Contact Dermatitis最新文献

{"title":"Long-Term Risk of Allergic Contact Dermatitis in Children With Atopic Respiratory Disease When They Reach Adulthood","authors":"Sergio De Marchi, Emanuela Cecchin, Sergio Umberto De Marchi, Leonardo Alberto Sechi","doi":"10.1111/cod.70198","DOIUrl":"10.1111/cod.70198","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The long-term risk of allergic contact dermatitis (ACD) in children with atopic disease is a matter of debate.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The study aimed to assess the long-term risk of patients with childhood-onset atopic asthma and/or rhinitis (AtRD), with and without childhood-onset atopic dermatitis (CoAD), to develop ACD in adulthood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A prospective cohort study with 15-year follow-up was conducted on 620 consecutive young adult patients (age 18–25 years) with childhood-onset AtRD (before the age of 16), and 173 healthy control subjects. All participants underwent skin prick tests for inhalant and food allergens. Patients were assigned to 2 cohorts. The NAD cohort included 483 patients with AtRD who had never had signs of atopic dermatitis. The AD cohort included 137 patients who, in addition to AtRD, had a presence or previous history of CoAD (onset within the first 5 years of life). Patients who showed clinical suspicion of contact dermatitis during follow up performed a patch test with a panel of 40 contact allergens. Those who tested positive for at least one contact allergen were considered to have contact allergy (CA). Patients with CA in whom the positive patch test had clinical relevance, assessed through detailed exposure analysis, were considered to be suffering from ACD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At the end of follow-up, the proportions of patients with CA (77.4% [106 of 137 patients] vs. 20.7% [100 of 483 patients]; <i>p</i> < 0.001) and patients suffering from ACD (52.6% [72 of 137 patients] vs. 14.7% [71 of 483 patients]; <i>p</i> < 0.001) were higher in the AD cohort than in the NAD cohort. In both cohorts, CA and ACD rates were higher than in control subjects (5.2% [9 of 173] controls; <i>p</i> < 0.001 and 1.7% [3 of 173 controls]; <i>p</i> < 0.001). In the overall group of participants, the multivariate Cox proportional hazards regression model showed that ACD was positively associated with AtRD (hazard ratio 1.67, 95% CI, 1.21–2.28, <i>p</i> = 0.001) and CoAD (hazard ratio 7.40, 95% CI, 5.74–9.52, <i>p</i> < 0.001) but not with IgE-mediated food allergy. In the AD cohort, the proportion of ACD did not differ between patients who had healed AD and those whose disease persisted into adulthood (49.2% [32 of 65 patients] vs. 55.5% [40 of 72 patients]), and the relative risk of ACD did not differ significantly between the two groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Patients wi","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"95 4","pages":"370-379"},"PeriodicalIF":4.1,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148257716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: Acrylate Copolymers/Crosspolymers in Sunscreens: Minimally Allergenic, Without Evidence of Need for Avoidance by (Meth)acrylate-Sensitized Individuals","authors":"Emily J. Levin, Christopher Chung, Katia Hermes, Henry W. Lim, Natalie H. Matthews","doi":"10.1111/cod.70214","DOIUrl":"10.1111/cod.70214","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"95 4","pages":"432-433"},"PeriodicalIF":4.1,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Tralokinumab in a Hairdresser With Severe Chronic Hand Eczema and Occupational Allergic Contact Dermatitis","authors":"Gabriel Portero-Campillo, Laura Ortiz-Granjo, Fernando Navarro-Blanco, Mercedes Rodríguez-Serna","doi":"10.1111/cod.70208","DOIUrl":"10.1111/cod.70208","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"95 4","pages":"428-429"},"PeriodicalIF":4.1,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148307291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alkyl Glucosides in Rinse-Off and Leave-On Cosmetics Available on the Dutch Market","authors":"Mounir Yaâkoubi, Norbertus A. Ipenburg, Anton C. de Groot, Thomas Rustemeyer","doi":"10.1111/cod.70200","DOIUrl":"10.1111/cod.70200","url":null,"abstract":"<p>Alkyl glucosides (decyl, lauryl, cetearyl, coco-, others) are nonionic surfactants and emulsifiers produced by the reaction of glucose with fatty alcohols. Their use in cosmetics has increased in recent years. These compounds are considered to have a low irritation potential and favourable ecological properties, as they are derived from renewable resources and are biodegradable. Contact allergy and allergic contact dermatitis caused by alkyl glucosides are increasingly recognized. In routine patch testing, positive reactions are reported in up to 2.4% of patients in North America and up to 1.5% in Europe. The majority of these reactions (> 80%) are currently relevant, most often due to the presence of alkyl glucosides in personal care products. Alkyl glucosides are most commonly found in shampoos and body washes marketed for infants. However, data on their presence in cosmetic products are largely limited to the United States (manuscripts under review). We therefore analysed the occurrence of alkyl glucosides in 650 cosmetic products (350 leave-on and 300 rinse-off) available on the Dutch market.</p><p>Ingredient lists of 350 leave-on and 300 rinse-off cosmetics were collected from www.bol.com, the largest online retailer in the Netherlands. Details of the selection procedure and data collection can be found in the Supporting Information Materials and Methods in Data S1.</p><p>Details of the cosmetics investigated (brands, countries of origin, number of products per brand and per country) are shown in the Supporting Information Tables S1–S3 (350 leave-on cosmetics) and Supporting Information Tables S4–S6 (300 rinse-off cosmetics).</p><p>The presence of the various alkyl glucosides in the 350 leave-on cosmetics is shown in Table 1. 24% of sunscreens, 22% of day creams, 17% of night creams, and 14% of eye creams contained at least one alkyl glucoside, whereas only one of 50 lip salves did. The percentage of all products with ≥ 1 glucoside was 16.9%, which increased to 19.3% when lip salves were excluded.</p><p>The most frequently identified alkyl glucoside was cetearyl glucoside (33 products, 9.4%), followed by decyl glucoside (15 products, 4.3%) and arachidyl glucoside (8 products, 2.3%). Few products contained coco-glucoside (<i>n</i> = 5), C12-20 alkyl glucoside (<i>n</i> = 4), glyceryl glucoside (<i>n</i> = 3) or lauryl glucoside (<i>n</i> = 1).</p><p>The presence of the various alkyl glucosides in the 300 rinse-off cosmetics is shown in Table 2 (separate file). 62% of the baby shampoos, 62% of shower gels, 56% of baby shower gels, 40% of facial wipes, 38% of liquid hand soaps, 32% of shampoos and 28% of cleansing milks contained at least one alkyl glucoside. Of the entire group of 300 rinse-off products, 47.3% contained one or more alkyl glucosides.</p><p>The most frequently identified alkyl glucoside was coco-glucoside (101 products, 33.7%), followed by decyl glucoside (31 products, 10.3%) and lauryl glucoside (23 products, 7.7%). Few o","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"95 4","pages":"419-421"},"PeriodicalIF":4.1,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.70200","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148249608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic Contact Dermatitis With Erythema Multiforme-Like Features Induced by Isoconazole Nitrate","authors":"Giorgia Sbarra, Giuseppe Demichele, Francesca Ambrogio, Alexandre Raphael Meduri, Paolo Antonio Danza, Caterina Foti","doi":"10.1111/cod.70204","DOIUrl":"10.1111/cod.70204","url":null,"abstract":"<p>Polymorphous eruptions with erythema multiforme-like features represent a rare non-eczematous presentation of allergic contact dermatitis. Unlike true erythema multiforme, these reactions occur in the context of contact sensitization and may show targetoid, erythemato-vesicular, urticarial or oedematous lesions, usually without mucosal involvement [<span>1, 2</span>].</p><p>We report the case of a 22-year-old female student with a history of atopic dermatitis who developed an acute eruption after topical application of Travocort (isoconazole nitrate 1% + diflucortolone valerate 0.1%) for tinea corporis. The reaction started at the application site as an eczematous plaque and, over 14 days, progressed to a widespread polymorphous eruption.</p><p>Clinical examination showed a large erythematous-oedematous plaque on the left lateral trunk with targetoid, urticarial and erythemato-vesicular features, associated with similar lesions involving the inguinal folds and thighs. Direct mycological examination performed at presentation and after clinical resolution was negative.</p><p>Patch tests were performed using the SIDAPA 2023 baseline series (Società Italiana di Dermatologia Allergologica Professionale e Ambientale; SmartPractice, Rome, Italy) in occlusion for 2 days (D2) with allergEAZE patch test chambers (SmartPractice, Phoenix, USA) on Soffix tape (Artsana, Grandate, Italy), and read on D2, D4 and D7 according to ICDRG criteria. Travocort cream was also tested (Figure 1).</p><p>The SIDAPA baseline series was negative at all readings. Travocort cream showed a positive reaction graded ++ at D2, D4 and D7, with erythematous-oedematous and urticarial-like morphology at D4, when photographs were taken. The active components were then tested separately: isoconazole nitrate, CAS 27523-40-6, 1% pet., and diflucortolone valerate, CAS 59198-70-8, 0.1% pet. Isoconazole nitrate showed a typical eczematous reaction graded ++ at D2, D4 and D7, whereas diflucortolone valerate remained negative at all readings.</p><p>The eruption progressively resolved after withdrawal of Travocort and treatment with topical clobetasol propionate.</p><p>In the present case, we describe allergic contact dermatitis to isoconazole nitrate presenting with an unusual polymorphous clinical morphology.</p><p>This presentation required distinction from true erythema multiforme and dermatophytid reaction. True erythema multiforme was considered unlikely because mucosal involvement was absent and the eruption followed topical exposure. Dermatophytid reaction was also considered, given the eruption developed on presumably active tinea corporis; however, the onset at the treated site, rapid spreading after Travocort application, negative direct mycological examination at presentation and positive delayed patch test reactions were more consistent with allergic contact dermatitis.</p><p>Erythema multiforme-like patterns in allergic contact dermatitis remain incompletely understood. Although","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"95 4","pages":"422-424"},"PeriodicalIF":4.1,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.70204","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148239093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational Allergic Contact Dermatitis Caused by Cyclohexyl Diethanolamine in a Metalworking Fluid","authors":"Maria Pesonen, Sari Suomela, Katri Suuronen","doi":"10.1111/cod.70210","DOIUrl":"10.1111/cod.70210","url":null,"abstract":"<p>The patient is a machinist involved in this work for the past 25 years. He has had regular skin contact with a metalworking fluid (MWF) in the form of splashes and aerosol and the MWF leaking through the protective gloves, which are textile gloves partially coated with rubber. The MWF product used at the worksite has remained the same during the past few years. The patient has no previous history of dermatitis. He developed eczema on the hands, forearms, face and anterior side of the trunk and legs. The eczema healed on sick leave and has remained in remission after the patient retired from his work. The patient gave informed consent for publishing his case. At the manufacturer's request, the name of the MWF product and the manufacturer is not disclosed.</p><p>Patch testing was performed with Finn Chambers (SmartPractice, Calgary, Canada) with baseline series and a selection of Finnish Institute of Occupational Health (FIOH)'s patch test series including rubber, antimicrobial, oils and cutting fluids, ethanolamines, coconut fatty acid derivatives, glues and plastics and cosmetics series. The patient patch tested weakly positive to monoethanolamine (MEA, CAS 141–43-5) 2% and showed doubtful reactions to MEA 1%, and to diethanolamine (CAS 111–42-2) 2% and 1% present in the ethanolamines series (Table 1). As workplace material, an unused, undiluted sample of the patient's MWF was tested as 10% pet, 3.2% pet and 1.0% pet (Figure 1A). As the patient tested positive to it, the ingredients of the product were inquired about and were kindly provided by the manufacturer of the MWF. A dilution series of the MWF down to 0.01% (Figure 1B) and its 16 ingredients were then patch tested on the patient. One of them, cyclohexyl diethanolamine (cyclohexyl-DEA, or (cyclohexylimino)-bisethanol, CAS 4500-29-2) whose concentration in the MWF was 3%, gave a strong positive reaction (Figure 1C) and another ingredient described as “monoethanolamine dilutions,” gave a weak positive reaction (Table 1).</p><p>Patch tests of unexposed volunteers with cyclohexyl-DEA 2.0% pet (<i>n</i> = 20) were negative. As the ingredient “monoethanolamine dilutions” turned out to be identical to the MEA patch tested in the FIOH ethanolamines series and which is a known contact allergen, there was no need to test control patients with it. Repeated open application test (ROAT) with cyclohexyl-DEA was not performed in the patient. The patient was diagnosed with occupational allergic contact dermatitis caused by cyclohexyl-DEA and MEA in a MWF.</p><p>To our knowledge, this is the first report on contact allergy to cyclohexyl-DEA. Allergy to it was only discovered by testing the patient's own MWF and its ingredients.</p><p>Cyclohexyl-DEA resembles other alkanolamine derivatives that are used for example as pH adjusters and corrosion inhibitors in water-miscible MWF. According to the Finnish Chemical Products Register [<span>1</span>], cyclohexyl-DEA is currently listed in only two active chem","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"95 4","pages":"413-415"},"PeriodicalIF":4.1,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.70210","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148307257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Allergic Contact Sensitizations to UVA Sunscreen Filters Including Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate (Mexoryl 400).","authors":"Antoine Badaoui","doi":"10.1111/cod.70244","DOIUrl":"https://doi.org/10.1111/cod.70244","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Facial Pustules With 'In Situ' Patch Test Positivity.","authors":"Mariana Ventura Pedroso, André Pinho, David Caetano, Ana Carolina Figueiredo, Margarida Gonçalo","doi":"10.1111/cod.70237","DOIUrl":"https://doi.org/10.1111/cod.70237","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aluminium Sensitization After Vaccination: Report of Three Adult Cases.","authors":"Marie de Broqueville, Nadia Raison-Peyron, Florence Libon, Juliette Caron, Axel De Greef, Anne Herman","doi":"10.1111/cod.70242","DOIUrl":"https://doi.org/10.1111/cod.70242","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148879334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic Contact Dermatitis Caused by Magnolia officinalis Bark Extract and Ascorbyl Palmitate in a BB Cream.","authors":"Antoine Badaoui","doi":"10.1111/cod.70240","DOIUrl":"https://doi.org/10.1111/cod.70240","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}