2014 - 2023年防腐剂接触性过敏趋势：苯并异噻唑啉酮呈上升趋势

IF 4.8 1区医学 Q2 ALLERGY

Contact Dermatitis Pub Date : 2025-05-30 DOI:10.1111/cod.14818

Rebekka Søgaard, Christoffer Kursawe Larsen, Jeanne Duus Johansen, Jakob Ferløv Baselius Schwensen

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引用次数: 0

摘要

背景：皮肤致敏防腐剂通常用于消费品和工业产品。防腐剂的广泛使用导致了接触性过敏的反复流行。目的：了解2014 - 2023年我国接触性防腐剂过敏的时间变化趋势。材料和方法：纳入2014年至2023年Gentofte医院连续使用欧洲基线系列和补充基线系列防腐剂进行贴片试验的患者。结果：研究人群包括6435例患者。接触性苯并异噻唑啉酮（BIT）过敏率由2014年的≤0.3%显著上升至2023年的5.0%。油漆工、机器操作员和装配工对BIT最敏感，洗涤剂和油漆是BIT最常见的暴露点。甲基氯异噻唑啉酮/甲基异噻唑啉酮（MCI/MI）接触性过敏由2014年的3.3%显著下降至2023年的2.2%。同样，接触性过敏对MI的影响也从2014年的3.9%显著下降到2023年的2.5%。接触性防腐剂过敏的总体患病率呈稳定趋势，从2014年的9.0%上升到2023年的10.2%。结论：化妆品中使用MI和MCI/MI的监管限制导致接触性过敏的减少。然而，接触性BIT过敏的增加强调了持续监测和预防措施的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Trends in Contact Allergy to Preservatives From 2014 to 2023: Benzisothiazolinone on the Rise.

Background: Skin sensitising preservatives are commonly used in consumer and industrial products. The widespread use of preservatives has led to recurrent epidemics of contact allergy.

Objectives: To investigate temporal trends of contact allergy to preservatives from 2014 to 2023.

Materials and methods: Patients consecutively patch tested with preservatives from the European baseline series and the supplementary baseline series at Gentofte hospital from 2014 to 2023 were included.

Results: The study population included 6435 patients. Contact allergy to benzisothiazolinone (BIT) increased significantly from ≤ 0.3% in 2014 to 5.0% in 2023. Painters and machine operators, and assemblers were most often sensitised to BIT, and detergents and paints were the most common exposures to BIT. Contact allergy to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) decreased significantly from 3.3% in 2014 to 2.2% in 2023. Likewise, contact allergy to MI declined significantly from 3.9% in 2014 to 2.5% in 2023. Stable trends were found for the overall prevalence of contact allergy to preservatives from 9.0% in 2014 to 10.2% in 2023.

Conclusions: Regulatory restrictions on the use of MI and MCI/MI in cosmetic products have led to a decrease in contact allergy. However, the rise in contact allergy to BIT underscores the need for ongoing monitoring and preventive measures.

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来源期刊

Contact Dermatitis 医学-过敏

CiteScore

4.60

自引率

30.90%

发文量

227

审稿时长

4-8 weeks

期刊介绍： Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".