Contact Dermatitis最新文献

{"title":"Allergic Contact Cheilitis due to Vitamin E Derivatives in Lipstick.","authors":"Angèle Soria, Emmanuelle Amsler","doi":"10.1111/cod.70245","DOIUrl":"https://doi.org/10.1111/cod.70245","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stratum Corneum Biomarkers for Differentiating Irritant and Allergic Contact Dermatitis.","authors":"F L de Boer, S Kezic, Ivone Jakasa, Nique M Grob, Nariman K A Metwally, Jϋrgen Claesen, Karen Ghauharali-van der Vlugt, Femke S Beers-Stet, Wouter Ouwerkerk, Thomas Rustemeyer, Henk F van der Molen","doi":"10.1111/cod.70268","DOIUrl":"https://doi.org/10.1111/cod.70268","url":null,"abstract":"<p><strong>Background/objectives: </strong>Occupational hand dermatitis (HD) comprises irritant and allergic contact dermatitis (ICD and ACD), which share clinical features, often overlap, and may coexist with atopic dermatitis (AD), complicating diagnosis. The objective of this study is to explore whether stratum corneum (SC) biomarkers discriminate ICD from ACD.</p><p><strong>Patients: </strong>We recruited 126 patients from the Occupational Dermato-allergology Clinics of the Amsterdam UMC.</p><p><strong>Methods: </strong>SC samples were collected from lesional HD skin and patch test reactions to nickel, chromium, methylisothiazolinone, sodium lauryl sulfate (irritant), and control sites. Thirty-three biomarkers were analyzed. Random forest and penalized regression models were trained on the patch test dataset and validated in HD; an additional model was trained and validated in HD. Exploratory analyses evaluated discrimination among individual allergens and between AD, ICD and ACD.</p><p><strong>Results: </strong>The patch test model showed good discrimination between ICD and ACD (mean AUC 0.85, 95% CI 0.82-0.87), driven primarily by skin barrier-related biomarkers. In HD, performance declined (mean AUC 0.51, 95% CI 0.26-0.76); sensitivity for ACD was 88%. Model trained and validated within HD achieved mean AUC of 0.60 (95% CI 0.57-0.64). Discrimination between individual allergens yielded mean AUC of 0.75 (95% CI 0.72-0.77).</p><p><strong>Conclusion: </strong>SC biomarkers discriminated ICD from ACD good in acute patch test, but showed limited discrimination in HD, reflecting differences between acute and chronic inflammation.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Localized Exanthematous Pustulosis-Like Dermatitis Induced by Nigella sativa Seed Oil.","authors":"Estelle Burle, Françoise Giordano","doi":"10.1111/cod.70276","DOIUrl":"https://doi.org/10.1111/cod.70276","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic Contact Dermatitis Caused by Miconazole With Investigation of Cutaneous and Systemic Cross-Reactivity.","authors":"Florence Libon, Juliette Caron, Arjen Nikkels","doi":"10.1111/cod.70273","DOIUrl":"https://doi.org/10.1111/cod.70273","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and Outcomes of Patients With Negative Patch Test Results and Systematic Literature Review.","authors":"Conan H Lee, Lauren W Hastings, Nicholas T Le, Olivia Keller, Christian Bryan De Guzman, Sydney Sullivan, Jasmin K Johl, Bruce Abbott, Peggy A Wu","doi":"10.1111/cod.70270","DOIUrl":"https://doi.org/10.1111/cod.70270","url":null,"abstract":"<p><strong>Background: </strong>Patients with negative patch test (NPT) results do not receive allergy avoidance counselling, and their experiences are important to understand.</p><p><strong>Objective: </strong>To describe the clinical presentation and outcomes associated with NPT results.</p><p><strong>Methods: </strong>Cross-sectional study analysing data from an IRB-approved REDCap registry. A systematic review was performed searching Ovid MEDLINE, Embase and Cochrane Library Databases.</p><p><strong>Results: </strong>161/1001 patients (769 female, 230 male) 16.1%, had NPTs. Mean age was 52.2 years (standard deviation 20.6). Median age, female predominance, race/ethnicity, duration of rash and number of patches placed was not significantly different between negative and positive patch test results. More NPT patients had leg involvement (p = 0.04) and prior biopsy (p = 0.002). 29.9% had a non-dermatitis diagnosis. The investigator and patient assessments were significantly improved post-patch testing. In a systematic review of 34 studies, 77261 patients, the NPT rate ranged between 16.7% and 83.1% and number of patches placed from 20 to 102. The most common areas of dermatitis were the hands.</p><p><strong>Conclusions: </strong>In our cohort and systematic review, a minority of patients have NPTs, with no major demographic differences. NPT patients have had prior biopsies, suggesting an unusual presentation. They were also commonly diagnosed with other forms of dermatitis, although 30% had a non-dermatitis diagnosis.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sunscreen Intolerance in Frontal Fibrosing Alopecia Due to Clinically Relevant Benzyl Salicylate Sensitization Despite Negative Baseline and Sunscreen Patch Test Series.","authors":"Álvaro González-González, José Jaime Goday Buján, Jesús Del Pozo Losada","doi":"10.1111/cod.70271","DOIUrl":"https://doi.org/10.1111/cod.70271","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isothiazolinone Sensitization During School-Based Vocational Training: Occupational Hand Dermatitis in a Teenage Motorcycle Mechanic Trainee.","authors":"Paolo Antonio Danza, Giulia Ciccarese, Françoise Giordano, Giorgia Sbarra, Francesca Ambrogio, Thérèse Nocera, William Andrew Rosato, Giuseppe Demichele, Paolo Romita, Domenico Bonamonte, Caterina Foti","doi":"10.1111/cod.70272","DOIUrl":"https://doi.org/10.1111/cod.70272","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generalized Nummular Eczema Linked to a Knee Prosthesis.","authors":"Ines Chebbi, Juliette Caron, Arjen Nikkels, William Kurth, Florence Libon","doi":"10.1111/cod.70266","DOIUrl":"https://doi.org/10.1111/cod.70266","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of 2-Cyanoethyl Dimethyldithiocarbamate in Another Rubber Glove Marketed as Accelerator-Free.","authors":"Andreas Hansen, Christoph Skudlik, Rachid Ngazi, Silke Werner, Cecilia Svedman, Linda Ljungberg Silic, Ola Bergendorff, Richard Brans","doi":"10.1111/cod.70269","DOIUrl":"https://doi.org/10.1111/cod.70269","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium Metabisulphite Contact Allergy: Think Wine and Food!","authors":"Thomas R. Brasher,&nbsp;Amanda Palmer,&nbsp;Rosemary L. Nixon","doi":"10.1111/cod.70224","DOIUrl":"10.1111/cod.70224","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Sodium metabisulphite (SMBS) is a known contact hapten in beverages, foodstuffs, hair dyes, topical and systemic medications, and cosmetics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To investigate SMBS contact allergy in our tertiary referral patch testing clinics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective audit was performed of 1367 patients patch tested to 1.0% SMBS in petrolatum between 1/1/2014 and 31/12/2023, and added to the Australian Baseline Series in 2020. Relevance was assessed by consultant dermatologists.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>87/1367 (6.4%) patients patch tested to SMBS had a positive reaction; 24/87 (27.6%) of these reactions were relevant. No cases were occupational. Eight (33.3%) cases presented with oral lichen planus (OLP) whilst four (16.7%) presented with allergic contact cheilitis (ACC). Overall, 19 (79.2%) patients had facial, oral or lip-related involvement. The most common exposure sources were alcoholic beverages (12 patients, 50%), mostly wine, and foodstuffs (10 patients, 41.7%), mostly dried fruits. Eight patients had more than one source of exposure. However, patients often reacted to multiple haptens, so other factors may have contributed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>SMBS contact allergy is not uncommon, but relevance can be difficult to ascertain. OLP, ACC, and facial rashes predominated. Wine and foodstuffs were the most important sources of exposure. SMBS should be included in baseline patch series.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"95 5","pages":"461-474"},"PeriodicalIF":4.1,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148561126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}