Current Opinion in Neurobiology最新文献_第5页

Neurodevelopmental impact of CNV models in ASD: Recent advances and future directions CNV模型对ASD神经发育的影响：最新进展和未来方向

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-03-15 DOI: 10.1016/j.conb.2025.103001

Kota Tamada, Toru Takumi

{"title":"Neurodevelopmental impact of CNV models in ASD: Recent advances and future directions","authors":"Kota Tamada, Toru Takumi","doi":"10.1016/j.conb.2025.103001","DOIUrl":"10.1016/j.conb.2025.103001","url":null,"abstract":"<div><div>Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social communication impairments and restricted, repetitive behaviors. ASD exhibits a strong genetic basis, with rare and common genetic variants contributing to its etiology. Copy number variations (CNVs), deletions or duplications of chromosomal segments, have emerged as key contributors to ASD risk. Rare CNVs often demonstrate large effect sizes and can directly cause ASD, while common variants collectively exert subtle influences. Recent advances have identified numerous ASD-associated CNVs, including recurrent loci such as 1q21.1, 2p16.3, 7q11.23, 15q11.2, 15q11-q13, 16p11.2 and 22q11.2. Mouse models carrying these CNVs have provided profound insights into the underlying neurobiological mechanisms. Recent studies integrating transcriptomic, proteomic, and functional imaging approaches have revealed alterations in synaptic function, neuronal differentiation, myelination, metabolic pathways, and circuit connectivity. Notably, investigations leveraging conditional knockout models, high magnetic field MRI, and single-cell analyses highlight disruptions in excitatory-inhibitory balance, white matter integrity, and dynamic gene regulatory networks. Parallel human-based approaches, including iPSC-derived neurons, cerebral organoids, and large-scale single-nucleus sequencing, are combined with animal model data. These integrative strategies promise to refine our understanding of ASD's genetic architecture, bridging the gap between fundamental discoveries in model organisms and clinically relevant biomarkers, subtypes, and therapeutic targets in humans. This review summarizes key findings from recent CNV mouse model studies and highlights emerging technologies applied to human ASD samples. Finally, we outline prospects for translating findings from mouse studies to humans. By illuminating both unique and convergent genetic mechanisms, these advances offer a critical framework for unraveling etiological complexity in ASD.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"92 ","pages":"Article 103001"},"PeriodicalIF":4.8,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serotonin signaling at cilia synapses 纤毛突触中的血清素信号

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-03-12 DOI: 10.1016/j.conb.2025.102994

Katherine DeLong , Shu-Hsien Sheu

引用次数: 0

Building and modifying diverse synaptic properties: Insights from Drosophila 建立和修改不同的突触特性：来自果蝇的见解

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-03-09 DOI: 10.1016/j.conb.2025.102995

Kaikai He, Dion Dickman

{"title":"Building and modifying diverse synaptic properties: Insights from Drosophila","authors":"Kaikai He, Dion Dickman","doi":"10.1016/j.conb.2025.102995","DOIUrl":"10.1016/j.conb.2025.102995","url":null,"abstract":"<div><div>Neuronal synapses are endowed with tremendous structural, functional, and molecular diversity, honed according to the physiological needs of the circuits in which they are embedded. This diversity, once established in development, can subsequently be further modified by plasticity. It is now widely appreciated that even closely related neurons sharing the same molecular machinery can exhibit remarkable diversity in synaptic structure, function, and plasticity. How such synaptic heterogeneity is achieved is now beginning to be elucidated in a powerful model system, the glutamatergic Drosophila neuromuscular junction (NMJ). In this review, we will first discuss recent discoveries about the structural, functional, and genetic diversity at synapses made by two closely related glutamatergic motor neurons at the Drosophila NMJ, MN-Ib and -Is. Next, we detail how inherent synaptic diversity can be subsequently modified by plasticity in response to altered synaptic growth, excess glutamate release, diminished glutamate receptor functionality, and disease. Together, these insights at the Drosophila NMJ have revealed fundamental principles about how closely related synapses are differentially sculpted in development and remodeled through plasticity to ultimately stabilize neural circuit function.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"92 ","pages":"Article 102995"},"PeriodicalIF":4.8,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutting-edge methodologies for tagging and tracing active neuronal coding in the brain 标记和追踪大脑中活跃神经元编码的尖端方法

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-03-08 DOI: 10.1016/j.conb.2025.102997

Kenichiro Nagahama , Veronica Hyeyoon Jung , Hyung-Bae Kwon

{"title":"Cutting-edge methodologies for tagging and tracing active neuronal coding in the brain","authors":"Kenichiro Nagahama , Veronica Hyeyoon Jung , Hyung-Bae Kwon","doi":"10.1016/j.conb.2025.102997","DOIUrl":"10.1016/j.conb.2025.102997","url":null,"abstract":"<div><div>Decoding the neural substrates that underlie learning and behavior is a fundamental goal in neuroscience. Identifying “key players” at the molecular, cellular, and circuit levels has become possible with recent advancements in molecular technologies offering high spatiotemporal resolution. Immediate-early genes are effective markers of neural activity and plasticity, allowing for the identification of active cells involved in memory-based behavior. A calcium-dependent labeling system coupled with light or biochemical proximity labeling allows characterization of active cell ensembles and circuitry across broader brain regions within short time windows, particularly during transient behaviors. The integration of these systems expands the ability to address diverse research questions across behavioral paradigms. This review examines current molecular systems for activity-dependent labeling, highlighting their applications in identifying specific cell ensembles and circuits relevant to various scientific questions and further discuss their significance, along with future directions for the development of innovative methodologies.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"92 ","pages":"Article 102997"},"PeriodicalIF":4.8,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diverse synaptic mechanisms underlying learning and memory consolidation 学习和记忆巩固的不同突触机制

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-03-05 DOI: 10.1016/j.conb.2025.102996

Yuki Murai , Akihiro Goto

{"title":"Diverse synaptic mechanisms underlying learning and memory consolidation","authors":"Yuki Murai , Akihiro Goto","doi":"10.1016/j.conb.2025.102996","DOIUrl":"10.1016/j.conb.2025.102996","url":null,"abstract":"<div><div>Memory consolidation is defined as the process by which labile short-term memories are stabilized and transformed into persistent long-term memories. This process relies heavily on synaptic plasticity, particularly long-term potentiation and depression (LTP and LTD, respectively), which have been extensively investigated in previous studies. The advent of optical tools that allow the observation and manipulation of LTP and LTD <em>in vivo</em> has advanced our understanding of their roles in learning and memory consolidation. In addition to LTP and LTD, recent research has indicated the presence of a more rapid plasticity mechanism, termed behavioral timescale synaptic plasticity (BTSP), which is crucial for encoding space and context. Sharp-wave ripples and sleep also play indispensable roles in memory consolidation, with some studies alternately linking them to LTP and LTD. At the systems level, sharp-wave ripples and sleep contribute to the transmission of information to broader brain areas, as well as the modification of synaptic strength in cortical areas for the long-term storage of memory. Furthermore, recent findings have highlighted the role of non-neuronal cells in learning, as they modulate synaptic plasticity in various ways.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"92 ","pages":"Article 102996"},"PeriodicalIF":4.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative approaches to the neurobiology of avian vocal learning 鸟类声乐学习的神经生物学比较方法

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-03-04 DOI: 10.1016/j.conb.2025.102993

Zhilei Zhao, Jesse H. Goldberg

引用次数: 0

Single-cell technology grows up: Leveraging high-resolution omics approaches to understand neurodevelopmental disorders 单细胞技术发展：利用高分辨率组学方法来理解神经发育障碍

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-03-03 DOI: 10.1016/j.conb.2025.102990

Joseph D. Dougherty , Simona Sarafinovska , Sneha M. Chaturvedi , Travis E. Law , Titilope M. Akinwe , Harrison W. Gabel

{"title":"Single-cell technology grows up: Leveraging high-resolution omics approaches to understand neurodevelopmental disorders","authors":"Joseph D. Dougherty , Simona Sarafinovska , Sneha M. Chaturvedi , Travis E. Law , Titilope M. Akinwe , Harrison W. Gabel","doi":"10.1016/j.conb.2025.102990","DOIUrl":"10.1016/j.conb.2025.102990","url":null,"abstract":"<div><div>The identification of hundreds of neurodevelopmental disorder (NDD) genes in the last decade led to numerous genetic models for understanding NDD gene mutation consequences and delineating putative neurobiological mediators of disease. In parallel, single-cell and single-nucleus genomic technologies have been developed and implemented to create high-resolution atlases of cell composition, gene expression, and circuit connectivity in the brain. Here, we discuss the opportunities to leverage mutant models (or human tissue, where available) and genomics approaches to systematically define NDD etiology at cellular resolution. We review progress in applying single-cell and spatial transcriptomics to interrogate developmental trajectories, cellular composition, circuit activity, and connectivity across human tissue and NDD models. We discuss considerations for implementing these approaches at scale to maximize insights and facilitate reproducibility. Finally, we highlight how standardized application of these technologies promises to not only define etiologies of individual disorders but also identify molecular, cellular, and circuit level convergence across NDDs.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"92 ","pages":"Article 102990"},"PeriodicalIF":4.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Defense or death? A review of the neural mechanisms underlying sensory modality-triggered innate defensive behaviors 防御还是死亡？感觉模态触发先天防御行为的神经机制综述

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-02-27 DOI: 10.1016/j.conb.2025.102977

Huating Gu , Feiran Zhao , Zhihui Liu , Peng Cao

{"title":"Defense or death? A review of the neural mechanisms underlying sensory modality-triggered innate defensive behaviors","authors":"Huating Gu , Feiran Zhao , Zhihui Liu , Peng Cao","doi":"10.1016/j.conb.2025.102977","DOIUrl":"10.1016/j.conb.2025.102977","url":null,"abstract":"<div><div>Defense or death presents a canonical dilemma for animals when encountering predators. Threatening sensory cues provide essential information that signals predator presence, driving the evolution of a spectrum of defensive behaviors. In rodents, these behaviors, as described by the classic “predatory imminence continuum” model, range from risk assessment and freezing to rapid escape responses. During the pre-encounter phase, risk assessment and avoidance responses are crucial for monitoring the environment with vigilance and cautiousness. Once detected during the post-encounter phase or physically attacked during the circa-strike phase, multiple sensory systems are rapidly activated, triggering escape responses to increase the distance from the threat. Although there are species-specific variations, the brain regions underpinning these defensive strategies, including the thalamus, hypothalamus, and midbrain, are evolutionarily conserved. This review aims to provide a comprehensive overview of the universal innate defensive circuit framework to enrich our understanding of how animals respond to life-threatening situations.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"92 ","pages":"Article 102977"},"PeriodicalIF":4.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic regulation of cortical interneuron wiring 皮层神经元间连线的动态调节

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-02-26 DOI: 10.1016/j.conb.2025.102980

Claudia Rosés-Novella , Clémence Bernard

引用次数: 0

Timing neural development and regeneration 定时神经发育和再生

IF 4.8 2区医学

Current Opinion in Neurobiology Pub Date : 2025-02-25 DOI: 10.1016/j.conb.2025.102976

Seth Blackshaw , Michel Cayouette

引用次数: 0