Contact Dermatitis最新文献

{"title":"Severe allergic contact dermatitis caused by methoxypropylamino cyclohexenylidene ethoxyethylcyanoacetate","authors":"Audrey Loretan, Federica Bertone, Sebastien Menzinger, Pierre Piletta, Yassaman Alipour Tehrany","doi":"10.1111/cod.14700","DOIUrl":"10.1111/cod.14700","url":null,"abstract":"<p>Methoxypropylamino cyclohexenylidene ethoxyethylcyanoacetate (MCE) is a new UVA1 filter utilised in sunscreen formulations. We report a case of an allergic contact dermatitis (ACD) caused by MCE.</p><p>A 59-year-old woman with a history of atopic dermatitis presented with chronic and severe facial dermatitis persisting for 1 year. Initially, she was treated with topical corticosteroids and calcineurin inhibitors leading to partial improvement. Physical examination revealed well-demarcated infiltrated erythematous plaques on the face (Figure 1). A biopsy was performed, and histological examination showed a slight epidermal spongiosis associated with a moderate perivascular and perifollicular infiltrate composed of lymphocytes and histiocytes in the superficial dermis with many vascular ectasia. We concluded the diagnosis of mixed facial dermatitis, comprising atopic dermatitis/ACD and rosacea induced by chronic use of topical corticosteroids. Topical corticosteroids were discontinued, and treatment with topical calcineurin inhibitors was continued. A treatment with doxycycline was initiated. However, the patient continued to present flares of her dermatitis.</p><p>Patch tests were first performed with the European baseline series, preservatives, emulsifiers, corticosteroids and personal products. Patch test materials were supplied by Chemotechnique Diagnostics Vellinge, Sweden. At the readings at 48 and 96 h, the patch tests showed positive results (++) for her sunscreen (Anthelios UVMUNE 400 SPF 50+ from LaRoche-Posay, France). Photopatch tests were also performed with the European baseline series (Chemotechnique Diagnostics Vellinge, Sweden) and the Antelios sunscreen. The results were positive for Anthelios (++) both before and after exposure to 5 J/cm<sup>2</sup> of UVA, with a final reading at 96 h, confirming the diagnosis of contact allergic dermatitis to the sunscreen. We completed the patch tests with different components of this product provided by LaRoche-Posay and the test was positive for MCE 1% 50 aqua (aq)/50 alcool (alc) (++) at 48 and 96 h (Figure 2). To ensure that MCE was not an irritant, we patch-tested this UV filter on 12 healthy atopic controls, and the readings at 48 and 96 h were negative. Discontinuing the sunscreen resulted in the resolution of the lesions within approximately 1 week.</p><p>The use of sunscreen with effective UVA and UVB protection is essential for preventing sun-induced skin damage and cancer.</p><p>Sunscreens efficiently filtrate UVB, UVA2 and UVA1 up to 370 nm radiations. However, it is known that UVA1 (340–400 nm) have a higher potential of penetrating and producing harmful skin damage. Until recently, there was a lack of absorption in the 370–400 nm wavelength range. MCE is a new UVA1 filter with an absorption peak at 385 nm and a coverage ranging between 360 and 400 nm.<span><sup>1</sup></span> In 2020, the European Commission approved the use of MCE as a UV filter, following the conclusions of ","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"92 1","pages":"80-81"},"PeriodicalIF":4.8,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute generalised exanthematous pustulosis induced by betamethasone sodium phosphate: A case report","authors":"Ayaki Matsumoto, Eriko Hayashi, Chiharu Tateishi, Daisuke Tsuruta","doi":"10.1111/cod.14694","DOIUrl":"10.1111/cod.14694","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"92 1","pages":"77-80"},"PeriodicalIF":4.8,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of patch testing with plants “as is” in diagnosing plant sensitization","authors":"Evy Paulsen,&nbsp;Charlotte G. Mortz","doi":"10.1111/cod.14680","DOIUrl":"10.1111/cod.14680","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The number of commercially available plant allergens/extracts is limited and therefore patch testing with fresh/dried plant material may be a necessary supplement in diagnosing plant allergy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the usefulness of patch testing with plants “as is” compared to patch testing with commercial and in-house produced plant test materials and to report on species eliciting positive patch test reactions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients/Materials/Methods</h3>\u0000 \u0000 <p>Consecutive eczema patients, who were patch tested between January 2019 and December 2023 and who had at least one positive reaction to a plant allergen and/or extract and/or plant “as is” were included in the study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total 57 out of 1893 patients tested (3%) were sensitised to plants. Compositae plants were the most frequent sensitizers, followed by tomato, tulipalin A, falcarinol, and <i>Philodendron</i> plants. In 12 patients (21%), the diagnosis was based on patch testing with fresh plants only. Occupational sensitization occurred in 32%. Other sensitizers included <i>Hydrangea</i>, <i>Pelargonium zonale</i>, and <i>Monstera</i>.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A large minority of plant-sensitised patients would have been undiagnosed without patch testing with plants “as is.” Most of the culprit plants were known sensitizers, but not commercially available, and these and new species taken into cultivation makes patch testing with fresh plants unavoidable and worthwhile.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"91 6","pages":"459-464"},"PeriodicalIF":4.8,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142250278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extensive allergic contact dermatitis to dexpanthenol with distant facial and symmetrical intertriginous involvement: An unusual clinical presentation","authors":"Elisabeth Victoria Goessinger,&nbsp;Tamara Merkel,&nbsp;Sibylla Chantraine,&nbsp;Karin Hartmann","doi":"10.1111/cod.14693","DOIUrl":"10.1111/cod.14693","url":null,"abstract":"&lt;p&gt;Dexpanthenol, a derivative of panthothenic acid, is a common agent in wound-healing ointments, cosmetics and moisturising lotions due to its anti-inflammatory and regenerative properties.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; Its potential to cause allergic contact reactions is rare and is therefore often overlooked.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;A 38-year-old male technician presented with pruritic erythematous confluent papules and plaques on the ventral left forearm, left cubital fossa and left ventral abdomen with symmetrical exanthematous involvement of the intertriginous folds (Figure 1A–D). Periorbital oedema and oozing erythematous plaques with honey-yellow crusts were observed on the face and neck (Figure 1E).&lt;/p&gt;&lt;p&gt;He had previously applied Bepanthen® Plus Cream (containing dexpanthenol and chlorhexidine dihydrochloride) for 8 days to a newly engraved tattoo on his left lower forearm, where the rash was most severe. Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) was ruled out by lack of systemic drug use in the temporal context. Biopsy of the left arm revealed a spongiotic dermatitis compatible with disseminated eczema. Suspicion of secondary impetiginisation was confirmed by detection of &lt;i&gt;Staphylococcus aureus&lt;/i&gt; in cheek and ear swabs and colonisation of the nose. Intertriginous Candida infection was mycologically excluded.&lt;/p&gt;&lt;p&gt;Skin testing with repeated open application of Bepanthen® Plus Cream showed a clearly positive reaction with manifestation of erythematous papules and plaques after 24 h (Figure 2A). Antiseptic treatment with chlorhexidine digluconate and antibiotic- and steroid-containing cream was well tolerated. Skin Patch Testing was carried out according to the German Contact Dermatitis Research Group (DKG) guidelines using Finn Chambers on Scanpor tape. The testallergens were provided by SmartPractice, especially chlorhexidin gluconat 0.5% in aqua and dexpanthenol 5% in petrolatum. Bepanthen® Plus and Bepanthen® Cream (Bayer, Switzerland AG, Zurich) were tested ‘as is’. Readings on day 2 and 3 showed type IV hypersensitivity only to dexpanthenol, confirming allergic contact dermatitis due to exposure to this ointment component (Figure 2B).&lt;/p&gt;&lt;p&gt;According to data from the Information Network of Departments of Dermatology (IVDK) in cooperation with the German Contact Allergy Group (DKG), only 1.2% of patients with dexpanthenol patch testing between 1992 and 1999 had a positive reaction.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; Previous case reports in the literature predominantly describe only localised contact allergic reactions with regional spread, most commonly on the hands, face, and lower legs.&lt;span&gt;&lt;sup&gt;1-4&lt;/sup&gt;&lt;/span&gt; In contrast, our case demonstrates the potential of dexpanthenol-containing ointments to also induce extensive allergic contact reactions that can involve distant anatomical sites and even clinically imitate SDRIFE.&lt;/p&gt;&lt;p&gt;Thus, caution is warranted when applying hapten containing products to new","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"92 1","pages":"75-77"},"PeriodicalIF":4.8,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14693","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142250279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atopic dermatitis and hand eczema in Danish adults: A nationwide population-based study","authors":"Anna Schultz Vinge,&nbsp;Lone Skov,&nbsp;Jeanne Duus Johansen,&nbsp;Anna Sophie Quaade","doi":"10.1111/cod.14691","DOIUrl":"10.1111/cod.14691","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Atopic dermatitis (AD) and hand eczema often co-occur, particularly among adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To examine the interplay between AD and hand eczema in the general population, by characterising prevalence, disease severity, contact sensitization, and comorbidities in individuals with one or both conditions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In this cross-sectional study, 100 000 randomly selected adults in the Danish general population received a questionnaire via a secure, digital mailbox linked to their civil registration number. Participants answered questions regarding eczema, disease severity, patch testing, and comorbidities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 40 007 individuals responded to the question on a lifetime prevalence of AD, and the prevalence among adult Danes was 9.0%. Nearly one third of individuals with AD reported moderate to severe disease. AD was associated with contact sensitization and increased hand eczema prevalence. Individuals with both AD and hand eczema reported worse disease severity. Furthermore, having both conditions was associated with an increased risk of psychiatric comorbidities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study provided updated information about unselected adults with AD in Denmark. Individuals with both AD and hand eczema represent a vulnerable subgroup that physicians should be attentive to.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"92 1","pages":"21-30"},"PeriodicalIF":4.8,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14691","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142188588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomonitoring of hand and forearm transepidermal water loss and skin pH among nursing apprentices","authors":"Željka Babić,&nbsp;Franka Šakić,&nbsp;Jelena Macan","doi":"10.1111/cod.14690","DOIUrl":"10.1111/cod.14690","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Measurements of transepidermal water loss (TEWL) and <i>stratum corneum</i> (SC) pH can help indicate work-related skin barrier damage, but sensitivity to confounding personal and ambient factors limits their potential as biomonitoring tools.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the difference between hand and forearm skin barrier conditions as a tool for early recognition of workers with occupational contact dermatitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Participants and Methods</h3>\u0000 \u0000 <p>The participants were nursing apprentices (<i>N</i> = 238, median age 19 years) from Zagreb, Croatia. They filled out a questionnaire based on the Nordic Occupational Skin Questionnaire, underwent a clinical examination of skin on the hands, and were evaluated for their TEWL and SC pH on the dorsum of the hand and volar part of the forearm.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We found that the difference between hand and forearm TEWL values (ΔTEWL) greater than 7 g/m²/h, or &gt;50%, or the difference in SC ΔpH &gt;0.50, predicted visible skin changes found on clinical examination. However, only the association with ΔpH &gt;0.50 retained statistical significance when controlled for sex, age, ambient temperature, and relative humidity in a multiple regression model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The difference between hand and forearm SC pH values is suggested as a reliable biomonitoring tool in recognition of damaged skin barrier conditions in occupational settings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"92 1","pages":"41-50"},"PeriodicalIF":4.8,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142250280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low sensitivity of a self-report questionnaire for hand eczema in hairdressing apprentices","authors":"Jelena Kovačić,&nbsp;Zrinka Franić,&nbsp;Adrijana Bjelajac,&nbsp;Jelena Macan","doi":"10.1111/cod.14686","DOIUrl":"10.1111/cod.14686","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The validity of the self-report questionnaire for hand eczema (HE) among Croatian hairdressers was not investigated previously, leading to uncertainty in the prevalence estimated from self-reported data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To (1) investigate the validity of the self-report questionnaire for HE in hairdressing apprentices and (2) examine the differences between apprentices who recognised their HE symptoms and those who did not.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Clinical examination for HE signs on hands and wrists was performed by the Osnabrueck Hand Eczema Severity Index for 408 apprentices at four visits covering the entire schooling period. Self-report HE was based on the Nordic Occupational Skin Questionnaire.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Low sensitivity (7%–37%) with high specificity (≥95%) was observed, with both measures improving from baseline to last visit. The severity of HE signs was the only factor associated with the correct identification of HE signs in analyses adjusted for previous HE signs, health-related quality of life, and atopic dermatitis (adjusted odds ratios of 1.58 with 95% confidence interval [1.06–2.35] and 1.74[1.38–2.19] at second and third follow-up visit, respectively).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Self-report questionnaire for HE showed low sensitivity in hairdressing apprentices, especially at the beginning of training and in those with mild symptoms. Further validation studies following questionnaire modifications aimed at adolescent population are advised.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"91 6","pages":"506-512"},"PeriodicalIF":4.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142188590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of allergic contact dermatitis in Finland 1998–2021: A nationwide registry-based study","authors":"Ville Wikström,&nbsp;Suvi-Päivikki Sinikumpu,&nbsp;Jari Jokelainen,&nbsp;Laura Huilaja","doi":"10.1111/cod.14688","DOIUrl":"10.1111/cod.14688","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Allergic contact dermatitis (ACD) may be chronic and can cause distress, disability, and absence from work. Nationwide epidemiological studies of ACD are sparse.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To use national registry data to study the incidence and aetiology of ACD in the working age population of Finland.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patient records from the years 1998–2021 were obtained from the Finnish Care Register for Health Care. Study subjects aged 18–65 years were selected on the basis of a diagnosis of ACD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Total number of study subjects was 26 701. The incidence of ACD increased until 2016 after which it started to decrease. The increase was more marked in females and ACD was particularly common in women reporting reactions to cosmetics and other chemical products and in people of both sexes reacting to adhesives. The incidence ‘ACD of unspecific cause’ has decreased since 2016. The most commonly reported allergens were metals, followed by cosmetics. One fourth of subjects had ≥2 ACD diagnoses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The incidence of ACD in working age subjects rose from 1998 to 2016, especially in females. However, the incidence has been decreasing since 2016. Our findings highlight the ongoing and even increasing burden of ACD among the working age population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"92 2","pages":"113-119"},"PeriodicalIF":4.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14688","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142188589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic contact dermatitis to octyl and butylcyanoacrylate as well as formaldehyde in Leukosan® surgical glue","authors":"Antoine Badaoui,&nbsp;Anne-Claire Fougerousse,&nbsp;Aude Roussel","doi":"10.1111/cod.14689","DOIUrl":"10.1111/cod.14689","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"92 1","pages":"73-75"},"PeriodicalIF":4.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patch testing in non-immediate hypersensitivity to cotrimoxazole: Is it useful?","authors":"João Nuno Soares,&nbsp;João Pedro Teixeira,&nbsp;Ana Carolina Figueiredo,&nbsp;André Castro Pinho,&nbsp;Margarida Gonçalo","doi":"10.1111/cod.14692","DOIUrl":"10.1111/cod.14692","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Existing literature has questioned the sensitivity of patch testing (PT) with cotrimoxazole (CTX) in the study of drug hypersensitivity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Assess the sensitivity of PT with CTX in non-immediate cutaneous adverse drug reactions (CADR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients/Materials/Methods</h3>\u0000 \u0000 <p>Retrospective analysis (2000–2022) of PT with an antibiotic series including CTX 10% pet (Chemotechnique Diagnostics©) performed according to ESCD guidelines in patients with suspected non-immediate CADR reactions to CTX. Some patients were additionally tested with in-house preparations of CTX from Bactrim DS® tablets at 10% in pet or water and trimethoprim 10% pet (Laboratórios Edol©).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sixty-four patients (48F/16M; mean age 47 ± 18) were included, mostly with maculopapular exanthema (51, 80%). Notably, CTX was sole suspect in 24 patients. There was no positive reaction to CTX at 10% from Chemotechnique or Bactrim DS® tablets prepared at 10% pet for patch testing. One patient reacted exclusively to trimethoprim with 1+ reaction. Two patients had a faint reaction (1+) only with the powder of Bactrim DS® tablets in water at D2, but as the reactions faded completely in 24 or 48 h, they were interpreted as irritant non-specific reactions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings suggest that patch testing may lack sufficient sensitivity to diagnose CTX-induced non-immediate CADR. Therefore, clinicians should be cautious interpreting CTX patch test results.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"91 6","pages":"503-505"},"PeriodicalIF":4.8,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}