Targeted cravings: Unraveling the drivers of nutrient-specific appetite

IF 4.8 2区医学 Q1 NEUROSCIENCES

Current Opinion in Neurobiology Pub Date : 2025-06-09 DOI:10.1016/j.conb.2025.103063

Clare E. Hancock , Binod Aryal , Tianji Ma , Guangyan Wu , Qili Liu

引用次数: 0

Abstract

Feeding behaviors are driven not just by caloric needs but also by nutrient-specific appetites, which guide animals to seek out foods that correct specific nutritional deficiencies and fulfill diverse nutrient requirements. Despite the longstanding behavioral manifestations of nutrient-specific appetites for various nutrients, progress in understanding the underlying mechanisms has been slow. In this review, we summarize the challenges and recent advances in the study of nutrient-specific appetites for macronutrients and micronutrients, focusing on sodium- and protein-specific hunger. We examine central mechanisms that integrate peripheral, interceptive, and internal state signals to drive nutrient-specific preference and ingestion. We also explore conserved features and interactions across different nutrient-specific appetites, and discuss their implications for future research.

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有针对性的渴望：揭示特定营养食欲的驱动因素

喂养行为不仅受热量需求的驱动，还受营养特异性食欲的驱动，这种食欲引导动物寻找能够纠正特定营养缺陷并满足多种营养需求的食物。尽管长期以来对各种营养素的营养特异性食欲的行为表现，但对其潜在机制的理解进展缓慢。在这篇综述中，我们总结了大量营养素和微量营养素的营养特异性食欲研究的挑战和最新进展，重点是钠和蛋白质特异性饥饿。我们研究了整合外围、拦截和内部状态信号的中枢机制，以驱动营养特异性偏好和摄入。我们还探讨了不同营养特异性食欲之间的保守特征和相互作用，并讨论了它们对未来研究的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Neurobiology 医学-神经科学

CiteScore

11.10

自引率

1.80%

发文量

130

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Neurobiology publishes short annotated reviews by leading experts on recent developments in the field of neurobiology. These experts write short reviews describing recent discoveries in this field (in the past 2-5 years), as well as highlighting select individual papers of particular significance. The journal is thus an important resource allowing researchers and educators to quickly gain an overview and rich understanding of complex and current issues in the field of Neurobiology. The journal takes a unique and valuable approach in focusing each special issue around a topic of scientific and/or societal interest, and then bringing together leading international experts studying that topic, embracing diverse methodologies and perspectives. Journal Content: The journal consists of 6 issues per year, covering 8 recurring topics every other year in the following categories: -Neurobiology of Disease- Neurobiology of Behavior- Cellular Neuroscience- Systems Neuroscience- Developmental Neuroscience- Neurobiology of Learning and Plasticity- Molecular Neuroscience- Computational Neuroscience