慢性手湿疹患者治疗意愿及皮肤清除率的重要性。

IF 4.6 1区医学 Q2 ALLERGY

Contact Dermatitis Pub Date : 2025-08-30 DOI:10.1111/cod.70013

Maria O Christensen, Lea K Nymand, Caroline Meyer Olesen, Silvia Mariel Ferrucci, Christoph Schlapbach, Swen Malte John, Sonja Molin, Claus Zachariae, Simon F Thomsen, Jacob P Thyssen, Alexander Egeberg

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引用次数: 0

摘要

背景：慢性手湿疹（CHE）对生活质量有显著的负面影响，并造成较高的疾病负担。目的：探讨皮肤清除率和每日时间权衡（dTTO）在成人CHE患者中的重要性。方法：向来自丹麦皮肤队列的CHE患者发送有关人口统计学，生活方式因素，CHE特征，获得皮肤清除的重要性和dTTO的数字调查。结果：在372例当前CHE患者中，分别有58.1%、26.3%、11.0%和4.6%报告为轻度、中度、重度和极重度CHE。当被问及获得50%、75%、90%和100%皮肤清除率的重要性时，患者报告的中位数分别为9（四分位数范围：[5-10]、9[7-10]、10[8-10]和10[9-10]）（数值评分从0[最低]到10[最高]）。皮肤清除的重要性随着CHE严重程度的增加而增加（每天1小时治疗CHE）。结论：皮肤清除率在CHE患者中很重要，疾病更严重的患者愿意每天分配大量时间来治疗他们的CHE。

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Treatment Willingness and Importance of Skin Clearance for Patients With Chronic Hand Eczema.

Background: Chronic hand eczema (CHE) has a significant negative impact on quality of life and a high disease burden.

Objective: To investigate the importance of skin clearance and daily time trade off (dTTO) in adult patients with CHE.

Methods: Patients with CHE from the Danish Skin Cohort were sent a digital survey regarding demographics, lifestyle factors, CHE characteristics, importance of obtaining skin clearance, and dTTO.

Results: Of 372 patients with current CHE, 58.1%, 26.3%, 11.0%, and 4.6% reported having mild, moderate, severe, and very severe CHE, respectively. Patients reported a median of 9 (interquartile range: [5-10], 9 [7-10], 10 [8-10] and 10 [9-10]) when asked about the importance of obtaining 50%, 75%, 90%, and 100% skin clearance, respectively (numerical rating scale from 0 [lowest] to 10 [highest]). Importance of skin clearance increased with increasing CHE severity (p < 0.001). One in three patients (41.2%) with either severe or very severe CHE was willing to allocate > 1 h a day to treat their CHE.

Conclusions: Skin clearance was important among CHE patients, and patients with more severe disease were willing to allocate a substantial amount of time every day to treat their CHE.

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来源期刊

Contact Dermatitis 医学-过敏

CiteScore

4.60

自引率

30.90%

发文量

227

审稿时长

4-8 weeks

期刊介绍： Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".