Contact Dermatitis最新文献

Trends in Contact Allergy to Preservatives From 2014 to 2023: Benzisothiazolinone on the Rise. 2014 - 2023年防腐剂接触性过敏趋势：苯并异噻唑啉酮呈上升趋势

IF 4.8 1区医学

Contact Dermatitis Pub Date : 2025-05-30 DOI: 10.1111/cod.14818

Rebekka Søgaard, Christoffer Kursawe Larsen, Jeanne Duus Johansen, Jakob Ferløv Baselius Schwensen

{"title":"Trends in Contact Allergy to Preservatives From 2014 to 2023: Benzisothiazolinone on the Rise.","authors":"Rebekka Søgaard, Christoffer Kursawe Larsen, Jeanne Duus Johansen, Jakob Ferløv Baselius Schwensen","doi":"10.1111/cod.14818","DOIUrl":"https://doi.org/10.1111/cod.14818","url":null,"abstract":"Background: Skin sensitising preservatives are commonly used in consumer and industrial products. The widespread use of preservatives has led to recurrent epidemics of contact allergy.Objectives: To investigate temporal trends of contact allergy to preservatives from 2014 to 2023.Materials and methods: Patients consecutively patch tested with preservatives from the European baseline series and the supplementary baseline series at Gentofte hospital from 2014 to 2023 were included.Results: The study population included 6435 patients. Contact allergy to benzisothiazolinone (BIT) increased significantly from ≤ 0.3% in 2014 to 5.0% in 2023. Painters and machine operators, and assemblers were most often sensitised to BIT, and detergents and paints were the most common exposures to BIT. Contact allergy to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) decreased significantly from 3.3% in 2014 to 2.2% in 2023. Likewise, contact allergy to MI declined significantly from 3.9% in 2014 to 2.5% in 2023. Stable trends were found for the overall prevalence of contact allergy to preservatives from 9.0% in 2014 to 10.2% in 2023.Conclusions: Regulatory restrictions on the use of MI and MCI/MI in cosmetic products have led to a decrease in contact allergy. However, the rise in contact allergy to BIT underscores the need for ongoing monitoring and preventive measures.","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Requirements for Alternative In Vitro and In Silico Skin Models of Irritant and Allergic Contact Dermatitis. 刺激性和过敏性接触性皮炎的体外和硅皮肤模型的替代要求。

IF 4.8 1区医学

Contact Dermatitis Pub Date : 2025-05-30 DOI: 10.1111/cod.14815

Meital Portugal-Cohen, Warangkana Lohcharoenkal, Evelyn Kelemen, Inge Kortekaas Krohn, Shauni De Vriese, Danuta Gutowska-Owsiak, Ivone Jakasa, Dijana Furundžić, Anna Zalewska-Janowska, Sandrine Dubrac

引用次数: 0

Allergic Contact Dermatitis of the Vulva. 外阴过敏性接触性皮炎。

IF 4.8 1区医学

Contact Dermatitis Pub Date : 2025-05-23 DOI: 10.1111/cod.14816

Tirza Blom, Thirza G Peschar, Thomas Rustemeyer, Sylvie M Franken, Norbertus A Ipenburg

{"title":"Allergic Contact Dermatitis of the Vulva.","authors":"Tirza Blom, Thirza G Peschar, Thomas Rustemeyer, Sylvie M Franken, Norbertus A Ipenburg","doi":"10.1111/cod.14816","DOIUrl":"https://doi.org/10.1111/cod.14816","url":null,"abstract":"Background: While previous studies have investigated allergic contact dermatitis (ACD) in patients with chronic vulvar complaints, data on the clinical relevance of patch test results, particularly from spices and herbs series, remain limited.Objectives: To determine the frequency and clinical relevance of contact sensitisation to allergens in the European Baseline Series (EBS) and a spices and herbs series in patients with chronic vulvar complaints.Methods: A retrospective analysis was conducted on all patients with chronic vulvar complaints who underwent patch testing with the EBS and spices and herbs series between January 2015 and January 2024.Results: Among the 67 patients tested, 86.6% exhibited at least one positive reaction, of which 37.9% were clinically relevant. Nearly half of the patients (43.3%) showed reactions to spices and herbs, with 34.5% having clinically relevant reactions. Bell pepper was the most frequent sensitizer throughout all spices. Metals were the most commonly identified allergens (50.8%), but only one case was clinically relevant. Fragrances elicited positive reactions in 37.3% of patients, with a higher clinical relevance (60%). Preservatives also showed a considerable clinical relevance (35%) among the 29.9% of patients who reacted positively. Conversely, reactions to surfactants, rubber additives, wool wax alcohols, and antibiotics were not deemed relevant to vulvar complaints.Conclusions: ACD is prevalent in patients with chronic vulvar complaints, underscoring the critical role of patch testing as a diagnostic tool. Both topically applied cosmetic and medicinal products, as well as systemically ingested substances, such as spices and herbs, may contribute to ACD affecting the vulvar region. To enhance diagnostic accuracy, patch test series should be tailored to the patient's clinical history and specific allergen exposures.","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequent Positive Patch Test Reactions to Glucosides in Children: A Call for Caution? 儿童对糖苷类药物频繁的斑贴试验阳性反应：应引起警惕？

IF 4.8 1区医学

Contact Dermatitis Pub Date : 2025-05-20 DOI: 10.1111/cod.14812

Silada Kanokrungsee, Julie Leysen, Olivier Aerts, Ella Dendooven

{"title":"Frequent Positive Patch Test Reactions to Glucosides in Children: A Call for Caution?","authors":"Silada Kanokrungsee, Julie Leysen, Olivier Aerts, Ella Dendooven","doi":"10.1111/cod.14812","DOIUrl":"https://doi.org/10.1111/cod.14812","url":null,"abstract":"Background: Alkyl glucosides are surfactants commonly found in cosmetics and household products. However, data on glucoside contact allergy in paediatric populations is limited.Objectives: To determine the prevalence, relevance and clinical characteristics of contact allergy to glucosides in children.Methods: A retrospective review of the files of paediatric patients (≤ 16 years) who underwent patch testing for decyl glucoside (DG) and/or lauryl glucoside (LG) at the Antwerp University Hospital (UZA) in the period between January 2018 and December 2024.Results: Among 241 children tested for DG, 148 (61.4%) were also tested for LG. DG reactions were observed in 47 patients (19.5%), with 27 (11.2%) considered positive. LG reactions occurred in 17/148 (13%), but only 4 (2.7%) were positive, all with concomitant DG reactions. Most positive DG reactions were weak (+) (25/27), whereas only 2 were strong (++). The median age was 7 years (range: 2-15), with 51.9% female. Culprit sources mostly included cosmetics.Conclusions: Patch test reactions to glucosides readily occur in children, and the positivity rate is surprisingly high. Besides many irritant and doubtful reactions, false-positive (+) reactions likely occur, particularly in young atopic children. Careful interpretation of positive results and complementary work-up may thus be necessary.","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

p-Phenylenediamine-Free Hair Dye?-Misleading Labelling Causing Allergic Contact Dermatitis. 无对苯二胺染发剂？-误导标签导致过敏性接触性皮炎。

IF 4.8 1区医学

Contact Dermatitis Pub Date : 2025-05-19 DOI: 10.1111/cod.14813

Wimolsiri Iamsumang, Kevin Bertilsson, Jakob Dahlin, Pichamon Promsena, Ploychompoo Srisuwanwattana, Pranee Svetvilas, Penpun Wattanakrai, Annarita Antelmi, Cecilia Svedman, Thanisorn Sukakul

引用次数: 0

Burden of Pain and Use of Analgesics in Patients With Chronic Hand Eczema-Findings From the Danish Skin Cohort. 慢性手湿疹患者的疼痛负担和镇痛药的使用——来自丹麦皮肤队列的发现。

IF 4.8 1区医学

Contact Dermatitis Pub Date : 2025-05-16 DOI: 10.1111/cod.14814

Jeanette Halskou Haugaard, Johan Sieborg, Emma Guttman-Yassky, David Thein, Jonathan I Silverberg, Lars Erik Kristensen, Jacob P Thyssen, Alexander Egeberg

{"title":"Burden of Pain and Use of Analgesics in Patients With Chronic Hand Eczema-Findings From the Danish Skin Cohort.","authors":"Jeanette Halskou Haugaard, Johan Sieborg, Emma Guttman-Yassky, David Thein, Jonathan I Silverberg, Lars Erik Kristensen, Jacob P Thyssen, Alexander Egeberg","doi":"10.1111/cod.14814","DOIUrl":"https://doi.org/10.1111/cod.14814","url":null,"abstract":"Background: Skin pain is a common symptom in patients with chronic hand eczema (CHE); however, its association with increased analgesic use has not been thoroughly investigated.Objectives: To examine analgesic use (paracetamol, nonsteroidal anti-inflammatory drugs [NSAIDs], opioids and gabapentin/pregabalin) among patients with CHE compared to a control group.Methods: Data were obtained from the Danish Skin Cohort and the Danish national registries. Patients with dermatologist-verified CHE were systematically interviewed, including questions on skin and joint pain experienced within the past 7 days.Results: The study included 1032 patients with CHE and 11 166 controls. We observed an overall higher utilisation of analgesics among patients with CHE compared to the control group. The highest utilisation of analgesics was observed for paracetamol (35.3% vs. 25.7%) followed by NSAIDs (21.5% vs. 15.3%). When stratified by disease severity, patients with moderate-to-very-severe CHE consistently used more analgesics compared to those with mild CHE.Conclusion: This study highlights the significant burden of pain in patients with CHE, as evidenced by their higher utilisation of analgesics compared to the general population in Denmark.","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Reported Severity of Hand Eczema: Important Outcome but How Can We Measure It? 自我报告的手部湿疹严重程度：重要的结果，但我们如何衡量它？

IF 4.8 1区医学

Contact Dermatitis Pub Date : 2025-05-16 DOI: 10.1111/cod.14811

Annika Wilke, Marc Rocholl, Christoph Skudlik, Kathrin Nordheider

引用次数: 0

Thresholds for Contact Allergy to a Rubber Accelerator: TETD-Determined by Serial Dilution Patch Testing and a Simulated Glove-Use Model. 橡胶促进剂接触过敏的阈值：tetd -由系列稀释斑贴试验和模拟手套使用模型确定。

IF 4.8 1区医学

Contact Dermatitis Pub Date : 2025-05-16 DOI: 10.1111/cod.14817

Christoffer Kursawe Larsen, Jeanne D Johansen, Claus Zachariae, Cecilia Svedman, Ola Bergendorff, Charlotte G Mortz, Jakob F B Schwensen

{"title":"Thresholds for Contact Allergy to a Rubber Accelerator: TETD-Determined by Serial Dilution Patch Testing and a Simulated Glove-Use Model.","authors":"Christoffer Kursawe Larsen, Jeanne D Johansen, Claus Zachariae, Cecilia Svedman, Ola Bergendorff, Charlotte G Mortz, Jakob F B Schwensen","doi":"10.1111/cod.14817","DOIUrl":"https://doi.org/10.1111/cod.14817","url":null,"abstract":"Background: Rubber accelerators found in rubber gloves may cause contact allergy and thus allergic contact dermatitis.Objectives: To investigate which doses of tetraethylthiuram disulfide (TETD) elicit allergic contact dermatitis by patch testing and in a repeated occluded application test simulating glove use.Patients and methods: A multicentre study was conducted. Eight patients with contact allergy to TETD and eight controls comprised the study group. Doses of TETD 1% (400 μg/cm2), 0.33% (130 μg/cm2), 0.11% (44 μg/cm2), 0.037% (15 μg/cm2), 0.012% (4.9 μg/cm2), 0.0041% (1.6 μg/cm2) and pure vehicle (petrolatum) were used for the patch test. Doses of TETD 1% (39 μg/cm2), 0.33% (13 μg/cm2), 0.11% (4.3 μg/cm2) and pure vehicle (99:1 ethanol: water) were used for the repeated occluded application test.Results: Three patients (3/8) reacted to the lowest TETD dose of 0.0041% (1.6 μg/cm2) in the patch test. All patients reacted to all doses of TETD in the repeated occluded application test, none to the vehicle. The patch test dose of TETD that elicited allergic contact dermatitis in 10% of the patients (ED10) was estimated to be 0.75 μg/cm2.Conclusion: A content of 0.75 μg/cm2 TETD in rubber gloves may elicit allergic contact dermatitis. We suggest that future studies investigating contact allergy to rubber accelerators should base their methodology on the repeated occluded application test design presented in this study.Trial registration: ClinicalTrial.gov identifier: NCT06042309.","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Alcohol-Based Virucidal Hand Sanitizers on Skin Barrier Function-A Randomised Experimental Study. 含酒精的抗病毒洗手液对皮肤屏障功能的影响——一项随机实验研究。

IF 4.8 1区医学

Contact Dermatitis Pub Date : 2025-05-12 DOI: 10.1111/cod.14808

Michal Gina, Robert Ofenloch, Ingeborg Schwebke, Nils-Olaf Hübner, Thomas Brüning, Manigé Fartasch

{"title":"The Effect of Alcohol-Based Virucidal Hand Sanitizers on Skin Barrier Function-A Randomised Experimental Study.","authors":"Michal Gina, Robert Ofenloch, Ingeborg Schwebke, Nils-Olaf Hübner, Thomas Brüning, Manigé Fartasch","doi":"10.1111/cod.14808","DOIUrl":"https://doi.org/10.1111/cod.14808","url":null,"abstract":"Background: Applying alcohol-based hand rubs (ABHRs) is a proven means of combating hand-borne microorganisms. In addition to their bactericidal activity, some rubs also have virucidal properties (ABVHRs). Frequent use of ABHRs can result in skin irritation.Objectives: This study investigates the impact of four commercially available ABVHRs on skin function (ABVHR A-D). ABVHR-A and ABVHR-B contained ethanol in higher concentrations, whereas ABVHR-C and ABVHR-D comprised ethanol and 1-propanol at lower concentrations combined with phosphoric acid (PA).Methods: Using occlusion-modified tandem irritation tests and standard bioengineering methods, we assessed the effects of these ABVHRs and controls (ethanol, isopropanol, PA, water) on 48 healthy Caucasian volunteers' skin.Results: In general, alcohols and ABVHRs were well tolerated. However, the results revealed significant changes in transepidermal water loss (TEWL), corneometry, and colorimetry between baseline and day 3 for all ABVHRs and controls, particularly for ABVHR-D (TEWL change 6.43 (SD 1.40) to 8.76 (SD 3.87)). Although the differences between the ABVHRs were not statistically significant, ABVHR-A and ABVHR-D significantly increased TEWL compared to water. Most ABVHRs demonstrated a better skin irritation profile than pure ethanol (80%) and isopropanol (70%). PA slightly reduced corneometry values.Conclusions: This study suggests that the irritative potential of ABVHRs varies, likely due to differences in alcohol type (1-propanol in particular) and concentration. At the tested concentration, PA appears to be well tolerated and may enhance virucidal activity without significantly increasing skin irritation.","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occupational Protein Contact Dermatitis and Allergic Contact Dermatitis From Different Vegetables in a Market Gardener. 某菜农职业性蛋白质接触性皮炎和过敏性接触性皮炎。

IF 4.8 1区医学

Contact Dermatitis Pub Date : 2025-05-07 DOI: 10.1111/cod.14801

Alexis Lefebvre, Clémence Gautier, Mathieu Lagassy, Florence Tetart

引用次数: 0