Contact Dermatitis最新文献

{"title":"Epidemiology of Sensitivity to Nickel, Cobalt and Chromium in Israel: A Retrospective Cohort Study","authors":"Daniel Hilewitz, Akiva Trattner, Asher Hackett, Adi Raviv, Yehonatan Noyman, Stav Endelman, Dan Slodownik, Danny Daniely, Rivka Friedland, Daniel Mimouni, Igor Snast","doi":"10.1111/cod.14820","DOIUrl":"10.1111/cod.14820","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Nickel, cobalt and chromium are three common allergens included in the European baseline series (EBS). It was shown that sensitivity to nickel and cobalt is more frequent among young women, most commonly due to contact with inexpensive jewellery, while sensitivity to chromium is more common among older men. Israel is located in West Asia and hosts the largest Jewish population in the world. There is limited data regarding the epidemiology of these metals in Israel or in the Mediterranean region.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the epidemiology of sensitivity to nickel, cobalt and chromium in the EBS in a single center in Israel between 2009 and 2023.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Retrospective cohort study that included all patients who underwent patch testing with the EBS in a tertiary center in Israel between 2009 and 2023.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 5234 consecutive patients (1679 males [32.1%]) 2158 (41%) were sensitive to nickel, 541 (10.3%) to cobalt and 383 (7.3%) to chromium. During the study period, nickel sensitivity was stable and was associated with female sex and age 18–40 years. Among both sexes, cobalt sensitivity decreased significantly from 11.7% in 2009–2011 to 7.9% in 2020–2023 and was associated with female sex and age < 18 years. Chromium sensitivity decreased significantly from 11.1% in 2009–2011 to 5% in 2020–2023 and was associated with male sex and older age (> 60 years). Among both sexes, cobalt strongly co-reacted with nickel (OR = 1.69, 95% CI 1.38–2.06, <i>p</i> < 0.001) and chromium (OR = 3.57, 95% CI 2.67–4.55, <i>p</i> < 0.001). Nickel-cobalt co-sensitization was significantly more common among patients with strong (++) or very strong (+++) nickel sensitivity compared to patients with weak (+) sensitivity. Males, but not females, with nickel sensitivity positively co-reacted with chromium. Among patients with nickel sensitivity, the strong (++) or very strong (+++) reaction (36.3%) was significantly more common compared to patients with cobalt or chromium sensitivity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In this retrospective Israeli study, the prevalence of sensitivity to nickel was stable but much higher compared to European and North American studies, highlighting the necessity for multicenter and general population studies and possibly a legislation regarding nickel restriction of i","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 3","pages":"204-213"},"PeriodicalIF":4.6,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14820","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic Contact Dermatitis to Isobutylamido Thiazolyl Resorcinol (Thiamidol)","authors":"Thanisorn Sukakul,&nbsp;Jakob Dahlin,&nbsp;Sigrid Lundgren,&nbsp;Josefin Ulriksdotter,&nbsp;Cecilia Svedman","doi":"10.1111/cod.14821","DOIUrl":"10.1111/cod.14821","url":null,"abstract":"<p>We report a case of facial allergic contact dermatitis to isobutylamido thiazolyl resorcinol (Thiamidol), which has become available in cosmetics in recent years.</p><p>A 76-year-old non-atopic female presented with a facial rash for 1 year (Figure 1a). The rash was initially suspected to be a side effect of adalimumab for Crohn's disease, which was therefore discontinued. During the same period, she also applied Eucerin Hyaluron-Filler Day and Night creams and Sun Pigment Control SPF50+.</p><p>The patient was patch tested with the series listed in Table 1, own products, and possible allergens listed on the products. A photopatch test was also performed. The patient reacted positively to all Eucerin products tested as is (++). Thus, isobutylamido thiazolyl resorcinol, an ingredient in all the products, was procured (Fluorochem EU Limited, Cork, Ireland), diluted, and tested at different concentrations in petrolatum. A positive reaction to 0.2% and doubtful reactions to 0.06% and 0.02% of the substance were observed (Figure 1b), whereas patch testing with resorcinol was negative. Although photocontact allergy to benzophenone-3 was diagnosed, none of the patient's products contained benzophenone-3 (unknown relevance). The rash resolved after the patient discontinued using the products.</p><p>To exclude irritantancy and active sensitisation, 23 controls were tested with 0.2% isobutylamido thiazolyl resorcinol in petrolatum. No skin reactions were reported. Chemical analysis was performed using LC–MS, and isobutylamido thiazolyl resorcinol was found in all three products in concentrations between 0.11%–0.18%.</p><p>Isobutylamido thiazolyl resorcinol (N-[4-(2,4-Dihydroxyphenyl)-1,3-thiazol-2-yl]-2-methylpropanamide, CAS.1428450-95-6), a derivative of resorcinol, is a tyrosinase inhibitor, serving as a cosmetic skin-lightening ingredient [<span>1</span>]. Contact dermatitis to the substance was suspected in two participants (8%) in a control-trial study, and two confirmed cases of allergic contact dermatitis have recently been reported [<span>1, 2</span>].</p><p>Skin-lightening substances are important treatment options and frequently used in cosmetics. The market has expanded, and the new substances used are not automatically included in cosmetic patch test series. Therefore, possible contact allergy may not be diagnosed.</p><p>Despite publications on contact allergy to resorcinol and its derivatives [<span>3-5</span>], cross-reactions between the substances have not been established. Testing only with the commercially available substance, resorcinol, may not be sufficient. In this report, patch testing with 0.2% isobutylamido thiazolyl resorcinol was confirmed to be safe, did not cause irritation or active sensitisation, and could elicit an allergic reaction. However, there is a need for further studies on contact allergy, patch test doses and possible cross-reactivity.</p><p>In conclusion, isobutylamido thiazolyl resorcinol is an emerging cosmeti","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 3","pages":"260-262"},"PeriodicalIF":4.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14821","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotional Burden of Patients With Work-Related Hand Eczema: Results of an Exploratory Study in a Tertiary Individual Prevention Setting in Germany","authors":"Marc Rocholl,&nbsp;Richard Brans,&nbsp;Annika Wilke,&nbsp;Julia Meyer,&nbsp;Swen Malte John,&nbsp;Michaela Ludewig","doi":"10.1111/cod.14819","DOIUrl":"10.1111/cod.14819","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Work-related hand eczema (WRHE) is a prevalent skin condition associated with reduced health-related quality of life (HRQoL), sleep disturbances or depression. While prior studies primarily explored emotional effects as part of HRQoL, emotions have been less studied separately.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the psychometric properties of the ‘Atopic Eczema Score of Emotional Consequences’ (AESEC) in patients with WRHE and to investigate the emotional impact of WRHE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Self-reported sociodemographic data as well as self-reported and clinically assessed disease severity of 223 patients (55.6% female; mean age: 48.1 ± 12.0 years) taking part in a tertiary prevention program for WRHE were included in the analysis. The factor structure was checked using an exploratory factor analysis. The emotional burden was determined using the AESEC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The three underlying facets of emotional consequences, as previously described in the validation study of the AESEC, could not be replicated in patients with WRHE. Positive emotions were emphasised by items such as optimism, balance and self-confidence. Emotional burden was most evident in worries about life, sadness, lack of control, feelings of constraint and disturbance by itch.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Patients with WRHE face a significant emotional burden indicating a great need for psychological support. Further studies on the psychometric properties of the AESEC in patients with WRHE are warranted.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 3","pages":"243-251"},"PeriodicalIF":4.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14819","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photo-Aggravated Allergic Contact Dermatitis due to Hydroxyacetophenone Present in a Sunscreen: A Case Report.","authors":"David Pesqué, Emilio Berná-Rico, Gabija Rudzikaitė, Ramon M Pujol, Fernando Gallardo, Ana M Giménez-Arnau","doi":"10.1111/cod.14823","DOIUrl":"https://doi.org/10.1111/cod.14823","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Contact Allergy to Preservatives From 2014 to 2023: Benzisothiazolinone on the Rise","authors":"Rebekka Søgaard,&nbsp;Christoffer Kursawe Larsen,&nbsp;Jeanne Duus Johansen,&nbsp;Jakob Ferløv Baselius Schwensen","doi":"10.1111/cod.14818","DOIUrl":"10.1111/cod.14818","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Skin sensitising preservatives are commonly used in consumer and industrial products. The widespread use of preservatives has led to recurrent epidemics of contact allergy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To investigate temporal trends of contact allergy to preservatives from 2014 to 2023.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Patients consecutively patch tested with preservatives from the European baseline series and the supplementary baseline series at Gentofte hospital from 2014 to 2023 were included.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study population included 6435 patients. Contact allergy to benzisothiazolinone (BIT) increased significantly from ≤ 0.3% in 2014 to 5.0% in 2023. Painters and machine operators, and assemblers were most often sensitised to BIT, and detergents and paints were the most common exposures to BIT. Contact allergy to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) decreased significantly from 3.3% in 2014 to 2.2% in 2023. Likewise, contact allergy to MI declined significantly from 3.9% in 2014 to 2.5% in 2023. Stable trends were found for the overall prevalence of contact allergy to preservatives from 9.0% in 2014 to 10.2% in 2023.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Regulatory restrictions on the use of MI and MCI/MI in cosmetic products have led to a decrease in contact allergy. However, the rise in contact allergy to BIT underscores the need for ongoing monitoring and preventive measures.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 3","pages":"214-223"},"PeriodicalIF":4.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14818","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Requirements for Alternative In Vitro and In Silico Skin Models of Irritant and Allergic Contact Dermatitis","authors":"Meital Portugal-Cohen,&nbsp;Warangkana Lohcharoenkal,&nbsp;Evelyn Kelemen,&nbsp;Inge Kortekaas Krohn,&nbsp;Shauni De Vriese,&nbsp;Danuta Gutowska-Owsiak,&nbsp;Ivone Jakasa,&nbsp;Dijana Furundžić,&nbsp;Anna Zalewska-Janowska,&nbsp;Sandrine Dubrac","doi":"10.1111/cod.14815","DOIUrl":"10.1111/cod.14815","url":null,"abstract":"<p>Contact dermatitis is an inflammatory disease characterised by skin redness and swelling, oozing of fluid or pus and pain, caused by direct skin contact with an irritant or allergen. Its prevalence has skyrocketed worldwide, probably because human skin is in daily contact with an increasing gamut of irritants and allergens, which should require systematic surveillance. Large-scale testing is feasible by using organotypic and in silico skin models, which are becoming commonplace in industry and academic labs. In this work, we summarise the literature on models of contact dermatitis and provide insights on advantages, limitations and options for improvement.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 3","pages":"187-203"},"PeriodicalIF":4.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14815","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic Contact Dermatitis of the Vulva","authors":"Tirza Blom,&nbsp;Thirza G. Peschar,&nbsp;Thomas Rustemeyer,&nbsp;Sylvie M. Franken,&nbsp;Norbertus A. Ipenburg","doi":"10.1111/cod.14816","DOIUrl":"10.1111/cod.14816","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>While previous studies have investigated allergic contact dermatitis (ACD) in patients with chronic vulvar complaints, data on the clinical relevance of patch test results, particularly from spices and herbs series, remain limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To determine the frequency and clinical relevance of contact sensitisation to allergens in the European Baseline Series (EBS) and a spices and herbs series in patients with chronic vulvar complaints.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective analysis was conducted on all patients with chronic vulvar complaints who underwent patch testing with the EBS and spices and herbs series between January 2015 and January 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 67 patients tested, 86.6% exhibited at least one positive reaction, of which 37.9% were clinically relevant. Nearly half of the patients (43.3%) showed reactions to spices and herbs, with 34.5% having clinically relevant reactions. Bell pepper was the most frequent sensitizer throughout all spices. Metals were the most commonly identified allergens (50.8%), but only one case was clinically relevant. Fragrances elicited positive reactions in 37.3% of patients, with a higher clinical relevance (60%). Preservatives also showed a considerable clinical relevance (35%) among the 29.9% of patients who reacted positively. Conversely, reactions to surfactants, rubber additives, wool wax alcohols, and antibiotics were not deemed relevant to vulvar complaints.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>ACD is prevalent in patients with chronic vulvar complaints, underscoring the critical role of patch testing as a diagnostic tool. Both topically applied cosmetic and medicinal products, as well as systemically ingested substances, such as spices and herbs, may contribute to ACD affecting the vulvar region. To enhance diagnostic accuracy, patch test series should be tailored to the patient's clinical history and specific allergen exposures.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 3","pages":"234-242"},"PeriodicalIF":4.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14816","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Italian Trend of Contact Allergy to 2-Hydroxyethyl Methacrylate: Is the Current European Legislation Working?","authors":"Elena Sofia Caroppo,&nbsp;Gabriele Casciola,&nbsp;Katharina Hansel,&nbsp;Alba Guglielmo,&nbsp;Silvia Mariel Ferrucci,&nbsp;Fabrizio Guarneri,&nbsp;Maria Michela Lauriola,&nbsp;Maddalena Napolitano,&nbsp;Cataldo Patruno,&nbsp;Paolo Romita,&nbsp;Donatella Schena,&nbsp;Ilaria Trave,&nbsp;Leonardo Bianchi,&nbsp;Luca Stingeni,&nbsp;2-HEMA Study Group","doi":"10.1111/cod.14800","DOIUrl":"10.1111/cod.14800","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>(Meth)acrylates are well-known causes of allergic contact dermatitis, and nail products are the major source of exposure, especially in a non-occupational setting. In 2020, the European legislation restricted 2-hydroxyethyl methacrylate (2-HEMA) only in nail cosmetics to professional use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the Italian prevalence trend of positive patch test reactions to 2-HEMA, the best marker for delayed hypersensitivity to (meth)acrylates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective descriptive study on consecutive patients patch tested with the Italian baseline series containing 2-HEMA was performed in 8 Italian Dermatology Clinics. Demographics, patch test results, exposure settings and sources were analysed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Amongst 7133 patch tested patients, 147 (2.1%) resulted positive to 2-HEMA with an increasing trend from 2019 (1.6%) to 2023 (2.7%). The median age of sensitised female patients with a relevant positive patch test reaction to 2-HEMA was significantly decreasing over time (<i>p</i> = 0.004). Non-occupational allergic contact dermatitis was documented in 68.7%; artificial nails were the leading source of exposure in both occupational (75.0%) and non-occupational (72.2%) settings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The prevalence of contact allergy to 2-HEMA in Italy shows a progressively increasing trend over time. Currently, the European legislation does not appear to be effective in preventing or reducing this phenomenon.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 3","pages":"224-233"},"PeriodicalIF":4.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14800","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequent Positive Patch Test Reactions to Glucosides in Children: A Call for Caution?","authors":"Silada Kanokrungsee,&nbsp;Julie Leysen,&nbsp;Olivier Aerts,&nbsp;Ella Dendooven","doi":"10.1111/cod.14812","DOIUrl":"10.1111/cod.14812","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alkyl glucosides are surfactants commonly found in cosmetics and household products. However, data on glucoside contact allergy in paediatric populations is limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To determine the prevalence, relevance and clinical characteristics of contact allergy to glucosides in children.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective review of the files of paediatric patients (≤ 16 years) who underwent patch testing for decyl glucoside (DG) and/or lauryl glucoside (LG) at the Antwerp University Hospital (UZA) in the period between January 2018 and December 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 241 children tested for DG, 148 (61.4%) were also tested for LG. DG reactions were observed in 47 patients (19.5%), with 27 (11.2%) considered positive. LG reactions occurred in 17/148 (13%), but only 4 (2.7%) were positive, all with concomitant DG reactions. Most positive DG reactions were weak (+) (25/27), whereas only 2 were strong (++). The median age was 7 years (range: 2–15), with 51.9% female. Culprit sources mostly included cosmetics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Patch test reactions to glucosides readily occur in children, and the positivity rate is surprisingly high. Besides many irritant and doubtful reactions, false-positive (+) reactions likely occur, particularly in young atopic children. Careful interpretation of positive results and complementary work-up may thus be necessary.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 2","pages":"148-158"},"PeriodicalIF":4.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"p-Phenylenediamine-Free Hair Dye?—Misleading Labelling Causing Allergic Contact Dermatitis","authors":"Wimolsiri Iamsumang,&nbsp;Kevin Bertilsson,&nbsp;Jakob Dahlin,&nbsp;Pichamon Promsena,&nbsp;Ploychompoo Srisuwanwattana,&nbsp;Pranee Svetvilas,&nbsp;Penpun Wattanakrai,&nbsp;Annarita Antelmi,&nbsp;Cecilia Svedman,&nbsp;Thanisorn Sukakul","doi":"10.1111/cod.14813","DOIUrl":"10.1111/cod.14813","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>We report three cases of contact allergy to a mislabelled hair dye product. A hair dye product labelled as <i>p</i>-phenylenediamine-free has been found to contain <i>p</i>-phenylenediamine by a chemical analysis at the level above the limits allowed in the product.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 3","pages":"257-259"},"PeriodicalIF":4.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14813","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}