Burden of Pain and Use of Analgesics in Patients With Chronic Hand Eczema-Findings From the Danish Skin Cohort.

IF 4.8 1区医学 Q2 ALLERGY

Contact Dermatitis Pub Date : 2025-05-16 DOI:10.1111/cod.14814

Jeanette Halskou Haugaard, Johan Sieborg, Emma Guttman-Yassky, David Thein, Jonathan I Silverberg, Lars Erik Kristensen, Jacob P Thyssen, Alexander Egeberg

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引用次数: 0

Abstract

Background: Skin pain is a common symptom in patients with chronic hand eczema (CHE); however, its association with increased analgesic use has not been thoroughly investigated.

Objectives: To examine analgesic use (paracetamol, nonsteroidal anti-inflammatory drugs [NSAIDs], opioids and gabapentin/pregabalin) among patients with CHE compared to a control group.

Methods: Data were obtained from the Danish Skin Cohort and the Danish national registries. Patients with dermatologist-verified CHE were systematically interviewed, including questions on skin and joint pain experienced within the past 7 days.

Results: The study included 1032 patients with CHE and 11 166 controls. We observed an overall higher utilisation of analgesics among patients with CHE compared to the control group. The highest utilisation of analgesics was observed for paracetamol (35.3% vs. 25.7%) followed by NSAIDs (21.5% vs. 15.3%). When stratified by disease severity, patients with moderate-to-very-severe CHE consistently used more analgesics compared to those with mild CHE.

Conclusion: This study highlights the significant burden of pain in patients with CHE, as evidenced by their higher utilisation of analgesics compared to the general population in Denmark.

查看原文本刊更多论文

慢性手湿疹患者的疼痛负担和镇痛药的使用——来自丹麦皮肤队列的发现。

背景：皮肤疼痛是慢性手湿疹（CHE）患者的常见症状；然而，其与增加止痛药使用的关系尚未被彻底调查。目的：比较CHE患者与对照组的镇痛药使用情况（扑热息痛、非甾体抗炎药[NSAIDs]、阿片类药物和加巴喷丁/普瑞巴林）。方法：数据来自丹麦皮肤队列和丹麦国家登记处。对经皮肤科医生证实的CHE患者进行系统访谈，包括过去7天内皮肤和关节疼痛的问题。结果：本研究纳入1032例CHE患者和11166例对照。我们观察到，与对照组相比，CHE患者镇痛药的总体利用率更高。镇痛药使用率最高的是扑热息痛（35.3%对25.7%），其次是非甾体抗炎药（21.5%对15.3%）。当按疾病严重程度分层时，与轻度CHE患者相比，中度至极重度CHE患者一贯使用更多的镇痛药。结论：这项研究强调了CHE患者的显著疼痛负担，与丹麦的普通人群相比，他们对镇痛药的使用更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Contact Dermatitis 医学-过敏

CiteScore

4.60

自引率

30.90%

发文量

227

审稿时长

4-8 weeks

期刊介绍： Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".