Contact Dermatitis最新文献_第3页

Titanium: An Unusual Allergen With Various Presentations-A Retrospective Cohort Study. 钛：具有多种表现的不寻常过敏原——一项回顾性队列研究。

IF 4.6 1区医学

Contact Dermatitis Pub Date : 2025-08-26 DOI: 10.1111/cod.70021

Danny Daniely, Valentina Zemser-Werner, Roy Gilon-Omer, Jonathan Bar, Dan Slodownik

{"title":"Titanium: An Unusual Allergen With Various Presentations-A Retrospective Cohort Study.","authors":"Danny Daniely, Valentina Zemser-Werner, Roy Gilon-Omer, Jonathan Bar, Dan Slodownik","doi":"10.1111/cod.70021","DOIUrl":"https://doi.org/10.1111/cod.70021","url":null,"abstract":"Background: Titanium, a rare allergen tested within a designated metal series, has a unique exposure profile, warranting evaluation in specific clinical scenarios. Our study aims to characterise the clinical features of patients with Titanium sensitisation.Methods: A retrospective cohort analysis was conducted on 255 patients patch tested with the metal series at a tertiary contact dermatitis clinic between 2012 and 2024. Clinical characteristics and sensitisation patterns were evaluated.Results: The metal series was performed in several main indications: occupational scenarios, exposure to jewellery, post-dental or orthopaedic implants and tattoo-related dermatitis. The cohort predominantly comprised Caucasian females (57%) with a mean age of 51. Only ~20% of cases with occupational exposure and post-orthopaedic implant elicited a positive reaction to metals. 67% of patients in the latter group and all patients with tattoo-induced dermatitis would have been missed unless the metal series was performed. A positive relevant reaction to titanium oxalate was evoked in 5% of cases; 38% were associated with jewellery. Co-sensitisation with other metals including nickel, cobalt and vanadium was common. Titanium typically caused dermatitis adjacent to the contact site, mainly involving fingers and hands. Two cases associated with medical implants developed a generalised rash, 1 of whom was diagnosed with Bullous pemphigoid (BP), confirmed by immunofluorescence.Conclusions: While nickel, cobalt and chrome are considered common allergens, we hypothesise that sensitisation to other metals, including titanium, will become more prevalent in the following years through exposure via medical devices and implants as well as recreationally via 'nickel free' jewellery and tattoos. Titanium-induced BP is an intriguing phenomenon that should be further investigated, on the verge between allergology and immunology.","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systemic Allergic Dermatitis to Cyanoacrylate Used for Embolisation. 氰基丙烯酸酯栓塞的全身性过敏性皮炎。

IF 4.6 1区医学

Contact Dermatitis Pub Date : 2025-08-26 DOI: 10.1111/cod.70018

Salomé Allichon, Xavier Stefanovic, Nadia Raison-Peyron, Marie Lagreula

引用次数: 0

Urticarial Systemic Allergic Dermatitis Following Mitomycin C Instillation. 丝裂霉素C注射后的荨麻疹全身性过敏性皮炎。

IF 4.6 1区医学

Contact Dermatitis Pub Date : 2025-08-25 DOI: 10.1111/cod.70012

Dani Heuts, Bashar Razoki, Frank van Leersum, Valerie Verstraeten, Anton de Groot

引用次数: 0

Eyelid Allergic Contact Dermatitis Caused by Nickel From a Surprising Source: An Illustrating Case of Illuminating Eye Care. 意外来源的镍引起的眼睑过敏性接触性皮炎：一个启发性眼部护理的实例。

IF 4.6 1区医学

Contact Dermatitis Pub Date : 2025-08-24 DOI: 10.1111/cod.70009

Thanisorn Sukakul, Jakob Dahlin, Cecilia Svedman

引用次数: 0

1,6-Hexanediol Diacrylate, Isocyanates and Other Skin Sensitizers Are Emerging Contact Allergens in Guardian Glucose Sensors. 1,6-己二醇二丙烯酸酯，异氰酸酯和其他皮肤致敏剂是监护人血糖传感器中出现的接触过敏原。

IF 4.6 1区医学

Contact Dermatitis Pub Date : 2025-08-21 DOI: 10.1111/cod.70010

Ella Dendooven, Fleur Haentjens, Silada Kanokrungsee, Tania Naessens, Emmy Tuenter, Kenn Foubert, Nina Hermans, Eveline Dirinck, Christophe De Block, Olivier Aerts

{"title":"1,6-Hexanediol Diacrylate, Isocyanates and Other Skin Sensitizers Are Emerging Contact Allergens in Guardian Glucose Sensors.","authors":"Ella Dendooven, Fleur Haentjens, Silada Kanokrungsee, Tania Naessens, Emmy Tuenter, Kenn Foubert, Nina Hermans, Eveline Dirinck, Christophe De Block, Olivier Aerts","doi":"10.1111/cod.70010","DOIUrl":"https://doi.org/10.1111/cod.70010","url":null,"abstract":"Background: Allergic contact dermatitis (ACD) from diabetes devices remains a significant concern.Objective: To report ACD from Guardian 3 and 4 glucose sensors (G3/4 sensors) due to multiple skin sensitizers, that is, isobornyl acrylate (IBOA), N,N-dimethylacrylamide (DMAA) and also 1,6-hexanediol diacrylate (HDDA), isocyanates, colophonium derivatives, tert-butylphenols (TBPs) and salicylates.Methods: Twenty-seven patients with ACD from G3/4 sensors, evaluated between January 2020 and December 2024, were patch-tested to a baseline, acrylate, isocyanate and plastics and glue series. The sensors and their overtape (Oval Tape) were analysed with gas chromatography-mass spectrometry (GC-MS).Results: Most patients (44%) reacted to colophonium (derivatives), followed by IBOA (31%) and isocyanates (29%). Fewer, yet remarkable reactions were observed to HDDA (20%), TBPs (12.5%) and DMAA (8%). All IBOA and DMAA-allergic patients had been previously sensitised by the FreeStyle I sensor, whereas patients using G3/4 sensors as their first diabetes device were not sensitised to these two allergens. Chemical analyses confirmed the presence of colophonium derivatives, IBOA, DMAA, HDDA, isocyanates, TBPs and, interestingly, also salicylates, as skin sensitizers in these sensors.Conclusions: The newer glucose sensors Guardian 3 and 4 contain, besides IBOA and DMAA, also HDDA, together with a multitude of other skin sensitizers that put patients at risk of developing ACD.","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interpretability and Minimal Important Change of the Greek Quality of Life in Hand Eczema Questionnaire (QOLHEQ). 手部湿疹问卷（QOLHEQ）希腊生活质量的可解释性和最小重要变化。

IF 4.6 1区医学

Contact Dermatitis Pub Date : 2025-08-12 DOI: 10.1111/cod.70006

Robert F Ofenloch, Christian Apfelbacher, Dimitra Koumaki

引用次数: 0

Gold Allergy Associated With Persistent Reactions Post Fractional Radiofrequency Microneedling Treatment. 部分射频微针治疗后与持续反应相关的金过敏。

IF 4.6 1区医学

Contact Dermatitis Pub Date : 2025-08-06 DOI: 10.1111/cod.70004

Nirin Seatamanoch, Pariya Ruxrungtham, Narisa Brownell, Suwimon Loplumlert

引用次数: 0

Occupational Allergic Contact Dermatitis Caused by Mercaptobenzothiazole in DS2 Dust Mask Straps During the COVID-19 Pandemic: A Study of Outbreak and Proposal of Safer Alternatives. COVID-19大流行期间DS2防尘口罩带中巯基苯并噻唑致职业性变应性接触性皮炎：疫情研究及安全替代方案建议

IF 4.6 1区医学

Contact Dermatitis Pub Date : 2025-08-03 DOI: 10.1111/cod.70007

Shigeruko Iijima, Tsuyoshi Kawakami, Masayo Kimura, Nobuko Sasaki, Fumiko Miyazawa, Yoko Mori, Maiko Tahara, Kayoko Matsunaga

{"title":"Occupational Allergic Contact Dermatitis Caused by Mercaptobenzothiazole in DS2 Dust Mask Straps During the COVID-19 Pandemic: A Study of Outbreak and Proposal of Safer Alternatives.","authors":"Shigeruko Iijima, Tsuyoshi Kawakami, Masayo Kimura, Nobuko Sasaki, Fumiko Miyazawa, Yoko Mori, Maiko Tahara, Kayoko Matsunaga","doi":"10.1111/cod.70007","DOIUrl":"https://doi.org/10.1111/cod.70007","url":null,"abstract":"Background: The global COVID-19 pandemic has necessitated the widespread use of dust masks, including N95 and DS2, in healthcare settings. Although allergic contact dermatitis caused by dust mask straps has been reported, component analysis of the straps is rare. We encountered an outbreak of dermatitis cases due to rubber straps of a DS2 mask (Mask A) at our hospital.Objectives: To investigate the cause of dermatitis associated with Mask A rubber strap, identify the allergens responsible for allergic contact dermatitis and propose suitable alternative masks.Patients/methods: Twelve healthcare workers who developed contact dermatitis after wearing Mask A were enrolled. A detailed questionnaire, chemical analyses of Mask A rubber straps and alternatives and patch testing with identified components of the straps were performed.Results: Twelve cases (nine females, three males; mean age 47.8 ± 11.1 years) had no prior history of contact rubber allergy. The straps of Mask A contained thiazole-type vulcanisation accelerators and degradation products. Patch testing revealed sensitisation to 2-mercaptobenzothiazole, 2,2'-dithiobis(benzothiazole) and 2-(methylthio)benzothiazole in eight, three and five cases, respectively.Conclusion: Occupational allergic contact dermatitis due to 2-mercaptobenzothiazole in Mask A straps was diagnosed in eight cases. All affected individuals successfully switched to alternative masks without recurrence.","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug Provocation Testing in Allergological Work-Up of DRESS: A Retrospective Real-Life Experience From a Specialist Centre. DRESS过敏检查中的药物激发试验：来自专家中心的回顾性现实生活经验。

IF 4.6 1区医学

Contact Dermatitis Pub Date : 2025-07-31 DOI: 10.1111/cod.70003

Haudrey Assier, Thomas Bettuzzi, Elio Kechichian, Reine Merhy, Margaux Fleck, Amandine Weill, Olivier Gaudin, Gwendeline Gener, Pierre Wolkenstein, Saskia Ingen-Housz-Oro

{"title":"Drug Provocation Testing in Allergological Work-Up of DRESS: A Retrospective Real-Life Experience From a Specialist Centre.","authors":"Haudrey Assier, Thomas Bettuzzi, Elio Kechichian, Reine Merhy, Margaux Fleck, Amandine Weill, Olivier Gaudin, Gwendeline Gener, Pierre Wolkenstein, Saskia Ingen-Housz-Oro","doi":"10.1111/cod.70003","DOIUrl":"https://doi.org/10.1111/cod.70003","url":null,"abstract":"Background: In drug reaction with eosinophilia and systemic symptoms (DRESS), cutaneous tests help to identify the responsible drug. However, uncertainty may persist and drug provocation tests (DPTs) could enable contraindications for essential drugs to be avoided.Objectives: To report the experience of DPTs in a series of DRESS patients managed in a referral centre for severe drug reactions.Methods: We performed a single-centre retrospective study (October 2015-October 2021) of patients referred for an allergological work-up after DRESS.Results: Seventy-five patients were included (49 females, mean age 55 years, 212 suspected drugs). Cutaneous tests, realised in all patients, were positive in 38, and DPTs were performed in 39 patients (65 drugs: 41 suspected and 24 alternative drugs, all with negative cutaneous tests). DPTs were performed regardless of DRESS severity or RegiSCAR score, at full dose (FD) for 40 drugs and graduated dose (from 1/100 FD) for 25 drugs. The objective was always to avoid contra-indications or to propose alternative drugs. Mild reactions occurred following challenge with 13 drugs (all suspected drugs), of which 6 could be continued. DPTs were more often positive when more drugs were suspected or reintroduced, but less often when a high-notoriety drug was suspected and avoided.Conclusions: DPTs can be considered in DRESS by experienced teams to avoid unnecessary contraindications for essential drugs.","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lettuce Anaphylaxis in a Florist With Hand Dermatitis and Contact Allergy to the Compositae (Asteraceae) Family of Plants. 莴苣过敏反应的花店与手皮炎和接触过敏的菊科植物（菊科）家族。

IF 4.6 1区医学

Contact Dermatitis Pub Date : 2025-07-30 DOI: 10.1111/cod.70008

Lara Obermeyer, Monika Raulf, Irene Mittermann, Martina Aumayr, Christoph Skudlik, Richard Brans

引用次数: 0