Contact Dermatitis最新文献

{"title":"Allergic Contact Dermatitis After Use of Headphones: A New Case of Contact Allergy to Dimethylfumarate (DMF)","authors":"Christoffer Kursawe Larsen, Malin Glindvad Ahlström, Jakob F. B. Schwensen","doi":"10.1111/cod.14806","DOIUrl":"10.1111/cod.14806","url":null,"abstract":"<p>Dimethylfumurate (DMF; CAS: 624-49-7) is an antifungal agent [<span>1</span>]. DMF used in Chinese-manufactured recliners and sofas led to a significant outbreak of allergic contact dermatitis across Europe, commonly referred to as “toxic sofa dermatitis”. The first reported cases emerged in Finland in 2006 [<span>1, 2</span>]. Subsequently, a DMF content above 0.1 mg/kg was banned in consumer products in the European Union (EU) in 2009 [<span>3</span>]. Fifteen years after this ban, we report a Danish case of allergic contact dermatitis probably due to DMF exposure from headphones.</p><p>A 22-year-old man with keratosis pilaris was referred for patch testing due to bilateral periauricular red pruritic eczema (Figure 1). The eczema developed after the patient wore headphones during a two-hour flight (Sony WH-1000XM5–Black). Prior to this, the patient had only used the over-ear headphones a couple of times. A few months before the flight, the patient had experienced the same symptoms 1–2 days after exercising with the headphones on.</p><p>In July 2024, the patient was patch tested with the European baseline series, the supplementary baseline series at Gentofte Hospital, a fragrance series and the ear pads of his own headphones (Sony WH-1000XM5–Black; occluded with 12-mm Finn chamber and tested “as is”). Allergens were supplied by Allergeaze allergens (Smart Practice, Phoenix, Arizona, USA) or Chemotechnique Diagnostics (Vellinge, Sweden). Allergens were occluded with 8-mm Finn chambers (Smart Practice) to the upper back using Scanpor tape (Norgesplaster, Alpharma, Vennesla, Norway) for 48 h. Reactions were read day(D)2, D5 and D7. Patch testing was conducted according to the ESCD-guidelines [<span>4</span>]. The patient had a doubtful reaction to textile dye mix (6.6% pet.) (D2) and a positive reaction (++) to the headphones (D5). In January 2025, a second patch test was performed with a supplementary rubber series and a textile series. The patient had a positive reaction (++) to DMF (0.01% pet.) (D2), a doubtful reaction to disperse yellow 3 (D2) and disperse red 3 (both 1.0% pet.) (D5) and an irritant reaction to 4-Aminophenol (1.0% pet.) (D5).</p><p>The eczema resolved after treatment with hydrocortisone-17-butyrate. The patient changed his headphones to a different brand and has never had any problems since.</p><p>In the present case, the patient had positive reactions (++) to both his own headphones and DMF. We asked the manufacturer for the ingredient list of the headphones without success. However, according to the Danish retailer, the patient's headphones were made in Malaysia. DMF may be added to the product as an antifungal agent for shipping to Europe: For example, DMF has been found in “MouldProof” sachets that are often attached to products and which caused the toxic sofa dermatitis crisis [<span>2, 5</span>]. The patient also found sachets together with his earphones. Therefore, we concluded that the headphones were the probable r","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 2","pages":"183-185"},"PeriodicalIF":4.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14806","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational Allergic Contact Dermatitis to Ethylhexylglycerin in an Alcohol-Based Hand Disinfectant","authors":"Richard Brans, Christoph Skudlik","doi":"10.1111/cod.14802","DOIUrl":"10.1111/cod.14802","url":null,"abstract":"<p>Ethylhexylglycerin rarely causes allergic contact dermatitis (ACD) which mainly is related to cosmetics [<span>1-4</span>]. Here, we present a case of occupational ACD caused by ethylhexylglycerin in an alcohol-based hand disinfectant.</p><p>A 30-year-old woman without a history of atopy had worked as a surgical assistant for 5 years before developing severe dermatitis on her lower arms, which evolved within a couple of days. As usual, she had performed surgical disinfections of her hands and lower arms several times a day using one of the following alcohol-based hand disinfectants provided at work: Desmanol pure, Desmanol care, or Desderman (all from Schülke & Mayr, Norderstedt, Germany). Allocation of the skin lesions to one of them was not possible, as she had alternated their use. Afterwards, she disinfected her lower arms with different alcohol-based disinfectants but had the impression that she would not tolerate any of them. Therefore, she was exempted from surgical assistance and thus from performing surgical disinfections of her lower arms.</p><p>A patch test was performed and read according to the guidelines of the German Contact Dermatitis Research Group (DKG) [<span>2</span>] using the DKG baseline series and the DKG series for ‘ingredients of topical preparations’, ‘preservatives’, ‘rubber’, ‘disinfectants’, the patient's own three hand disinfectants, and another product (Descoderm, Dr. Schumacher, Malsfeld, Germany) which according to the patient had also caused skin lesions on her lower arms. The commercial patch test preparations were purchased from SmartPractice Europe (Greven, Germany). The hand disinfectants were patch tested ‘as is’ and in a 50% aqueous dilution with an occlusion time of one day (D). The shorter occlusion time was chosen as the patient had reported severe skin reactions after open application of the disinfectans during regular use. All other patches were removed on D2 and readings were done on (D1), D2, D3, and D4. Strong positive patch tests reactions to ethylhexylglyerin 5% pet. (++) were observed on D2, D3 and D4. No positive reaction to any of the other commercial patch test preparations, including povidone iodine 10% aq., occurred, but the patient developed positive reactions to both tested concentrations of Desmanol pure (D2 +, D3/D4: ++) and Desderman (D2-D4: +) (Figure 1). During patch testing, a Repeated Open Application Test (ROAT) with all four hand disinfectants ‘as is’ was performed on the inside of her lower arms. Starting from D2, she developed a positive reaction to Desmanol pure. No reactions to the other three hand disinfectants occurred until D4. The patient was advised to continue the ROAT with Descoderm at home for up to ten days and it remained negative. Upon request, the manufacturer confirmed that Desmanol pure contains ethylhexylgycerin. No complete list of its constituents was publicly available or provided by the manufacturer stating that Desmanol pure is registered as biocida","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 2","pages":"180-182"},"PeriodicalIF":4.8,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14802","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contact Urticaria and Related Conditions: Clinical Review","authors":"Mojca Bizjak,&nbsp;Olivier Aerts,&nbsp;David Pesqué,&nbsp;Melba Muñoz,&nbsp;Riccardo Asero,&nbsp;Margarida Gonçalo,&nbsp;Thomas Rustemeyer,&nbsp;Mitja Košnik,&nbsp;Mark Kačar,&nbsp;An Goossens,&nbsp;Jose Hernán Alfonso,&nbsp;Charlotte G. Mortz,&nbsp;Maryam Ali Al-Nesf,&nbsp;Joachim W. Fluhr,&nbsp;Howard I. Maibach,&nbsp;Ana Maria Giménez-Arnau","doi":"10.1111/cod.14794","DOIUrl":"10.1111/cod.14794","url":null,"abstract":"<p>Contact urticaria (CoU) is an immediate contact reaction occurring within minutes to an hour after exposure to specific proteins or chemicals. CoU is categorised into non-immunologic (NI-CoU) and immunologic (I-CoU) types, with I-CoU potentially leading to anaphylaxis. Both forms of CoU can be associated with protein contact dermatitis and the CoU syndrome. Patients with I-CoU may also have other type I (immediate) allergic diseases, such as allergic conjunctivitis, rhinitis, asthma or food allergy. This review provides a detailed overview of CoU and related conditions, focusing on triggers, diagnostic methods and management strategies. NI-CoU is typically triggered by low molecular weight chemicals, while I-CoU involves IgE-mediated hypersensitivity to both high molecular weight proteins and low molecular weight chemicals. Early diagnosis is crucial, though CoU is often underrecognized. The diagnostic approach includes a thorough medical history, physical examination, evaluation of photographs, (non)invasive skin tests and in vitro assessments. Management strategies prioritise trigger avoidance and pharmacological treatments when avoidance is not fully possible. For I-CoU, second-generation H₁-antihistamines are the first-line treatment. Severe cases of I-CoU may benefit from anti-IgE therapy (omalizumab). Patients at risk of anaphylaxis should carry an adrenaline auto-injector and wear a medical alert bracelet.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 2","pages":"87-107"},"PeriodicalIF":4.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14794","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Composition of Brazilian and Chinese Propolis for Patch Testing","authors":"Evelyn Calta,&nbsp;Anton de Groot,&nbsp;Emma M. van Oers,&nbsp;Norbertus A. Ipenburg,&nbsp;Thomas Rustemeyer","doi":"10.1111/cod.14796","DOIUrl":"10.1111/cod.14796","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>In Amsterdam, in 2024, patch testing with Brazilian propolis yielded high rates of positive reactions (&gt; 20%), whereas reactivity to Chinese propolis was significantly lower (3.5%). Differences in the composition were suggested as a possible explanation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>1. To study the composition of 3 propolis samples (2 Chinese and 1 Brazilian) used for preparing commercial test allergens; 2. To study the influence of different enrichment times on the qualitative and quantitative composition of Brazilian propolis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Analyses were performed using gas chromatography–mass spectrometry/flame ionisation detection (GC–MS/FID) of the volatile components obtained by headspace SPME (solid phase microextraction).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A strong difference between the composition of the Brazilian propolis sample and both samples of Chinese propolis was found. Major ingredients in Brazilian propolis were hydrocinnamic acid (16.9%), (<i>E</i>)-nerolidol (7.41%), spathulenol (5.45%) and junenol (4.01%). Major ingredients in Chinese propolis were (<i>E</i>)-cinnamyl alcohol (8.08% and 24.96%), 2-phenethyl alcohol (8.93% and 11.25%), α-curcumene (8.77% and 8.81%) and guaiol (5.96% and 5.72%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The volatile fractions of Brazilian propolis and Chinese propolis used for patch testing have very different compositions. Whether this causes or contributes to the differences in patch test reactivity has to be investigated further.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 1","pages":"56-60"},"PeriodicalIF":4.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14796","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Art and Allergens: Non-Occupational Allergic Contact Dermatitis From Epoxy Resin, With Possible Sensitisation to Cobalt and Nickel","authors":"Leo Wan,&nbsp;Xiner Jiang,&nbsp;Jacky Lin,&nbsp;John Byrne,&nbsp;Anthony Szema","doi":"10.1111/cod.14795","DOIUrl":"10.1111/cod.14795","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 2","pages":"177-179"},"PeriodicalIF":4.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patch Testing in Cutaneous Adverse Drug Reactions: Insights From an Established UK Tertiary Referral Allergy Service","authors":"Joseph Jayasundera,&nbsp;Claire Leck,&nbsp;Xhoana Dashi-Smaili,&nbsp;Elizabeth Barachina,&nbsp;Dayana Angel,&nbsp;Thippeswamy Billahalli,&nbsp;Timothy J. Watts","doi":"10.1111/cod.14799","DOIUrl":"10.1111/cod.14799","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 2","pages":"159-162"},"PeriodicalIF":4.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of Aluminium Sensitisation in a French Paediatric Population","authors":"Laux Miranda,&nbsp;Letertre-lelou Oriane,&nbsp;Naimi Nour,&nbsp;Segretin Pierre,&nbsp;Labrèze Christine,&nbsp;Milpied Brigitte","doi":"10.1111/cod.14782","DOIUrl":"10.1111/cod.14782","url":null,"abstract":"&lt;p&gt;In 2018, we reported a high sensitization prevalence for aluminium (21.6%) in our paediatric population [&lt;span&gt;1&lt;/span&gt;]. At that time, we related this high level of sensitization in children to the number of vaccinations received in their first year of life. Six years later, we wanted to analyse the evolution of this sensitization in the same paediatric unit.&lt;/p&gt;&lt;p&gt;We used the same methods as the previous study, especially the same collection time of 3 years and the same paediatric department. But we have removed the metallic aluminium from the patch tests and have tested only with the aluminium chloride hexahydrate 2% pet. (Chemotechnique Diagnostics, Vellinge, Sweden) which is a better marker of aluminium sensitisation than metallic aluminium, as demonstrated in our previous study and other authors [&lt;span&gt;1-3&lt;/span&gt;]. From January 2021 to April 2024, all children patch tested for contact allergy were thereby tested with aluminium chloride. The reading was performed according to ICDRG recommendations and by the same dermatoallergologist as in the previous study [&lt;span&gt;1&lt;/span&gt;]. We have checked that all children tested had correctly received a classic vaccination schedule.&lt;/p&gt;&lt;p&gt;One hundred fifty-nine children were patch tested. The mean age was 8.14 years (2–17 years old) with 88 girls (55.35%) and 71 boys (44.65%). A history of atopy was found in 77 cases (48.43%). About 42 children had a positive test reaction to aluminium chloride (26.42%). The mean age of the children with positive reactions was 6.34 years. Of the 42 children who reacted positively to aluminium, 21 (50%) were atopic and only 4 (9.52%) had a history of persistent itching nodules. The evolution of the aluminium sensitisation according to the age of the children was represented in Table 1. Figure 1 illustrates the evolution of the aluminium sensitisation according to the number of vaccine injections.&lt;/p&gt;&lt;p&gt;We report here the persistence of a high sensitization prevalence for aluminium (26.42%) affecting a very young paediatric population, with or without persistent itching nodules.&lt;/p&gt;&lt;p&gt;In the previous study, we linked this high level of aluminium sensitisation with the vaccination calendar, in relation to the many injections of aluminium-containing vaccines in the first year of life. This higher level of sensitisation in this study compared to our first study has probably the same origin. We have also found a much higher level of sensitisation compared to others reported [&lt;span&gt;4, 5&lt;/span&gt;] This higher sensitisation may be due to our vaccination schedule. For instance, a Swedish study has found only 5.1% of aluminium sensitisation [&lt;span&gt;4&lt;/span&gt;]. In comparison with the French vaccination schedule, the Swedish one has fewer mandatory injections, like meningococcus B and C, BCG and VHB [&lt;span&gt;6, 7&lt;/span&gt;]. The age of the mandatory vaccines is also different from the French. They recommend the measles, mumps, rubella vaccine at 18 months and 1–2 years compared to 12 and 1","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 2","pages":"171-173"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14782","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Two Cases of Allergic Contact Dermatitis From Isobutylamido Thiazolyl Resorcinol (‘Thiamidol’) in Depigmenting Skin Care Routine","authors":"Léopoldine Vernhet,&nbsp;Ella Dendooven,&nbsp;Justine Pasteur,&nbsp;Lucas Belahssen,&nbsp;Olivier Aerts,&nbsp;Aude Clement","doi":"10.1111/cod.14793","DOIUrl":"10.1111/cod.14793","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 1","pages":"63-65"},"PeriodicalIF":4.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic Reaction to Dental Composite Resin: A Case Report","authors":"Yong-Wei Fu","doi":"10.1111/cod.14797","DOIUrl":"10.1111/cod.14797","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 1","pages":"71-72"},"PeriodicalIF":4.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benzalkonium Chloride Allergy Mimicking Tattoo Infection","authors":"Juliette Caron,&nbsp;Florence Libon,&nbsp;Christine Delebarre-Sauvage","doi":"10.1111/cod.14798","DOIUrl":"10.1111/cod.14798","url":null,"abstract":"&lt;p&gt;Benzalkonium chloride (BAK) is an antiseptic that has long been known to be an irritant. In recent years, its allergenicity has been highlighted [&lt;span&gt;1&lt;/span&gt;]. This cationic surfactant from the quaternary ammonium family is widely used in the health field, particularly as a skin disinfectant in France in the form of Biseptine [chlorhexidine 0.25%, benzyl alcohol 4%, BAK 0.25%] (Bayer Healthcare, Gaillard, France).&lt;/p&gt;&lt;p&gt;We report the case of a 42-year-old woman who had recurring vesicular, eczematous, and itchy lesions on her right forearm for 3 months following a tattoo in the same location. She had a history of contact reactions to dressings without investigation. From the first day of tattooing, the patient developed local skin inflammation with a vesicular reaction attributed to \u0000 &lt;i&gt;Staphylococcus aureus&lt;/i&gt;\u0000 infection by her general practitioner (GP) (Figure 1). She had no fever. She was treated with amoxicillin-clavulanic acid 3 g/d orally for 14 days, which partially improved her condition. She applied to the skin concomitantly Biseptine and Septivon 1.5% [chlorhexidine] (Perrigo France, Chatillon, France). Due to the persistence of inflammatory skin lesions on her forearm (Figure 1), she continued to apply antiseptics topically several times a day with locoid 0.1% [hydrocortisone-17-butyrate] (Cheplapharm France, Levallois-Perret, France). In the absence of improvement, she was treated a second time by her GP with amoxicillin-clavulanic acid 3 g/d orally for 10 days without success. The skin condition finally improved with Dermoval 0.05% [clobetasol propionate] (GlaxoSmithKline, Rueil-Malmaison, France) locally and oral desloratadine 5 mg/d on the advice of a dermatologist after stopping local antiseptics. A contact allergy to local antiseptics was suspected. We performed patch testing with Biseptine and its components (benzyl alcohol, chlorhexidine, BAK). The reading was done according to the International Contact Dermatitis Research Group criteria. The occlusion time was 48 h according to the European Society of Contact Dermatitis guidelines. The haptens were applied on the back using Finn Chambers. Patch tests were positive for BAK 0.1% aq (+) and Biseptine (BAK 0.25%, chlorhexidine 0.25%, benzyl alcool 4%) aq (++) (Figure 2) at D2. The rest of the substances were negative at D2 and D3. Patient consent was obtained for this article.&lt;/p&gt;&lt;p&gt;This case illustrates a vesicular reaction due to an allergy to BAK present in Biseptine. A similar reaction was described with a contact allergy to the topical antibacterials polymyxin B and bacitracin [&lt;span&gt;2&lt;/span&gt;]. Only 15 cases of monosensitisation to BAK in case of allergy to Biseptine have been described in the literature [&lt;span&gt;3&lt;/span&gt;]. The patient's history of allergy to dressings is likely due to her allergy to BAK, as it may be a component of dressings [&lt;span&gt;4&lt;/span&gt;]. BAK allergy is probably underestimated because sensitisation to BAK is not systematicall","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 2","pages":"174-176"},"PeriodicalIF":4.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14798","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}