{"title":"Shiitake Dermatitis: First Report From Turkey","authors":"Ceyda Çaytemel, Cüyan Demirkesen","doi":"10.1111/cod.14783","DOIUrl":"10.1111/cod.14783","url":null,"abstract":"<p>A 54-year-old male patient presented with complaints of itching, redness, and swelling that had been present for two days. His general condition was good, and he had no systemic complaints. The patient had previously consulted a doctor twice with a similar rash and recovered in a short time. He had a history of hypertension and use of anti-hypertensive drugs. Dermatological examination showed wheals with a linear, flagellate appearance, concentrated on the neck and trunk, involving the upper extremities (Figure 1) and face. There was no mucosal involvement. In the punch biopsy specimen, a spongiotic dermatitis with marked papillary dermal oedema and some eosinophils was observed (Figure 2). When questioned, the patient stated that he liked eating and trying different types of mushrooms and Asian foods. He had also travelled to Japan thirteen times for business reasons. The day before the onset of the rash, he had consumed soup containing shiitake mushrooms at a Japanese restaurant in Turkey. With these clinical and pathological findings, the patient was diagnosed with shiitake dermatitis. It regressed in 3 days with topical steroid and antihistamine treatment.</p><p>Shiitake dermatitis is a self-limiting condition presenting with typical flagellate erythema that begins approximately 1–2 days after consumption of undercooked or uncooked shiitake mushrooms. Its pathogenesis is not clear. It is thought to be a toxidermia caused by the thermolabile polysaccharide component called lentinan found in the fungal cell wall. Some authors think that it is a hypersensitivity reaction seen in people with a genetic predisposition. Skin tests such as patch tests and prick tests were found to be positive in some patients and negative in others, and their results are contradictory [<span>1</span>]. This Turkish patient's frequent travels to Japan and consumption of Asian cuisine suggested that there may be an individual upper limit threshold in the mechanism of formation of this dermatitis, and it may occur with cumulative toxicity.</p><p>Differential diagnosis of linear/flagellate pruritic papules includes dermatographic urticaria, chemotherapy-associated flagellate erythema, dermatomyositis-associated flagellate erythema, adult-onset Still's Disease, and photophytodermatitis. In dermographism, the lesions are transient and short-lived. In flagellate erythema associated with chemotherapy, there is a drug history. Dermatomyositis can be distinguished by laboratory findings. In Shiitake dermatitis, there are no systemic symptoms as in adult-onset Still's Disease. In photophytodermatitis, there is a contact history.</p><p>Shiitake mushroom (<i>Lentinula edodes</i>) is the second most frequently consumed mushroom species in the world [<span>2</span>]. Due to the spread of East Asian cuisine culture in many countries, the number of countries where shiitake dermatitis is seen is increasing [<span>3</span>]. This case is the first case reported from Turkey. It is pr","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"92 6","pages":"500-501"},"PeriodicalIF":4.8,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14783","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A New Case of Allergic Contact Dermatitis to Topical Simvastatin Used for Treatment of Porokeratosis","authors":"Nadia Raison-Peyron, Céline Girard, Manon Girod, Olivier Dereure","doi":"10.1111/cod.14786","DOIUrl":"10.1111/cod.14786","url":null,"abstract":"<p>Topical statins (primarily simvastatin and lovastatin) have recently been introduced as a pathogenesis-directed treatment for disseminated actinic porokeratosis and other related forms of porokeratosis. We report a new case of allergic contact dermatitis following the use of a compounded preparation containing simvastatin and cholesterol in this context.</p><p>A 74-year-old patient with no significant medical history presented with linear porokeratosis on the right lower limb, which developed a few days after a total hip prosthesis implantation. The diagnosis of porokeratosis was confirmed histologically through a skin biopsy. Several topical treatments, including high-potent corticosteroids, calcipotriol and 5-fluoro-uracil ointments, were ineffective. He was subsequently treated with a compounded topical preparation containing 2% simvastatin and 2% cholesterol in a cold cream base (paraffinum liquidum, cera alba, cetyl palmitate and water) applied twice daily, which resulted in significant improvement of the skin lesions. Two months later, the patient received a second magistral preparation with the same concentration of simvastatin and cholesterol but in a different cream base, which included other excipients such as cetyl alcohol, propylene glycol, pentylene glycol and chlorphenesin. A few days after using this second preparation, the patient developed large, pruritic, erythematous, vesicular, crusted and/or squamous lesions over the porokeratotic areas of the right lower limb, with extension to the left calf, ankle and buttocks (Figure 1). The topical treatment was discontinued, and a high-potent corticosteroid cream was applied, leading to an improvement in the inflammatory lesions.</p><p>Patch tests were conducted on the upper back using IQ Ultra chambers (Chemotechnique Diagnostics, Vellinge, Sweden) occluded for 2 days with Opertape (Iberhospitex, Innovative Health Technologies, Barcelona, Spain). The European baseline series was tested along with additional haptens recommended by the REVIDAL-GERDA network (Réseau de Vigilance en Dermato-Allergologie du Groupe d'Etude et de Recherche en Dermato-Allergologie), 1% simvastatin in petrolatum (pet.) and 1% cholesterol in pet. from our hospital pharmacy. The patient's personal products (both preparations containing simvastatin and cholesterol) were tested ‘as is’ along with some of the ingredients from the second preparation such as propylene glycol 30% in water (aq.), pentylene glycol 10%aq., chlorphenesin 0,3% aq. and cetyl alcohol 5% in pet. The haptens were supplied by Chemotechnique Diagnostics except for pentylene glycol (Dipta, Aix-en-Provence, France) and chlorphenesin (provided by a cosmetic manufacturer). Patch tests were read on days 2 (D2) and 4 (D4) according to the ESCD recommendations [<span>1</span>].</p><p>All tests were negative except for simvastatin 1%pet. + on D2 and ++ on D4, and both preparations containing simvastatin ++ on D2 and D4, resulting in a final diagnosis o","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 1","pages":"73-75"},"PeriodicalIF":4.8,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14786","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cille Van Echelpoel, Silada Kanokrungsee, Olivier Aerts, Ella Dendooven
{"title":"Two Cases of Facial Allergic Contact Dermatitis From Hexyl Resorcinol, a ‘New’ Resorcinol Derivative in Depigmenting Products","authors":"Cille Van Echelpoel, Silada Kanokrungsee, Olivier Aerts, Ella Dendooven","doi":"10.1111/cod.14785","DOIUrl":"10.1111/cod.14785","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 1","pages":"61-62"},"PeriodicalIF":4.8,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Morten Bahrt Haulrig, Anna M. Andersson, Julia-Tatjana Maul, Jingyuan Xu, Su M. Lwin, Carsten Flohr, Lone S. Hove, Christopher E. M. Griffiths, Anders Koch, Claus Zachariae, Jacob Pontoppidan Thyssen, Tove Agner
{"title":"The Prevalence and Severity of Hand Eczema Among Adults in Tasiilaq, East Greenland","authors":"Morten Bahrt Haulrig, Anna M. Andersson, Julia-Tatjana Maul, Jingyuan Xu, Su M. Lwin, Carsten Flohr, Lone S. Hove, Christopher E. M. Griffiths, Anders Koch, Claus Zachariae, Jacob Pontoppidan Thyssen, Tove Agner","doi":"10.1111/cod.14781","DOIUrl":"10.1111/cod.14781","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hand eczema (HE) is described as a common disease in Greenland, but studies on its epidemiology and severity are lacking.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To investigate the point prevalence and severity of HE among adults in East Greenland in relation to age, sex, and occupation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In May 2022, we conducted a cross-sectional study in Tasiilaq, East Greenland. All adults aged ≥ 18 years were invited (<i>n</i> = 1311 individuals).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 295 participants accepted the invitation. Among these, the point prevalence of HE was 22.4% (95% confidence interval [CI]: 18.0–27.5, <i>n</i> = 66/295), and 5.0% based on the total invited population (<i>n</i> = 66/1311). The median age of participants with HE was 40 years (interquartile range [IQR]: 30–54), and the median age at disease onset was 25 years ([IQR]: 19–40). Females were more frequently affected than males (65.2%, <i>n</i> = 43/66). Atopic dermatitis was diagnosed in 7.6% of participants with HE. The mean Hand Eczema Severity Index (HECSI) score was 21 (range 2–112), and exposure to wet work was reported by 57.4% of the participants with HE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Hand eczema is common in East Greenland, with a point prevalence similar to that in Nordic countries. The severity and distribution of HE in relation to age, sex, and occupation were comparable to those reported in other European studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"93 1","pages":"49-55"},"PeriodicalIF":4.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14781","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence of Contact Allergy to Propolis—Testing With Different Propolis Patch Test Materials","authors":"Annarita Antelmi, Ilaria Trave, Rosella Gallo, Emanuele Cozzani, Aurora Parodi, Magnus Bruze, Cecilia Svedman","doi":"10.1111/cod.14773","DOIUrl":"10.1111/cod.14773","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Propolis is a sticky substance produced by honeybees from plant resins collected from locally growing vegetation. Its chemical composition varies depending on the plant species visited by the bees. Contact dermatitis is commonly reported following exposure to cosmetics containing propolis or following the intake of food supplements.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To investigate the prevalence of contact allergy to propolis in two dermatology clinics in Europe.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>From February to July 2023, consecutive adult dermatitis patients were patch tested in the Department of Dermatology in Genova, Italy and in the Department of Occupational and Environmental Dermatology in Malmö, Sweden, with propolis (10% in petrolatum) originating from China. In Genova, propolis (10% in petrolatum) originating from Brazil was also tested.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Out of 257 consecutive dermatitis patients patch tested in Genova, 16 (6.2%) reacted to propolis. Of these, 13 patients (5.1%) reacted to Brazilian propolis, one patient (0.4%) reacted to Chinese propolis, and two patients (0.8%) reacted to both. On patch testing 329 consecutive Swedish dermatitis patients with Chinese propolis, three patients (0.9%) reacted.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>A significant difference was observed in the number of reactors to Brazilian propolis and Chinese propolis within the Italian group. When testing with Chinese propolis, a low prevalence of contact allergy was observed in both countries.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"92 5","pages":"349-357"},"PeriodicalIF":4.8,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14773","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}