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PCP-B peptides and CrRLK1L receptor kinases control pollination via pH gating of aquaporins in Arabidopsis PCP-B肽和CrRLK1L受体激酶通过水通道蛋白的pH门控控制拟南芥授粉
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-01-09 DOI: 10.1016/j.devcel.2024.12.026
Zhiwen Liu, Xiaonan Chu, Weiwei Ren, Lijun Cheng, Chen Liu, Congcong Wang, Sihan Gao, Shaojun Dai, Chao Li
{"title":"PCP-B peptides and CrRLK1L receptor kinases control pollination via pH gating of aquaporins in Arabidopsis","authors":"Zhiwen Liu, Xiaonan Chu, Weiwei Ren, Lijun Cheng, Chen Liu, Congcong Wang, Sihan Gao, Shaojun Dai, Chao Li","doi":"10.1016/j.devcel.2024.12.026","DOIUrl":"https://doi.org/10.1016/j.devcel.2024.12.026","url":null,"abstract":"During pollen-stigma interaction, pollen coat protein B-class peptides (PCP-Bs) compete with stigmatic rapid alkalinization factor (RALF) for interaction with FERONIA/ANJEA receptor kinases (FER/ANJ), stimulating pollen hydration and germination. However, the molecular mechanism underlying PCP-Bs-induced, FER/ANJ-regulated compatible responses remains largely unknown. Through PCP-Bγ-induced phosphoproteomic analysis, we characterized a series of pollination-related signaling pathways regulated by FER/ANJ. Interestingly, on stigmatic papillary cells, pollen PCP-Bγ induced an elevation in cytosolic pH near the plasma membrane (PM), sustained by stigmatic RALF23/33 through regulation of the autoinhibited H<sup>+</sup>-ATPase 1/2 (AHA1/2) activity. We further found that RALFs/PCP-Bs and FER/ANJ regulated the pH alterations via phosphorylation of AHA1/2 C terminus. Furthermore, RALF23/33–FER/ANJ maintained the protonation of H197 in plasma membrane intrinsic proteins (PIPs), whereas PCP-B relieved the protonation through AHA activity. Altogether, this study reveals that pollen PCP-Bs trigger FER/ANJ-controlled compatible responses, particularly the opening of aquaporins via AHA-mediated pH changes, thereby facilitating pollen hydration in <em>Arabidopsis</em>.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"15 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In toto biological framework: Modeling interconnectedness during human development 总的生物学框架：人类发展过程中相互联系的建模
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-01-06 DOI: 10.1016/j.devcel.2024.09.027
Yosuke Yoneyama, Yunheng Wu, Kensaku Mori, Takanori Takebe
{"title":"In toto biological framework: Modeling interconnectedness during human development","authors":"Yosuke Yoneyama, Yunheng Wu, Kensaku Mori, Takanori Takebe","doi":"10.1016/j.devcel.2024.09.027","DOIUrl":"https://doi.org/10.1016/j.devcel.2024.09.027","url":null,"abstract":"Recent advancements in pluripotent stem cell and synthetic tissue technology have brought significant breakthroughs in studying early embryonic development, particularly within the first trimester of development in humans. However, during fetal stage development, investigating further biological events represents a major challenge, partly due to the evolving complexity and continued interaction across multiple organ systems. To bridge this gap, we propose an “<em>in toto</em>” biological framework that leverages a triad of technologies: synthetic tissues, intravital microscopy, and computer vision to capture <em>in vivo</em> cellular morphodynamics, conceptualized as single-cell choreography. This perspective will discuss the inherent challenges in capturing such complexities and explore engineering technologies to delve into the less-explored phase of human development. We also propose reframing the organ-centric to a system-centric paradigm, as such a framework broadens the value of the <em>in vivo</em>-embedded synthetic-tissue-based approach for interrogating the multifaceted interplay of human developmental processes during this crucial stage.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"27 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lineage tracing senescence in vivo shows not all senescent cells are created equal 在体内追踪衰老的谱系显示，并非所有的衰老细胞都是一样的
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-01-06 DOI: 10.1016/j.devcel.2024.12.008
Marcus Ruscetti
{"title":"Lineage tracing senescence in vivo shows not all senescent cells are created equal","authors":"Marcus Ruscetti","doi":"10.1016/j.devcel.2024.12.008","DOIUrl":"https://doi.org/10.1016/j.devcel.2024.12.008","url":null,"abstract":"Understanding the impact of senescence on disease is limited by the lack of tools to lineage label senescent cells. In a recent <em>Cell</em> issue, Zhao et al. create mouse models to genetically manipulate and trace p16<sup>+</sup> cells, identifying contrasting roles for senescent macrophages and endothelial cells (ECs) in liver fibrosis.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"34 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The mechanical state of pre-tumoral epithelia controls subsequent Drosophila tumor aggressiveness 肿瘤前上皮的机械状态控制果蝇肿瘤的侵袭性
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-01-06 DOI: 10.1016/j.devcel.2024.12.006
Marianne Montemurro, Bruno Monier, Magali Suzanne
{"title":"The mechanical state of pre-tumoral epithelia controls subsequent Drosophila tumor aggressiveness","authors":"Marianne Montemurro, Bruno Monier, Magali Suzanne","doi":"10.1016/j.devcel.2024.12.006","DOIUrl":"https://doi.org/10.1016/j.devcel.2024.12.006","url":null,"abstract":"Tumors evolve through the acquisition of increasingly aggressive traits associated with dysplasia. This progression is accompanied by alterations in tumor mechanical properties, especially through extracellular matrix remodeling. However, the contribution of pre-tumoral tissue mechanics to tumor aggressiveness remains poorly known <em>in vivo</em>. Here, we show that adherens junction tension in pre-tumoral tissues dictates subsequent tumor evolution in <em>Drosophila</em>. Increased cell contractility, observed in aggressive tumors before any sign of tissue overgrowth, proved sufficient to trigger dysplasia in normally hyperplastic tumors. In addition, high contractility precedes any changes in cell polarity and contributes to tumor evolution through cell death induction, which favors cell-cell junction weakening. Overall, our results highlight the need to re-evaluate the roles of tumoral cell death and identify pre-tumoral cell mechanics as an unsuspected early marker and key trigger of tumor aggressiveness.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"21 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age-associated interplay between zinc deficiency and Golgi stress hinders microtubule-dependent cellular signaling and epigenetic control 锌缺乏和高尔基应激之间年龄相关的相互作用阻碍了微管依赖的细胞信号传导和表观遗传控制
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-01-06 DOI: 10.1016/j.devcel.2024.12.024
Sofia Brito, Hyojin Heo, Jinyoung Kim, Byungsun Cha, Youngdo Jeong, Wooseon Choi, Chandani Shrestha, Gang Hyoung Lee, Sun Ju Park, Ki Bok Yoon, Kentaro Oh-Hashi, Sung Tae Kim, Sehyun Chae, Sung Kweon Cho, Byung Mook Weon, Jiyoon Kim, Bum-Ho Bin
{"title":"Age-associated interplay between zinc deficiency and Golgi stress hinders microtubule-dependent cellular signaling and epigenetic control","authors":"Sofia Brito, Hyojin Heo, Jinyoung Kim, Byungsun Cha, Youngdo Jeong, Wooseon Choi, Chandani Shrestha, Gang Hyoung Lee, Sun Ju Park, Ki Bok Yoon, Kentaro Oh-Hashi, Sung Tae Kim, Sehyun Chae, Sung Kweon Cho, Byung Mook Weon, Jiyoon Kim, Bum-Ho Bin","doi":"10.1016/j.devcel.2024.12.024","DOIUrl":"https://doi.org/10.1016/j.devcel.2024.12.024","url":null,"abstract":"Golgi abnormalities have been linked to aging and age-related diseases, yet the underlying causes and functional consequences remain poorly understood. This study identifies the interaction between age-associated zinc deficiency and Golgi stress as a critical factor in cellular aging. Senescent Golgi bodies from human fibroblasts show a fragmented Golgi structure, associated with a decreased interaction of the zinc-dependent Golgi-stacking protein complex Golgin45-GRASP55. Golgi stress is increased, and functions such as glycosylation and vesicle transport are impaired. These disturbances promote Golgi and perinuclear microtubule disassembly and subsequent mislocalization of intracellular proteins associated with cellular signaling and epigenetic control. Pharmacological induction of Golgi stress or zinc deficiency, or ablation of the Golgi-associated zinc transporter gene <em>Zip13</em> in mouse fibroblasts, replicate the characteristics of cellular senescence, emphasizing the critical role of Golgi-zinc homeostasis. These findings highlight the importance of adequate zinc intake and suggest targeting Golgi dysfunction as a therapeutic strategy for alleviating age-related cellular decline.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"19 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How structural interactions and receptor phosphorylation shape strigolactone signaling in rice 结构相互作用和受体磷酸化如何形成水稻独角麦内酯信号
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-01-06 DOI: 10.1016/j.devcel.2024.12.029
Kawthar F. Alashoor, Salim Al-Babili
{"title":"How structural interactions and receptor phosphorylation shape strigolactone signaling in rice","authors":"Kawthar F. Alashoor, Salim Al-Babili","doi":"10.1016/j.devcel.2024.12.029","DOIUrl":"https://doi.org/10.1016/j.devcel.2024.12.029","url":null,"abstract":"The phytohormone strigolactone (SL) regulates various developmental processes and plant adaptation to nutrient availability, which in turn regulates strigolactone biosynthesis. In the recent issue of <em>Cell</em>, Hu et al.<span><span><sup>1</sup></span></span> advance the understanding of the interaction of the SL receptor complex and reveal exciting insights into the nitrogen-dependent regulation of SL signaling and SL-dependent tillering in rice.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"100 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Matrix interactions regulate epithelial polarity and cohesion in the second heart field 基质相互作用调节上皮极性和内聚在第二心脏区
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-01-06 DOI: 10.1016/j.devcel.2024.12.017
Robert G. Kelly
{"title":"Matrix interactions regulate epithelial polarity and cohesion in the second heart field","authors":"Robert G. Kelly","doi":"10.1016/j.devcel.2024.12.017","DOIUrl":"https://doi.org/10.1016/j.devcel.2024.12.017","url":null,"abstract":"Addition of epithelial progenitor cells drives progressive extension of the heart tube during cardiac morphogenesis. In this issue of <em>Developmental Cell,</em> Arriagada et al. (2024) refine our understanding of how these cells condition and interact with the underlying extracellular matrix, demonstrating that autonomous fibronectin synthesis controls their apicobasal polarity and deployment to the heart.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"34 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lactate shuttling links histone lactylation to adult hippocampal neurogenesis in mice 乳酸穿梭将组蛋白乳酸化与小鼠成年海马神经发生联系起来
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-01-06 DOI: 10.1016/j.devcel.2024.12.021
Zhimin Li, Ziqi Liang, Huan Qi, Xing Luo, Min Wang, Zhuo Du, Weixiang Guo
{"title":"Lactate shuttling links histone lactylation to adult hippocampal neurogenesis in mice","authors":"Zhimin Li, Ziqi Liang, Huan Qi, Xing Luo, Min Wang, Zhuo Du, Weixiang Guo","doi":"10.1016/j.devcel.2024.12.021","DOIUrl":"https://doi.org/10.1016/j.devcel.2024.12.021","url":null,"abstract":"Lactate has emerged as a central metabolic fuel and an important signaling molecule. Its availability participates in various brain functions. Although lactate homeostasis is vital for adult hippocampal neurogenesis and cognition, it is still unknown how shuttles lactate across the plasma membrane of neural stem cells (NSCs) to control their activity and neurogenic potential. In this study, we show that monocarboxylate transporter (MCT)1 and MCT2, respectively, control efflux and influx of lactate in the murine NSCs, thereby maintaining intracellular lactate homeostasis. Mechanistically, lactate shuttling links histone lactylation to govern NSC proliferation through MDM2-p53 signaling pathway. Notably, genetic ablation of MCT2 from NSCs or pharmacological inhibition of MDM2-P53 interaction prevents voluntary running-induced NSC proliferation in the murine adult hippocampus. Taken together, our findings demonstrate that lactate shuttling controls histone lactylation, which acts as a nexus for controlling adult hippocampal neurogenesis.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"42 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut microbiota protect against colorectal tumorigenesis through lncRNA Snhg9 肠道微生物群通过lncRNA Snhg9保护结肠直肠癌的发生
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-01-03 DOI: 10.1016/j.devcel.2024.12.013
Meng Wang, Kailin Liu, Wu Bao, Bingqing Hang, Xianjiong Chen, Xinyi Zhu, Guifang Li, Lihong Liu, Haoyi Xiang, Hai Hu, Yanhui Lu, Zhangfa Song, Jiaxin Chen, Yuhao Wang
{"title":"Gut microbiota protect against colorectal tumorigenesis through lncRNA Snhg9","authors":"Meng Wang, Kailin Liu, Wu Bao, Bingqing Hang, Xianjiong Chen, Xinyi Zhu, Guifang Li, Lihong Liu, Haoyi Xiang, Hai Hu, Yanhui Lu, Zhangfa Song, Jiaxin Chen, Yuhao Wang","doi":"10.1016/j.devcel.2024.12.013","DOIUrl":"https://doi.org/10.1016/j.devcel.2024.12.013","url":null,"abstract":"The intestinal microbiota is a key environmental factor in the development of colorectal cancer (CRC). Here, we report that, in the context of mild colonic inflammation, the microbiota protects against colorectal tumorigenesis in mice. This protection is achieved by microbial suppression of the long non-coding RNA (lncRNA) <em>Snhg9</em>. <em>Snhg9</em> promotes tumor growth through inhibition of the tumor suppressor p53. <em>Snhg9</em> suppresses p53 activity by dissociating the p53 deacetylase sirtuin 1 (SIRT1) from the cell cycle and apoptosis regulator 2 (CCAR2). Consequently, the depletion of the microbiota by antibiotics causes upregulation of <em>Snhg9</em> and accelerates CRC progression. Moreover, <em>Snhg9</em> is functionally conserved. Human <em>SNHG9</em> promotes tumor growth via the same mechanism as mouse <em>Snhg9</em>, despite their low sequence similarity.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"155 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glutathione accelerates the cell cycle and cellular reprogramming in plant regeneration 谷胱甘肽加速植物再生中的细胞周期和细胞重编程
IF 11.8 1区 生物学
Developmental cell Pub Date : 2025-01-03 DOI: 10.1016/j.devcel.2024.12.019
Laura R. Lee, Bruno Guillotin, Ramin Rahni, Chanel Hutchison, Bénédicte Desvoyes, Crisanto Gutierrez, Kenneth D. Birnbaum
{"title":"Glutathione accelerates the cell cycle and cellular reprogramming in plant regeneration","authors":"Laura R. Lee, Bruno Guillotin, Ramin Rahni, Chanel Hutchison, Bénédicte Desvoyes, Crisanto Gutierrez, Kenneth D. Birnbaum","doi":"10.1016/j.devcel.2024.12.019","DOIUrl":"https://doi.org/10.1016/j.devcel.2024.12.019","url":null,"abstract":"The plasticity of plant cells underlies their wide capacity to regenerate, with increasing evidence in plants and animals implicating cell-cycle dynamics in cellular reprogramming. To investigate the cell cycle during cellular reprogramming, we developed a comprehensive set of cell-cycle-phase markers in the Arabidopsis root. Using single-cell RNA sequencing profiles and live imaging during regeneration, we found that a subset of cells near an ablation injury dramatically increases division rate by truncating G1 phase. Cells in G1 undergo a transient nuclear peak of glutathione (GSH) prior to coordinated entry into S phase, followed by rapid divisions and cellular reprogramming. A symplastic block of the ground tissue impairs regeneration, which is rescued by exogenous GSH. We propose a model in which GSH from the outer tissues is released upon injury, licensing an exit from G1 near the wound to induce rapid cell division and reprogramming.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"34 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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