Contact Dermatitis最新文献

{"title":"Contact Dermatitis Caused by Propyl Gallate: The Rabbit Was the Key","authors":"Silvia Ojea Varona, Marina Senent Valero, Laura Taboada Paz, Elena Vicente Basanta, Adrián Santiago López Caamaño, Catarina Livana Fernández Traba, Juan Francisco Silvestre Salvador","doi":"10.1111/cod.14829","DOIUrl":"10.1111/cod.14829","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 4","pages":"350-352"},"PeriodicalIF":4.6,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergy to Neem Oil: An Emerging Cause of Contact Dermatitis","authors":"Yousra El Kaderi, Stefan Kerre, Anne Herman","doi":"10.1111/cod.14832","DOIUrl":"10.1111/cod.14832","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 4","pages":"339-340"},"PeriodicalIF":4.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caprylhydroxamic Acid: A Growing Allergen in Skincare Products","authors":"Valentine Theret, Estelle Burle, Françoise Giordano","doi":"10.1111/cod.14830","DOIUrl":"10.1111/cod.14830","url":null,"abstract":"<p>A 70-year-old woman presented with bilateral upper and lower eyelid eczema and cheilitis persisting for 1 year despite dermocorticoids (Figure 1A).</p><p>Initial patch testing with European baseline series revealed contact allergy to methylchloroisothiazolinone and methylisothiazolinone (MCI/MI). However, the eczema persisted and spread despite MCI/MI avoidance.</p><p>A second-round of patch testing with the European baseline series, cosmetic series (Chemotechnique Diagnostics, Vellinge, Sweden) and 11 personal care products was carried out and found out to be positive 2+ on day 3 for the semi-open test with her cleaning lotion, universal lotion NOREVA (NOREVA laboratory, France), despite the absence of MCI/MI. Thus, patch testing was performed with lotion's ingredients provided by the firm and revealed strong contact allergy 3+ for a component named SPECTRA STAT E, a commercial blend containing caprylhydroxamic acid (CHA), methylpropanediol (MP), and ethylhexylglycerin (EE). As the latter had previously tested negative, CHA and MP were suspected allergens.</p><p>Further patch testing was conducted using SPECTRA STAT E (CHA, MP and EE) and SPECTRA STAT (CHA alone) with three different concentrations in petrolatum (1%, 2% and 5% pet). All formulations tested positive for 1+ or 2+ at lower concentrations, and 3+ at higher concentrations on D3 (Figure 1B), confirming CHA as the responsible allergen. The results of the key patch tests are detailed in Table 1. The contact allergy to the universal lotion NOREVA is, therefore, linked to caprylhydroxamic acid, although the responsibility of methylpropanediol cannot be ruled out as it is not available from the firm on its own.</p><p>Contact allergies to cosmetics are very common, with a wide variety of clinical presentations [<span>1</span>] and often leading to patch testing. The majority of these cases are caused by fragrances and preservatives [<span>2</span>].</p><p>Spectrastat E is a preservative system developed by INOLEX that contains caprylhydroxamic acid, a natural chelating agent inhibiting yeast and mould growth; ethylhexylglycerin, a skin-conditioning agent preventing bacterial proliferation; and methylpropanediol, a formulation carrier. This is, therefore, used in emulsions, creams, lotions and surfactant-based products such as shower gels, facial cleansers and shampoos.</p><p>In the published literature, there has been only one documented contact allergy being attributed to CHA related to Apobase moisturisers. This occurrence coincided with a modification in the formulation of cosmetic products, which included the preservative Phenostat between the years 2014 and 2016. This mixture contains phenoxyethanol, caprylhydroxamic acid and methylpropanediol [<span>3</span>]. The study, which was conducted on 39 patients in Finland, showed positive reactions to the novel Apobase formulas and to caprylhydroxamic acid. However, no positive reactions were observed to the old formulas or to the other ","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 3","pages":"265-266"},"PeriodicalIF":4.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14830","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nothing New Under the Sun?: Sunflower Oil Shows No Cross-Reactivity With Nickel or Compositae Allergens","authors":"Sarah Karels, Sara Hylwa, Solvieg Ophaug, Katherine Lee, Anne Neeley","doi":"10.1111/cod.14834","DOIUrl":"10.1111/cod.14834","url":null,"abstract":"<p>Sunflower oil (<i>Helianthus Annuus</i> (Sunflower) Seed Oil, INCI) is a common emollient in personal care products. As a member of the Compositae plant family and a seed high in nickel content, its potential relevance for patients allergic to Compositae or nickel is of clinical interest. This study aimed to assess patch test reactivity to sunflower oil and examine potential sensitisation to these two allergens.</p><p>We retrospectively reviewed 568 patients patch-tested with sunflower oil at our tertiary referral clinic in Minneapolis, MN, between October 2023 and November 2024. Testing was performed using 100% sunflower oil (La Tourangelle, Woodland, CA) in Finn Chambers (SmartPractice, Phoenix, AZ) applied to the upper back or thighs for 48 h. Readings were conducted on Day 2 and Day 4 or 7 using ICDRG criteria. The NACDG 2021–2022 standard series was tested concurrently, which included nickel sulfate 2.5% and 5% (pet.), Compositae mix 6% (pet.) and sesquiterpene lactone mix 0.1% (pet.) (Chemotechnique Diagnostics, Vellinge, Sweden).</p><p>Zero reactions to sunflower oil were observed (0/568; 0%). In contrast, 122 patients (21.5%) reacted to nickel and 36 (6.3%) to Compositae-related allergens. No patients reacted to sunflower oil, including those positive to nickel or Compositae.</p><p>Despite its widespread use, sunflower oil has rarely been studied as a potential allergen. Our data show no contact sensitization in over 500 patients, including those allergic to nickel or Compositae, suggesting it is not a clinically relevant allergen.</p><p>Though sunflower is a member of the Compositae family, allergenic sesquiterpene lactones are typically confined to secretory plant structures like trichomes, found on leaves and flowers—not seeds [<span>1, 2</span>]. Solvent extracts of seeds may show trace allergen presence, but oil pressed from dehulled seeds contains only minute quantities [<span>3, 4</span>].</p><p>Additionally, sunflower seeds rank high among nickel-containing foods, which may prompt concern for nickel-allergic patients [<span>5</span>]. However, refined sunflower oil contains undetectable nickel levels even when derived from plants irrigated with nickel-contaminated water [<span>6, 7</span>]. Refining removes metal residues to improve stability and product quality [<span>8</span>].</p><p>Only one case report has implicated sunflower oil in contact allergy, and the case involved a lip balm with multiple consituents [<span>9</span>]. Our findings support its overall safety for topical use, even among populations sensitive to related allergens. This study is limited by its single-centre design and use of only one commercially available sunflower oil. Broader testing across formulations would further support these findings.</p><p><b>Sarah Karels:</b> conceptualization, investigation, writing – original draft, methodology, formal analysis, data curation. <b>Sara Hylwa:</b> data curation. <b>Solvieg Ophaug:</b> data curation. <b>Kather","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 3","pages":"267-268"},"PeriodicalIF":4.6,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14834","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic Contact Dermatitis to Octyldodecanol in a Men's Anti-Aging Cream: A Case Report","authors":"Antoine Badaoui","doi":"10.1111/cod.14828","DOIUrl":"10.1111/cod.14828","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 3","pages":"263-264"},"PeriodicalIF":4.6,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variability in Paediatric Patch Test Practices Across Europe: A Survey From the European Baseline Series (EBS) Working Party on Behalf of the European Society of Contact Dermatitis (ESCD)","authors":"Olivier Aerts,&nbsp;Thomas Rustemeyer,&nbsp;Anna Belloni-Fortina,&nbsp;Sonia Badulici,&nbsp;Heinrich Dickel,&nbsp;Jose Luis Garcia Abujeta,&nbsp;Ana Maria Giménez-Arnau,&nbsp;Margarida Gonçalo,&nbsp;Catherine R. Holden,&nbsp;Marléne Isaksson,&nbsp;Faheem Latheef,&nbsp;Suzana Ljubojevic Hadzavdic,&nbsp;Vera Mahler,&nbsp;Esen Özkaya,&nbsp;Gyorgyi Ponyai,&nbsp;Nives Pustišek,&nbsp;Marie-Louise Schuttelaar,&nbsp;Jakob Schwensen,&nbsp;Radoslaw Spiewak,&nbsp;Luca Stingeni,&nbsp;Cecilia Svedman,&nbsp;Wolfgang Uter,&nbsp;Jonathan M. L. White,&nbsp;Mark Wilkinson,&nbsp;Anne-Birgitte Simonsen,&nbsp;Jeanne Duus Johansen","doi":"10.1111/cod.14824","DOIUrl":"10.1111/cod.14824","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Allergic contact dermatitis (ACD) is an increasingly recognised condition in children and adolescents. However, there is limited knowledge about the different paediatric patch test procedures in European patch test clinics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To map current European paediatric patch test practices, and to relate these to the existing literature, with the aim of guiding the development of a future paediatric patch test guideline, and a corresponding paediatric European baseline series (pEBS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In the course of late 2023/early 2024, a standardised paediatric patch test e-mail questionnaire was developed, distributed, and discussed among members of the European Baseline Series (EBS) Working Party of the European Society of Contact Dermatitis (ESCD).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Areas of agreement and discussion were identified regarding patch testing in children of different ages, with and without atopic dermatitis: (contra)indications, choice of allergens and patch test chambers, peculiarities regarding the application and fixation of tests, occlusion and reading times.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Although variability exists in paediatric patch test practices across Europe, there is broad agreement on common procedures, and only a few areas of debate; these findings may be used to inform the development of a future paediatric patch test guideline and pEBS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 4","pages":"285-297"},"PeriodicalIF":4.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-Sensitization After Single-Dose Antibiotic Exposure During Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS): The Role of Repeat Drug Patch Testing","authors":"Brent J. Doolan,&nbsp;Louise Cunningham,&nbsp;Ian R. White,&nbsp;Elizabeth Powell,&nbsp;Ying X. Teo","doi":"10.1111/cod.14825","DOIUrl":"10.1111/cod.14825","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 3","pages":"271-273"},"PeriodicalIF":4.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational Allergic Contact Dermatitis to Formaldehyde Released by Work Clothes","authors":"Tina Lejding,&nbsp;Anna Kiuru,&nbsp;Ola Bergendorff","doi":"10.1111/cod.14827","DOIUrl":"10.1111/cod.14827","url":null,"abstract":"<p>Formaldehyde (FA) is one of the oldest and still widely used preservatives. It is a common allergen and has been included in the standard series since the 1930s [<span>1</span>]. FA is commonly found in consumer products such as cosmetics, household detergents, pharmaceuticals, industrial products [<span>2</span>] and in occupational exposures such as protective gloves [<span>3</span>]. FA can also be released from clothing [<span>4</span>].</p><p>At the time of the investigation, the patient was a 54-year-old man with no history of atopy. He had been working in the home health care service for more than 20 years without any skin problems. However, due to changes in hygiene practices during the COVID-19 pandemic, work clothes were introduced instead of the wearing of his own civil clothes. Since the introduction of the new garment (a set of trousers and a shirt in 50% cotton/50% polyester, made in Laos) the patient had started to experience itch on the skin exposed to the garment, that is, the trunk, upper arms and legs. The itch was strongly related to wearing the new garment at work and decreased during weekends and holidays. At the time of the investigation, the patient was clear of symptoms from the skin, and he could not give an objective description of any efflorescence.</p><p>The patient was patch-tested with the Swedish baseline series [<span>5</span>], textile series, and textile dye mix series. The patch tests were occluded for 48 h, and patch test readings were performed according to the ICDRG and ESCD guidelines [<span>6, 7</span>] on day 3 and day 7. Patch testing was performed using Finn Chamber Aqua (Chemotechnique Diagnostics, Vellinge, Sweden). Twenty milligrams of petrolatum preparations (40 mg/cm²) or 15 μL of liquid preparations (31 μL/cm²) were applied [<span>8</span>].</p><p>At the patch test reading on day 3, the patient showed a positive reaction to FA (2% aq) in the Swedish baseline series and to multiple FA-related chemicals in the textile series. He had a weak positive reaction to chromium that was not assessed as relevant, and no contact allergies for textile dyes. He was further tested with a dilution series of FA, in which he had strong positive reactions to the highest concentrations, successively tapering down (Table 1).</p><p>The release of FA from the new, unwashed work clothes and old multiply washed work clothes was analysed by the chromotropic acid method [<span>9</span>]. The analysis of the new work clothes indicated a high release of FA with darkly coloured reagent, whereas no release of FA was indicated from the old work clothes.</p><p>We interpreted the patient as suffering from an OACD to FA in his new work clothes, based on the aggregated information and test results. FA-releasing preservatives are widely used, and the patient might have been sensitised to them elsewhere, but he was not aware of any excessive exposure to FA in the past, and he had never had any skin problems bef","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 3","pages":"255-256"},"PeriodicalIF":4.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14827","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infrared Radiation-Induced Urticaria: A Case Report","authors":"Angéline Charansol,&nbsp;V. Bourdenet,&nbsp;Anatole Hanniet,&nbsp;Fabien Pelletier,&nbsp;François Aubin,&nbsp;Florence Castelain","doi":"10.1111/cod.14826","DOIUrl":"10.1111/cod.14826","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 3","pages":"269-270"},"PeriodicalIF":4.6,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Glove Liners Made of Semipermeable and Textile Materials in Patients With Hand Dermatoses: Results of a Multicenter Intervention Study (ProTection II)","authors":"Theres Heichel,&nbsp;Jan F. Kersten,&nbsp;Antje Braumann,&nbsp;Kathrin Krambeck,&nbsp;Sonja Bonness,&nbsp;Claudia Schröder-Kraft,&nbsp;Robert Ofenloch,&nbsp;Elke Weisshaar,&nbsp;Kerstin Strom,&nbsp;Christoph Skudlik,&nbsp;Flora Sonsmann,&nbsp;Annika Wilke,&nbsp;Albert Nienhaus,&nbsp;Swen Malte John,&nbsp;Richard Brans","doi":"10.1111/cod.14822","DOIUrl":"10.1111/cod.14822","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Glove liners (GLs) are worn under impermeable gloves to prevent occlusion effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the acceptance and tolerability of cotton gloves (COT) and semipermeable Sympatex gloves (SYM) as GLs in patients with hand dermatoses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In a prospective multicenter study, 210 patients with work-related hand dermatoses were invited to wear either COT or SYM as GLs for 4 weeks underneath occlusive protective gloves during their regular work tasks. Acceptance of GL and health-related quality of life (HRQoL) were assessed by questionnaires and the disease severity by the Osnabrueck Hand Eczema Severity Index.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 178 data sets were available (SYM: <i>n</i> = 89/103, 86.4%; COT: <i>n</i> = 89/107, 83.2%). Both GLs did not impair work performance and were applicable in various work activities. SYM received better ratings regarding climate conditions, mobility and tactility. COT showed superiority in fit, donning and doffing. No substantial intergroup differences regarding disease severity and HRQoL were observed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>SYM and COT were well tolerated and accepted, suggesting that SYM is a reasonable alternative for COT as GL in patients with hand dermatoses. The choice of material of GLs may depend on occupation-specific requirements for the performed tasks, individual needs and preferences.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 4","pages":"305-315"},"PeriodicalIF":4.6,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14822","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}