Contact Dermatitis最新文献

{"title":"Formaldehyde Emissions From 2-Octyl Cyanoacrylate: Quantified Risk for Allergic Contact Dermatitis.","authors":"Daniel S Rouhani, Paul M Villalobos, Steven Zeng, Reza Ghodsi, Kavana M Sanjay, Simrin A Singh, M Mark Mofid","doi":"10.1111/cod.70110","DOIUrl":"10.1111/cod.70110","url":null,"abstract":"<p><strong>Background: </strong>2-octyl-cyanoacrylate-mesh-systems are used as topical wound closure devices in surgery and are increasingly associated with allergic and irritant contact dermatitis. Formaldehyde, a degradation byproduct of cyanoacrylates and a potent sensitiser, is believed to be associated with this reaction, but emission levels have not been quantified.</p><p><strong>Methods: </strong>A bench microchamber study was performed using standardised 4 × 4 cm polyester mesh with applied 2-octyl cyanoacrylate adhesive in a 30 L chamber (25°C, 1 atm, 1 h^-1 air exchange). Formaldehyde off-gassing was captured with DNPH cartridges (NIOSH 2016) and quantified via HPLC-UV over 2 h. Data were upscaled to simulate clinical use and projected to 14 days under constant-flux and flux-halving scenarios.</p><p><strong>Results: </strong>Dermal loads at 14 days reached 8.4 μg/cm², over eight times the EPA 1 μg/cm² benchmark and above the 4.5-7.5 μg/cm² elicitation range reported in formaldehyde-sensitive patients. Under flux-halving conditions, dermal exposure remained at 4.8 μg/cm², nearly five times the EPA benchmark and above the elicitation threshold. Mean 2-h airborne concentrations of 0.020-0.0385 ppm exceeded the NIOSH limit of 0.016 ppm by approximately 1.25-2.41-fold.</p><p><strong>Conclusion: </strong>2-octyl-cyanoacrylate-mesh-systems emit formaldehyde at levels exceeding sensitization and inhalation thresholds, raising concern for dermal and respiratory exposure, particularly in sensitised individuals. Prior sensitisation from adhesives such as nail, eyelash or super glues may heighten risk.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":"635-644"},"PeriodicalIF":4.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13139693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146206609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Contact Allergy to Epoxy Resin and Fragrance Mix I in the General Population: EDEN Fragrance Study Group.","authors":"Magnus Bruze, Peter Elsner, Margarida Goncalo, Luigi Naldi, Marie-Louise A Schuttelaar, Åke Svensson, Simone Cazzaniga, Robert Ofenloch","doi":"10.1111/cod.70128","DOIUrl":"10.1111/cod.70128","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":"706-708"},"PeriodicalIF":4.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147363597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proposed Modification of the European Baseline Series: Textile Dye Mix Without Disperse Orange 3-A Recommendation From the European Baseline Series Working Party on Behalf of the European Society of Contact Dermatitis.","authors":"Marléne Isaksson","doi":"10.1111/cod.70148","DOIUrl":"10.1111/cod.70148","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":"720-721"},"PeriodicalIF":4.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repeated Exposure to Hydroperoxides of Linalool Induces Immunologically Verified Allergic Contact Dermatitis.","authors":"Sofia Botvid, Niels Højsager Bennike, Jeanne Duus Johansen, Alexandra T Seibel, Helen Vaher, Charlotte Menné Bonefeld, Aaron I Moore, Niamh O'Boyle, Lina Hagvall","doi":"10.1111/cod.70119","DOIUrl":"10.1111/cod.70119","url":null,"abstract":"<p><strong>Background: </strong>Fragrance allergens are a leading cause of contact allergy (CA). Linalool, common in cosmetics and household products, forms sensitising hydroperoxides (Lin-OOH) upon air exposure. Lin-OOH is linked to a high prevalence (3.9%-11.7%) of positive patch test results, but often gives rise to doubtful or irritant reactions.</p><p><strong>Objectives: </strong>To reassess patch test concentrations of Lin-OOH, determine elicitation threshold under repeated exposure, and explore associated immunological responses.</p><p><strong>Methods: </strong>Patch testing was followed by a twice daily, 21 days repeated open application test (ROAT) using a Lin-OOH-containing simulated perfume at three different concentrations (blinded to the participants and the investigators). Twelve sensitised individuals with CA to Lin-OOH and 20 healthy controls were included. Skin biopsies from a subset were analysed via RT-qPCR.</p><p><strong>Results: </strong>Lin-OOH 1.0% was the most reliable patch test concentration to confirm CA in our patient cohort. Positive ROAT reactions occurred in 4/12 (33%) patients at 0.163% Lin-OOH (1630 ppm), 2/12 (17%) at 0.054% (538 ppm) and 1/12 (8%) at 0.018% (179 ppm); none in controls. Gene expression analysis showed upregulation of IL1 family members (IL1β and IL1RN), type 2 immune response (IL4 and GATA3) and chemokines (CCL22).</p><p><strong>Conclusions: </strong>Lin-OOH elicited dose-dependent reactions in sensitised individuals during both patch testing and simulated use (ROAT). Molecular profiling of biopsy samples confirmed activation of immune pathways consistent with CA to fragrances following patch testing.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":"652-661"},"PeriodicalIF":4.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13139705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-Life Workup of Chronic Hand Eczema Using a Dedicated Case Report Form: A SIDAPA Multicentre Study.","authors":"Rosella Gallo, Fabrizio Guarneri, Katharina Hansel, Luca Stingeni, Maddalena Napolitano, Cataldo Patruno, Monica Corazza, Alessandro Borghi, Ilaria Trave, Emanuela Martina, Maria Michela Lauriola, Rosanna Rita Satta, Caterina Foti, Paolo Romita, Roberta Giuffrida, Silvia Mariel Ferrucci","doi":"10.1111/cod.70105","DOIUrl":"10.1111/cod.70105","url":null,"abstract":"<p><strong>Background: </strong>Chronic hand eczema (CHE) is a challenging condition with multifactorial pathomechanisms and a wide clinical polymorphism. It is often resistant to treatments.</p><p><strong>Objectives: </strong>To clinically and etiologically investigate CHE patients using a case report form (CRF) developed for this purpose.</p><p><strong>Methods: </strong>A cross-sectional study on adult patients affected by CHE was performed from January 2024 to May 2025 in 10 Italian dermatology clinics. Demographic data, clinical features, disease severity and duration, endogenous/environmental risk factors, patch test results, response to past/current treatments, and burden of disease were recorded in the dedicated CRF and analysed.</p><p><strong>Results: </strong>A total of 207 patients were enrolled in the study (mean age 41.1 ± 15.6 years), 142 (68.6%) females. CHE was moderate-severe in 58.9% of cases, refractory to topical potent corticosteroids in 81.4%. The etiological subtypes were irritant contact dermatitis in 52.7%, allergic contact dermatitis in 24.2%, and atopic dermatitis in 16.9%; clinical subtypes were identified in only 29.0% of patients, the most frequent ones being hyperkeratotic eczema (12.1%) and acute recurrent vesicular eczema (9.7%). The CRF proved to be easy to fill in and useful.</p><p><strong>Conclusions: </strong>An accurate clinical workup can lead to CHE clinical and etiological classification in about 80% of patients and may facilitate tailored treatment strategies.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":"662-676"},"PeriodicalIF":4.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13139691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146199819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Contact Sensitisation Among Patients With Atopic Dermatitis in Thailand: A 20-Year Retrospective Study.","authors":"Silada Kanokrungsee, Rungsima Kiratiwongwan, Nicha Wareesawetsuwan, Sasitorn Yenyuwadee, Pichanee Chaweekulrat, Titinun Kumpangsin, Waranya Boonchai","doi":"10.1111/cod.70135","DOIUrl":"10.1111/cod.70135","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":"689-693"},"PeriodicalIF":4.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13139690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Factors Associated With Current Relevance in Allergic Contact Dermatitis: Development of Predictive Models Based on Data From the Spanish Contact Dermatitis Register (REIDAC).","authors":"David Pesqué, Francisco Javier Ortiz de Frutos, Francisco Navarro-Triviño, Tatiana Sanz-Sánchez, Violeta Zaragoza-Ninet, Susana Córdoba-Guijarro, Javier Miquel-Miquel, Juan Francisco Silvestre-Salvador, Ricardo González-Pérez, Inmaculada Ruiz-González, Pedro Mercader-García, Esther Serra-Baldrich, José Manuel Carrascosa-Carrillo, Fátima Tous-Romero, Mercedes Rodríguez-Serna, María Elena Gatica-Ortega, Carmen Paredes-Suárez, María Antonia Pastor-Nieto, Pablo Chicharro, Marta Andreu, Araceli Sánchez-Gilo, José Juan Pereyra-Rodríguez, Gemma Melé-Ninot, Paloma Sánchez-Pedreño Guillén, Enrique Gómez de la Fuente, Marta Elosua-González, Fernando Gallardo, Ramon M Pujol, Ignacio García-Doval, Leopoldo Borrego, Miguel Ángel Descalzo, Ana M Giménez-Arnau","doi":"10.1111/cod.70089","DOIUrl":"10.1111/cod.70089","url":null,"abstract":"<p><strong>Background: </strong>Current relevance of positive patch-test reactions guides management in allergic contact dermatitis (ACD), yet its clinical predictors and the use of predictive models in clinical practice remain underused.</p><p><strong>Objectives: </strong>To identify demographic and clinical factors associated with current relevance in ACD and to develop overall and allergen-specific predictive models.</p><p><strong>Methods: </strong>A multicentric REIDAC study included data from patch-tested patients with the Spanish baseline series. Exposure history, anatomical sites, atopic status, and occupational data were recorded. Logistic regression (LR) models were trained and internally validated to predict current relevance overall and for top frequent allergens. Model discrimination was assessed with area under the receiver-operating characteristic curve (AUC).</p><p><strong>Results: </strong>Among 17 005 patients, 4077 (24.0%) had at least one currently relevant reaction. The final overall LR model achieved an AUC for the validation sample of 0.679. Allergen-specific AUC parameters (LR) varied among allergens but performed best for nickel (AUC = 0.770). The independent factors associated with current relevance were female gender, specific body sites (hand, neck, head, leg, feet) and two occupations (hairdresser and construction workers). The use of other models (LASSO, gradient boosting) revealed similar results.</p><p><strong>Conclusions: </strong>Prediction modelling may moderately predict current relevance in ACD and several clinical variables are associated with current relevance in ACD.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":"614-623"},"PeriodicalIF":4.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13139698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncommon Source of Chromium Sensitization: Allergic Contact Dermatitis From Potassium Dichromate in Milk Adulteration Testing.","authors":"Arushi Sharma, Asit Kumar Mittal, Manisha Balai","doi":"10.1111/cod.70127","DOIUrl":"10.1111/cod.70127","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":"700-702"},"PeriodicalIF":4.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Contact Allergy to Isothiazolinones in Dermatitis Patients From 2000 to 2025: A Systematic Review and Meta-Analysis.","authors":"Daniel Isufi, Kian Karimian, Mikkel Bak Jensen, Christoffer Kursawe Larsen, Rebekka Søgaard, Jeanne Duus Johansen, Jakob Ferløv Baselius Schwensen","doi":"10.1111/cod.70124","DOIUrl":"10.1111/cod.70124","url":null,"abstract":"<p><p>Isothiazolinones are employed in the preservation of cosmetic, consumer and industrial products, with the objective of preventing deterioration and spoilage. However, the utilization of isothiazolinones is associated with an elevated risk of developing contact allergy (CA). Herein, we assess the epidemiology of CA to isothiazolinones among dermatitis patients from year 2000 onwards. We systematically searched PubMed, Embase, and Web of Science from 1 January 2000 to 19 April 2025 yielding 115 studies comprising 1 514 781 dermatitis patients. The prevalence of CA to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) was 4.58%, methylisothiazolinone (MI) was 5.48%, and benzisothiazolinone (BIT) was 2.09%. The clinical relevance ranged from 60.1% for MCI/MI, 55.6% for MI, and 35.3% for BIT. Asia and North and South America exhibited the highest rates of CA to isothiazolinones, whereas Europe showed lower rates. These findings underscore the efficacy of proactive risk management for post-marketed substances such as MI, underscoring substantial regional variations in usage patterns, which are contingent on the strictness or permissiveness of their incorporation into everyday consumer products. There is an indication of a decline, particularly regarding MI and MCI/MI. However, there has been an increase in the use of substances such as BIT, which necessitates enhanced surveillance measures.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":"577-591"},"PeriodicalIF":4.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13139707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychopathological Burden in Allergic Contact Dermatitis: Results From a Case-Control Study Using the SCL-90-R.","authors":"Francisco José Navarro-Triviño, Álvaro Prados-Carmona, Ricardo Ruiz-Villaverde, María Isabel Peralta-Ramírez","doi":"10.1111/cod.70120","DOIUrl":"10.1111/cod.70120","url":null,"abstract":"<p><strong>Background: </strong>Allergic Contact Dermatitis (ACD) is a chronic inflammatory skin disease that may be accompanied by psychological distress. Previous studies have suggested an association between ACD and various psychopathological symptoms, which can negatively affect patients' well-being.</p><p><strong>Objectives: </strong>To evaluate the psychopathological symptom burden in patients with ACD using the Symptom Checklist-90-Revised (SCL-90-R) and to explore associations with clinical and sociodemographic variables.</p><p><strong>Patients/materials/methods: </strong>This cross-sectional case-control study included 450 participants (225 patients with ACD and 225 controls). Group comparisons and association analyses were performed to examine differences between patients and controls and to explore relationships with clinical and sociodemographic characteristics.</p><p><strong>Results: </strong>Patients with ACD scored significantly higher than controls across all SCL-90-R dimensions. The highest proportions of patients scoring above the 70th percentile were observed for phobic anxiety (64.4%), somatization (42.2%) and anxiety (36.9%). Female sex, lower educational level and single marital status were independently associated with higher psychopathological scores. In addition, disease severity was associated with interpersonal sensitivity and psychoticism, while self-perceived disease severity was associated with somatization and anxiety.</p><p><strong>Conclusions: </strong>Patients with ACD exhibit a significantly higher burden of psychopathological symptoms compared with controls. This finding highlights the relevance of psychological distress as a common feature of ACD and supports the inclusion of mental health considerations in the clinical assessment of these patients.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":"603-613"},"PeriodicalIF":4.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13139692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}