Clinical and Experimental Dental Research最新文献

{"title":"Advanced Platelet-Rich Fibrin in Surgical Management of Medication-Related Osteonecrosis of the Jaw: A Prospective Case Series Study.","authors":"Besim Hajdari, Lavdie Leci Morina, Granit Gashi, Gloriosa Dobra, Besir Salihu, Venera Bimbashi","doi":"10.1002/cre2.70346","DOIUrl":"10.1002/cre2.70346","url":null,"abstract":"<p><strong>Background: </strong>Medication-related osteonecrosis of the jaw (MRONJ) is a severe complication associated with antiresorptive or antiangiogenic therapy. Surgical debridement is the mainstay of treatment for moderate to advanced disease, while adjunctive regenerative approaches such as advanced platelet-rich fibrin (A-PRF) may enhance soft tissue healing. This study aimed to evaluate the clinical outcomes of A-PRF as an adjunct to surgical management of MRONJ.</p><p><strong>Methods: </strong>Seventeen patients diagnosed with MRONJ according to AAOMS criteria were prospectively enrolled. All patients underwent surgical removal of necrotic bone followed by placement of A-PRF membranes and tension-free mucosal closure. A-PRF was prepared from autologous venous blood using a low-speed centrifugation protocol. Mean follow-up was 11.6 months. Treatment success was defined as complete mucosal healing without clinical signs of infection or bone exposure.</p><p><strong>Results: </strong>The mean age was 60.2 ± 7.8 years; 70.6% were female and 70.6% had cancer-related disease. Stage 2 MRONJ was most prevalent (58.8%). Complete mucosal healing was achieved in 13 patients (76.5%). Four patients (23.5%) showed persistent bone exposure but reported symptomatic improvement.</p><p><strong>Conclusion: </strong>Adjunctive use of A-PRF in MRONJ surgery was associated with favorable soft tissue healing and clinical improvement. Larger controlled studies are needed to confirm these findings.</p>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 2","pages":"e70346"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Path Analysis Results on Bone Markers That Influence Accelerated Bone Remodeling: An Experimental Study.","authors":"Renie Kumala Dewi, Sri Oktawati, Asdar Gani, Eko Suhartono, Nurlindah Hamrun, Rasmidar Samad, Nurhayaty Natsir, Maharani Laillyza Apriasari, Hasanuddin Hasanuddin","doi":"10.1002/cre2.70326","DOIUrl":"https://doi.org/10.1002/cre2.70326","url":null,"abstract":"<p><strong>Objective: </strong>We examined the effectiveness of combining nanochitosan Black Soldier Fly (BSF) pupae and demineralized dentin matrix (DDM) for accelerated bone remodeling by path analysis of osteoblasts, OPG, osteocalcin (OCN), osteoclasts, and RANKL.</p><p><strong>Methods: </strong>Laboratory research using eighteen samples of male guinea pigs that met the inclusion and exclusion criteria, the lower left incisor teeth were extracted, then taken randomly and divided into a control group (C), which applied polyethylene glycol (PEG) gel as a placebo and sutured with nonabsorbable silk, and a treatment group (T) applied a combination of nanochitosan BSF pupae and DDM gel, then sutured with nonabsorbable silk. Samples were euthanized on days 7, 14, and 21 to examine osteoblasts, OPG, OCN, osteoclasts, and RANKL. Data were analyzed using One-way ANOVA (p < 0.05). Pathway analysis was performed using a goodness-of-fit model and effect size, testing the hypothesis that OPG has a direct and dominant influence on RANKL and OCN, resulting in increased osteoblasts and decreased osteoclasts.</p><p><strong>Results: </strong>There was a decrease in the number of osteoclasts, RANKL expression, and an increase in the number of osteoblasts, OPG, and OCN expression between the C and T groups. One-way ANOVA analysis showed a significant difference (0.000) (p < 0.05). The pathway analysis that contributed most significantly in reducing osteoclasts and increasing osteoblasts, thereby accelerating bone remodeling, was OPG affecting OCN (0.952), rather than OPG affecting the RANKL pathway (-0.001).</p><p><strong>Conclusions: </strong>The combination of nanochitosan BSF pupae and DDM has a maximum impact on bone remodeling, so that it can be used as an alternative bone graft material for socket healing treatment and accelerating alveolar bone regeneration.</p>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 2","pages":"e70326"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Periodontitis and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Cross-Sectional Study.","authors":"Mizuki Saito, Yoshihiro Shimazaki, Saori Yoshii, Tetsuhito Kojima","doi":"10.1002/cre2.70355","DOIUrl":"10.1002/cre2.70355","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the association between periodontitis and metabolic dysfunction-associated steatotic liver disease (MASLD), with particular attention paid to sex differences.</p><p><strong>Material and methods: </strong>Participants aged 40-74 years who underwent health examinations were included. Logistic regression analyses were conducted with MASLD as the dependent variable and periodontitis and other variables as independent variables. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated separately for men and women. The women were divided into three age groups (40-49, 50-59, and 60-74 years) to account for the influence of sex hormones. Interaction analyses were performed to examine sex differences in the association between periodontitis and MASLD.</p><p><strong>Results: </strong>The OR for MASLD was significantly higher for women with moderate or severe periodontitis than for those without periodontitis [1.40 (95% CI: 1.04-1.89) and 1.64 (95% CI: 1.04-2.59)]. Periodontitis was associated significantly with MASLD among women aged 50-59 years, but not among women in other age groups or men. A significant multiplicative, but not additive, interaction between sex and periodontitis was found to affect the risk of MASLD.</p><p><strong>Conclusions: </strong>Periodontitis was associated with MASLD in women. The association of periodontitis with MASLD may differ between men and women.</p>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 2","pages":"e70355"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13060762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Hypochlorous Acid Obtained From an Electrolytic Device on the Mechanical Properties of Root Dentin.","authors":"Matheus Albino Souza, Carolina Bianchi Farina, Anna Vithoria da Costa Longhi, Felipe Gomes Dallepiane, Camila Yasmin Monteiro Pizzi, Nathan Mateus Piccolo, Ana Beatriz Canabarro Zart, Bianca Gonçalves Trindade, Leonardo Scarparo Rissardo, Natália Ulmi Ziglioli, Vicenzo Ghisleni Arenhardt, Liviu Steier, José Antônio Poli de Figueiredo","doi":"10.1002/cre2.70332","DOIUrl":"https://doi.org/10.1002/cre2.70332","url":null,"abstract":"<p><strong>Objectives: </strong>Sodium hypochlorite (NaOCl) exhibits antimicrobial activity. However, it is associated with negative effects in endodontics, such as cytotoxicity and alterations in the mechanical properties of root dentin, leading to the search for new alternatives. Hypochlorous acid (HClO) exhibits antimicrobial activity and low cytotoxicity as irrigation solution. Therefore, the aim of this study was to evaluate the influence of HClO on the mechanical properties of root dentin.</p><p><strong>Material and methods: </strong>Samples were obtained from 120 mandibular bovine incisors, which were distributed into four experimental groups: microhardness (30 teeth/60 samples), flexural strength (15 teeth/60 samples), cohesive strength (15 teeth/60 samples), and fracture resistance (60 teeth/60 samples). For all tests, the samples were subdivided into six groups (n = 10): G1: distilled water (DW); G2:1% NaOCl; G3:2.5% NaOCl; G4:5.25% NaOCl; G5:250 ppm HClO; and G6:500 ppm HClO. The irrigation protocol was set at 30 min. Then, a Vickers tester was used to evaluate microhardness, and flexural strength, cohesive strength, and fracture resistance were evaluated in a universal testing machine. One-way ANOVA and Tukey tests were used for multiple comparisons in all evaluations (α = 5%).</p><p><strong>Results: </strong>The highest microhardness was observed in DW, 250 ppm HClO and 500 ppm HClO, with no statistical differences between them (p > 0.05). The highest flexural and cohesive strength were observed in DW, 1% NaOCl, HClO 250 ppm, and HClO 500 ppm, with no statistical differences between them (p > 0.05). Regarding the fracture resistance, there were no statistical differences between all groups (p > 0.05).</p><p><strong>Conclusion: </strong>It was concluded that HClO preserved the mechanical properties of root dentin.</p>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 2","pages":"e70332"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13122125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of an Oral Health Education Program on Knowledge, Attitude, and Clinical Oral Health Indices in Pregnant Women in Urmia, Iran: A Nonrandomized Controlled Intervention Study.","authors":"Seyyed Amir Seyyedi, Zohreh Dalirsani, Fatemeh Bahadori, Nava Askari, Mohadese Maleki, Mohammad Reza Ghorbani Afkhami","doi":"10.1002/cre2.70357","DOIUrl":"10.1002/cre2.70357","url":null,"abstract":"<p><strong>Objectives: </strong>Hormonal changes during pregnancy can increase susceptibility to plaque-induced gingivitis, and at the same time, dental care visits during pregnancy have been reported to be low. This study evaluated the effect of an oral health education program on knowledge, attitude, and clinical indices of oral health in pregnant women.</p><p><strong>Methods: </strong>This nonrandomized controlled intervention study was conducted at Kowsar Hospital, Urmia. Allocation to groups was based on the day of visit (even/odd days). In addition to routine prenatal care, the intervention group received an individual education session of approximately 60 min with a brochure, and the control group received routine care only. Knowledge, attitude, plaque index (PI), gingival index (GI), and decayed, missing, and filled teeth (DMFT) indices were measured at baseline and 3 months later. Statistical analysis was performed in Statistical Package for the Social Sciences.</p><p><strong>Results: </strong>Of 240 enrolled participants, 200 (100 per group) provided complete follow-up data. Baseline characteristics and oral health indices were comparable between groups. At 3 months, the intervention group demonstrated improved knowledge and attitude, lower PI, and modest improvement in GI. In the control group, knowledge and attitude changed little, GI worsened, and PI remained largely unchanged. DMFT increased in both groups over the 3-month period.</p><p><strong>Conclusions: </strong>Short-term, structured oral health education with a brochure can improve knowledge and attitude of pregnant women in the short term and improve plaque and gingivitis.</p>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 2","pages":"e70357"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13082685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Clinical Algorithm for Full-Mouth Rehabilitation in Patients With Generalized Severe Tooth Wear: A Case Report.","authors":"Łukasz Lassmann, Adam Pióro, Javier Calatrava, Hom-Lay Wang","doi":"10.1002/cre2.70349","DOIUrl":"https://doi.org/10.1002/cre2.70349","url":null,"abstract":"<p><strong>Objectives: </strong>To present a structured decision-making approach to full-mouth rehabilitation in patients with generalized severe tooth wear, using functional risk classification (Green, Yellow, Red) and the Smile Design and Space (SDS) Concept for vertical dimension planning.</p><p><strong>Material and methods: </strong>A 65-year-old male presented with generalized erosion and attrition, affecting esthetics and speech. A structured diagnostic protocol began with symptom-based questionnaires and clinical examination. He was categorized as \"Yellow\" indicating the absence of temporomandibular disorders (TMD), repeatable occlusion, but need for interdisciplinary pretreatment. The SDS Concept guided the vertical dimension of occlusion (VDO) increase, based on incisal display, smile line, and prosthetic space, using the formula A + B - C = VDO. Functional crown lengthening was performed to restore the ferrule. Restorations were done with adhesively bonded lithium disilicate crowns and layered ceramics.</p><p><strong>Results: </strong>A 10 mm VDO increase was well tolerated, with restored esthetics, stable occlusion, and improved phonetics. The SDS protocol provided a reproducible, esthetically driven method for VDO and prosthetic space evaluation with no complications.</p><p><strong>Conclusions: </strong>Integrating functional risk classification with the SDS concept enables individualized, systematic full-mouth rehabilitation in severe tooth wear cases, improving diagnostic precision and interdisciplinary communication.</p>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 2","pages":"e70349"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence in Dental Treatment Planning and Diagnostic Decision-Making: A Systematic Review and Meta-Analysis.","authors":"Mohammad Alabdulkareem, Momen Atieh, Ammar AbuMostafa, Khaled Aldalaan, Nada Alturki","doi":"10.1002/cre2.70343","DOIUrl":"10.1002/cre2.70343","url":null,"abstract":"<p><strong>Objectives: </strong>This systematic review and meta-analysis aimed to synthesize the available evidence on the use of AI in dental diagnostic decision-making and treatment planning, evaluating both diagnostic accuracy and its influence on clinical decision-making across different dental specialties and imaging modalities.</p><p><strong>Methods: </strong>A comprehensive search of MEDLINE, Embase, Cochrane CENTRAL, Web of Science, and Scopus was conducted from database inception to December 2025. Eligible studies evaluated AI algorithms used for dental diagnostic tasks or treatment planning and reported quantitative performance metrics or measurable decision-making outcomes. Random-effects meta-analyses were conducted to pool diagnostic performance measures.</p><p><strong>Results: </strong>Twenty-seven studies involving 60,857 radiographic images were included. AI systems demonstrated a pooled sensitivity of 0.85 (95% CI: 0.76-0.91) and specificity of 0.94 (95% CI: 0.86-0.97). The pooled F1-score was 0.90 (95% CI: 0.77-0.96), and pooled precision was 0.88 (95% CI: 0.71-0.96). For segmentation tasks, the pooled Dice Similarity Coefficient was 0.89 (95% CI: 0.13-1.00). Substantial heterogeneity was observed across studies (I² > 95%). YOLO-based architectures achieved the highest performance for tooth detection and segmentation, with sensitivities approaching 99% and mean average precision exceeding 0.96. AI assistance also improved diagnostic efficiency and interobserver agreement while reducing diagnostic interpretation time.</p><p><strong>Conclusions: </strong>AI systems demonstrate strong diagnostic performance in dental imaging and decision support, particularly for tooth detection, segmentation, and pathology identification. However, substantial heterogeneity, retrospective study designs, and limited external validation highlight the need for rigorous prospective evaluation before widespread clinical implementation.</p>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 2","pages":"e70343"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preservation of Dental Structure in Prosthetic Restorations: Vertical and Horizontal Preparation Techniques. Systematic Review.","authors":"Maria Lisa Florescu, Gelsy Arrien-Barrenetxea, Luca Fiorillo, Artak Heboyan, Cosimo Galletti, Santi Costa-Palau, Francisco Real-Voltas","doi":"10.1002/cre2.70360","DOIUrl":"10.1002/cre2.70360","url":null,"abstract":"<p><strong>Objectives: </strong>Crown preparation leads to irreversible dental tissue loss, which affects long-term restoration success. The advantages of horizontal (chamfer) versus vertical preparation techniques (BOPT, BOPTm) remain debated. This systematic review evaluates which method is most conservative regarding dental structure removal and examines their clinical indications, advantages, and limitations.</p><p><strong>Materials and methods: </strong>This systematic review followed the Cochrane Handbook and PRISMA 2020 guidance. The electronic search was performed in PubMed, Cochrane and Web of Science for studies published between 2012 and 2023. The PROSPERO record (CRD420251161178; registered on 06 October 2025) was retrospective. Clinical studies, in vitro/ex vivo investigations and contextual narrative sources were included for different purposes. The >=6-month follow-up criterion was applied only to longitudinal clinical outcome studies; laboratory and descriptive studies were included only for mechanistic or contextual evidence. The primary outcome was direct or indirect quantification of tooth-structure removal. Secondary outcomes included periodontal health, function, tooth morphology, esthetics, and pulpal implications. Certainty of evidence was evaluated using the GRADE methodology.</p><p><strong>Results: </strong>Twenty-three studies were included. Six studies directly quantified tooth-structure removal or residual dentin thickness using gravimetric analysis, micro-CT, digital volumetric analysis, or related methods. Across studies that compared preparation geometries at a comparable margin level, BOPT was generally more conservative than BOPTm; however, supragingival or juxtagingival horizontal chamfer preparations remained the most conservative option when margins could be maintained outside or at the gingival sulcus. Periodontal advantages of BOPT were mainly reported for subgingival clinical scenarios.</p><p><strong>Conclusions: </strong>The apparent difference between vertical and horizontal preparations is scenario-dependent. When a subgingival restorative margin is required, BOPT may preserve more tooth structure than BOPTm and may offer favorable periodontal behavior compared with subgingival horizontal preparations. When margins can be placed supra- or juxtagingivally, horizontal chamfer preparations remain the most conservative and clinically predictable approach.</p>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 2","pages":"e70360"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13095066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjunctive Use of Locally Delivered Statins in Periodontal Therapy and Pre-Implant Bone Regeneration: A Systematic Review and Meta-Analysis.","authors":"Koki Yoshida, Sofia Heller, Nur Mousa, Lovisa Olén, Farah Asa'ad","doi":"10.1002/cre2.70364","DOIUrl":"https://doi.org/10.1002/cre2.70364","url":null,"abstract":"<p><strong>Objectives: </strong>This systematic review and meta-analysis aimed to evaluate the adjunctive beneficial effects of locally delivered statins on probing pocket depth (PPD), clinical attachment level (CAL), bleeding on probing (BoP), and radiographic bone outcomes in both periodontal therapy (Step 2 non-surgical periodontal therapy and Step 3 periodontal surgery) and pre-implant bone regeneration procedures.</p><p><strong>Methods: </strong>The review followed the PRISMA 2020 statement and was registered in PROSPERO (CRD420251105739). PubMed and Scopus were searched through July 2025 for randomized controlled trials (RCTs) evaluating the adjunctive use of locally delivered atorvastatin (ATV), rosuvastatin (RSV), or simvastatin (SIM) in periodontal therapy and pre-implant regenerative procedures. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool (RoB 2). Random-effects meta-analysis was conducted when extractable data were available at commonly reported follow-ups (6 months for Step 2; 9 months for Step 3).</p><p><strong>Results: </strong>Twenty-one RCTs were included (13 Step 2, 6 Step 3, 2 pre-implant bone regeneration). In Step 2 therapy, adjunctive statins improved clinical outcomes compared with scaling and root planing alone, with pooled mean differences (MDs) of approximately 1.4-2.3 mm for PPD and 1.7-2.2 mm for CAL. Numerically larger pooled effects were observed for SIM; however, no direct head-to-head comparisons between statins were performed, and heterogeneity was high. In Step 3 therapy, three trials contributed to 9-month pooling, showing smaller but significant benefits (PPD MD 0.80 mm; CAL MD 0.69 mm), with moderate heterogeneity. Pre-implant bone regeneration trials were clinically heterogeneous and showed inconsistent radiographic outcomes, precluding quantitative synthesis.</p><p><strong>Conclusions: </strong>Locally delivered statins provide clinically relevant adjunctive benefits in Step 2 periodontal therapy and modest additional improvements in Step 3 therapy, particularly when incorporated into regenerative protocols. Evidence for pre-implant bone regeneration remains limited and heterogeneous. Further multicenter RCTs with standardized clinical and radiographic outcomes are needed.</p>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 2","pages":"e70364"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13122124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Post-Cementation Sensitivity Between Resin Modified Glass Ionomer Cement and Conventional Glass Ionomer Cement as a Luting Material—A Randomized Clinical Trial","authors":"Shamsul Alam,&nbsp;Naveed Sadiq,&nbsp;Hend Mohamed Elsayed,&nbsp;Sheema Shakir,&nbsp;Nasser Hussein Shaheen,&nbsp;Ahmed Mohammed Elmarakby,&nbsp;Asif Rehman","doi":"10.1002/cre2.70339","DOIUrl":"10.1002/cre2.70339","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To compare post-cementation sensitivity between resin-modified glass ionomer cement (RMGIC) and conventional glass ionomer cement (GIC) used as luting agents for single crowns.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This randomized controlled trial was conducted at Saidu College of Dentistry, Swat, Pakistan. A total of 496 eligible participants were randomized into two groups: GIC (<i>n</i> = 248) and RMGIC (<i>n</i> = 248). Post-cementation sensitivity was recorded at 24 h, 1 week, and 1 month using a 10-point visual analog scale (VAS), with scores categorized as no, mild, moderate, or severe sensitivity. Data were analyzed using Mann–Whitney <i>U</i> tests, and linear mixed-effects models adjusted for age, gender, jaw, and prosthesis location.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Baseline demographic and clinical characteristics were comparable between groups. Post-cementation sensitivity was consistently lower in the RMGIC group compared to the GIC group across all time points. Median sensitivity scores at 24 h were 4.0 (GIC) versus 3.0 (RMGIC, <i>p</i> &lt; 0.001); at 1 week, 2.0 versus 1.0 (<i>p</i> &lt; 0.001); and at 1 month, both minimal but significantly lower in the RMGIC group (<i>p</i> &lt; 0.001). The adjusted mixed-effects model confirmed that RMGIC significantly reduced sensitivity compared to GIC (<i>β</i> = −0.53; OR 0.59, 95% CI 0.46–0.75; <i>p</i> &lt; 0.001). Sensitivity was highest at 24 h (<i>β</i> = 2.96; OR 19.3, 95% CI 15.3–24.3; <i>p</i> &lt; 0.001), followed by 1 week (<i>β</i> = 0.81; OR 2.25, 95% CI 1.77–2.86; <i>p</i> &lt; 0.001), and declined markedly by 1 month. Age showed a modest protective effect (<i>β</i> = −0.008; OR 0.99, 95% CI 0.99–1.00; <i>p</i> = 0.04), while gender, jaw, and prosthesis location were not significant predictors. A significant interaction at 24 h showed RMGIC provided an additional reduction in sensitivity compared to GIC (<i>β</i> = −0.83; OR 0.44, 95% CI 0.31–0.61; <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>RMGIC demonstrated significantly lower post-cementation sensitivity compared to conventional GIC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>This trial was retrospectively registered with Clinical Trials Registry of ClinicalTrials.gov(registration#NCT07102121) on August 3, 2025.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70339","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}