Chemogenetic and optogenetic tools revolutionizing the study of astrocytes in memory

IF 4.8 2区医学 Q1 NEUROSCIENCES

Current Opinion in Neurobiology Pub Date : 2025-05-28 DOI:10.1016/j.conb.2025.103057

Shay Meron Asher, Inbal Goshen

引用次数: 0

Abstract

Memory research has been historically centered around neurons, but the understanding that neurons do not work alone is lately gaining traction. Investigation of astrocytes provides evidence of the involvement of these glial cells throughout all memory stages and in many types of memory tests. This field is constantly developing and changing through the adoption of a variety of techniques. In this review, we will focus on recent papers that have used optogenetic and chemogenetic tools, which are time-restricted and cell-type specific, to investigate astrocytic involvement in memory. We will also discuss some new tools that are starting to be implemented in astrocyte research and how they may be used in future exploration of the link between specific astrocytic activity and memory.

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化学遗传学和光遗传学工具革新了记忆中星形胶质细胞的研究

历史上，记忆研究一直以神经元为中心，但神经元不是单独工作的这一认识最近越来越受到关注。对星形胶质细胞的研究提供了这些胶质细胞参与所有记忆阶段和许多类型记忆测试的证据。通过采用各种技术，该领域不断发展和变化。在这篇综述中，我们将重点介绍近年来利用具有时间限制和细胞类型特异性的光遗传学和化学遗传学工具研究星形胶质细胞参与记忆的论文。我们还将讨论一些正在星形胶质细胞研究中开始实施的新工具，以及它们如何在未来探索特定星形胶质细胞活动与记忆之间的联系中使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Neurobiology 医学-神经科学

CiteScore

11.10

自引率

1.80%

发文量

130

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Neurobiology publishes short annotated reviews by leading experts on recent developments in the field of neurobiology. These experts write short reviews describing recent discoveries in this field (in the past 2-5 years), as well as highlighting select individual papers of particular significance. The journal is thus an important resource allowing researchers and educators to quickly gain an overview and rich understanding of complex and current issues in the field of Neurobiology. The journal takes a unique and valuable approach in focusing each special issue around a topic of scientific and/or societal interest, and then bringing together leading international experts studying that topic, embracing diverse methodologies and perspectives. Journal Content: The journal consists of 6 issues per year, covering 8 recurring topics every other year in the following categories: -Neurobiology of Disease- Neurobiology of Behavior- Cellular Neuroscience- Systems Neuroscience- Developmental Neuroscience- Neurobiology of Learning and Plasticity- Molecular Neuroscience- Computational Neuroscience