CaMKII mechanisms that promote pathological LTP impairments.

IF 4.8 2区医学 Q1 NEUROSCIENCES

Current Opinion in Neurobiology Pub Date : 2024-12-31 DOI:10.1016/j.conb.2024.102961

Matthew E Larsen, Nicole L Rumian, Nidia Quillinan, K Ulrich Bayer

引用次数: 0

Abstract

The Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) is extremely abundant in the brain, where it prominently mediates hippocampal long-term potentiation (LTP), a form of synaptic plasticity thought to be required for learning and memory. However, CaMKII also mediates LTP impairments related to Alzheimer's disease (AD) and global cerebral ischemia (GCI), two conditions that are very distinct but are both associated with impairments in learning and memory. In both cases, CaMKII inhibitors prevented these LTP impairments. Thus, CaMKII actively mediates both physiological LTP and the pathological LTP impairments related to AD and GCI. Notably, these active LTP impairment mechanisms are in stark contrast to other conditions, like normal aging, where milder LTP impairments are caused instead by passive lack of CaMKII function.

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Ca2+/钙调蛋白依赖性蛋白激酶II（CaMKII）在大脑中含量极高，它在海马长期电位（LTP）中起着重要的介导作用，LTP是一种突触可塑性，被认为是学习和记忆所必需的。然而，CaMKII 也能介导与阿尔茨海默病（AD）和全脑缺血（GCI）有关的 LTP 损伤，这两种疾病非常不同，但都与学习和记忆损伤有关。在这两种情况下，CaMKII 抑制剂都能阻止这些 LTP 损伤。因此，CaMKII 积极介导了生理性 LTP 以及与 AD 和 GCI 相关的病理性 LTP 损伤。值得注意的是，这些积极的 LTP 损伤机制与正常衰老等其他情况形成了鲜明对比，在正常衰老情况下，较轻微的 LTP 损伤是由于被动缺乏 CaMKII 功能造成的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Neurobiology 医学-神经科学

CiteScore

11.10

自引率

1.80%

发文量

130

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Neurobiology publishes short annotated reviews by leading experts on recent developments in the field of neurobiology. These experts write short reviews describing recent discoveries in this field (in the past 2-5 years), as well as highlighting select individual papers of particular significance. The journal is thus an important resource allowing researchers and educators to quickly gain an overview and rich understanding of complex and current issues in the field of Neurobiology. The journal takes a unique and valuable approach in focusing each special issue around a topic of scientific and/or societal interest, and then bringing together leading international experts studying that topic, embracing diverse methodologies and perspectives. Journal Content: The journal consists of 6 issues per year, covering 8 recurring topics every other year in the following categories: -Neurobiology of Disease- Neurobiology of Behavior- Cellular Neuroscience- Systems Neuroscience- Developmental Neuroscience- Neurobiology of Learning and Plasticity- Molecular Neuroscience- Computational Neuroscience