Thresholds for Contact Allergy to a Rubber Accelerator: TETD-Determined by Serial Dilution Patch Testing and a Simulated Glove-Use Model.

IF 4.8 1区医学 Q2 ALLERGY

Contact Dermatitis Pub Date : 2025-05-16 DOI:10.1111/cod.14817

Christoffer Kursawe Larsen, Jeanne D Johansen, Claus Zachariae, Cecilia Svedman, Ola Bergendorff, Charlotte G Mortz, Jakob F B Schwensen

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引用次数: 0

Abstract

Background: Rubber accelerators found in rubber gloves may cause contact allergy and thus allergic contact dermatitis.

Objectives: To investigate which doses of tetraethylthiuram disulfide (TETD) elicit allergic contact dermatitis by patch testing and in a repeated occluded application test simulating glove use.

Patients and methods: A multicentre study was conducted. Eight patients with contact allergy to TETD and eight controls comprised the study group. Doses of TETD 1% (400 μg/cm²), 0.33% (130 μg/cm²), 0.11% (44 μg/cm²), 0.037% (15 μg/cm²), 0.012% (4.9 μg/cm²), 0.0041% (1.6 μg/cm²) and pure vehicle (petrolatum) were used for the patch test. Doses of TETD 1% (39 μg/cm²), 0.33% (13 μg/cm²), 0.11% (4.3 μg/cm²) and pure vehicle (99:1 ethanol: water) were used for the repeated occluded application test.

Results: Three patients (3/8) reacted to the lowest TETD dose of 0.0041% (1.6 μg/cm²) in the patch test. All patients reacted to all doses of TETD in the repeated occluded application test, none to the vehicle. The patch test dose of TETD that elicited allergic contact dermatitis in 10% of the patients (ED₁₀) was estimated to be 0.75 μg/cm².

Conclusion: A content of 0.75 μg/cm² TETD in rubber gloves may elicit allergic contact dermatitis. We suggest that future studies investigating contact allergy to rubber accelerators should base their methodology on the repeated occluded application test design presented in this study.

Trial registration: ClinicalTrial.gov identifier: NCT06042309.

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橡胶促进剂接触过敏的阈值：tetd -由系列稀释斑贴试验和模拟手套使用模型确定。

背景：橡胶手套中发现的橡胶促进剂可能引起接触性过敏，从而引起过敏性接触性皮炎。目的：通过斑贴试验和模拟手套使用的重复封闭应用试验，研究哪种剂量的四乙基硫脲（TETD）会引起过敏性接触性皮炎。患者和方法：采用多中心研究。8名接触性过敏的TETD患者和8名对照者组成研究组。贴片试验采用TETD 1% （400 μg/cm2）、0.33% （130 μg/cm2）、0.11% （44 μg/cm2）、0.037% （15 μg/cm2）、0.012% （4.9 μg/cm2）、0.0041% （1.6 μg/cm2）和纯对照品（石油油）剂量。采用TETD 1% （39 μg/cm2）、0.33% （13 μg/cm2）、0.11% （4.3 μg/cm2）和纯对照（99:1乙醇：水）剂量进行重复闭塞应用试验。结果：3例（3/8）患者在贴片试验中TETD最低剂量为0.0041% （1.6 μg/cm2）。在重复封闭应用试验中，所有患者对所有剂量的TETD均有反应，对载具无反应。据估计，10%的患者（ED10）中TETD引起过敏性接触性皮炎的斑贴试验剂量为0.75 μg/cm2。结论：橡胶手套中TETD含量为0.75 μg/cm2可引起过敏性接触性皮炎。我们建议未来研究橡胶促进剂接触性过敏的方法应基于本研究中提出的重复封闭应用试验设计。试验注册：ClinicalTrial.gov标识符：NCT06042309。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Contact Dermatitis 医学-过敏

CiteScore

4.60

自引率

30.90%

发文量

227

审稿时长

4-8 weeks

期刊介绍： Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".