Contact Dermatitis最新文献_第2页

Patch testing in non-immediate hypersensitivity to cotrimoxazole: Is it useful? 对复方新诺明非即刻过敏的斑贴试验：有用吗？

IF 4.8 1区医学

Contact Dermatitis Pub Date : 2024-09-04 DOI: 10.1111/cod.14692

João Nuno Soares, João Pedro Teixeira, Ana Carolina Figueiredo, André Castro Pinho, Margarida Gonçalo

{"title":"Patch testing in non-immediate hypersensitivity to cotrimoxazole: Is it useful?","authors":"João Nuno Soares, João Pedro Teixeira, Ana Carolina Figueiredo, André Castro Pinho, Margarida Gonçalo","doi":"10.1111/cod.14692","DOIUrl":"https://doi.org/10.1111/cod.14692","url":null,"abstract":"Background: Existing literature has questioned the sensitivity of patch testing (PT) with cotrimoxazole (CTX) in the study of drug hypersensitivity.Objectives: Assess the sensitivity of PT with CTX in non-immediate cutaneous adverse drug reactions (CADR).Patients/materials/methods: Retrospective analysis (2000-2022) of PT with an antibiotic series including CTX 10% pet (Chemotechnique Diagnostics©) performed according to ESCD guidelines in patients with suspected non-immediate CADR reactions to CTX. Some patients were additionally tested with in-house preparations of CTX from Bactrim DS® tablets at 10% in pet or water and trimethoprim 10% pet (Laboratórios Edol©).Results: Sixty-four patients (48F/16M; mean age 47 ± 18) were included, mostly with maculopapular exanthema (51, 80%). Notably, CTX was sole suspect in 24 patients. There was no positive reaction to CTX at 10% from Chemotechnique or Bactrim DS® tablets prepared at 10% pet for patch testing. One patient reacted exclusively to trimethoprim with 1+ reaction. Two patients had a faint reaction (1+) only with the powder of Bactrim DS® tablets in water at D2, but as the reactions faded completely in 24 or 48 h, they were interpreted as irritant non-specific reactions.Conclusion: These findings suggest that patch testing may lack sufficient sensitivity to diagnose CTX-induced non-immediate CADR. Therefore, clinicians should be cautious interpreting CTX patch test results.","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}