SUMOylation of the transcription factor Etv1 in cancer stem cells induces tumorigenesis of non-stem cancer cells

IF 8.7 1区 生物学 Q1 CELL BIOLOGY
Yuan Chen
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引用次数: 0

Abstract

In this issue of Developmental Cell, Li et al. show that ETS variant transcription factor 1 (Etv1) SUMOylation not only maintains cancer stem cells (CSCs) but also enables their communications with non-CSC cancer cells to induce tumorigenesis of non-CSCs. The finding reveals a new function of CSCs in driving aggressive tumorigenesis that is SUMOylation dependent.
肿瘤干细胞中转录因子Etv1的sumo化可诱导非干细胞肿瘤的发生
在本期的Developmental Cell中,Li等人发现ETS变体转录因子1 (Etv1) summoylation不仅维持了癌症干细胞(CSCs),而且使其与非csc癌细胞的通讯能够诱导非csc的肿瘤发生。这一发现揭示了CSCs在驱动侵袭性肿瘤发生中的一种新功能,这种功能依赖于SUMOylation。
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来源期刊
Developmental cell
Developmental cell 生物-发育生物学
CiteScore
18.90
自引率
1.70%
发文量
203
审稿时长
3-6 weeks
期刊介绍: Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.
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