Potential Allergens in Medical Adhesives in Tapes, Wound Dressings, and Ostomy Care: A Scoping Review.

IF 4.6 1区医学 Q2 ALLERGY

Contact Dermatitis Pub Date : 2025-08-26 DOI:10.1111/cod.70016

An Goossens, Olivier Aerts, Ella Dendooven

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引用次数: 0

Abstract

Background: Medical adhesives are increasingly reported, although still underestimated as causes of allergic contact dermatitis, for which identification of the sensitising culprits is often impossible, mainly because of non-declaration of components on medical device packaging and lack of cooperation from manufacturers.

Objectives: To report on the allergens identified in medical adhesives in tapes, wound dressings, and ostomy care.

Methods: The relevant literature (1980-2024) on sensitization sources and allergens was analysed and the results reported.

Conclusion: The main reported contact allergens present as tackifiers in the production of medical adhesive tapes and wound dressings are colophonium and derivatives, (meth)acrylates and isocyanates. 2-HEMA is a screening agent for contact allergy to acrylics, though other derivatives are important as well. Unexpectedly, d-limonene and other fragrance components were identified in so-called 'hypoallergenic', 'non-latex', or 'non-colophonium' containing materials, even in some types of colophonium itself. In ostomy adhesive pastes, besides colophonium and (meth)acrylates, various PMV/MA copolymer esters with different alkyl chain lengths (Gantrez-ES derivatives) are frequent sensitizers.

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医用胶粘剂在胶带、伤口敷料和造口护理中的潜在过敏原：范围综述。

背景：医用胶粘剂作为过敏性接触性皮炎的原因被越来越多地报道，尽管仍然被低估，而确定致敏的罪魁祸首往往是不可能的，主要是因为医疗器械包装上没有申报成分以及缺乏制造商的合作。目的：报告医用胶粘剂在胶带、伤口敷料和造口护理中的过敏原。方法：对1980 ~ 2024年有关致敏源和致敏原的相关文献进行分析并报道结果。结论：在医用胶带和创面敷料的生产中，作为粘接剂的接触性过敏原主要是树脂及其衍生物、（甲基）丙烯酸酯和异氰酸酯。2-HEMA是一种对丙烯酸接触性过敏的筛选剂，尽管其他衍生物也很重要。出乎意料的是，d-柠檬烯和其他香味成分被发现存在于所谓的“低过敏性”、“非乳胶”或“不含树脂”的材料中，甚至存在于某些类型的树脂中。在造口粘接剂中，除树脂和（甲基）丙烯酸酯外，具有不同烷基链长的各种PMV/MA共聚物酯（Gantrez-ES衍生物）是常见的增敏剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Contact Dermatitis 医学-过敏

CiteScore

4.60

自引率

30.90%

发文量

227

审稿时长

4-8 weeks

期刊介绍： Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".