Contact Dermatitis最新文献

{"title":"Dental Acrylate-Induced Systemic Contact Dermatitis Misattributed to Local Anaesthetic Hypersensitivity: A Case Report.","authors":"Meida Baublytė, Linas Griguola","doi":"10.1111/cod.70263","DOIUrl":"https://doi.org/10.1111/cod.70263","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexpected Positive Patch Test Reactions to Disperse Blue 106 and 124 in Patients Sensitized to Sulphites, Likely due to Cross-Reactivity.","authors":"Ella Dendooven, Julie van Reusel, Silada Kanokrungsee, An Goossens, Olivier Aerts","doi":"10.1111/cod.70262","DOIUrl":"https://doi.org/10.1111/cod.70262","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patch Test Relevance and Systemic Exposure Pathways in Eczema Patterns Suspected of Systemic Contact Dermatitis.","authors":"Venus Garg, Anuradha Bishnoi, Dipankar De, Hitaishi Mehta, Sanjeev Handa","doi":"10.1111/cod.70258","DOIUrl":"https://doi.org/10.1111/cod.70258","url":null,"abstract":"<p><strong>Background: </strong>Systemic contact dermatitis (SCD) occurs when sensitised individuals react to an allergen delivered systemically. Indian data that relate clinical patterns, patch-test relevance and systemic exposures are limited.</p><p><strong>Objectives: </strong>(i) Characterise the clinico-demographic profile of four eczema patterns historically linked to SCD-non-specific eczema, pompholyx, recalcitrant hand eczema and symmetrical drug-related intertriginous-flexural exanthema (SDRIFE), and (ii) map probable systemic exposure pathways for the six allergens selected a priori based on their relevance in Indian patch-test populations and their recognised or plausible systemic exposure pathways (para-phenylenediamine, nickel, parthenium, potassium dichromate, cobalt and Balsam of Peru).</p><p><strong>Methods: </strong>We performed a prospective observational study at a tertiary care centre in North India from July 2023 to July 2024. Consecutive patients ≥ 12 years with the target eczema patterns underwent detailed exposure history, Indian Standard Series patch testing and COADEX grading. Diagnosis of SCD required a relevant positive patch test, documented systemic exposure and temporal flare correlation. Oral provocation was not performed. Descriptive statistics were performed, with exploratory categorical comparisons using chi-square or Fisher's exact tests, as appropriate.</p><p><strong>Results: </strong>One hundred patients (mean ± SD age 37.7 ± 14.7 years; 59% female) were enrolled. Clinical distribution was non-specific eczema 38%, pompholyx 32%, hand eczema 29% and SDRIFE-like eruption 1%. Patch tests were positive in 40%, and leading sensitisers were para-phenylenediamine 13%, nickel 9%, parthenium 9% and potassium dichromate 8%. Two women (2%; 95% CI 0.24%-7.04%) fulfilled the study's prespecified clinical criteria for SCD: one nickel-associated case classified as clinically definite and one garlic-associated case classified as probable. No SCD was diagnosed in pompholyx or hand eczema subgroups.</p><p><strong>Conclusions: </strong>Although clinically relevant contact sensitisation is frequently observed, only two of 100 patients fulfilled the study's clinical criteria for SCD. These findings support targeted patch testing and structured exposure assessment in specific eczema patterns associated with SCD. Larger prospective multicentre studies are needed to refine criteria and capture the true burden of disease.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational Exposure to Nickel and Cobalt From Hairdressing Tools: A Cross-Sectional Study in 58 Danish Salons.","authors":"Kian Karimian, Daniel Isufi, Ulrik Ahrensbøll-Friis, Jakob Ferløv Baselius Schwensen, Jeanne Duus Johansen, Mikkel Bak Jensen","doi":"10.1111/cod.70261","DOIUrl":"https://doi.org/10.1111/cod.70261","url":null,"abstract":"<p><strong>Background: </strong>Hairdressers frequently perform wet work, which weakens the skin barrier. Repeated skin contact with metallic tools introduces an occupational allergen exposure. However, data on nickel and cobalt release from commonly handled cutting tools remain limited.</p><p><strong>Objectives: </strong>To estimate nickel and cobalt spot-test positivity in hairdressing tools used in Danish hair salons.</p><p><strong>Materials and methods: </strong>In this cross-sectional field study, 58 voluntarily participating Danish salons were visited from 1 March to 30 June 2026. Scissors, hair clippers and razors were each tested once for nickel with dimethylglyoxime and for cobalt with nitroso-R salt colorimetric spot tests.</p><p><strong>Results: </strong>Among 266 tools (167 scissors, 95 hair clippers and 4 razors), 37 (13.9%) were positive to nickel and 18 (6.8%) to cobalt. Nickel positivity was 15.6% in scissors and 10.5% in hair clippers; cobalt positivity was 6.6% and 6.3%, respectively. At least one positive tool occurred in 22/58 (37.9%) salons for nickel and 12/58 (20.7%) for cobalt.</p><p><strong>Conclusions: </strong>Nickel and cobalt release from commonly used hairdressing tools is a prevalent occupational hazard. These findings underscore the necessity of proactive preventive strategies, such as careful material selection and stricter regulatory oversight.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Frequency of Sensitisation to Decyl and Lauryl Glucoside in Routine Patch Testing in the Netherland.","authors":"Norbertus A Ipenburg, Anton C de Groot, Thomas Rustemeyer","doi":"10.1111/cod.70260","DOIUrl":"https://doi.org/10.1111/cod.70260","url":null,"abstract":"<p><strong>Background: </strong>Contact allergy to the alkyl glucosides decyl and lauryl glucoside is increasingly recognized.</p><p><strong>Objectives: </strong>To determine the frequencies of sensitization to decyl glucoside and lauryl glucoside, to assess changes over the study period, to characterize their co-reactivity pattern, to evaluate the clinical relevance of positive reactions and to investigate whether patients with an atopic history had an increased likelihood of sensitization.</p><p><strong>Materials and methods: </strong>Retrospective study of routine testing with decyl glucoside 5% pet. and lauryl glucoside 3% pet. in a cohort of 4343 patients patch tested between 1 November 2019 and 5 January 2026.</p><p><strong>Results: </strong>Positivity rates were 3.5% for decyl and 3.1% for lauryl glucoside; 5.2% of the patients reacted to at least one glucoside. Doubtful reactions (?+) were common (decyl glucoside 2.5%; lauryl glucoside 3.1%). 1.9% of the total cohort had reactions considered certainly or probably clinically relevant. Co-reactivity between decyl and lauryl glucoside occurred in 40%-47% of positive patients, and atopic history was associated with modestly increased odds of positivity.</p><p><strong>Conclusions: </strong>Contact allergy to alkyl glucosides was frequent in our patch test population. A substantial proportion of doubtful reactions and the virtual absence of strongly positive reactions suggest that the glucoside patch test materials used have irritant properties.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gold and Nickel Release From Jeweller-Purchased 10K and 14K Gold Earrings in Cysteine-Modified Artificial Sweat.","authors":"Mikkel Bak Jensen, Saman Nikpour, René D Pütz, Bruce Guan, Yolanda S Hedberg, Jeanne Duus Johansen","doi":"10.1111/cod.70257","DOIUrl":"https://doi.org/10.1111/cod.70257","url":null,"abstract":"<p><strong>Background: </strong>Gold contact allergy is common, but its clinical relevance is often uncertain. A previous study of low-cost gold-plated earrings found frequent nickel release and detectable gold release under cysteine-modified artificial sweat.</p><p><strong>Objectives: </strong>To assess surface composition and release of gold, nickel and copper from jeweller-purchased earrings marketed as 10K or 14K gold.</p><p><strong>Methods: </strong>Five pairs of earrings were examined by scanning electron microscopy (SEM) with energy-dispersive spectroscopy (EDS). Release testing used cysteine-modified artificial sweat at pH 8.0 ± 0.2 and 30°C for 168 h. Metals were quantified by inductively coupled plasma mass spectrometry (ICP-MS).</p><p><strong>Results: </strong>Surfaces consisted mainly of gold, copper, silver and zinc. EDS-detected gold ranged from 40 to 63 wt%, and nickel from 0.085 to 0.20 wt%. Nickel release was < LOD in all pairs. Gold release was detected from all pairs (median 0.057 μg/cm²/week, range: 0.016-0.15). Copper release exceeded gold release in all samples (median: 0.53 μg/cm²/week, range: 0.36-2.2).</p><p><strong>Conclusion: </strong>Jeweller-purchased 10K/14K gold earrings released measurable gold but not detectable nickel under cysteine-modified artificial sweat conditions. Gold release provides a plausible exposure pathway but does not establish sensitization or elicitation risk.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond HEMA: Shifts in the (Meth)acrylate Composition of Matched Nail Cosmetics Between 2023 and 2026.","authors":"Norbertus A Ipenburg, Anton C de Groot, Thomas Rustemeyer","doi":"10.1111/cod.70255","DOIUrl":"https://doi.org/10.1111/cod.70255","url":null,"abstract":"<p><strong>Background: </strong>Allergic contact dermatitis from nail cosmetics is common. Most patients are allergic to HEMA. Increasingly, products are labelled 'HEMA-free'.</p><p><strong>Objectives: </strong>To use ingredient lists to assess changes in the use of HEMA, Di-HEMA trimethylhexyl dicarbamate (Di-HEMA TMHDC), and other (meth)acrylates in nail cosmetics, and to investigate whether HEMA and Di-HEMA TMHDC occur in products not marketed for professional use.</p><p><strong>Materials and methods: </strong>We searched online for 394 products from 2023 and compared the 2023 and 2026 ingredient lists of products with the same brand and commercial name.</p><p><strong>Results: </strong>Among 127 matched products, HEMA decreased from 65.4% to 16.5% (-75%) and Di-HEMA TMHDC from 27.6% to 7.1% (-74%). Trimethylolpropane triacrylate and urethane acrylate decreased by 63% and 54%, respectively. Benzyl methacrylate, urethane methacrylate, and trimethylolpropane trimethacrylate increased by 100%-225%. Four of 24 products containing HEMA and/or Di-HEMA TMHDC (16.7%; 3.1% overall) were apparently marketed directly to consumers without an identifiable online professional-use restriction.</p><p><strong>Conclusions: </strong>Among matched nail cosmetics, ingredient lists indicated that the use of HEMA and Di-HEMA TMHDC decreased by approximately 75% over 3 years, while the use of several other (meth)acrylates changed substantially. Few products containing HEMA and/or Di-HEMA TMHDC appeared to be marketed directly to consumers.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symmetrical Drug-Related Intertriginous and Flexural Exanthema (SDRIFE) due to Dexamethasone Used as Oncologic Premedication.","authors":"Tommaso Galeotti, Luca Stingeni, Leonardo Bianchi, Daniela Agostinelli, Marta Tramontana, Katharina Hansel","doi":"10.1111/cod.70256","DOIUrl":"https://doi.org/10.1111/cod.70256","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic Contact Dermatitis to Zinc Ricinoleate in a Deodorant.","authors":"Antoine Badaoui","doi":"10.1111/cod.70259","DOIUrl":"https://doi.org/10.1111/cod.70259","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational Allergic Contact Dermatitis due to Rubber Additives in Tunisia: A 27-Year Retrospective Study of Clinical and Occupational Characteristics.","authors":"Emna Baraketi, Jihen Hsinet, Nihel Khouja, Aida Benzarti","doi":"10.1111/cod.70253","DOIUrl":"https://doi.org/10.1111/cod.70253","url":null,"abstract":"<p><strong>Background: </strong>Rubber additives are established causes of occupational allergic contact dermatitis (OACD), but data from North Africa are scarce.</p><p><strong>Objectives: </strong>To characterize OACD due to rubber additives in a Tunisian tertiary referral population and assess its impact on fitness for work.</p><p><strong>Methods: </strong>A retrospective study included all adult patients diagnosed with OACD to rubber additives between 1998 and 2025. Patch testing was performed with the European baseline series, with additional rubber series in selected cases. Clinical, occupational and allergological data were analysed. Associations with MOAHLFA index and temporal trends were assessed using logistic regression.</p><p><strong>Results: </strong>Eighty patients were included. Thiurams were the most frequent sensitizers (74%), followed by benzothiazole derivatives (24%) and p-phenylenediamine derivatives (14%). The healthcare sector predominated (51%) and gloves were the main exposure source (88%). Sensitization to multiple rubber additive families occurred in 19% of cases. No significant associations were found with MOAHLFA index after adjustment and no significant temporal trends were observed. Workplace adaptation was required in all cases and OACD met criteria for compensation as an occupational disease in 92%.</p><p><strong>Conclusions: </strong>OACD due to rubber additives remains frequent and is associated with a substantial occupational impact, emphasizing the need for preventive measures.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}