Current Opinion in Neurobiology最新文献_第3页

Plasticity of brain sexual dimorphism as revealed by sex changing fish 变性鱼揭示的脑两性二态性的可塑性

IF 5.2 2区医学

Current Opinion in Neurobiology Pub Date : 2025-08-14 DOI: 10.1016/j.conb.2025.103094

Gabriel J. Graham, Justin S. Rhodes

{"title":"Plasticity of brain sexual dimorphism as revealed by sex changing fish","authors":"Gabriel J. Graham, Justin S. Rhodes","doi":"10.1016/j.conb.2025.103094","DOIUrl":"10.1016/j.conb.2025.103094","url":null,"abstract":"<div><div>Sex determination in coral reef fish is highly plastic, with many species displaying socially controlled sequential hermaphroditism. In these species, social hierarchy cues trigger sex change, initiating transformations in neuroanatomy, physiology, morphology, and behavior. The process begins in the brain, where shifts in dominance status alter cortisol release and neuromodulator signaling, including dopamine and arginine vasotocin. Radial glia detect these changes and modulate local estradiol synthesis via brain aromatase production that in turn influences neurogenesis and gene expression in multiple types of glia and neurons involved in pituitary-gonadotroph regulation. The altered gonadotroph control directs the gonadal transformation. Mechanistically, protogyny (female-to-male) typically occurs faster than protandry (male-to-female), with differences in the order of behavioral, gonadal, and morphological changes. Understanding these processes in sex-changing fish provides valuable insights into the neural and endocrine mechanisms underlying reproductive plasticity, with broader implications for neuroendocrinology and the evolution of sex differences in vertebrates.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"94 ","pages":"Article 103094"},"PeriodicalIF":5.2,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144829435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astroglial regulation of critical period plasticity in the developing brain 星形胶质细胞对发育中的大脑关键期可塑性的调节

IF 5.2 2区医学

Current Opinion in Neurobiology Pub Date : 2025-08-14 DOI: 10.1016/j.conb.2025.103092

Jérôme Ribot , Rachel Breton , Glenn Dallérac , Nathalie Rouach

引用次数: 0

Increased heavy-tailed distribution of synaptic weights distorts neurocomputation in schizophrenia 突触权重重尾分布的增加扭曲了精神分裂症患者的神经计算

IF 5.2 2区医学

Current Opinion in Neurobiology Pub Date : 2025-08-06 DOI: 10.1016/j.conb.2025.103089

Akiko Hayashi-Takagi

引用次数: 0

Immunity meets inhibition: Immunomodulation of cortical inhibitory synaptic networks 免疫与抑制：皮层抑制性突触网络的免疫调节

IF 5.2 2区医学

Current Opinion in Neurobiology Pub Date : 2025-07-30 DOI: 10.1016/j.conb.2025.103090

Carolina Piletti Chatain , Zachary H. Gursky , Daniel F. Camacho , Emilia Favuzzi

{"title":"Immunity meets inhibition: Immunomodulation of cortical inhibitory synaptic networks","authors":"Carolina Piletti Chatain , Zachary H. Gursky , Daniel F. Camacho , Emilia Favuzzi","doi":"10.1016/j.conb.2025.103090","DOIUrl":"10.1016/j.conb.2025.103090","url":null,"abstract":"<div><div>Interactions between the nervous and immune systems are increasingly recognized as pivotal in normal physiology, brain function, and behavior. This review explores an emerging frontier in neurobiology focusing on the regulation of cortical inhibitory synapses and circuits by immune mediators and effectors, with a particular emphasis on microglia and meningeal immune cells. Microglia, the primary immune cells in the brain parenchyma, regulate inhibitory synapse development and function. Recent evidence revealed the crucial role of gamma-aminobutyric acid (GABA) signaling in mobilizing microglia and modulating their interactions with inhibitory neurons. These include physical shielding, remodeling or stripping of inhibitory synapses, and releasing soluble factors. Meningeal immune cells, comprising innate and adaptive populations, also influence cortical inhibition under physiological conditions via secretion of cytokines such as interferon-gamma and interleukins. This review highlights the mechanisms through which immune cells modulate cortical inhibition, and more broadly, the role of neuroimmune interactions in normal brain development and function.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"94 ","pages":"Article 103090"},"PeriodicalIF":5.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statistical regularities and the sensory consequences of self-action: A multi-species, multi-modal perspective 统计规律和自我行为的感觉后果：一个多物种，多模态的视角

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-07-21 DOI: 10.1016/j.conb.2025.103087

Ziad M. Hafed , Aristides Arrenberg , Cornelius Schwarz , Jan Benda , Jan Grewe

{"title":"Statistical regularities and the sensory consequences of self-action: A multi-species, multi-modal perspective","authors":"Ziad M. Hafed , Aristides Arrenberg , Cornelius Schwarz , Jan Benda , Jan Grewe","doi":"10.1016/j.conb.2025.103087","DOIUrl":"10.1016/j.conb.2025.103087","url":null,"abstract":"<div><div>Active sensing is integral for survival in many organisms. While statistical regularities in natural scenes, as well as ecological relevance, are particularly relevant for shaping motor behaviors, significantly less is known about how these factors additionally influence the brain's compensatory mechanisms for the sensory consequences of self-action. Here, using different sensory modalities, species, and timescales, we review recent developments demonstrating that both state estimation and sensory gating, fundamental functions related to sensory processing during movement, are malleable and reflect statistical regularities. Such regularities exist in both the natural environment as well as in the sensory-motor contingencies specific to a given action type. In some species and modalities, the mechanisms for state estimation are well characterized, whereas in others, sensory gating is more developed. We provide a comparative approach that not only identifies common underlying principles, but also highlights upcoming research questions that are relevant for each sensory modality and species.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"94 ","pages":"Article 103087"},"PeriodicalIF":4.8,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A neurobiology perspective on the assembly of retinal vasculature from 2D to 3D 从2D到3D视网膜血管组装的神经生物学观点

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-07-15 DOI: 10.1016/j.conb.2025.103085

Mahima Bose , Mengya Zhao , Kenichi Toma , Xin Ye , Xin Duan

{"title":"A neurobiology perspective on the assembly of retinal vasculature from 2D to 3D","authors":"Mahima Bose , Mengya Zhao , Kenichi Toma , Xin Ye , Xin Duan","doi":"10.1016/j.conb.2025.103085","DOIUrl":"10.1016/j.conb.2025.103085","url":null,"abstract":"<div><div>The reciprocal regulation of the neural ensemble and vascular network within the mammalian central nervous system (CNS) is crucial for its development and functionality. Neuron-derived pro-angiogenic factors, such as growth factors, morphogens, and guidance cues, play a key role in forming stereotypical vascular architectures in the cortex, spinal cord, and cerebellum during development. Notably, the CNS vasculature forms distinct 3D lattice structures composed of laminar vascular networks interconnected by penetrating vessels. This contrasts with the more random 3D arborizations found in tumors. While the morphogen gradients for vascular network growth have been well-studied, the mechanisms contributing to vascular patterning and lattice maintenance in 3D are not fully understood. The mammalian retina provides an ideal model for studying these mechanisms, given its laminar organization of neurons and plexus organization of vessels, allowing for the investigation of 2D growth to 3D lattice establishment in a stepwise manner. Notably, recent studies have highlighted the roles of neurons and glia in retinal vascular patterning in 2D, as well as the involvement of neurotransmitters in regulating vascular growth. Additionally, direct neuron-to-vessel interactions have been found to contribute to 3D retinal vascular lattice formation. As emerging technologies provide new insights into retinal vascular assembly in 3D, understanding the developmental regulation and the physiological and pathophysiological effects of 3D lattice disruption remains a fertile field of research.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"93 ","pages":"Article 103085"},"PeriodicalIF":4.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Learning, prediction accuracy, and neural plasticity in sensory cortex 感觉皮质的学习、预测准确性和神经可塑性

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-07-12 DOI: 10.1016/j.conb.2025.103088

Alison L. Barth, Joseph A. Christian, Ajit Ray

引用次数: 0

Cracking the cadherin codes that wire the nervous system 破解连接神经系统的钙粘蛋白密码

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-07-07 DOI: 10.1016/j.conb.2025.103086

Madison T. Gray , Julie L. Lefebvre

引用次数: 0

Toward a multidisciplinary neurobiology of interoception and mental health 向内感受和心理健康的多学科神经生物学迈进

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-07-05 DOI: 10.1016/j.conb.2025.103084

Charles Verdonk , Olujimi A. Ajijola , Sahib S. Khalsa

{"title":"Toward a multidisciplinary neurobiology of interoception and mental health","authors":"Charles Verdonk , Olujimi A. Ajijola , Sahib S. Khalsa","doi":"10.1016/j.conb.2025.103084","DOIUrl":"10.1016/j.conb.2025.103084","url":null,"abstract":"<div><div>Interoception, the process by which the nervous system senses, interprets and integrates internal physiological signals, is fundamental to health, playing a key role in brain-body feedback loops that maintain homeostasis. Disruptions in interoceptive processing are common across psychiatric disorders, highlighting its relevance for diagnosis, prognosis, and treatment. This review examines recent translational advances in interoception research, with a focus on anxiety disorders, depression, eating disorders, and functional gastrointestinal disorders, where altered interoceptive signaling contributes to core symptoms. We discuss emerging cellular and molecular insights from animal models and address barriers to translating these findings to human psychopathology. To bridge this gap, we propose a “roving lens” approach, a multidisciplinary framework that dynamically integrates findings across biological scales, species, and methods. Here, multidisciplinary denotes team-based collaboration in which multiple fields contribute complementary expertise to a shared question, without fully dissolving disciplinary boundaries. By uniting mechanistic animal research with human clinical insight, this approach can advance interoceptive neuroscience and inform novel therapeutic strategies for psychiatric disorders.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"94 ","pages":"Article 103084"},"PeriodicalIF":4.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sexual dimorphism in the behaviour and sensory systems of mosquitoes 蚊子行为和感觉系统中的两性异形现象

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-07-03 DOI: 10.1016/j.conb.2025.103070

Prashali Bansal, Sonia Q. Sen

引用次数: 0