发布求助
文献互助 智能选刊 最新文献

Current Opinion in Neurobiology最新文献

筛选
英文 中文
Neural-circuit architecture underlying non-image-forming visual functions 非图像形成视觉功能的神经电路结构
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2025-05-24 DOI: 10.1016/j.conb.2025.103052
Jiawei Shen , Tian Xue
{"title":"Neural-circuit architecture underlying non-image-forming visual functions","authors":"Jiawei Shen ,&nbsp;Tian Xue","doi":"10.1016/j.conb.2025.103052","DOIUrl":"10.1016/j.conb.2025.103052","url":null,"abstract":"<div><div>Perceiving and responding to environmental cues underpins survival and cognition. Light, emerging as one of the most ancient and powerful signals, has shaped life on Earth for billions of years. In mammals, light information is primarily detected by retinal photoreceptors: rods, cones, and intrinsically photosensitive retinal ganglion cells. While rods and cones enable image-forming vision, evolution has preserved and extended evolutionarily ancient yet critical non-image-forming visual functions, including circadian photoentrainment, pupillary light reflexes, and light-mediated modulation of metabolism, mood, and neurodevelopment. Although non-image-forming visual functions have been partially characterized in humans and model organisms, our understanding of the neural circuit mechanisms by which light orchestrates diverse behavior remains fragmented. The discovery of ipRGCs, combined with recent advances in systems neuroscience tools, has yielded critical breakthroughs in three domains: (1) light information encoding within photoreceptors, (2) systematic mapping of retinofugal pathways, and (3) central mechanisms of light-regulated physiological functions. These advances have progressively unraveled causal relationships between non-image-forming visual functions and their underlying eye-brain circuitry. This review summarizes groundbreaking progress in the three domains discussed above, highlighting key unresolved questions in the field.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"93 ","pages":"Article 103052"},"PeriodicalIF":4.8,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macroautophagy at the service of synapses 为突触服务的巨噬
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2025-05-24 DOI: 10.1016/j.conb.2025.103054
Erin Wosnitzka, Lisa Gambarotto, Vassiliki Nikoletopoulou
{"title":"Macroautophagy at the service of synapses","authors":"Erin Wosnitzka,&nbsp;Lisa Gambarotto,&nbsp;Vassiliki Nikoletopoulou","doi":"10.1016/j.conb.2025.103054","DOIUrl":"10.1016/j.conb.2025.103054","url":null,"abstract":"<div><div>Post-mitotic and highly polarized neurons are dependent on the fitness of their synapses, which are often found a long distance away from the soma. How the synaptic proteome is maintained, dynamically reshaped, and continuously turned over is a topic of intense investigation. Autophagy, a highly conserved, lysosome-mediated degradation pathway has emerged as a vital component of long-term neuronal maintenance, and now more specifically of synaptic homeostasis. Here, we review the most recent findings on how autophagy undergoes both dynamic and local regulation at the synapse, and how it contributes to pre- and post-synaptic proteostasis and function. We also discuss the insights and open questions that this new evidence brings.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"93 ","pages":"Article 103054"},"PeriodicalIF":4.8,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuromodulatory processing in the bi-pathway brain architecture 双通路脑结构中的神经调节加工
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2025-05-23 DOI: 10.1016/j.conb.2025.103055
Fu-Ning Li , Chang-Mei Zhang , Jiu-Lin Du
{"title":"Neuromodulatory processing in the bi-pathway brain architecture","authors":"Fu-Ning Li ,&nbsp;Chang-Mei Zhang ,&nbsp;Jiu-Lin Du","doi":"10.1016/j.conb.2025.103055","DOIUrl":"10.1016/j.conb.2025.103055","url":null,"abstract":"<div><div>The brain is inherently a complex and parallel system that processes both external and internal sensory cues to generate adaptive responses. Sensory cues encapsulate not only objective information about their physical and chemical properties but also subjective information related to their ecological significance. Objective information is processed and conveyed through relatively stereotyped sensorimotor pathways to drive behaviors, while subjective information is received and transmitted through relatively flexible neuromodulatory systems. These neuromodulatory pathways influence signal processing of the sensorimotor pathways at multiple stages by modulating neuronal excitability and the efficiency of synaptic transmission, thereby endowing animals with flexibility. This sophisticated neuromodulatory processing is finely tuned by the spatiotemporal dynamics of various neuromodulators released from specialized neuromodulatory neurons that encode sensory, motor as well as cognitive variables. Dysfunctions in neuromodulatory pathways disrupt spatiotemporal patterns of neuromodulators, which in turn compromise sensorimotor transformation and cognitive functions. This review aims to delineate the mechanisms and roles of neuromodulatory processing within the bi-pathway brain architecture and propose prospective research topics along with innovative experimental paradigms.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"93 ","pages":"Article 103055"},"PeriodicalIF":4.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Noncoding RNA gives agency to the molecular and cellular substrates of learning and memory 非编码RNA为学习和记忆的分子和细胞底物提供代理
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2025-05-19 DOI: 10.1016/j.conb.2025.103044
Alexander D. Walsh , Timothy W. Bredy
{"title":"Noncoding RNA gives agency to the molecular and cellular substrates of learning and memory","authors":"Alexander D. Walsh ,&nbsp;Timothy W. Bredy","doi":"10.1016/j.conb.2025.103044","DOIUrl":"10.1016/j.conb.2025.103044","url":null,"abstract":"<div><div>In the past decade, there has been a virtual explosion in the appreciation and study of noncoding RNA (ncRNA) in the brain. Rapidly emerging evidence suggests that many classes of ncRNA coordinate processes related to learning and memory, achieved via their precise subcellular localisation and interactions with DNA, mRNA and RNA binding proteins. Here we discuss these mechanisms using examples of recently discovered and well-studied ncRNAs, including long noncoding RNAs (lncRNAs), circular RNAs (circRNAs) and microRNAs (miRNAs), which are directly involved in regulating experience-dependent neural plasticity.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"93 ","pages":"Article 103044"},"PeriodicalIF":4.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accessing the viscera: Technologies for interoception research 访问内脏：内感受研究技术
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2025-05-17 DOI: 10.1016/j.conb.2025.103050
Karen K.L. Pang , Rajib Mondal , Atharva Sahasrabudhe , Polina Anikeeva
{"title":"Accessing the viscera: Technologies for interoception research","authors":"Karen K.L. Pang ,&nbsp;Rajib Mondal ,&nbsp;Atharva Sahasrabudhe ,&nbsp;Polina Anikeeva","doi":"10.1016/j.conb.2025.103050","DOIUrl":"10.1016/j.conb.2025.103050","url":null,"abstract":"<div><div>Interoception, or the perception and regulation of body signals by the central nervous system, is critical for maintaining homeostasis and coordination of behaviors. Deciphering the mechanisms of interoception requires identifying pathways and decoding of diverse signals across the brain-body axis. These studies are enabled by tools to modulate and record physiological processes in the brain and visceral organs. While numerous advanced neurotechnologies are well-established in the brain, these techniques often offer limited utility for other organs, such as the gastrointestinal tract, heart, liver, or bladder. In this review, we highlight recent advances in technologies for recording and modulation of visceral organ physiology in small animals <em>in vivo,</em> with a focus on implantable bioelectronic organ interfaces that can be deployed in behaving animals. We discuss how such interfaces are made possible through innovations in materials and electronics and outline unmet technological challenges in interoception research.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"93 ","pages":"Article 103050"},"PeriodicalIF":4.8,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How radial glia progenitor lineages generate cell-type diversity in the developing cerebral cortex 放射状胶质祖细胞谱系如何在发育中的大脑皮层中产生细胞类型多样性
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2025-05-17 DOI: 10.1016/j.conb.2025.103046
Fabrizia Pipicelli , Ana Villalba , Simon Hippenmeyer
{"title":"How radial glia progenitor lineages generate cell-type diversity in the developing cerebral cortex","authors":"Fabrizia Pipicelli ,&nbsp;Ana Villalba ,&nbsp;Simon Hippenmeyer","doi":"10.1016/j.conb.2025.103046","DOIUrl":"10.1016/j.conb.2025.103046","url":null,"abstract":"<div><div>The cerebral cortex is arguably the most complex organ in humans. The cortical architecture is characterized by a remarkable diversity of neuronal and glial cell types that make up its neuronal circuits. Following a precise temporally ordered program, radial glia progenitor (RGP) cells generate all cortical excitatory projection neurons and glial cell-types. Cortical excitatory projection neurons are produced either directly or via intermediate progenitors, through indirect neurogenesis. How the extensive cortical cell-type diversity is generated during cortex development remains, however, a fundamental open question. How do RGPs quantitatively and qualitatively generate all the neocortical neurons? How does direct and indirect neurogenesis contribute to the establishment of neuronal and lineage heterogeneity? Whether RGPs represent a homogeneous and/or multipotent progenitor population, or if RGPs consist of heterogeneous groups is currently also not known. In this review, we will summarize the latest findings that contributed to a deeper insight into the above key questions.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"93 ","pages":"Article 103046"},"PeriodicalIF":4.8,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of moonlighting proteins in neurogenesis 兼职蛋白在神经发生中的作用
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2025-05-15 DOI: 10.1016/j.conb.2025.103047
Florencia Merino , Magdalena Götz
{"title":"The role of moonlighting proteins in neurogenesis","authors":"Florencia Merino ,&nbsp;Magdalena Götz","doi":"10.1016/j.conb.2025.103047","DOIUrl":"10.1016/j.conb.2025.103047","url":null,"abstract":"<div><div>The complexity of the mammalian brain must arise from a comparably small number of genes. Proteins with moonlighting functions, i.e. entirely different functions in different compartments or cell types, contribute to multiply functional diversity. Here we review examples of such proteins with moonlighting functions during neurogenesis and in neuronal maturation. These range from cytoskeletal proteins acting as transcriptional regulators or synaptic proteins or exon junction proteins binding to and regulating the cytoskeleton to immediate early gene transcription factors regulating lipid metabolism in the endoplasmic reticulum. We further discuss how proteins with such moonlighting functions contribute to the heterogeneity of organelles shaping cell-type diversity in the brain.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"93 ","pages":"Article 103047"},"PeriodicalIF":4.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular mechanisms of stimulus detection and secretion in enteroendocrine cells 肠内分泌细胞刺激检测和分泌的分子机制
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2025-05-15 DOI: 10.1016/j.conb.2025.103045
Adam Davison, Frank Reimann , Fiona M. Gribble
{"title":"Molecular mechanisms of stimulus detection and secretion in enteroendocrine cells","authors":"Adam Davison,&nbsp;Frank Reimann ,&nbsp;Fiona M. Gribble","doi":"10.1016/j.conb.2025.103045","DOIUrl":"10.1016/j.conb.2025.103045","url":null,"abstract":"<div><div>Enteroendocrine cells (EECs) secrete over 20 different gut hormones in response to changes to the gut environment. They detect a range of nutritional stimuli through activation of a host of nutrient-sensing G-protein–coupled receptors and electrogenic nutrient cotransport. These activate intracellular signalling pathways which converge on membrane depolarisation and action potential generation, which elicit secretion. Emerging evidence has demonstrated that EECs also respond to non-nutritional stimuli, including mechanosensation, pH changes, and metabolites produced by the gut microbiome. EECs are polyhormonal cells, in which hormone expression is plastic and dependent on location in the gut. Hormones and small-molecule neurotransmitters secreted by EECs can activate extrinsic vagal afferents, modulating central processes such as appetite and food preference. While neuronal afferents are sometimes found in close proximity to EECs, the extent to which EEC/neuronal connections recapitulate traditional synaptic connections remains undefined.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"92 ","pages":"Article 103045"},"PeriodicalIF":4.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interoceptive modulation of emotions 情绪的内感受性调节
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2025-05-15 DOI: 10.1016/j.conb.2025.103049
Leo Zsembik , Poppy Oldroyd , Ritchie Chen
{"title":"Interoceptive modulation of emotions","authors":"Leo Zsembik ,&nbsp;Poppy Oldroyd ,&nbsp;Ritchie Chen","doi":"10.1016/j.conb.2025.103049","DOIUrl":"10.1016/j.conb.2025.103049","url":null,"abstract":"<div><div>The metaphorical use of the heart to represent emotions has been documented since our earliest known writings, which reflects a historical recognition of the deep connection between bodily sensations and emotions. However, it remains an active topic of investigation to determine the degree to which bodily physiology modulates emotion states. Recent advances in the neuroscience of interoception—the process by which we sense, interpret, and integrate internal bodily signals and physiology—are uncovering neurobiological mechanisms by which visceral signals can influence emotions. Here we review interoceptive pathways that relay visceral signals to the brain and discuss how these signals influence emotion states as well as challenges and opportunities to better understand interoceptive modulation of emotions.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"92 ","pages":"Article 103049"},"PeriodicalIF":4.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developmental roles of astrocytes in circuit wiring 星形胶质细胞在电路布线中的发育作用
IF 4.8 2区 医学
Current Opinion in Neurobiology Pub Date : 2025-05-13 DOI: 10.1016/j.conb.2025.103042
Kavya Raghunathan , Cagla Eroglu
{"title":"Developmental roles of astrocytes in circuit wiring","authors":"Kavya Raghunathan ,&nbsp;Cagla Eroglu","doi":"10.1016/j.conb.2025.103042","DOIUrl":"10.1016/j.conb.2025.103042","url":null,"abstract":"<div><div>Astrocytes, the perisynaptic glial cells of the brain, play fundamental roles in sculpting synaptic circuits and instructing their remodeling and maturation during development. Astrocytes do so through a plethora of cell adhesion and secretory signaling to neurons. This rich communication between astrocytes and neurons is critical for balancing inhibitory and excitatory synaptic connectivity. Additionally, astrocytes refine neural circuits via synaptic engulfment and elimination. Here, we will review recent findings highlighting the diversity and significance of astrocyte-to-neuron communication during developmental circuit wiring. Moreover, we will point out emerging mechanisms of how neurons instruct astrocytes’ maturation and synaptic functions to spotlight the essential bidirectional communication between these two cell types in shaping synaptic circuits during neurodevelopment.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"92 ","pages":"Article 103042"},"PeriodicalIF":4.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信