Current Opinion in Neurobiology最新文献_第3页

Cutting-edge methodologies for tagging and tracing active neuronal coding in the brain 标记和追踪大脑中活跃神经元编码的尖端方法

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-03-08 DOI: 10.1016/j.conb.2025.102997

Kenichiro Nagahama , Veronica Hyeyoon Jung , Hyung-Bae Kwon

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引用次数: 0

Diverse synaptic mechanisms underlying learning and memory consolidation

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-03-05 DOI: 10.1016/j.conb.2025.102996

Yuki Murai , Akihiro Goto

{"title":"Diverse synaptic mechanisms underlying learning and memory consolidation","authors":"Yuki Murai , Akihiro Goto","doi":"10.1016/j.conb.2025.102996","DOIUrl":"10.1016/j.conb.2025.102996","url":null,"abstract":"<div><div>Memory consolidation is defined as the process by which labile short-term memories are stabilized and transformed into persistent long-term memories. This process relies heavily on synaptic plasticity, particularly long-term potentiation and depression (LTP and LTD, respectively), which have been extensively investigated in previous studies. The advent of optical tools that allow the observation and manipulation of LTP and LTD <em>in vivo</em> has advanced our understanding of their roles in learning and memory consolidation. In addition to LTP and LTD, recent research has indicated the presence of a more rapid plasticity mechanism, termed behavioral timescale synaptic plasticity (BTSP), which is crucial for encoding space and context. Sharp-wave ripples and sleep also play indispensable roles in memory consolidation, with some studies alternately linking them to LTP and LTD. At the systems level, sharp-wave ripples and sleep contribute to the transmission of information to broader brain areas, as well as the modification of synaptic strength in cortical areas for the long-term storage of memory. Furthermore, recent findings have highlighted the role of non-neuronal cells in learning, as they modulate synaptic plasticity in various ways.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"92 ","pages":"Article 102996"},"PeriodicalIF":4.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative approaches to the neurobiology of avian vocal learning

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-03-04 DOI: 10.1016/j.conb.2025.102993

Zhilei Zhao, Jesse H. Goldberg

引用次数: 0

Single-cell technology grows up: Leveraging high-resolution omics approaches to understand neurodevelopmental disorders

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-03-03 DOI: 10.1016/j.conb.2025.102990

Joseph D. Dougherty , Simona Sarafinovska , Sneha M. Chaturvedi , Travis E. Law , Titilope M. Akinwe , Harrison W. Gabel

{"title":"Single-cell technology grows up: Leveraging high-resolution omics approaches to understand neurodevelopmental disorders","authors":"Joseph D. Dougherty , Simona Sarafinovska , Sneha M. Chaturvedi , Travis E. Law , Titilope M. Akinwe , Harrison W. Gabel","doi":"10.1016/j.conb.2025.102990","DOIUrl":"10.1016/j.conb.2025.102990","url":null,"abstract":"<div><div>The identification of hundreds of neurodevelopmental disorder (NDD) genes in the last decade led to numerous genetic models for understanding NDD gene mutation consequences and delineating putative neurobiological mediators of disease. In parallel, single-cell and single-nucleus genomic technologies have been developed and implemented to create high-resolution atlases of cell composition, gene expression, and circuit connectivity in the brain. Here, we discuss the opportunities to leverage mutant models (or human tissue, where available) and genomics approaches to systematically define NDD etiology at cellular resolution. We review progress in applying single-cell and spatial transcriptomics to interrogate developmental trajectories, cellular composition, circuit activity, and connectivity across human tissue and NDD models. We discuss considerations for implementing these approaches at scale to maximize insights and facilitate reproducibility. Finally, we highlight how standardized application of these technologies promises to not only define etiologies of individual disorders but also identify molecular, cellular, and circuit level convergence across NDDs.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"92 ","pages":"Article 102990"},"PeriodicalIF":4.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Defense or death? A review of the neural mechanisms underlying sensory modality-triggered innate defensive behaviors

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-02-27 DOI: 10.1016/j.conb.2025.102977

Huating Gu , Feiran Zhao , Zhihui Liu , Peng Cao

{"title":"Defense or death? A review of the neural mechanisms underlying sensory modality-triggered innate defensive behaviors","authors":"Huating Gu , Feiran Zhao , Zhihui Liu , Peng Cao","doi":"10.1016/j.conb.2025.102977","DOIUrl":"10.1016/j.conb.2025.102977","url":null,"abstract":"<div><div>Defense or death presents a canonical dilemma for animals when encountering predators. Threatening sensory cues provide essential information that signals predator presence, driving the evolution of a spectrum of defensive behaviors. In rodents, these behaviors, as described by the classic “predatory imminence continuum” model, range from risk assessment and freezing to rapid escape responses. During the pre-encounter phase, risk assessment and avoidance responses are crucial for monitoring the environment with vigilance and cautiousness. Once detected during the post-encounter phase or physically attacked during the circa-strike phase, multiple sensory systems are rapidly activated, triggering escape responses to increase the distance from the threat. Although there are species-specific variations, the brain regions underpinning these defensive strategies, including the thalamus, hypothalamus, and midbrain, are evolutionarily conserved. This review aims to provide a comprehensive overview of the universal innate defensive circuit framework to enrich our understanding of how animals respond to life-threatening situations.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"92 ","pages":"Article 102977"},"PeriodicalIF":4.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic regulation of cortical interneuron wiring

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-02-26 DOI: 10.1016/j.conb.2025.102980

Claudia Rosés-Novella , Clémence Bernard

引用次数: 0

Timing neural development and regeneration

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-02-25 DOI: 10.1016/j.conb.2025.102976

Seth Blackshaw , Michel Cayouette

引用次数: 0

The barn owl in systems and behavioral neuroscience: Progress and promise

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-02-22 DOI: 10.1016/j.conb.2025.102983

Lilian Zhang , Shreesh P. Mysore

引用次数: 0

Octopus as a comparative model for understanding the neural control of limb movement and limb-based behaviors

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-02-21 DOI: 10.1016/j.conb.2025.102982

Melina E. Hale

引用次数: 0

Sources of behavioral variability in C. elegans: Sex differences, individuality, and internal states

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-02-21 DOI: 10.1016/j.conb.2025.102984

Steven W. Flavell , Meital Oren-Suissa , Shay Stern

{"title":"Sources of behavioral variability in C. elegans: Sex differences, individuality, and internal states","authors":"Steven W. Flavell , Meital Oren-Suissa , Shay Stern","doi":"10.1016/j.conb.2025.102984","DOIUrl":"10.1016/j.conb.2025.102984","url":null,"abstract":"<div><div>Animal behavior varies across different timescales. This includes rapid shifts in behavior as animals transition between states and long-term changes that develop throughout an organism’s life. This review presents the contributions of sex differences, individuality, and internal states to behavioral variability in the roundworm <em>Caenorhabditis elegans</em>. Sex is determined by chromosome composition, which directs neuronal development through gene regulation and experience to shape dimorphic behaviors. Genetically identical individuals within the same sex and reared in the same conditions still display distinctive, long-lasting behavioral traits that are controlled by neuromodulatory systems. At all life stages, internal states within the individual, shaped by external factors like food and stress, modulate behavior over minutes to hours. The interplay between these factors gives rise to rich behavioral diversity in <em>C. elegans</em>. These factors impact behavior in a sequential manner, as genetic sex, individuality, and internal states influence behavior over progressively finer timescales.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"91 ","pages":"Article 102984"},"PeriodicalIF":4.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0