Contact Dermatitis最新文献

{"title":"Photo-Aggravated Allergic Contact Dermatitis due to Hydroxyacetophenone Present in a Sunscreen: A Case Report.","authors":"David Pesqué, Emilio Berná-Rico, Gabija Rudzikaitė, Ramon M Pujol, Fernando Gallardo, Ana M Giménez-Arnau","doi":"10.1111/cod.14823","DOIUrl":"https://doi.org/10.1111/cod.14823","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Contact Allergy to Preservatives From 2014 to 2023: Benzisothiazolinone on the Rise.","authors":"Rebekka Søgaard, Christoffer Kursawe Larsen, Jeanne Duus Johansen, Jakob Ferløv Baselius Schwensen","doi":"10.1111/cod.14818","DOIUrl":"https://doi.org/10.1111/cod.14818","url":null,"abstract":"<p><strong>Background: </strong>Skin sensitising preservatives are commonly used in consumer and industrial products. The widespread use of preservatives has led to recurrent epidemics of contact allergy.</p><p><strong>Objectives: </strong>To investigate temporal trends of contact allergy to preservatives from 2014 to 2023.</p><p><strong>Materials and methods: </strong>Patients consecutively patch tested with preservatives from the European baseline series and the supplementary baseline series at Gentofte hospital from 2014 to 2023 were included.</p><p><strong>Results: </strong>The study population included 6435 patients. Contact allergy to benzisothiazolinone (BIT) increased significantly from ≤ 0.3% in 2014 to 5.0% in 2023. Painters and machine operators, and assemblers were most often sensitised to BIT, and detergents and paints were the most common exposures to BIT. Contact allergy to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) decreased significantly from 3.3% in 2014 to 2.2% in 2023. Likewise, contact allergy to MI declined significantly from 3.9% in 2014 to 2.5% in 2023. Stable trends were found for the overall prevalence of contact allergy to preservatives from 9.0% in 2014 to 10.2% in 2023.</p><p><strong>Conclusions: </strong>Regulatory restrictions on the use of MI and MCI/MI in cosmetic products have led to a decrease in contact allergy. However, the rise in contact allergy to BIT underscores the need for ongoing monitoring and preventive measures.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Requirements for Alternative In Vitro and In Silico Skin Models of Irritant and Allergic Contact Dermatitis.","authors":"Meital Portugal-Cohen, Warangkana Lohcharoenkal, Evelyn Kelemen, Inge Kortekaas Krohn, Shauni De Vriese, Danuta Gutowska-Owsiak, Ivone Jakasa, Dijana Furundžić, Anna Zalewska-Janowska, Sandrine Dubrac","doi":"10.1111/cod.14815","DOIUrl":"https://doi.org/10.1111/cod.14815","url":null,"abstract":"<p><p>Contact dermatitis is an inflammatory disease characterised by skin redness and swelling, oozing of fluid or pus and pain, caused by direct skin contact with an irritant or allergen. Its prevalence has skyrocketed worldwide, probably because human skin is in daily contact with an increasing gamut of irritants and allergens, which should require systematic surveillance. Large-scale testing is feasible by using organotypic and in silico skin models, which are becoming commonplace in industry and academic labs. In this work, we summarise the literature on models of contact dermatitis and provide insights on advantages, limitations and options for improvement.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic Contact Dermatitis of the Vulva.","authors":"Tirza Blom, Thirza G Peschar, Thomas Rustemeyer, Sylvie M Franken, Norbertus A Ipenburg","doi":"10.1111/cod.14816","DOIUrl":"https://doi.org/10.1111/cod.14816","url":null,"abstract":"<p><strong>Background: </strong>While previous studies have investigated allergic contact dermatitis (ACD) in patients with chronic vulvar complaints, data on the clinical relevance of patch test results, particularly from spices and herbs series, remain limited.</p><p><strong>Objectives: </strong>To determine the frequency and clinical relevance of contact sensitisation to allergens in the European Baseline Series (EBS) and a spices and herbs series in patients with chronic vulvar complaints.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on all patients with chronic vulvar complaints who underwent patch testing with the EBS and spices and herbs series between January 2015 and January 2024.</p><p><strong>Results: </strong>Among the 67 patients tested, 86.6% exhibited at least one positive reaction, of which 37.9% were clinically relevant. Nearly half of the patients (43.3%) showed reactions to spices and herbs, with 34.5% having clinically relevant reactions. Bell pepper was the most frequent sensitizer throughout all spices. Metals were the most commonly identified allergens (50.8%), but only one case was clinically relevant. Fragrances elicited positive reactions in 37.3% of patients, with a higher clinical relevance (60%). Preservatives also showed a considerable clinical relevance (35%) among the 29.9% of patients who reacted positively. Conversely, reactions to surfactants, rubber additives, wool wax alcohols, and antibiotics were not deemed relevant to vulvar complaints.</p><p><strong>Conclusions: </strong>ACD is prevalent in patients with chronic vulvar complaints, underscoring the critical role of patch testing as a diagnostic tool. Both topically applied cosmetic and medicinal products, as well as systemically ingested substances, such as spices and herbs, may contribute to ACD affecting the vulvar region. To enhance diagnostic accuracy, patch test series should be tailored to the patient's clinical history and specific allergen exposures.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Italian Trend of Contact Allergy to 2-Hydroxyethyl Methacrylate: Is the Current European Legislation Working?","authors":"Elena Sofia Caroppo, Gabriele Casciola, Katharina Hansel, Alba Guglielmo, Silvia Mariel Ferrucci, Fabrizio Guarneri, Maria Michela Lauriola, Maddalena Napolitano, Cataldo Patruno, Paolo Romita, Donatella Schena, Ilaria Trave, Leonardo Bianchi, Luca Stingeni","doi":"10.1111/cod.14800","DOIUrl":"https://doi.org/10.1111/cod.14800","url":null,"abstract":"<p><strong>Background: </strong>(Meth)acrylates are well-known causes of allergic contact dermatitis, and nail products are the major source of exposure, especially in a non-occupational setting. In 2020, the European legislation restricted 2-hydroxyethyl methacrylate (2-HEMA) only in nail cosmetics to professional use.</p><p><strong>Objective: </strong>To investigate the Italian prevalence trend of positive patch test reactions to 2-HEMA, the best marker for delayed hypersensitivity to (meth)acrylates.</p><p><strong>Methods: </strong>A retrospective descriptive study on consecutive patients patch tested with the Italian baseline series containing 2-HEMA was performed in 8 Italian Dermatology Clinics. Demographics, patch test results, exposure settings and sources were analysed.</p><p><strong>Results: </strong>Amongst 7133 patch tested patients, 147 (2.1%) resulted positive to 2-HEMA with an increasing trend from 2019 (1.6%) to 2023 (2.7%). The median age of sensitised female patients with a relevant positive patch test reaction to 2-HEMA was significantly decreasing over time (p = 0.004). Non-occupational allergic contact dermatitis was documented in 68.7%; artificial nails were the leading source of exposure in both occupational (75.0%) and non-occupational (72.2%) settings.</p><p><strong>Conclusion: </strong>The prevalence of contact allergy to 2-HEMA in Italy shows a progressively increasing trend over time. Currently, the European legislation does not appear to be effective in preventing or reducing this phenomenon.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequent Positive Patch Test Reactions to Glucosides in Children: A Call for Caution?","authors":"Silada Kanokrungsee,&nbsp;Julie Leysen,&nbsp;Olivier Aerts,&nbsp;Ella Dendooven","doi":"10.1111/cod.14812","DOIUrl":"10.1111/cod.14812","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alkyl glucosides are surfactants commonly found in cosmetics and household products. However, data on glucoside contact allergy in paediatric populations is limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To determine the prevalence, relevance and clinical characteristics of contact allergy to glucosides in children.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective review of the files of paediatric patients (≤ 16 years) who underwent patch testing for decyl glucoside (DG) and/or lauryl glucoside (LG) at the Antwerp University Hospital (UZA) in the period between January 2018 and December 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 241 children tested for DG, 148 (61.4%) were also tested for LG. DG reactions were observed in 47 patients (19.5%), with 27 (11.2%) considered positive. LG reactions occurred in 17/148 (13%), but only 4 (2.7%) were positive, all with concomitant DG reactions. Most positive DG reactions were weak (+) (25/27), whereas only 2 were strong (++). The median age was 7 years (range: 2–15), with 51.9% female. Culprit sources mostly included cosmetics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Patch test reactions to glucosides readily occur in children, and the positivity rate is surprisingly high. Besides many irritant and doubtful reactions, false-positive (+) reactions likely occur, particularly in young atopic children. Careful interpretation of positive results and complementary work-up may thus be necessary.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 2","pages":"148-158"},"PeriodicalIF":4.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"p-Phenylenediamine-Free Hair Dye?-Misleading Labelling Causing Allergic Contact Dermatitis.","authors":"Wimolsiri Iamsumang, Kevin Bertilsson, Jakob Dahlin, Pichamon Promsena, Ploychompoo Srisuwanwattana, Pranee Svetvilas, Penpun Wattanakrai, Annarita Antelmi, Cecilia Svedman, Thanisorn Sukakul","doi":"10.1111/cod.14813","DOIUrl":"https://doi.org/10.1111/cod.14813","url":null,"abstract":"<p><p>We report three cases of contact allergy to a mislabelled hair dye product. A hair dye product labelled as p-phenylenediamine-free has been found to contain p-phenylenediamine by a chemical analysis at the level above the limits allowed in the product.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of Pain and Use of Analgesics in Patients With Chronic Hand Eczema—Findings From the Danish Skin Cohort","authors":"Jeanette Halskou Haugaard,&nbsp;Johan Sieborg,&nbsp;Emma Guttman-Yassky,&nbsp;David Thein,&nbsp;Jonathan I. Silverberg,&nbsp;Lars Erik Kristensen,&nbsp;Jacob P. Thyssen,&nbsp;Alexander Egeberg","doi":"10.1111/cod.14814","DOIUrl":"10.1111/cod.14814","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Skin pain is a common symptom in patients with chronic hand eczema (CHE); however, its association with increased analgesic use has not been thoroughly investigated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To examine analgesic use (paracetamol, nonsteroidal anti-inflammatory drugs [NSAIDs], opioids and gabapentin/pregabalin) among patients with CHE compared to a control group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data were obtained from the Danish Skin Cohort and the Danish national registries. Patients with dermatologist-verified CHE were systematically interviewed, including questions on skin and joint pain experienced within the past 7 days.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study included 1032 patients with CHE and 11 166 controls. We observed an overall higher utilisation of analgesics among patients with CHE compared to the control group. The highest utilisation of analgesics was observed for paracetamol (35.3% vs. 25.7%) followed by NSAIDs (21.5% vs. 15.3%). When stratified by disease severity, patients with moderate-to-very-severe CHE consistently used more analgesics compared to those with mild CHE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study highlights the significant burden of pain in patients with CHE, as evidenced by their higher utilisation of analgesics compared to the general population in Denmark.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 2","pages":"131-137"},"PeriodicalIF":4.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Reported Severity of Hand Eczema: Important Outcome but How Can We Measure It?","authors":"Annika Wilke, Marc Rocholl, Christoph Skudlik, Kathrin Nordheider","doi":"10.1111/cod.14811","DOIUrl":"https://doi.org/10.1111/cod.14811","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thresholds for Contact Allergy to a Rubber Accelerator: TETD—Determined by Serial Dilution Patch Testing and a Simulated Glove-Use Model","authors":"Christoffer Kursawe Larsen,&nbsp;Jeanne D. Johansen,&nbsp;Claus Zachariae,&nbsp;Cecilia Svedman,&nbsp;Ola Bergendorff,&nbsp;Charlotte G. Mortz,&nbsp;Jakob F. B. Schwensen","doi":"10.1111/cod.14817","DOIUrl":"10.1111/cod.14817","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Rubber accelerators found in rubber gloves may cause contact allergy and thus allergic contact dermatitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To investigate which doses of tetraethylthiuram disulfide (TETD) elicit allergic contact dermatitis by patch testing and in a repeated occluded application test simulating glove use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients and Methods</h3>\u0000 \u0000 <p>A multicentre study was conducted. Eight patients with contact allergy to TETD and eight controls comprised the study group. Doses of TETD 1% (400 μg/cm²), 0.33% (130 μg/cm²), 0.11% (44 μg/cm²), 0.037% (15 μg/cm²), 0.012% (4.9 μg/cm²), 0.0041% (1.6 μg/cm²) and pure vehicle (petrolatum) were used for the patch test. Doses of TETD 1% (39 μg/cm²), 0.33% (13 μg/cm²), 0.11% (4.3 μg/cm²) and pure vehicle (99:1 ethanol: water) were used for the repeated occluded application test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Three patients (3/8) reacted to the lowest TETD dose of 0.0041% (1.6 μg/cm²) in the patch test. All patients reacted to all doses of TETD in the repeated occluded application test, none to the vehicle. The patch test dose of TETD that elicited allergic contact dermatitis in 10% of the patients (ED₁₀) was estimated to be 0.75 μg/cm².</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>A content of 0.75 μg/cm² TETD in rubber gloves may elicit allergic contact dermatitis. We suggest that future studies investigating contact allergy to rubber accelerators should base their methodology on the repeated occluded application test design presented in this study.</p>\u0000 \u0000 <p>\u0000 <b>Trial Registration:</b> ClinicalTrial.gov identifier: NCT06042309</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 2","pages":"138-147"},"PeriodicalIF":4.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14817","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}