非典型异离子型谷氨酸受体在电路布线和可塑性中的跨突触功能

IF 4.8 2区医学 Q1 NEUROSCIENCES

Current Opinion in Neurobiology Pub Date : 2025-06-06 DOI:10.1016/j.conb.2025.103053

Doris Wennagel, Cécile Charrier

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引用次数: 0

摘要

在哺乳动物大脑中，嗜离子性谷氨酸受体（iGluRs）介导了绝大多数快速兴奋性突触传递。此外，kainate （GluKs）和delta （GluDs）家族的非规范iGluRs作为跨突触组织者，在选择性兴奋性和抑制性突触中介导非离子化信号传导。在这里，我们回顾了最近对这些受体在电路布线和可塑性中的作用和机制的见解。我们强调了它们在兴奋性突触连接规范中的分子编排，以及它们在由意想不到的药理特性驱动的抑制性神经元回路中的扩展作用。我们讨论了关于iGluR非规范功能和突触间隙相互作用网络的基础研究如何促进神经系统疾病和损伤中突触恢复的新治疗策略。

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Trans-synaptic functions of non-canonical ionotropic glutamate receptors in circuit wiring and plasticity

Ionotropic glutamate receptors (iGluRs) mediate the vast majority of fast excitatory synaptic transmission in the mammalian brain. In addition, non-canonical iGluRs of the kainate (GluKs) and delta (GluDs) families serve as trans-synaptic organizers and mediate non-ionotropic signaling in selective types of excitatory and inhibitory synapses. Here, we review recent insights into the roles and mechanisms of these receptors in circuit wiring and plasticity. We highlight their molecular choreography in the specification of excitatory synaptic connectivity, and their expanding role in inhibitory neuronal circuits driven by unexpected pharmacological properties. We discuss how fundamental research on iGluR non-canonical functions and interaction networks in the synaptic cleft fosters novel therapeutic strategies for synapse recovery in neurological disorders and injuries.

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来源期刊

Current Opinion in Neurobiology 医学-神经科学

CiteScore

11.10

自引率

1.80%

发文量

130

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Neurobiology publishes short annotated reviews by leading experts on recent developments in the field of neurobiology. These experts write short reviews describing recent discoveries in this field (in the past 2-5 years), as well as highlighting select individual papers of particular significance. The journal is thus an important resource allowing researchers and educators to quickly gain an overview and rich understanding of complex and current issues in the field of Neurobiology. The journal takes a unique and valuable approach in focusing each special issue around a topic of scientific and/or societal interest, and then bringing together leading international experts studying that topic, embracing diverse methodologies and perspectives. Journal Content: The journal consists of 6 issues per year, covering 8 recurring topics every other year in the following categories: -Neurobiology of Disease- Neurobiology of Behavior- Cellular Neuroscience- Systems Neuroscience- Developmental Neuroscience- Neurobiology of Learning and Plasticity- Molecular Neuroscience- Computational Neuroscience