-myogenic lineages that persist into adulthood 出生后表达pax7的肢体细胞是多能的，并产生持续到成年的非肌源性谱系

IF 11.8 1区生物学

Developmental cell Pub Date : 2026-08-21 DOI: 10.1016/j.devcel.2026.07.019

Stamatia Gioftsidi,Takuto Hayashi,Sidy Fall,Sabrina Jagot,Matthieu Dos Santos,Fabien Le Grand,Frederic Relaix,Philippos Mourikis

{"title":"Postnatal Pax7-expressing limb cells are multipotent and generate non-myogenic lineages that persist into adulthood","authors":"Stamatia Gioftsidi,Takuto Hayashi,Sidy Fall,Sabrina Jagot,Matthieu Dos Santos,Fabien Le Grand,Frederic Relaix,Philippos Mourikis","doi":"10.1016/j.devcel.2026.07.019","DOIUrl":"https://doi.org/10.1016/j.devcel.2026.07.019","url":null,"abstract":"Organs comprise diverse cell types originating from shared or distinct lineages. During embryogenesis, mesodermal Pax7+ progenitors give rise to skeletal muscle as well as non-muscle lineages like dermis and adipocytes. Here, we asked whether Pax7+ cells retain multipotency during early postnatal limb muscle growth. Lineage tracing in neonatal mice revealed unexpected early postnatal plasticity, yielding multiple non-myogenic lineages, including a previously unrecognized subpopulation of fibro-adipogenic progenitors, termed Pax7FAPs. Using mouse models, we demonstrated that Notch signaling primes neonatal Pax7+ cells toward a fibrogenic molecular identity, biasing their trajectory away from myogenesis. Long-term tracing confirmed that neonatally generated Pax7FAPs persist into adulthood. Furthermore, adult muscle injury triggered de novo generation of Pax7FAPs, which exhibited higher proliferative capacity than resident stromal cells. This postnatal Pax7+ multipotency reveals an additional cellular contribution to muscle development and regeneration.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"47 13 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148768884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0