Contact Dermatitis最新文献

{"title":"Prevalence, pattern, contact sensitisers and impact on quality-of-life of occupational dermatitis among beekeepers in North India","authors":"Misbah Qayoom,&nbsp;Iffat Hassan,&nbsp;Shazia Jeelani","doi":"10.1111/cod.14724","DOIUrl":"10.1111/cod.14724","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Beekeepers face specific occupational health risks due to exposure to bee products and chemicals. Propolis is a notable cause of contact hypersensitivity in beekeepers. Its chemical composition varies by region, complicating allergy investigations. While propolis allergies are documented in Western populations, no studies exist in India.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To assess the prevalence and patterns of dermatitis among beekeepers, identify contact sensitisers and evaluate its impact on quality-of-life (QoL).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>An 18-month community-based cross-sectional study was conducted involving 340 beekeepers from the Kashmir Valley in North India. Data collection included personal interviews, dermatological examinations and patch testing using self-made antigens of propolis, beeswax, royal jelly and standardised Baseline Indian Standard Series. The Dermatology Life Quality Index (DLQI) was used to measure the impact of dermatitis on QoL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Dermatitis prevalence among beekeepers was 17.1%, with the majority presenting with hand eczema. Onset or worsening of dermatitis was reported by 77.6% after working in apiaries. Significant associations were found with duration of beekeeping (<i>p</i> &lt; 0.05) and a history of atopy (<i>p</i> &lt; 0.001). Patch testing revealed 27.5% of beekeepers with positive reactions, primarily to propolis (10% in pet). The mean DLQI score was 3.5, indicating a generally small impact on QoL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Dermatitis was a common occupational condition among beekeepers, strongly associated with the duration of beekeeping and a history of atopy, though its overall impact on QoL was limited. Propolis emerged as a primary sensitiser in the study population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"92 3","pages":"217-223"},"PeriodicalIF":4.8,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational Airborne Allergic Contact Dermatitis Caused by a Metal-Working Fluid Containing Methylisothiazolinone.","authors":"Caterina Foti, Lucia Pacello, Benedetta Tirone, Giorgia Sbarra, Riccardo Ravallese, William Andrew Rosato, Nicoletta Cassano, Gino Antonio Vena, Paolo Romita, Piero Lovreglio","doi":"10.1111/cod.14728","DOIUrl":"https://doi.org/10.1111/cod.14728","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin sensitisation elicitation: Evaluation of the general threshold and considerations for use","authors":"Brian Palmer,&nbsp;Yuan Gao,&nbsp;Cindy Ryan,&nbsp;Petra Kern","doi":"10.1111/cod.14718","DOIUrl":"10.1111/cod.14718","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Allergic contact dermatitis (ACD) is an immune response to chemical haptens, involving induction and elicitation phases. Quantitative risk assessment (QRA) reviewing the skin sensitisation potential for all ingredients and using chemical-specific induction thresholds for skin allergens remains the current best approach for the safety evaluation of consumer products. However, elicitation thresholds have utility in secondary protection for pre-sensitised consumers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The objectives were to (1) review the current elicitation threshold database, (2) evaluate whether predicted relationships between chemical induction and elicitation potencies enable elicitation threshold prediction and (3) discuss elicitation threshold utility as a secondary method of consumer protection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In total, 28 publications (with 39 elicitation datasets) were included in non-linear regression analysis to derive elicitation thresholds for 22 allergens, including fragrances, preservatives and metals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The median elicitation threshold (ED₁₀) for the expanded database was 0.95 μg/cm², which supports previously published general elicitation thresholds. The derived ED₁₀ for each chemical had only weak to moderate correlation with corresponding induction thresholds, thus limiting suitability as the predictive model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Assessment of current EU fragrance allergen labelling and sensitiser labelling under the globally harmonised system in the context of general and chemical-specific elicitation thresholds shows that current practices are health protective.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"92 3","pages":"197-208"},"PeriodicalIF":4.8,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dimethylfumarate-Induced Persistent Shoe Contact Dermatitis in a Man: The First Reported Case From Türkiye With an Unusual Way of Sensitisation.","authors":"Esen Özkaya, Ömer Mangir","doi":"10.1111/cod.14726","DOIUrl":"https://doi.org/10.1111/cod.14726","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thresholds for ingredient labelling/identification","authors":"Carola Lidén,&nbsp;Wolfgang Uter,&nbsp;Ian R. White","doi":"10.1111/cod.14722","DOIUrl":"10.1111/cod.14722","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"92 3","pages":"161-163"},"PeriodicalIF":4.8,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic contact dermatitis to benzoyl peroxide mimics anaphylactic reaction","authors":"Magalie Coco-Viloin,&nbsp;Françoise Giordano","doi":"10.1111/cod.14720","DOIUrl":"10.1111/cod.14720","url":null,"abstract":"&lt;p&gt;A 38-year-old women was referred to allergist doctor for a possible anaphylactic reaction to an ingredient contained in a topical antiacne gel, Cutacnyl® (&lt;i&gt;Benzoyl peroxide 5%, Carbomère 940, Copolymère méthacrylique, Docusate sodique, Eau purifiée, Glycérol, Poloxamère 182, Propylèneglycol, Silice colloïdale anhydre, Sodium hydroxyde solution&lt;/i&gt;) (Galderma International, Paris, France).&lt;/p&gt;&lt;p&gt;On 3 April 2024, she had started a new topical antiacne treatment with a gel containing 5% benzoyl peroxide (BP) for acne. She began to experience facial pruritus on Day 2 and she stopped the treatment.&lt;/p&gt;&lt;p&gt;On Day 3, the patient experienced bright red erythema across her face with severe eyelid edema and strong pruritus (Figure 1A). She went to the emergency room due to the growing edema.&lt;/p&gt;&lt;p&gt;On the emergency report, a voluminous edema of eyelids, dysphonia, tachycardia and low arterial blood pressure were noted (Figure 1B,C). Suspecting anaphylaxis, the patient received an intramuscular adrenaline injection, an inhaled adrenaline spray, an intravenous antihistamine and intravenous corticosteroids. However, these treatments were not effective.&lt;/p&gt;&lt;p&gt;Emergency physicians also suggested bradykinin-induced angioedema. Diagnostic laboratory examinations for angioedema (serum levels of C3, C4 and C1INH) were normal.&lt;/p&gt;&lt;p&gt;In the emergency room, tryptase was also normal with a value of 3.26 μg/L, excluding anaphylaxis.&lt;/p&gt;&lt;p&gt;The reaction finally resolved in 1 week, with a desquamative rash.&lt;/p&gt;&lt;p&gt;She was then referred to allergy consulting in July 2024.&lt;/p&gt;&lt;p&gt;She mentioned she did not use any other topical treatments or cosmetics.&lt;/p&gt;&lt;p&gt;However, she had previously applied anti-acne creams, but could not remember which molecule she had used.&lt;/p&gt;&lt;p&gt;The patient applied Cutacnyl® all over her face, not just to the lesions as recommended by her general practioner. A prick-test to topical antiacne gel was performed and was negative at 20 min.&lt;/p&gt;&lt;p&gt;Patch testing was performed with the European and cosmetic series (Chemotechnique Diagnostics, Vellinge Sweden), BP 1% petrolatum and the Cutacnyl gel® (5% BP-containing) ‘as is’.&lt;/p&gt;&lt;p&gt;The haptens were applied on the back using IQ Ultra chambers (Chemotechnique Diagnostics), and following by an occlusion of 2 days, readings were performed on day (D)2 and D3.&lt;/p&gt;&lt;p&gt;Positive strong reactions were observed on D2 and D3 to BP 1% pet. (+++) and also, to topical antiacne cream as is (++) (Figure 2A,B).&lt;/p&gt;&lt;p&gt;A diagnostic of allergic contact dermatitis from BP was confirmed with an angioedema clinical aspect.&lt;/p&gt;&lt;p&gt;A positive patch test (+) reaction to nickel sulfate was found, relevant with reactions to costume jewellery in the past (Figure 2C).&lt;/p&gt;&lt;p&gt;ACD is a type IV hypersensitivity reaction which may also present as facial and eyelid edema.&lt;/p&gt;&lt;p&gt;Whereas anaphylaxis is a sudden IgE-mediated reaction occurring typically within 1–2 h, following contact with the allergen with several organ systems involved.&lt;span&gt;&lt;sup&gt;1&lt;","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"92 3","pages":"243-245"},"PeriodicalIF":4.8,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14720","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First case of pustular eyelid allergic contact dermatitis to methacrylates in artificial nails","authors":"Marion Menanteau,&nbsp;Lynda Bensefa-Colas,&nbsp;Marie-Noëlle Crepy","doi":"10.1111/cod.14717","DOIUrl":"10.1111/cod.14717","url":null,"abstract":"&lt;p&gt;We present the first case of pustular eyelid eczema due to contact allergy to methacrylates in artificial nails.&lt;/p&gt;&lt;p&gt;A 36-year-old African woman with a past history of ACD (allergic contact dermatitis) to fragrances and thiuram mix, was referred for acute pustular lesions, erythema and mild oedema of the eyelids and periorbital skin. The lesions had started the week before on the eyelids and were slowly extending to the temples and cheeks (Figure 1). She also had erythema and squamous lesions of the hands with a few pustules (Figure 2). She had received a prescription for oral Pristinamycin and local Fucidin with no improvement.&lt;/p&gt;&lt;p&gt;The patient had not recently been using gloves. She avoided the use of fragrances in her personal products since she had received her first diagnosis of ACD to fragrances.&lt;/p&gt;&lt;p&gt;The patient reported she had recently been to see a beautician for an artificial nail application, but 3 days later, she decided to pull the false nails out herself.&lt;/p&gt;&lt;p&gt;Patch tests had been performed with EBS (European baseline series) and acrylates series using test preparations from D'Estaing (Grasse France) or SmartPractice Europe (Greven, Germany), using IQ ultra chambers® from Chemotechnique MB Diagnostics AB (Vellinge, Sweden) and Mepilex® border tape with an occlusion time of 48 h according to the ESCD guidelines. Positive results were found for 2-hydroxypropyl methacrylate 2% pet (+) and ethylene glycol dimethacrylate 2% pet (+) at D3 and D10; as well as 2-hydroxyethyl methacrylate 2% pet (+), thiuram mix 1% pet (++), fragrance mix I 8% pet (++) and fragrance mix II 14% pet (++), linalool 0.5% pet (++), limonene 0.2% pet (+).&lt;/p&gt;&lt;p&gt;She healed a few days later with a topical dermocorticoid treatment and the avoidance of artificial nails and nail products.&lt;/p&gt;&lt;p&gt;The eyelids are one of the most sensitive areas of skin: frequently exposed to potential allergens, histologically the thinnest skin area of the body, and with an occluded eyelid skin while the eye is open. Contamination of the fingers with small amounts of allergen can result in the transfer of sufficient material to the eyelids to produce dermatitis via hand-to-face contact.&lt;span&gt;&lt;sup&gt;1, 2&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;Contact allergy from acrylic compounds is well known and often described related to artificial nails in the occupational setting, but also concerns the non-occupational setting.&lt;span&gt;&lt;sup&gt;3-6&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;The pustular form of ACD to acrylates is unusual with no other case reported to our knowledge.&lt;/p&gt;&lt;p&gt;Pustular ACD is rare and has been reported with fragrances, colophonium, rubber additives, textile dyes, triethanolamine and benzoic acid.&lt;span&gt;&lt;sup&gt;7-11&lt;/sup&gt;&lt;/span&gt; Pustular lesions can mimic an infectious skin disease, and hamper the diagnosis of ACD.&lt;/p&gt;&lt;p&gt;In conclusion, this is the first case of pustular eyelid ACD associated with methacrylates in artificial nails. This report highlights the importance of considering unusual location and presentations i","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"92 3","pages":"241-243"},"PeriodicalIF":4.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14717","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic contact cheilitis/stomatitis due to beverages and food, an underreported diagnosis","authors":"Stefan Kerre,&nbsp;An Goossens","doi":"10.1111/cod.14725","DOIUrl":"10.1111/cod.14725","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"92 3","pages":"248-250"},"PeriodicalIF":4.8,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of contact dermatitis caused by a cell phone grip ring","authors":"Saki Ueda,&nbsp;Kanako Akashi,&nbsp;Ken Washio","doi":"10.1111/cod.14719","DOIUrl":"10.1111/cod.14719","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"92 2","pages":"155-156"},"PeriodicalIF":4.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulpitis of the fingers, it is not always acrylates!","authors":"Nadia Raison-Peyron,&nbsp;Marwa El Gana,&nbsp;Cecilia Svedman,&nbsp;Jakob Dahlin","doi":"10.1111/cod.14716","DOIUrl":"10.1111/cod.14716","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"92 2","pages":"159-160"},"PeriodicalIF":4.8,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}