儿童对糖苷类药物频繁的斑贴试验阳性反应:应引起警惕?

IF 4.8 1区 医学 Q2 ALLERGY
Silada Kanokrungsee, Julie Leysen, Olivier Aerts, Ella Dendooven
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引用次数: 0

摘要

背景:烷基糖苷是化妆品和家用产品中常见的表面活性剂。然而,关于儿科人群中葡萄糖苷接触性过敏的数据有限。目的:了解儿童糖苷接触性过敏的患病率、相关性及临床特点。方法:回顾性分析2018年1月至2024年12月在安特卫普大学医院(UZA)接受癸基葡萄糖苷(DG)和/或十二烷基葡萄糖苷(LG)贴片试验的儿科患者(≤16岁)的档案。结果:在241名接受DG检测的儿童中,148名(61.4%)也接受了LG检测。47例(19.5%)患者出现了DG反应,其中27例(11.2%)为阳性。148例患者中有17例(13%)发生LG反应,但仅有4例(2.7%)阳性,均伴有DG反应。大多数阳性DG反应是弱(+)(25/27),而只有2个是强(++)。中位年龄为7岁(范围:2-15岁),女性占51.9%。罪魁祸首主要包括化妆品。结论:儿童对葡萄糖苷的斑贴试验反应容易发生,且阳性率高得惊人。除了许多刺激性和可疑反应外,假阳性(+)反应也可能发生,特别是在年轻的特应性儿童中。因此,可能需要仔细解释阳性结果和补充的后续工作。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Frequent Positive Patch Test Reactions to Glucosides in Children: A Call for Caution?

Frequent Positive Patch Test Reactions to Glucosides in Children: A Call for Caution?

Background

Alkyl glucosides are surfactants commonly found in cosmetics and household products. However, data on glucoside contact allergy in paediatric populations is limited.

Objectives

To determine the prevalence, relevance and clinical characteristics of contact allergy to glucosides in children.

Methods

A retrospective review of the files of paediatric patients (≤ 16 years) who underwent patch testing for decyl glucoside (DG) and/or lauryl glucoside (LG) at the Antwerp University Hospital (UZA) in the period between January 2018 and December 2024.

Results

Among 241 children tested for DG, 148 (61.4%) were also tested for LG. DG reactions were observed in 47 patients (19.5%), with 27 (11.2%) considered positive. LG reactions occurred in 17/148 (13%), but only 4 (2.7%) were positive, all with concomitant DG reactions. Most positive DG reactions were weak (+) (25/27), whereas only 2 were strong (++). The median age was 7 years (range: 2–15), with 51.9% female. Culprit sources mostly included cosmetics.

Conclusions

Patch test reactions to glucosides readily occur in children, and the positivity rate is surprisingly high. Besides many irritant and doubtful reactions, false-positive (+) reactions likely occur, particularly in young atopic children. Careful interpretation of positive results and complementary work-up may thus be necessary.

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来源期刊
Contact Dermatitis
Contact Dermatitis 医学-过敏
CiteScore
4.60
自引率
30.90%
发文量
227
审稿时长
4-8 weeks
期刊介绍: Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".
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