Kerstin Egele, Hans Drexler, Manigé Fartasch, Vera van Kampen, Hans F Merk, Dennis Nowak, Axel Schnuch, Wolfgang Uter, Patricia Kreis, Brunhilde Blömeke
{"title":"Benzoyl Peroxide's Sensitisation Potential and Potency in Experimental Methods and Review of Contact Allergy and Allergic Contact Dermatitis.","authors":"Kerstin Egele, Hans Drexler, Manigé Fartasch, Vera van Kampen, Hans F Merk, Dennis Nowak, Axel Schnuch, Wolfgang Uter, Patricia Kreis, Brunhilde Blömeke","doi":"10.1111/cod.14765","DOIUrl":"https://doi.org/10.1111/cod.14765","url":null,"abstract":"<p><p>Positive patch test responses to benzoyl peroxide (BPO) have been reported from patients without and with known exposure. Up to 6.5% were found in the United States and 7.8% in a study including patients from Germany, Austria and Switzerland. We provide an overview of the skin sensitisation potential and potency of BPO based on animal experiments and non-animal methods. BPO tested positive in Guinea Pig Tests and the Local Lymph Node Assay. Application of the current OECD guideline to identify a skin sensitizer by combining non-animal method results gave differing outcomes. Moreover, patch test responses of patients to BPO were considered to determine the importance of BPO as a relevant occupational contact allergen. Another well-known BPO exposure is the topical application to treat acne. Despite widespread use, extensive and long-term skin exposure, we found for this group only studies reporting few positive patch test reactions. Further, occupational handling of BPO and contact allergy is reported by dental technicians. In-depth evaluation of the prevalence of contact allergy in different professions with suspected BPO exposure did not reveal an association with occupational handling of BPO. Consequently, a generally increased risk for those professions is not supported.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction to \"Using Chemical Speciation Modelling to Discuss Variations in Patch Test Reactions to Different Aluminium and Chromium Salts\".","authors":"","doi":"10.1111/cod.14766","DOIUrl":"https://doi.org/10.1111/cod.14766","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Allergic Contact Dermatitis to Both Latanoprost and Dorzolamide in Eye Drops.","authors":"Antoine Badaoui","doi":"10.1111/cod.14761","DOIUrl":"https://doi.org/10.1111/cod.14761","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"If Left to Your Own Devices, Consider Colophony.","authors":"E Dimitra Bednar, Joel G DeKoven","doi":"10.1111/cod.14762","DOIUrl":"https://doi.org/10.1111/cod.14762","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Esen Özkaya, Yasemin Erdem, İmran Can Özdemir, Tuğrul Furkan Morgül
{"title":"Allergic Contact Dermatitis From Colophonium in Upholstery Adhesive: Two Case Reports of a Novel Source.","authors":"Esen Özkaya, Yasemin Erdem, İmran Can Özdemir, Tuğrul Furkan Morgül","doi":"10.1111/cod.14760","DOIUrl":"https://doi.org/10.1111/cod.14760","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Beatriz F Vilela, Pedro S Farinha, Bruno Duarte, Ana Brasileiro
{"title":"Dupilumab-Associated Unmasking of Allergic Contact Dermatitis.","authors":"Beatriz F Vilela, Pedro S Farinha, Bruno Duarte, Ana Brasileiro","doi":"10.1111/cod.14758","DOIUrl":"https://doi.org/10.1111/cod.14758","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel Isufi, Mikkel Bak Jensen, Christoffer Kursawe Larsen, Farzad Alinaghi, Jakob Ferløv Baselius Schwensen, Jeanne D Johansen
{"title":"Allergens Responsible for Contact Allergy in Children From 2010 to 2024: A Systematic Review and Meta-Analysis.","authors":"Daniel Isufi, Mikkel Bak Jensen, Christoffer Kursawe Larsen, Farzad Alinaghi, Jakob Ferløv Baselius Schwensen, Jeanne D Johansen","doi":"10.1111/cod.14753","DOIUrl":"https://doi.org/10.1111/cod.14753","url":null,"abstract":"<p><p>Contact allergy (CA) is a frequent condition in children; however, newer estimates of the prevalence of CA in children are lacking. Herein, we aim to provide an estimate of the prevalence of CA in children from 2010 to 2024. Two authors independently searched PubMed, Embase and Web of Science for studies reporting the prevalence of positive patch tests (PPTs) to allergens in populations including ≥ 100 children (< 18 years). Proportion meta-analyses were conducted to calculate the pooled prevalence estimates of CA in children. Seventeen studies comprising 11 593 children undergoing patch testing with 4176 (36%) PPTs were eligible for inclusion. The allergen with the highest prevalence was nickel (11.9% [95% confidence interval [CI], 8.6%-15.71%]), followed by cobalt (6.6% [95% CI, 4.2%-9.5%]), cocamidopropyl betaine (5.5% [95% CI, 3.1-8.7]), bacitracin (5.2% [95% CI, 1.2%-10.0%]), fragrance mix I (4.8% [95% CI, 2.9%-7.1%]) and methylisothiazolinone (4.3% [95% CI, 2.2%-7.2%]). Children with atopic dermatitis had higher rates of PPTs for cocamidopropyl betaine, propylene glycol, lanolin alcohol and carba mix. Across geographical areas, higher prevalences of several allergens were found in the United States compared to Europe, for example, for methylisothiazolinone. This meta-analysis confirmed that CA is frequent in children across geographical areas; however, differences in the frequency of top allergens depend on regulatory interventions, indicating their value.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Type I Hypersensitivity due to Basic Blue 99 in a Hair Colour Conditioning Agent.","authors":"Takafumi Numata, Kazuki Fujimori, Kana Kato, Tomonobu Ito, Kazutoshi Harada, Yukari Okubo","doi":"10.1111/cod.14755","DOIUrl":"https://doi.org/10.1111/cod.14755","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wolfgang Uter, Klaus Ejner Andersen, Richard Brans, Magnus Bruze, Steffen Schubert, Margarida Gonçalo
{"title":"The 'MOAHLFA(P) Index': An Attempt to Standardise a Widely Used Array of Descriptors of Patch-Tested Patients.","authors":"Wolfgang Uter, Klaus Ejner Andersen, Richard Brans, Magnus Bruze, Steffen Schubert, Margarida Gonçalo","doi":"10.1111/cod.14750","DOIUrl":"https://doi.org/10.1111/cod.14750","url":null,"abstract":"<p><strong>Background: </strong>Since its inception in 1980, the MOHL index (% patients who are male, have occupational, hand, or leg dermatitis, respectively) and its later evolutions until the presently used MOAHLFA(P) index (adding % patients with atopic dermatitis, face dermatitis, age 40+ years and positive reaction(s) to ≥ 1 baseline series allergen) have been intended to convey important demographic and clinical information on the patients patch tested in a certain area and time, aiding the interpretation of the observed spectrum of sensitisation.</p><p><strong>Objectives: </strong>To examine the current usage of the MOAHLFA(P) index and suggest consolidated definitions for its single items.</p><p><strong>Methods: </strong>A title/abstract search in Medline identified publications mentioning the evolving acronyms. A Delphi-like survey among contact dermatitis experts collected agreement with suggested definitions.</p><p><strong>Results: </strong>The search term 'MOAHLFA' was used in 35 publications from a broad geographical origin. More than 80% of the 24 participants of the survey (65% response) agreed on maintaining to use (i) sex for the 'M' criterion, (ii) occupation-related dermatitis irrespective of medicolegal definitions for the 'O', (iii) atopic dermatitis (but not rhinitis or asthma) for the 'A'. The possibility to use more than one site among 'H', 'L' and 'F' and a more detailed description of age distribution were favoured, and the difficult interpretability of the 'P' measure was highlighted.</p><p><strong>Conclusions: </strong>The 'classical' MOAHLFA(P) index may be extended. Some aspects, notably atopic dermatitis, need further standardisation.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}