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Current Opinion in Neurobiology最新文献

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Signaling in autism: Relevance to nutrients and sex 自闭症中的信号：与营养和性有关。
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2025-02-01 DOI: 10.1016/j.conb.2024.102962
Yi-Ping Hsueh
{"title":"Signaling in autism: Relevance to nutrients and sex","authors":"Yi-Ping Hsueh","doi":"10.1016/j.conb.2024.102962","DOIUrl":"10.1016/j.conb.2024.102962","url":null,"abstract":"<div><div>Autism spectrum disorders (ASD) are substantially heterogeneous neuropsychiatric conditions with over a thousand associated genetic factors and various environmental influences, such as infection and nutrition. Additionally, males are four times more likely than females to be affected. This heterogeneity underscores the need to uncover common molecular features within ASD. Recent studies have revealed interactions among genetic predispositions, environmental factors, and sex that may be critical to ASD etiology. This review focuses on emerging evidence for the impact of nutrients—particularly zinc and amino acids—on ASD, as demonstrated in mouse models and human studies. These nutrients have been shown to influence synaptic signaling, dendritic spine formation, and behaviors linked to autism. Furthermore, sex-based differences in nutritional requirements, especially for zinc and amino acids, may contribute to the observed male bias in autism, indicating that interactions between nutrients and genetic factors could be integral to understanding and potentially mitigating ASD symptoms.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"90 ","pages":"Article 102962"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bridging the fields of cognition and birdsong with corvids 用鸦类架起认知和鸟鸣领域的桥梁。
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2025-02-01 DOI: 10.1016/j.conb.2024.102965
Diana A. Liao, Felix W. Moll, Andreas Nieder
{"title":"Bridging the fields of cognition and birdsong with corvids","authors":"Diana A. Liao,&nbsp;Felix W. Moll,&nbsp;Andreas Nieder","doi":"10.1016/j.conb.2024.102965","DOIUrl":"10.1016/j.conb.2024.102965","url":null,"abstract":"<div><div>Corvids, readily adaptable across social and ecological contexts, successfully inhabit almost the entire world. They are seen as highly intelligent birds, and current research examines their cognitive abilities. Despite being songbirds with a complete ‘song system’, corvids have historically received less attention in studies of song production, learning, and perception compared to non-corvid songbirds. However, recent neurobiological studies have demonstrated that songbird vocal production and its neuronal representations are regularly influenced by environmental and cognitive factors. This opinion article discusses the literature on ‘corvid song’ before introducing other flexible vocal behaviors of corvids in both the wild and controlled laboratory studies. We suggest corvids with their flexible vocal control as promising model species to study the links between brain networks for cognition and vocalization. Studying corvid vocal flexibility and associated cognitive processes in both ecological and lab settings offers complementary insights, crucial for bridging the fields of cognition and birdsong.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"90 ","pages":"Article 102965"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Animal models of the human brain: Successes, limitations, and alternatives 人类大脑的动物模型：成功、局限和选择
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2025-02-01 DOI: 10.1016/j.conb.2024.102969
Nancy Kanwisher
{"title":"Animal models of the human brain: Successes, limitations, and alternatives","authors":"Nancy Kanwisher","doi":"10.1016/j.conb.2024.102969","DOIUrl":"10.1016/j.conb.2024.102969","url":null,"abstract":"<div><div>The last three decades of research in human cognitive neuroscience have given us an initial “parts list” for the human mind in the form of a set of cortical regions with distinct and often very specific functions. But current neuroscientific methods in humans have limited ability to reveal exactly what these regions represent and compute, the causal role of each in behavior, and the interactions among regions that produce real-world cognition. Animal models can help to answer these questions when homologues exist in other species, like the face system in macaques. When homologues do not exist in animals, for example for speech and music perception, and understanding of language or other people's thoughts, intracranial recordings in humans play a central role, along with a new alternative to animal models: artificial neural networks.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"90 ","pages":"Article 102969"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic advances and translational phenotypes in rodent models for Tourette disorder 图雷特病啮齿动物模型的遗传进展和翻译表型。
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2025-02-01 DOI: 10.1016/j.conb.2024.102967
Tess F. Kowalski , Riley Wang , Max A. Tischfield
{"title":"Genetic advances and translational phenotypes in rodent models for Tourette disorder","authors":"Tess F. Kowalski ,&nbsp;Riley Wang ,&nbsp;Max A. Tischfield","doi":"10.1016/j.conb.2024.102967","DOIUrl":"10.1016/j.conb.2024.102967","url":null,"abstract":"<div><div>Tourette disorder (TD) is a neurodevelopmental condition affecting approximately 0.3%–1% of children and adolescents. It is defined by motor and vocal tics but encompasses wide ranging phenotypes due to its complex genetic origins, involving hundreds of risk genes across various signaling pathways. Traditional animal models of TD have focused on circuit manipulation or neuron ablation strategies to investigate its underlying causes and associated brain changes. However, the recent identification of high-confidence risk genes has opened new possibilities for creating models that express the exact genetic variants associated with TD. This review discusses early attempts to model TD in rodents and highlights advancements in next-generation models with true construct validity through the expression of orthologous human mutations in high-confidence risk genes. Additionally, we examine the translational potential of integrating cognitive and sensorimotor approaches to evaluate TD-related phenotypes in rodents, including changes to reinforcement learning, habitual behavior, and incentive motivation.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"90 ","pages":"Article 102967"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Common alterations to astrocytes across neurodegenerative disorders 星形胶质细胞在神经退行性疾病中的常见改变。
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2025-02-01 DOI: 10.1016/j.conb.2025.102970
Aksinya Derevyanko , Tao Tao , Nicola J. Allen
{"title":"Common alterations to astrocytes across neurodegenerative disorders","authors":"Aksinya Derevyanko ,&nbsp;Tao Tao ,&nbsp;Nicola J. Allen","doi":"10.1016/j.conb.2025.102970","DOIUrl":"10.1016/j.conb.2025.102970","url":null,"abstract":"<div><div>Astrocytes perform multiple functions in the nervous system, many of which are altered in neurodegenerative disorders. In this review, we explore shared astrocytic alterations across neurodegenerative disorders, including Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and frontotemporal lobe degeneration. Assessing recent datasets of single-nucleus RNA-sequencing of human brains, a theme emerges of common alterations in astrocyte state across disorders including in neuroinflammation, synaptic organization, metabolic support, and the cellular stress response. Immune pathways are upregulated by astrocytes across disorders and may exacerbate neurodegeneration. Dysregulated expression of synaptogenic factors could contribute to synaptic loss, while compromised metabolic support affects neuronal homeostasis. On the other hand, upregulated responses to cellular stress may represent a protective response of astrocytes and thus mitigate pathology. Understanding these shared responses offers insights into disease progression and provides potential therapeutic targets for various neurodegenerative disorders.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"90 ","pages":"Article 102970"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Astrocyte regulation of critical period plasticity across neural circuits 星形胶质细胞对神经回路关键期可塑性的调节。
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2025-02-01 DOI: 10.1016/j.conb.2024.102948
Jacob P. Brandt , Sarah D. Ackerman
{"title":"Astrocyte regulation of critical period plasticity across neural circuits","authors":"Jacob P. Brandt ,&nbsp;Sarah D. Ackerman","doi":"10.1016/j.conb.2024.102948","DOIUrl":"10.1016/j.conb.2024.102948","url":null,"abstract":"<div><div>Critical periods are brief windows of heightened neural circuit plasticity that allow circuits to permanently reset their structure and function to facilitate robust organismal behavior. Understanding the cellular and molecular mechanisms that instruct critical period timing is of broad clinical interest, as altered developmental plasticity is linked to multiple neurodevelopmental disorders. While intrinsic, neuronal mechanisms shape both neural circuit remodeling and critical period timing, recent data indicate that signaling from astrocytes and surrounding glia can both promote and limit critical period plasticity. In this short review, we discuss recent breakthroughs in our understanding of astrocytes in critical period plasticity and highlight pioneering work in <em>Drosophila</em>.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"90 ","pages":"Article 102948"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging roles for tubulin PTMs in neuronal function and neurodegenerative disease 微管蛋白PTMs在神经元功能和神经退行性疾病中的新作用。
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2025-02-01 DOI: 10.1016/j.conb.2025.102971
JiaJie Teoh, Francesca Bartolini
{"title":"Emerging roles for tubulin PTMs in neuronal function and neurodegenerative disease","authors":"JiaJie Teoh,&nbsp;Francesca Bartolini","doi":"10.1016/j.conb.2025.102971","DOIUrl":"10.1016/j.conb.2025.102971","url":null,"abstract":"<div><div>Neurons are equipped with microtubules of different stability with stable and dynamic domains often coexisting on the same microtubule. While dynamic microtubules undergo random transitions between disassembly and assembly, stable ones persist long enough to serve as platforms for tubulin-modifying enzymes (known as writers) that attach molecular components to the α- or β-tubulin subunits. The combination of these posttranslational modifications (PTMs) results in a “tubulin code,” dictating the behavior of selected proteins (known as readers), some of which were shown to be crucial for neuronal function. Recent research has further highlighted that disturbances in tubulin PTMs can lead to neurodegeneration, sparking an emerging field of investigation with numerous questions such as whether and how tubulin PTMs can affect neurotransmission and synaptic plasticity and whether restoring balanced tubulin PTM levels could effectively prevent or mitigate neurodegenerative disease.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"90 ","pages":"Article 102971"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New insights into the molecular architecture of neurons by cryo-electron tomography 通过低温电子断层扫描对神经元分子结构的新见解。
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2025-02-01 DOI: 10.1016/j.conb.2024.102939
Arsen Petrovic , Thanh Thao Do , Rubén Fernández-Busnadiego
{"title":"New insights into the molecular architecture of neurons by cryo-electron tomography","authors":"Arsen Petrovic ,&nbsp;Thanh Thao Do ,&nbsp;Rubén Fernández-Busnadiego","doi":"10.1016/j.conb.2024.102939","DOIUrl":"10.1016/j.conb.2024.102939","url":null,"abstract":"<div><div>Cryo-electron tomography (cryo-ET) visualizes natively preserved cellular ultrastructure at molecular resolution. Recent developments in sample preparation workflows and image processing tools enable growing applications of cryo-ET in cellular neurobiology. As such, cryo-ET is beginning to unravel the <em>in situ</em> macromolecular organization of neurons using samples of increasing complexity. Here, we highlight advances in cryo-ET technology and review its recent use to study neuronal architecture and its alterations under disease conditions.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"90 ","pages":"Article 102939"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Turning garbage into gold: Autophagy in synaptic function 变废为宝突触功能中的自噬作用
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2025-02-01 DOI: 10.1016/j.conb.2024.102937
Erin Marie Smith , Maeve Louise Coughlan , Sandra Maday
{"title":"Turning garbage into gold: Autophagy in synaptic function","authors":"Erin Marie Smith ,&nbsp;Maeve Louise Coughlan ,&nbsp;Sandra Maday","doi":"10.1016/j.conb.2024.102937","DOIUrl":"10.1016/j.conb.2024.102937","url":null,"abstract":"<div><div>Trillions of synapses in the human brain enable thought and behavior. Synaptic connections must be established and maintained, while retaining dynamic flexibility to respond to experiences. These processes require active remodeling of the synapse to control the composition and integrity of proteins and organelles. Macroautophagy (hereafter, autophagy) provides a mechanism to edit and prune the synaptic proteome. Canonically, autophagy has been viewed as a homeostatic process, which eliminates aged and damaged proteins to maintain neuronal survival. However, accumulating evidence suggests that autophagy also degrades specific cargoes in response to neuronal activity to impact neuronal transmission, excitability, and synaptic plasticity. Here, we will discuss the diverse roles, regulation, and mechanisms of neuronal autophagy in synaptic function and contributions from glial autophagy in these processes.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"90 ","pages":"Article 102937"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endocytosis in the axon initial segment: Roles in neuronal polarity and plasticity 轴突初始段的内吞作用：在神经元极性和可塑性中的作用。
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2025-02-01 DOI: 10.1016/j.conb.2024.102949
Kelsie Eichel
{"title":"Endocytosis in the axon initial segment: Roles in neuronal polarity and plasticity","authors":"Kelsie Eichel","doi":"10.1016/j.conb.2024.102949","DOIUrl":"10.1016/j.conb.2024.102949","url":null,"abstract":"<div><div>The axon initial segment (AIS) is a specialized domain that maintains neuronal polarity and is the site of action potential generation, both of which underlie the neuron's ability to send and receive signals. Disruption of the AIS leads to a loss of neuronal polarity, altered neuronal signaling, and an array of neurological disorders. Therefore, understanding how the AIS forms and functions is a central question in cellular neuroscience that is essential to understanding neuronal physiology. Decades of study have identified many molecular components and mechanisms at the AIS. Recently, endocytosis at the AIS has been identified to function in both maintaining neuronal polarity and in mediating AIS plasticity through its ability to dynamically remodel the plasma membrane composition. This review discusses the emerging evidence for the roles of endocytosis in regulating AIS function and structural insights into how endocytosis can occur at the AIS.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"90 ","pages":"Article 102949"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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