胶质母细胞瘤干细胞如何将炎症信号转化为肿瘤生长和免疫抑制

IF 8.7 1区生物学 Q1 CELL BIOLOGY

Developmental cell Pub Date : 2025-10-06 DOI:10.1016/j.devcel.2025.06.011

Wenhui Chen, Yanjie Shen, Guangshuai Jia

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引用次数: 0

摘要

慢性炎症塑造肿瘤微环境并影响癌症干细胞行为。在这一期的Developmental Cell中，Gu等人发现TNFAIP6是肿瘤坏死因子α (TNF-α)的关键应答者，它促进胶质母细胞瘤干细胞的自我更新，并将促炎巨噬细胞重编程为免疫抑制表型，从而确定了胶质母细胞瘤的治疗脆弱性。

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How glioblastoma stem cells turn inflammatory cues into tumor growth and immune suppression

Chronic inflammation shapes the tumor microenvironment and influences cancer stem cell behavior. In this issue of Developmental Cell, Gu et al. identify TNFAIP6 as a key responder to tumor necrosis factor alpha (TNF-α) that promotes self-renewal of glioblastoma stem cells and reprograms pro-inflammatory macrophages toward an immunosuppressive phenotype, identifying a therapeutic vulnerability in glioblastoma.

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来源期刊

Developmental cell 生物-发育生物学

CiteScore

18.90

自引率

1.70%

发文量

203

审稿时长

3-6 weeks

期刊介绍： Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.