Contact Dermatitis最新文献

Allergy by Proxy to Penicillins Presenting as Recurrent Idiopathic Anaphylaxis Within the Household: A Case Report. 对青霉素的代用过敏在家庭中表现为复发性特发性过敏反应：一个病例报告。

IF 4.6 1区医学

Contact Dermatitis Pub Date : 2025-09-22 DOI: 10.1111/cod.70014

Adrien Bénic, Evangéline Clark, Pascal Demoly, Anca Mirela Chiriac

引用次数: 0

Contact Allergy in Children in Europe: A Proposal for a Paediatric European Baseline Series. 欧洲儿童接触性过敏：儿科欧洲基线系列的建议。

IF 4.6 1区医学

Contact Dermatitis Pub Date : 2025-09-19 DOI: 10.1111/cod.70033

Anne Birgitte Simonsen, Thomas Rustemeyer, Suzana Ljubojevicé Hadzavdic, Radoslaw Spiewak, Anna Belloni Fortina, Margarida Gonçalo, Ana Maria Giménez Arnau, Nidia Planella-Fontanillas, Marie L A Schuttelaar, Heinrich Dickel, Jonathan White, Györgyi Pónyai, S Mark Wilkinson, Esen Özkaya, Ella Dendooven, Nives Pustišek, Jeanne Duus Johansen, Olivier Aerts

{"title":"Contact Allergy in Children in Europe: A Proposal for a Paediatric European Baseline Series.","authors":"Anne Birgitte Simonsen, Thomas Rustemeyer, Suzana Ljubojevicé Hadzavdic, Radoslaw Spiewak, Anna Belloni Fortina, Margarida Gonçalo, Ana Maria Giménez Arnau, Nidia Planella-Fontanillas, Marie L A Schuttelaar, Heinrich Dickel, Jonathan White, Györgyi Pónyai, S Mark Wilkinson, Esen Özkaya, Ella Dendooven, Nives Pustišek, Jeanne Duus Johansen, Olivier Aerts","doi":"10.1111/cod.70033","DOIUrl":"https://doi.org/10.1111/cod.70033","url":null,"abstract":"Background: Contact allergy is common in children, but no paediatric baseline series (pEBS) exists in Europe, despite recommendations in several countries.Objectives: To collect and compare patch testing data from European centres to propose a common pEBS, possibly adapted by age group.Materials and methods: Data from 13 centres in 12 European countries were aggregated, covering 1816 children (1099 girls, 60.5%), aged 0-16 years, tested with the adult EBS (aEBS) and other frequent allergens between 2018 and 2022. Allergen selection followed adult criteria, with a stricter cut-off for inclusion, requiring at least 1% positive reactions (lower 95% CI) in children.Results: A total of 17 allergens from the aEBS caused positive reactions in ≥ 1% of children (lower 95% CI). Common allergens included metals, fragrances, and preservatives. Tixocortol-21-pivalate was included despite its lower frequency due to its difficult-to-suspect nature. Additional frequent allergens were hydroperoxides of limonene and linalool, Amerchol L-101, and sorbitan sesquioleate. In total, 18 allergens were identified as potentially qualifying for a pEBS, with a further 7 as recommended additions.Conclusion: Results from patch testing children across europe highlight a common set of frequent allergens, which should be considered for a pEBS.","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in Benzisothiazolinone Sensitization: A Retrospective Analysis From 2010 to 2022, in a Tertiary Belgian Hospital. 2010 - 2022年比利时某三级医院苯并异噻唑啉酮致敏趋势回顾性分析

IF 4.6 1区医学

Contact Dermatitis Pub Date : 2025-09-17 DOI: 10.1111/cod.70017

Anne Herman, Kiswendsida Sawadogo, Marie Baeck

{"title":"Trends in Benzisothiazolinone Sensitization: A Retrospective Analysis From 2010 to 2022, in a Tertiary Belgian Hospital.","authors":"Anne Herman, Kiswendsida Sawadogo, Marie Baeck","doi":"10.1111/cod.70017","DOIUrl":"https://doi.org/10.1111/cod.70017","url":null,"abstract":"Background: Benzisothiazolinone is a preservative responsible for allergic contact dermatitis, with occupational exposure being a common source of sensitisation.Objectives: To investigate the prevalence of positive patch test reactions to benzisothiazolinone (BIT) in Belgium, between January 2010 and December 2022, and to assess co-sensitisations to other isothiazolinone derivatives in sensitised patients.Methods: A retrospective monocentric study of patch test results with benzisothiazolinone (BIT) 0.1% petrolatum observed in patients attending a Belgian tertiary hospital. Prevalence, demographic data, concomitant patch test reactions, and clinical relevance were analysed.Results: Overall, 65 of 6128 patients (1.06%) had a positive patch test reaction to benzisothiazolinone, and its sensitisation rate increased from 0.39% in 2010 to 3.72% in 2019 (followed by a decline to 0.71% in 2022). Occupational exposure was relevant in 20% of cases, with painters and metalworkers being the most affected professions. Unexpectedly, 10.8% of BIT-sensitised patients underwent patch testing due to complications following orthopaedic prosthesis implantation.Conclusions: This study confirms a significant rise in BIT sensitisation over time, followed by a recent unexplained decline. Occupational exposure remains a major risk factor, but other environmental sources, including consumer products, such as leather products, should not be overlooked. The BIT sensitisation in orthopaedic prosthesis-related complications requires further investigation.","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Positive Patch Test Reactions to Dental Rubber Dams and Zinc Ethylphenyldithiocarbamate in a Patient Sensitised to Thiurams and Other Carbamates. 对硫脲类和其他氨基甲酸盐敏感的患者对牙科橡胶坝和乙基苯基二硫氨基甲酸锌的阳性斑贴试验反应。

IF 4.6 1区医学

Contact Dermatitis Pub Date : 2025-09-17 DOI: 10.1111/cod.70032

Annarita Antelmi, Ellen Rydhög, Kevin Bertilsson, Ola Bergendorff

引用次数: 0

Octylisothiazolinone-A New Sensitizer in Over-Ear Headphones. 一种新型耳戴式耳机增敏剂——辛基异噻唑啉酮。

IF 4.6 1区医学

Contact Dermatitis Pub Date : 2025-09-13 DOI: 10.1111/cod.70028

Blerand Berisha, Tina Lejding, Ola Bergendorff, Inese Hauksson

{"title":"Octylisothiazolinone-A New Sensitizer in Over-Ear Headphones.","authors":"Blerand Berisha, Tina Lejding, Ola Bergendorff, Inese Hauksson","doi":"10.1111/cod.70028","DOIUrl":"https://doi.org/10.1111/cod.70028","url":null,"abstract":"Background: Allergic contact dermatitis (ACD) caused by isothiazolinones is a growing concern, particularly in consumer products. Octylisothiazolinone (OIT) is a potent sensitiser and commonly used as a preservative in rubbers, plastics and coatings, including those found in headphones. Despite increasing regulations on isothiazolinones in cosmetics, their presence in wearable devices remains under-recognised.Aims: This investigation aims to identify OIT as a possible sensitiser in patients with presumed ACD due to over-ear headphones.Methods: Two patients with presumed ACD due to over-ear headphones were patch tested at the Department of Occupational and Environmental Dermatology, Skåne University Hospital, Malmö. Patch testing included Swedish baseline series, isothiazolinone compounds, and materials from headphones. To identify potential allergens, chemical analysis of components from headphones was conducted using high-performance liquid chromatography (HPLC).Results: Patch testing demonstrated strong positive reactions to OIT in both cases, with additional reactions to acetone extracts of artificial leather and blue plastic foam. OIT remained positive at dilutions as low as 0.00003%. Case 1 also showed positive reactions to MI/MCI. Chemical analysis confirmed OIT in both artificial leather (2.2 mg/g) and plastic foam (0.3 mg/g).Conclusions: These findings contribute to the understanding of ACD by identifying OIT as a potential allergen in over-ear headphones. It calls for further research into the prevalence of OIT in consumer electronics and its role in sensitisation.","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145052108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the Chemical Safety of Clothing Articles, Textiles and Footwear With Regard to the Presence of Carcinogenic, Mutagenic, or Reprotoxic Substances, Endocrine Disruptors and Skin Sensitizers Under EU Regulatory Restrictions. 在欧盟法规限制下，就致癌、诱变或生殖毒性物质、内分泌干扰物和皮肤致敏剂的存在，公布服装、纺织品和鞋类的化学安全性。

IF 4.6 1区医学

Contact Dermatitis Pub Date : 2025-09-12 DOI: 10.1111/cod.70026

Roberta Lavalle, Manuela Agnello, Roberto Mua, Marco Fontana, Barbara Cravello, Marco Piu, Federica Panico, Raffaella Cresti, Ida Marcello, Leonello Attias, Carolina Ferranti, Luca Palleschi, Lucilla Baldassarri, Rosa Draisci, Marco Famele

{"title":"Unveiling the Chemical Safety of Clothing Articles, Textiles and Footwear With Regard to the Presence of Carcinogenic, Mutagenic, or Reprotoxic Substances, Endocrine Disruptors and Skin Sensitizers Under EU Regulatory Restrictions.","authors":"Roberta Lavalle, Manuela Agnello, Roberto Mua, Marco Fontana, Barbara Cravello, Marco Piu, Federica Panico, Raffaella Cresti, Ida Marcello, Leonello Attias, Carolina Ferranti, Luca Palleschi, Lucilla Baldassarri, Rosa Draisci, Marco Famele","doi":"10.1111/cod.70026","DOIUrl":"https://doi.org/10.1111/cod.70026","url":null,"abstract":"Objectives: To assess the occurrence of carcinogenic, mutagenic, and reprotoxic substances (CMRs), endocrine disruptors, and skin sensitizers (i.e., polycyclic aromatic hydrocarbons (PAHs), phthalates, per- and polyfluoroalkyl substances (PFAS), bisphenols, isocyanates, isothiazolinones) in textiles, footwear, and clothing under in-force or proposed EU restrictions, and to evaluate exposure and risks for consumers related to bisphenols.Materials and methods: 111 items from the Italian market or online were tested by gas or liquid chromatography mass spectrometry.Results: 63% of the samples contained the investigated substances: 24% would exceed the proposed concentration limit for bisphenols under Regulation (EC) No. 1907/2006 (REACH); 19% could represent a significant source of exposure to phthalates and PAHs for consumers due to non-compliance with REACH; 7% contained octylisothiazolinone above the limit proposed to protect from skin sensitisation. Isocyanates and PFAS were quantified within concentration limits proposed or set by REACH and Regulation (EU) No. 2019/1021. No risks for consumers were related to the presence of bisphenols.Conclusions: Safety of clothing articles, textiles, and footwear, especially from online market, would be significantly impacted by the presence of CMRs and environmental endocrine disruptors (i.e., phthalates, PAHs, bisphenols), highlighting the need for enforcement of EU controls and reduced use of harmful chemicals by manufacturers.","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145052127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Susceptibility in the Association Between Exposures and Occupational Contact Dermatitis: A Scoping Review. 暴露与职业性接触性皮炎之间易感性的作用：一项范围综述。

IF 4.6 1区医学

Contact Dermatitis Pub Date : 2025-09-12 DOI: 10.1111/cod.70030

Renate Juścikowski, Pieter Coenen, Sanja Kezic, Damien M McElvenny, Faridi S Jamaludin, Henk F van der Molen, Jan L Hoving

{"title":"The Role of Susceptibility in the Association Between Exposures and Occupational Contact Dermatitis: A Scoping Review.","authors":"Renate Juścikowski, Pieter Coenen, Sanja Kezic, Damien M McElvenny, Faridi S Jamaludin, Henk F van der Molen, Jan L Hoving","doi":"10.1111/cod.70030","DOIUrl":"https://doi.org/10.1111/cod.70030","url":null,"abstract":"The objective of this review is to identify individual susceptibility factors and determine their role in the association between work-related exposures and contact dermatitis (CD). A scoping review was conducted using Medline, Embase, and CINAHL. Cohort and case-control studies were included for all types of CD, and cross-sectional studies for allergic contact dermatitis (ACD). In the absence of meta-analysis, we drew qualitative inferences summarising the findings. Twenty-one studies, primarily cross-sectional (n = 18), investigated how 44 individual susceptibility factors influenced associations between 53 work-related exposures (from six exposure categories) and CD. These factors were grouped into five categories: demographic, socioeconomic, host-related intrinsic factors, lifestyle, and exposures outside work. The factors variously mitigated, amplified, or had no effect on the exposure-CD association. The role of individual susceptibility factors in work-related exposure-CD associations remains underexplored and inconclusive. Determining their individual contributions is challenging, as studies often adjust for multiple factors, with inconsistent influence on the association. Age, sex, atopic history, hand eczema, smoking, and ethnicity may influence CD risk and should be considered in studies examining work-related exposure-CD associations. Further research is needed to clarify the role of individual susceptibility factors and guide effective prevention strategies for occupational CD.","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patch Testing Confirms Clindamycin-Induced Acute Generalised Exanthematous Pustulosis: A Case Report. 贴片试验证实克林霉素引起的急性全身性红斑性脓疱病1例。

IF 4.6 1区医学

Contact Dermatitis Pub Date : 2025-09-09 DOI: 10.1111/cod.70029

Carmen Cánovas Seva, Carmen Paredes-Suárez, Ana Batalla, Ángeles Flórez

引用次数: 0

Moisturising Gloves as a Solution for Occupational Skin Health: Advances and Challenges. 保湿手套作为职业皮肤健康的解决方案：进步和挑战。

IF 4.6 1区医学

Contact Dermatitis Pub Date : 2025-09-09 DOI: 10.1111/cod.70025

Sher Wei How, Janarthanan Supramaniam, Thet Thet Htar, Bey Fen Leo, Sivakumar Manickam, Bey Hing Goh, Siah Ying Tang

{"title":"Moisturising Gloves as a Solution for Occupational Skin Health: Advances and Challenges.","authors":"Sher Wei How, Janarthanan Supramaniam, Thet Thet Htar, Bey Fen Leo, Sivakumar Manickam, Bey Hing Goh, Siah Ying Tang","doi":"10.1111/cod.70025","DOIUrl":"https://doi.org/10.1111/cod.70025","url":null,"abstract":"Extended glove usage is crucial in various occupational settings to safeguard workers and maintain hygiene standards. However, prolonged wear creates an occlusive environment that disrupts normal skin evaporation, leading to temporary overhydration. This reversal of the diffusion gradient facilitates the penetration of residual soaps and alcohol from hand hygiene practices, which can deplete skin moisture and cause irritation. Moisturising agents have been integrated into gloves to address occupational dry skin, as conventional lotions often suffer from low compliance and incompatibility with latex. Their selection requires careful optimisation to ensure effective skin penetration without compromising glove integrity or introducing manufacturing complexities. Additionally, variations in activation stimuli among individuals must be taken into account to ensure consistent efficacy. This review discusses advancements in moisturising glove technologies, including interlayer coatings, direct surface applications, matrix integration, microencapsulation and hydrogel-based controlled-release systems. Despite these innovations, research gaps remain in standardising hydration assessment methods, evaluating real-world performance and comparing the efficacy of moisturising gloves with conventional skincare methods. Addressing these challenges through further clinical studies is crucial for refining the design and effectiveness of moisturising gloves in occupational applications.","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allergic Contact Dermatitis Triggered by a Mare's Milk-Based Soap. 由马奶皂引起的过敏性接触性皮炎。

IF 4.6 1区医学

Contact Dermatitis Pub Date : 2025-09-08 DOI: 10.1111/cod.70027

Nosria Boulakhrif, Julie Van Gysel, Christel Scheers, Carine Nootens, Gwendy Dupire

引用次数: 0