刺激性和过敏性接触性皮炎的体外和硅皮肤模型的替代要求。

IF 4.8 1区医学 Q2 ALLERGY

Contact Dermatitis Pub Date : 2025-05-30 DOI:10.1111/cod.14815

Meital Portugal-Cohen, Warangkana Lohcharoenkal, Evelyn Kelemen, Inge Kortekaas Krohn, Shauni De Vriese, Danuta Gutowska-Owsiak, Ivone Jakasa, Dijana Furundžić, Anna Zalewska-Janowska, Sandrine Dubrac

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引用次数: 0

摘要

接触性皮炎是一种炎症性疾病，其特征是皮肤发红和肿胀，渗出液体或脓液和疼痛，由皮肤直接接触刺激物或过敏原引起。它的流行率在世界范围内急剧上升，可能是因为人类皮肤每天接触越来越多的刺激物和过敏原，这应该需要系统的监测。通过使用有机型和硅皮肤模型进行大规模测试是可行的，这在工业和学术实验室中越来越普遍。在这项工作中，我们总结了接触性皮炎模型的文献，并提供了优势，局限性和改进方案的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Requirements for Alternative In Vitro and In Silico Skin Models of Irritant and Allergic Contact Dermatitis.

Contact dermatitis is an inflammatory disease characterised by skin redness and swelling, oozing of fluid or pus and pain, caused by direct skin contact with an irritant or allergen. Its prevalence has skyrocketed worldwide, probably because human skin is in daily contact with an increasing gamut of irritants and allergens, which should require systematic surveillance. Large-scale testing is feasible by using organotypic and in silico skin models, which are becoming commonplace in industry and academic labs. In this work, we summarise the literature on models of contact dermatitis and provide insights on advantages, limitations and options for improvement.

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来源期刊

Contact Dermatitis 医学-过敏

CiteScore

4.60

自引率

30.90%

发文量

227

审稿时长

4-8 weeks

期刊介绍： Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".