Evaluation of Patients With Positive Patch Test Reactions to Rubber Additives: A Retrospective Study From Turkey Between 1996 and 2023.

IF 4.8 1区医学 Q2 ALLERGY

Contact Dermatitis Pub Date : 2025-07-12 DOI:10.1111/cod.70000

İbrahim Halil Aydoğdu, Esen Özkaya

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引用次数: 0

Abstract

Background: Rubber additives are common causes of allergic contact dermatitis (ACD) worldwide, yet data from Turkey remain limited.

Objectives: To evaluate the prevalence of rubber additive sensitisation and its clinical/occupational relevance in a tertiary referral centre.

Methods: A retrospective study on 2687 consecutively patch-tested patients with rubber additives at our allergy unit between 1996 and 2023.

Results: Rubber sensitisation was found in 10.6%, with a slight increase after 2010. Male predominance was noted (female: male = 1:2.3). Thiurams and carbamates were the most frequent sensitizers. ACD was diagnosed in 7.9%, primarily caused by gloves (85.5%). Hands were most commonly affected (94.4%). Logistic regression analysis showed that thiuram and carbamate sensitisation was significantly associated with hand eczema, while benzothiazole derivatives were linked to foot eczema. Airborne ACD occurred in 4.2%, mainly in healthcare workers. Hand eczema with and without wrist extension was observed with similar frequency. Occupational ACD accounted for 79.3% of cases, especially among construction (56.8%) and healthcare workers (14.8%), with a relative increase in the latter group after 2015.

Conclusions: The high prevalence of sensitisation from rubber gloves is concerning. Legal measures are urgently needed, including safer additives and clearer glove labelling. Patch testing remains essential, even without the classic glove-pattern distribution.

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对橡胶添加剂贴片试验阳性反应患者的评价：1996年至2023年土耳其回顾性研究

背景：橡胶添加剂是世界范围内过敏性接触性皮炎（ACD）的常见原因，但来自土耳其的数据仍然有限。目的：评估橡胶添加剂致敏的流行程度及其在三级转诊中心的临床/职业相关性。方法：回顾性研究1996年至2023年在我院过敏科连续进行橡胶添加剂贴片试验的2687例患者。结果：橡胶致敏率为10.6%，2010年后略有上升。男性占优势（女性：男性= 1:3 .3）。硫脲类和氨基甲酸酯类是最常见的致敏剂。诊断为ACD的占7.9%，主要由手套引起（85.5%）。手最常见（94.4%）。Logistic回归分析显示，硫脲和氨基甲酸酯致敏与手部湿疹显著相关，而苯并噻唑衍生物与足部湿疹相关。空气传播ACD发生率为4.2%，主要发生在卫生保健工作者中。有或没有腕关节伸展的手湿疹发生率相似。职业ACD占病例总数的79.3%，尤其是建筑业（56.8%）和卫生保健工作者（14.8%），后者在2015年后相对增加。结论：橡胶手套致敏率高，值得关注。迫切需要采取法律措施，包括更安全的添加剂和更清晰的手套标签。斑贴测试仍然是必要的，即使没有经典的手套模式分布。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Contact Dermatitis 医学-过敏

CiteScore

4.60

自引率

30.90%

发文量

227

审稿时长

4-8 weeks

期刊介绍： Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".