Clinical and Experimental Dental Research最新文献

{"title":"Bond Strength of Injectable Composites Under Different Enamel Treatments and Bonding Strategies","authors":"João Daniel Paganella Chaves,&nbsp;Elisa Souza Camargo,&nbsp;Rodrigo Nunes Rached,&nbsp;Evelise Machado de Souza","doi":"10.1002/cre2.70464","DOIUrl":"10.1002/cre2.70464","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The effectiveness of enamel acid etching may be enhanced when combined with additional surface treatments, such as diamond bur grinding. However, there are no reports of the effect of enamel grinding and bonding strategies when a universal adhesive and highly filled flowable composites are used. The aim was to evaluate the effect of enamel grinding and adhesive strategy on the microshear bond strength (micro-SBS) of injectable composite resins.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>One hundred sixty enamel specimens were randomly allocated into 16 groups according to enamel preparation (diamond bur grinding or no grinding), adhesive strategy (self-etch or etch-and-rinse), and composite type (three injectable composites and one conventional composite). After 48 h of water storage, the specimens were tested for micro-SBS in a universal testing machine (0.5 mm/min). Data were analyzed using three-way ANOVA and Tukey's test for micro-SBS data, and Fisher's exact test and Chi-square test for failure mode (<i>α</i> = 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A significant main effect was observed for bonding strategy (<i>p</i> &lt; 0.001), but not for enamel preparation (<i>p</i> = 0.042) and composite resin (<i>p</i> = 0.044). The etch-and-rinse strategy resulted in significantly higher bond strength than the self-etch approach, irrespective of the enamel preparation, for all the resin composites (<i>p</i> &lt; 0.05). Adhesive strategy was the most frequent mode of failure (35%), with self-etching yielding a 70% rate of adhesive failures compared to 0% for the etch-and-rinse approach.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The etch-and-rinse strategy improved enamel bond strength and eliminated adhesive failures for all composites tested, regardless of enamel grinding.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Significance</h3>\u0000 \u0000 <p>Enamel should be etched before applying a universal adhesive for injectable composite restorations, as this increased bond strength and eliminated adhesive failures regardless of enamel grinding or composite type. Diamond bur grinding only reduced adhesive failures when the self-etch mode was used.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70464","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Oral Health Assessment Tool Findings With Periodontal Screening Outcomes in Adults With Diabetes","authors":"Grace Wong,&nbsp;Sarah Glastras,&nbsp;Sarah Brennan,&nbsp;Marija Saponja,&nbsp;Anna Cheng,&nbsp;Jami Walk,&nbsp;Kyle Cheng,&nbsp;Wenpeng You","doi":"10.1002/cre2.70465","DOIUrl":"10.1002/cre2.70465","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Periodontal disease is common among adults with diabetes, yet periodontal screening is rarely incorporated into routine outpatient diabetes care. The Oral Health Assessment Tool (OHAT) is a structured observational tool designed for non-dental healthcare professionals; however, its relationship with periodontal screening findings remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To examine the association between OHAT findings and periodontal screening outcomes in adults attending diabetes outpatient clinics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional study included adults with type 1 or type 2 diabetes at a tertiary hospital in Sydney, Australia. Periodontal screening was performed using the Periodontal Screening and Recording (PSR) system, and oral health was assessed using OHAT. Periodontal status was dichotomized as no/mild (PSR 0–2) versus moderate-to-severe (PSR ≥ 3). Logistic regression examined associations of OHAT domains and total OHAT burden with periodontal status. Covariate-adjusted models assessed robustness. Screening performance was evaluated using sensitivity, specificity, and predictive values.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 120 participants (mean age 61.5 years, 64.2% with type 2 diabetes), 71.4% demonstrated moderate-to-severe periodontal findings. Mean OHAT score was 4.99 (SD 2.02). Change/unhealthy ratings for tongue (OR 3.23, 95% CI 1.30–8.02), gums and oral tissues (OR 4.59, 95% CI 1.78–11.85), and increasing categories of decayed teeth (OR 2.06, 95% CI 1.05–4.05) were associated with moderate-to-severe findings. Higher total OHAT score (&gt; 5 vs. ≤ 5) was strongly associated with moderate-to-severe periodontal findings (OR 7.00, 95% CI 2.25–21.76), with consistent results. This threshold showed high specificity (87.5%) and positive predictive value (90.9%), but moderate sensitivity (50.0%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>OHAT findings were associated with moderate-to-severe periodontal screening findings among adults with diabetes, supporting further evaluation of OHAT as a pragmatic screening and referral aid in settings where formal periodontal assessment is not routinely available. Its performance when administered by non-dental clinicians requires further investigation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental Barotrauma and Pressure-Related Dental Pain Among Civilian Scuba Divers in Dakar, Senegal: A Cross-Sectional Study","authors":"Adjaratou Wakha Aidara,&nbsp;S. Kassir,&nbsp;F. Leye-Benoist","doi":"10.1002/cre2.70451","DOIUrl":"10.1002/cre2.70451","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study estimated the career-to-date prevalence of self-reported dental barotrauma and of pressure-related dental pain consistent with barodontalgia among civilian scuba divers in Dakar, Senegal, and explored associated factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A STROBE-compliant cross-sectional study was conducted between March 15 and October 20, 2023 across the three organized civilian diving clubs of Dakar. An anonymous questionnaire, adapted into French from published instruments, was offered to the 360 registered divers, online and then on paper. Outcomes were self-reported; no clinical examination was performed. Pain reported exclusively at constant depth was excluded from the primary case definition. Prevalences carry Wilson-score 95% confidence intervals; exploratory models used Firth penalized regression. No adjustment was made for multiple comparisons.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 160 participants (118 men, 73.8%; mean age 34.9 ± 11.2 years), 24 reported dental barotrauma (15.0%; 95% CI: 10.3–21.3) and 21 reported pressure-related dental pain (13.1%; 95% CI: 8.7–19.2), rising to 16.2% without the phase restriction; 36 divers (22.5%) reported at least one event. Most affected divers located an event at 20 m or shallower. Posterior, maxillary, and previously restored teeth were each frequently reported. Barotrauma showed crude associations with longer experience (median 10 vs. 4 years; <i>p</i> = 0.006), older age (<i>p</i> = 0.048), more than 60 lifetime dives (<i>p</i> = 0.029), and CMAS certification (<i>p</i> &lt; 0.001); certification and club membership were almost entirely collinear and were never modeled together.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>About one respondent in five reported a pressure-related dental event during their diving career, yet only half had told their dentist that they dive and fewer than one in five had received diving-specific advice. Because outcomes were self-reported and clinically unverified, these findings are hypothesis-generating.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic Computer-Assisted Dental Implant Surgery Versus Free-Hand and Guided Techniques: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","authors":"Sultan Ainoosah,&nbsp;Redhwan Saleh Al-Gabri,&nbsp;Omar M. Alaryani,&nbsp;Ahmad Abdulkareem Alnazzawi,&nbsp;Ahmed E. Farghal,&nbsp;Ahmed Yaseen Alqutaibi","doi":"10.1002/cre2.70460","DOIUrl":"10.1002/cre2.70460","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Robotic computer-assisted implant surgery (r-CAIS) aims to improve implant placement trueness, but existing reviews include heterogeneous designs, and no review has exclusively synthesized RCTs to date. This review aimed to evaluate the positional trueness and clinical outcomes of r-CAIS compared with free-hand implant surgery (FHIS), dynamic computer-assisted implant surgery (<span>d</span>-CAIS), and static computer-assisted implant surgery (s-CAIS), through a systematic review and meta-analysis of RCTs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This systematic review was conducted according to PRISMA 2020 guidelines. Electronic searches were performed in major biomedical databases from inception to March 2026. Only RCTs were eligible. Risk of bias was assessed using the RoB 2 tool and certainty of evidence was rated using the GRADE framework. Meta-analyses were performed using a random-effects model where feasible.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seven RCTs enrolling 529 implants were included. Moderate-certainty evidence demonstrated significantly improved positional trueness with r-CAIS over FHIS across all deviation parameters, with the largest effect observed for angular deviation (MD = −4.56°; 95% CI −6.25 to −2.86). High certainty evidence showed a significant angular deviation advantage of r-CAIS over <span>d</span>-CAIS (MD = −0.77°; 95% CI: −1.33 to −0.21), while platform and apical deviations did not differ significantly. All comparisons with s-CAIS were non-significant, rated low to very low certainty from a single small trial. Operative time evidence was very low certainty, precluding any directional conclusion. Early implant retention ranged from 93.3% to 100% across all modalities with no meaningful between-group differences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>r-CAIS improves implant positional trueness compared with free-hand surgery, supported by moderate certainty evidence, with a high certainty angular deviation advantage over dynamic navigation. However, improved trueness has not been shown to translate into better clinical or patient-reported outcomes. Wider clinical use should depend on long-term, multicenter RCTs using standardized patient-centered outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Periodontal Disease and Cumulative Coping Challenges: A Retrospective Cross-Sectional Exploratory Educational Study","authors":"David C. Johnsen,&nbsp;Lauren A. G. Erickson,&nbsp;Derek Smith,&nbsp;Carlos Garaicoa-Pazmino","doi":"10.1002/cre2.70457","DOIUrl":"10.1002/cre2.70457","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Scarce scientific evidence is available on the association of cumulative coping challenges and periodontitis. The present retrospective cross-sectional exploratory study explored a new method to depict the association between periodontal disease (extent/severity/rate of progression) and cumulative coping challenges.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A population sample was identified with an array of periodontal disease levels and coping challenges within an academic setting. In January 2026, a total of 39 student-led patient presentations were recorded using an ordinal scale based on the 2017 American Academy of Periodontology/European Federation of Periodontology framework of staging/grading and a cumulative coping challenges score, including biologic, sociologic, behavioral, demographic, and oral disability-related factors. Spearman's correlation analysis was used to correlate periodontal disease level and cumulative coping challenges.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A distinct and significant association was found between level of periodontal disease and cumulative coping challenges (Spearman's <i>ρ </i>= 0.77, 95% CI, <i>p</i> &lt; 0.01). Clusters of patients depicted that those with mild forms of periodontal disease (Stages I–II) had few coping challenges and another group with severe forms of periodontal disease (Stages III–IV) harbored higher cumulative coping challenges. No person appeared with high disease and low cumulative coping challenges, and only one person appeared with low disease and high coping challenges.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This retrospective cross-sectional exploratory study quantified risk factors from a series of cumulative coping challenges resulting in a single metric to be correlated with disease level based on the current staging/grading system for periodontal diseases. Periodontitis was observed among individuals with minimal disease and few coping challenges, and another group with severe stages and extensive coping challenges. Despite the theoretical limitation of the proposed scale, the present model has a practical use in an educational setting as an exploratory composite index.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occlusal Adjustment in Free-End Implant-Supported Restorations: Digital Scans Versus Conventional Impressions With Full- and Half-Arch Techniques","authors":"Mohammadreza Nakhaei,&nbsp;Hossein Dashti,&nbsp;Arsalan Shahri,&nbsp;Mahsa Rahmani,&nbsp;Ali Kazemian,&nbsp;Saeid Sabzevari,&nbsp;Masih Rezaee","doi":"10.1002/cre2.70454","DOIUrl":"10.1002/cre2.70454","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objectives&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To quantify the occlusal adjustment required for two-unit, implant-supported polymethyl-methacrylate (PMMA) crowns with either digital or conventional impression techniques, using full-arch and half-arch workflows.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Material and Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;An acrylic maxillary–mandibular model carrying two bone-level implant analogs (sites 46–47) was mounted on a semi-adjustable articulator. Twenty impressions were made (&lt;i&gt;n&lt;/i&gt; = 5 per group): digital full-arch, digital half-arch, conventional full-arch, and conventional half-arch. PMMA crowns were designed using computer-aided design (CAD) software, milled, and surface-scanned before adjustment. Occlusal contacts were refined on the articulator with 21 µm film while recording adjustment time. Pre- and post-adjustment scans were superimposed and analyzed using three-dimensional surface analysis software to quantify mean material reduction (µm). Data were analyzed with one-way ANOVA and independent-samples &lt;i&gt;t&lt;/i&gt;-tests (&lt;i&gt;α&lt;/i&gt; = 0.05).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Digital workflows required significantly less occlusal reduction (146 ± 35 µm vs. 226 ± 35 µm; &lt;i&gt;p&lt;/i&gt; = 0.035) and shorter adjustment times (144 ± 36 s vs. 385 ± 36 s; &lt;i&gt;p&lt;/i&gt; &lt; 0.001) than conventional, with no effect of arch span (full vs. half; &lt;i&gt;p&lt;/i&gt; &gt; 0.05). Within protocols, the digital half-arch group showed the smallest adjustment (127 ± 37 µm) and fastest finishing (98 ± 33 s), whereas the conventional half-arch group required the longest time (456 ± 21 s).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Fully digital impressions reduce both the amount of occlusal adjustment and the chairside time needed to seat implant-supported crowns compared with conventional silicone impressions. Reducing the scan to a half-arch does not compromise occlusal precision, making the digital half-arch workflow an efficient alternative for posterior, free-end implant restorations.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Clinical Relevance&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;In implant posterior PMMA crowns, the impact of impression/workflow choice on occlusal adjustment is unclear. This in-vitro study measured occlusal reduction and chairside time across digital versus conventional and full- versus half-arch workflows. Digital, especially half-arch, required less adjustment and shorter time. Clinically, a digital half-arch approach may streamline delivery and reduce unnecessary material removal,","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70454","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148988224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accessing Polyphenols Effect on Bond Strength and Dentin Enzymatic Degradation","authors":"Ana Catarina Rios Castro Alves,&nbsp;Adonias Antonio da Silva,&nbsp;Roberta Bruno da Silva,&nbsp;Rayan de Lima França,&nbsp;Dayse Andrade Romão,&nbsp; de Fragoso,&nbsp;Natanael Barbosa dos Santos,&nbsp; de Porto","doi":"10.1002/cre2.70449","DOIUrl":"10.1002/cre2.70449","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Polyphenols have been investigated in dental materials and restorative techniques due to their interactions with metal cations, antioxidant activity, and collagen crosslinking ability, which make them a promise for reinforcing the dental substrate and improving material adhesion. However, more studies are necessary before to support their use in clinical procedures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study evaluated the effects of quercetin and resveratrol on bond strength and the protection of dentin collagen fibrils against enzymatic degradation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Demineralized human dentin specimens were immersed for 1 min in solutions of quercetin or resveratrol (100, 250, and 500 µg/mL), 2% chlorhexidine (CHX), or 0.9% saline (control). The specimens were then incubated in collagenase for 24 h at 37°C, and changes in dry mass were measured. For microtensile bond strength testing, quercetin, resveratrol, CHX, or distilled water (DW) were applied to phosphoric acid–conditioned dentin, followed by application of Single Bond 2 (3 M/ESPE) adhesive and Z350XT resin (3 M/ESPE). Adhesive strength was measured after 24 h and after 1 year in distilled water. Data were analyzed using the Kruskal–Wallis and Dunn tests or ANOVA followed by Tukey's test (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Quercetin-treated specimens showed a significant weight increase compared with CHX (<i>p</i> &lt; 0.05). Both quercetin- and resveratrol-treated groups exhibited resistance to collagenase similar to CHX (<i>p</i> &gt; 0.05). After 1 year, only the DW group showed a significant decrease in bond strength (<i>p</i> = 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Dentin treatment with quercetin or resveratrol effectively preserved adhesive strength and protected collagen against enzymatic degradation, suggesting their potential as agents to improve the longevity of adhesive restorations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13577594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148976006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Vaping on Treatment Outcomes in Patients With Gingivitis, Periodontitis, and/or Peri-Implant Disease: A Systematic Review","authors":"Stacey May Gould,&nbsp;Catherine Anne Gilchrist,&nbsp;Hannah Dominique Gaza,&nbsp;Ibadat Kaur Sidhu,&nbsp;Kayleigh Jade Hugo,&nbsp;Rodrigo Rodrigues Amaral,&nbsp;João Martins de Mello-Neto","doi":"10.1002/cre2.70456","DOIUrl":"10.1002/cre2.70456","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This systematic review aimed to evaluate the effect of vaping on periodontal treatment outcomes for patients with gingivitis, periodontitis, and/or peri-implant disease.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>An electronic database search was conducted using Ovid MEDLINE, PubMed, Scopus, and Web of Science, with no date restrictions. An electronic search was conducted through June 30, 2026. Two independent reviewers extracted data according to predefined inclusion criteria and performed screening and quality appraisal. The risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Scale and the Cochrane Risk of Bias tool.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seven studies were included, involving 640 participants: 168 vapers, 138 traditional cigarette smokers, and 334 non-smokers. There was no significant difference in clinical response to periodontal and peri-implant therapy between tobacco and e-cigarette users, both of whom fared worse than non-smokers. Immunological outcomes were similar between smokers and vapers, with some exceptions, such as higher TNF-α levels in e-cigarette users. No meta-analysis was performed due to the heterogeneity of the included studies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Current limited evidence suggests that vaping may be associated with less favorable periodontal and peri-implant treatment outcomes compared with non-smoking, with trends resembling those observed in cigarette smokers. Further research is required to clarify the extent to which vaping affects treatment outcomes compared to cigarette smokers.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13577596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Craniofacial Morphology and Dental Age Assessment in Pediatric Craniosynostosis: A Comparative Cross-Sectional Study","authors":"Nutthakarn Ratanasereeprasert,&nbsp;Yanisa Wongbanthit,&nbsp;Narin Intarak,&nbsp;Preeya Suwanwitid,&nbsp;Chutimont Teekavanich,&nbsp;Anand Marya,&nbsp;Guang Hong,&nbsp;Thantrira Porntaveetus","doi":"10.1002/cre2.70445","DOIUrl":"10.1002/cre2.70445","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To delineate the craniofacial morphometric characteristics of Thai children with syndromic (SC) and non-syndromic craniosynostosis (NSC) and to assess dental maturation relative to Chronological Age (CA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This comparative cross-sectional study evaluated 19 patients (SC: <i>n</i> = 13; NSC: <i>n</i> = 6; mean age 9.32 ± 2.67 years). Seventeen skeletal and dental cephalometric variables were analyzed against age-matched ethnic norms. Dental age (DA) was quantified using the modified Demirjian's four-tooth method, calibrated via the Thai-specific Duangto model. One-sample and Welch's <i>t</i>-tests compared DA with CA and skeletal parameters with normative data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>SC patients demonstrated significant maxillary retrusion and midface hypoplasia, characterized by reduced SNA (73.63 ± 9.52°), ANB (−7.1 ± 10.51°), and maxillary depth (79.36 ± 11.2°) compared to normative data (<i>p</i> &lt; 0.05). Additionally, the SC group exhibited a hyperdivergent growth pattern (increased FMA: 32.61 ± 6.87°), a shortened anterior cranial base (41.47 ± 4.56 mm), and compensatory mandibular incisor retroclination (IMPA: 88.38 ± 8.57°) (<i>p</i> &lt; 0.05). In contrast, the NSC phenotype was primarily localized to a shortened anterior cranial base (48.17 ± 5.66 mm, <i>p</i> &lt; 0.05), with other skeletal parameters remaining within normative ranges. When evaluating dental maturation relative to chronological age, no statistically significant differences were detected in either cohort (mean difference: SC = 0.09 ± 1.50 years, <i>p</i> &gt; 0.05; NSC = 1.23 ± 1.61 years, <i>p</i> &gt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Children with SC present with severe multi-planar skeletal discrepancies and secondary dental compensations, whereas NSC-related dysmorphology is primarily confined to the cranial base. No statistically significant differences were detected between DA and CA in either group. Because dental development does not necessarily reflect the extent of craniofacial skeletal discrepancies, treatment timing must instead rely on comprehensive, patient-specific structures and skeletal malocclusion.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13573083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Treatments With Prevalence and Incidence of Periodontitis","authors":"Anna Liisa Suominen,&nbsp;Tuomas Saxlin,&nbsp;Marja-Leena Lamidi,&nbsp;Virva Vänttinen,&nbsp;Johanna Pasanen,&nbsp;Tiina Laatikainen","doi":"10.1002/cre2.70452","DOIUrl":"10.1002/cre2.70452","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The aim was to evaluate how treatment supplied in public oral health care services is associated with the prevalence and incidence of periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The data for this study comprised patients aged 20 years or older who had visited publicly funded oral health care services in the Wellbeing Services County of North Karelia (Siun sote) during the years 2021–2022 (<i>N</i> = 50,469). These patients were retrospectively followed in the patient register starting from 2014. Associations of treatments received during the follow-up period (years 2014–2020) with ICD-10 diagnoses of chronic and acute periodontitis at follow-up (in 2021–2022) were analyzed by logistic regressions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The prevalence of diagnoses of both chronic and acute periodontitis in 2021–2022 was quite low. The number of years of having received different treatments in 2014–2020 was associated with the odds of being diagnosed with periodontitis in 2021–2022. In the case of chronic periodontitis, an increasing number of years with preventive and restorative treatments was particularly associated with lower prevalence and incidence. Conversely, an increasing number of years with periodontal treatments and tooth extractions, in addition to earlier diagnosis, were associated with higher prevalence and incidence. For acute periodontitis, in contrast, an increasing number of years with preventive care among all participants and periodontal treatment in incident cases appeared to slightly increase the odds, whereas more years of examinations and tooth extractions were associated with reduced odds. In addition, smoking and diagnosis of diabetes mellitus were associated with higher odds of periodontitis diagnosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>While the association of treatments was similar for prevalence and incidence, it differed between chronic and acute periodontitis, highlighting their distinct pathophysiological profiles. Although preventive care is offered less frequently than other treatments and often for reasons unrelated to periodontal health, it shows a positive impact in reducing the risk of chronic but not acute periodontitis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13552863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}