Contact Dermatitis最新文献

{"title":"Allergic Contact Dermatitis to Zinc Ricinoleate in a Deodorant.","authors":"Antoine Badaoui","doi":"10.1111/cod.70259","DOIUrl":"https://doi.org/10.1111/cod.70259","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational Allergic Contact Dermatitis due to Rubber Additives in Tunisia: A 27-Year Retrospective Study of Clinical and Occupational Characteristics.","authors":"Emna Baraketi, Jihen Hsinet, Nihel Khouja, Aida Benzarti","doi":"10.1111/cod.70253","DOIUrl":"https://doi.org/10.1111/cod.70253","url":null,"abstract":"<p><strong>Background: </strong>Rubber additives are established causes of occupational allergic contact dermatitis (OACD), but data from North Africa are scarce.</p><p><strong>Objectives: </strong>To characterize OACD due to rubber additives in a Tunisian tertiary referral population and assess its impact on fitness for work.</p><p><strong>Methods: </strong>A retrospective study included all adult patients diagnosed with OACD to rubber additives between 1998 and 2025. Patch testing was performed with the European baseline series, with additional rubber series in selected cases. Clinical, occupational and allergological data were analysed. Associations with MOAHLFA index and temporal trends were assessed using logistic regression.</p><p><strong>Results: </strong>Eighty patients were included. Thiurams were the most frequent sensitizers (74%), followed by benzothiazole derivatives (24%) and p-phenylenediamine derivatives (14%). The healthcare sector predominated (51%) and gloves were the main exposure source (88%). Sensitization to multiple rubber additive families occurred in 19% of cases. No significant associations were found with MOAHLFA index after adjustment and no significant temporal trends were observed. Workplace adaptation was required in all cases and OACD met criteria for compensation as an occupational disease in 92%.</p><p><strong>Conclusions: </strong>OACD due to rubber additives remains frequent and is associated with a substantial occupational impact, emphasizing the need for preventive measures.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tin Sensitization in Belgium and the Netherlands: Complementary Findings From Two Independent Retrospective Studies.","authors":"Sylvie M Franken, Hannelore George, Isha C Anwar, Ella Dendooven, Olivier Aerts, Thomas Rustemeyer","doi":"10.1111/cod.70252","DOIUrl":"https://doi.org/10.1111/cod.70252","url":null,"abstract":"<p><strong>Background: </strong>Tin is a known but traditionally considered infrequent contact allergen. In recent years, several case reports have reported clinically relevant reactions to tin-containing oral hygiene products, particularly toothpastes.</p><p><strong>Objectives: </strong>To assess the prevalence and clinical relevance of tin sensitization in consecutive patch-tested patients, as well as in a selected cohort of patients referred because of suspected metal allergy or (peri)oral complaints.</p><p><strong>Materials/methods: </strong>Two independent retrospective cohorts were analyzed: 1919 consecutive patch-tested patients from the University Hospital Antwerp, tested with different tin preparations and 536 selected patients from Amsterdam UMC, referred because of suspected metal allergy or (peri)oral complaints and patch tested with tin chloride.</p><p><strong>Results: </strong>In the consecutive cohort, 128/1919 patients (6.7%) tested positive to at least one tin preparation, of whom 35 (27.3%) had clinically relevant sensitization. In the selected cohort, 61/536 patients (11.4%) were sensitized to tin, with 16/50 assessed patients (32.0%) considered clinically relevant. Amongst clinically relevant cases, (peri)oral involvement was the most common presentation in both cohorts, followed by periorbital dermatitis in the consecutive cohort.</p><p><strong>Conclusions: </strong>Tin sensitization appears to be more common than previously recognized. Although (peri)oral involvement was the predominant clinical presentation, periorbital dermatitis was also frequently observed amongst patients with clinically relevant sensitization.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproducibility of Patch Test Reactions and Interpretation of Doubtful Results: A Retrospective Study of Identical Haptens Tested Simultaneously in Different Series.","authors":"Norbertus A Ipenburg, Anton C de Groot, Thomas Rustemeyer","doi":"10.1111/cod.70251","DOIUrl":"https://doi.org/10.1111/cod.70251","url":null,"abstract":"<p><strong>Background: </strong>Reproducibility of patch test reactions remains debated, and the clinical significance of doubtful (?+) reactions is unclear.</p><p><strong>Objectives: </strong>To evaluate reproducibility of positive reactions to identical haptens tested simultaneously in different series and analyse doubtful reactions using paired co-reactivity patterns.</p><p><strong>Materials and methods: </strong>Patch test data from consecutive patients tested during 2015-2025 were analysed retrospectively. Six haptens were evaluated at standard concentrations in petrolatum: hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lyral, HICC) 5% pet., Amerchol L-101 50% pet., lanolin alcohol 30% pet., hydroxyethyl methacrylate (HEMA) 2% pet., mercaptobenzothiazole (MBT) 2% pet. and Myroxylon pereirae resin (balsam of Peru, MPR) 25% pet.</p><p><strong>Results: </strong>Reproducibility was hapten-dependent. HEMA and MBT showed substantial to almost perfect agreement. HICC showed substantial agreement but a significantly higher positivity rate in the perfume series than in the baseline series. Amerchol L-101, lanolin alcohol and MPR showed lower positive agreement and fair-to-moderate kappa values. Most doubtful reactions were isolated, particularly for Amerchol L-101 and lanolin alcohol, whereas 43.8% of doubtful HICC reactions in the baseline series were supported by perfume-series reactivity.</p><p><strong>Conclusions: </strong>Reproducibility was strongly hapten-dependent. In this dataset, paired co-reactivity provided clinical context for interpreting discordant positive and doubtful reactions.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149024061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paraphenylenediamine Contact Allergy and Post-Diagnostic Outcomes: A Single-Centre Study From the United Kingdom.","authors":"Zara Ali, Livia Francine Soriano, Michelle Oakford, Ying Teo","doi":"10.1111/cod.70250","DOIUrl":"https://doi.org/10.1111/cod.70250","url":null,"abstract":"<p><strong>Background: </strong>Paraphenylenediamine (PPD) is a potent allergen, frequently responsible for allergic contact dermatitis (ACD) from hair dyes and temporary 'black henna' tattoos. Misleading 'PPD-free' labelling may expose sensitised individuals to structurally related aromatic amines.</p><p><strong>Objectives: </strong>To characterise clinical features, cross-reactivity and outcomes of patients diagnosed with PPD ACD following diagnosis of PPD allergy, and to evaluate the accuracy and safety of 'PPD-free' products marketed in the United Kingdom.</p><p><strong>Methods: </strong>Retrospective study of PPD positivity between 2018 and 2025 at a university hospital was conducted. Demographic, clinical and exposure data were extracted from records, and outcomes post-diagnosis were surveyed by telephone. Ingredient lists of permanent 'PPD-free' hair dyes/tints identified through a structured online search were reviewed for cross-reactive amines.</p><p><strong>Results: </strong>Of 1306 patients tested for PPD over 7 years, 56 (4.3%) had a positive reaction. The mean age of affected patients was 49 years; 82% were female, and hair dye was the most frequently reported source of exposure (77%). Eight (14%) had occupational exposure. Among 37 tested to para-toluenediamine (PTD), 10 (27%) were positive. Among 31 followed up, 24 (77%) reported remission after avoidance. Only 1 of 10 permanent 'PPD-free' hair dyes/tints examined was found to be free of any potentially cross-reactive amines.</p><p><strong>Conclusions: </strong>PPD remains a prevalent allergen causing chronic and occupational ACD. 'PPD-free' products frequently contain cross-reactive amines, highlighting the need for improved labelling and careful counselling.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smelly Pig Manure: A Hypothetical Explanation for Sodium Metabisulphite Contact Allergy Mimicking Atopic and Seborrheic Dermatitis.","authors":"Ella Dendooven, Emmely Genouw, Olivier Aerts","doi":"10.1111/cod.70248","DOIUrl":"https://doi.org/10.1111/cod.70248","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous Adverse Drug Reaction Involving Piperacillin-Tazobactam: Tests and Rechallenges to Avoid Unnecessary Contraindications for All Penicillin Drugs.","authors":"Assier Haudrey, Morgane Renault-Mahieu, Fleck Margaux, Bel Hareth Kmar, Ingen-Housz-Oro Saskia","doi":"10.1111/cod.70243","DOIUrl":"https://doi.org/10.1111/cod.70243","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational Urticaria Caused by Different Platinum Group Elements (PGEs).","authors":"Katrien Goos, Jeff Lens, Silada Kanokrungsee, Veerle Frederickx, Olivier Aerts, Ella Dendooven","doi":"10.1111/cod.70247","DOIUrl":"https://doi.org/10.1111/cod.70247","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contact Sensitization and Polysensitization in a Tertiary Referral Cohort of Children With Moderate-To-Severe Atopic Dermatitis.","authors":"Najdova Anita, Damevska Katerina","doi":"10.1111/cod.70249","DOIUrl":"https://doi.org/10.1111/cod.70249","url":null,"abstract":"<p><strong>Background: </strong>Children with atopic dermatitis (AD) demonstrate increased susceptibility to contact sensitization (CS) due to epidermal barrier dysfunction and chronic cutaneous inflammation. However, the frequency and patterns of contact sensitization in paediatric AD remain incompletely defined.</p><p><strong>Objectives: </strong>To evaluate the frequency of CS in a selected tertiary referral cohort of children with AD, and to assess associations with age, disease severity, and topographic phenotypes.</p><p><strong>Materials and methods: </strong>In this cross-sectional study, 54 children (≤ 18 years) with AD underwent standardized patch testing using a modified paediatric baseline series. Reactions graded +, ++, or +++ were considered positive, whereas doubtful and irritant reactions were excluded. Polysensitization was defined as positivity to ≥ 3 allergens. Associations between sensitization status, topographic distribution (head and neck, trunk, palmo-plantar), and disease severity were analysed using Fisher's exact test and Mann-Whitney U test, as appropriate.</p><p><strong>Results: </strong>CS was identified in 49/54 patients (90.7%), while polysensitization was observed in 27/54 children (50.0%). The most frequent allergens were nickel sulphate and cobalt chloride, each detected in 17 patients (31.5%), followed by potassium dichromate in 15 patients (27.8%) and propolis in 13 patients (24.1%). Among polysensitized patients, propolis sensitization was identified in 40.7%, with propolis and cobalt representing the most frequent co-sensitization pattern. Exploratory analysis of the five most frequent allergens showed no statistically significant associations with topographic phenotypes. Furthermore, neither contact sensitization nor polysensitization burden demonstrated significant associations with age and disease severity.</p><p><strong>Conclusions: </strong>Our findings support consideration of patch testing in children with moderate-to-severe AD, regardless of their age, disease severity, and topographic phenotype.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic Contact Dermatitis in Children Over a 20-Year Period: A Danish Single-Centre Study.","authors":"Laura Krogh Herlin, Anne Bregnhøj, Mette Sommerlund","doi":"10.1111/cod.70241","DOIUrl":"https://doi.org/10.1111/cod.70241","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}