桥过远：桥细胞状态作为神经母细胞瘤可塑性驱动因素的鉴定

IF 8.7 1区生物学 Q1 CELL BIOLOGY

Developmental cell Pub Date : 2025-09-08 DOI:10.1016/j.devcel.2025.06.010

Lisa B. Earnest-Noble, Bradley J. Goldstein

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引用次数: 0

摘要

了解肿瘤细胞可塑性是许多癌症中驱动治疗耐药性的潜在机制，是一个关键的肿瘤学挑战。在这一期的Developmental Cell中，Xu等人利用神经母细胞瘤作为一个可处理的模型来探索肿瘤可塑性的机制，并为肿瘤细胞状态的驱动因素提供了关键的见解。

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A bridge too far: Identification of bridge cell states as drivers of plasticity in neuroblastoma

Understanding tumor cell plasticity, a potential mechanism driving therapeutic resistance in many cancers, represents a key oncologic challenge. In this issue of Developmental Cell, Xu et al. leverage neuroblastoma as a tractable model for exploring mechanisms of tumor plasticity and provide key insights into drivers of tumor cell states.

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来源期刊

Developmental cell 生物-发育生物学

CiteScore

18.90

自引率

1.70%

发文量

203

审稿时长

3-6 weeks

期刊介绍： Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.