Clinical and Experimental Dental Research最新文献

{"title":"Correction to “Impact of Autoclaving on the Dimensional Stability of 3D-Printed Guides for Orthodontic Mini-Implant Insertion—An In Vitro Study”","authors":"","doi":"10.1002/cre2.70125","DOIUrl":"https://doi.org/10.1002/cre2.70125","url":null,"abstract":"<p>David, S., Hüfner, H., Rauch, N., Kerberger, R., Drescher, D., Brunello, G., and Becker B. “Impact of Autoclaving on the Dimensional Stability of 3D-Printed Guides for Orthodontic Mini-Implant Insertion—An In Vitro Study.” <i>Clinical and Experimental Dental Research</i> 11, 2025: e70111.</p><p>On page 1, the text “Samuel David and Mira Hüfner contributed equally to this article.” is incorrect and should not have appeared. Samuel David is the first author and Mira Hüfner is the second author, with no shared first authorship.</p><p>We apologize for this error.</p>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Stainless Steel Mesh Size and Universal Adhesive Primer on Flexural Strength of Repaired PMMA Denture Base Resin","authors":"Gray H. Li,&nbsp;Vidya Mudaliar,&nbsp;Andrew B. Cameron,&nbsp;John M. Aarts,&nbsp;Joanne J. E. Choi","doi":"10.1002/cre2.70127","DOIUrl":"https://doi.org/10.1002/cre2.70127","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the effect of the size of stainless steel mesh and universal adhesive primer on the flexural strength of repaired polymethylmethacrylate (PMMA) denture base resin.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A total of 120 heat-cured PMMA specimens with dimensions of 5 × 50 × 30 mm were prepared and repaired with two different sizes of stainless steel mesh reinforcement, one group with med-fine mesh (size 0.42 mm²) and the second group with fine mesh (size 0.09 mm²). One subgroup was primed with a universal adhesive primer (Scotchbond Universal). Half of the specimens from each subgroup were subjected to artificial aging. The flexural strength was obtained by three-point bend testing. Data were statistically analyzed using ANOVA and post hoc analysis (SPSS V28). The probability of failure was calculated using Weibull analysis. Scanning electron microscopy analysis was used to identify the mode of failure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A significantly higher mean flexural strength (<i>p</i> &lt; 0.05) was recorded in primed groups non-thermocycled with fine mesh (174.80 ± 50.27 MPa) and medium mesh (160.87 ± 41.50 MPa) compared to non-primed groups. Non-primed specimens with fine mesh exhibited the highest Weibull modulus (5.86), whereas that of primed medium mesh had the lowest Weibull modulus (2.64). Adhesive failure was identified at the interface of the stainless steel mesh and the self-cure acrylic resin.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Application of the universal adhesive primer to both mid-fine and fine stainless steel mesh significantly improved the flexural strength of the repaired PMMA heat-cured acrylic resin, and reinforcement with primed fine stainless steel mesh resulted in significantly higher flexural strength of repaired PMMA heat-cured an acrylic resin.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143786637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Study of the Expressions of Nuclear (∆EX3) and Cytoplasmic (2B) Survivins in Oral Squamous Cell Carcinoma and Oral Lichen Planus Using Real-Time PCR","authors":"Maryam Amirchaghmaghi,&nbsp;Atessa Pakfetrat,&nbsp;Nooshin Mohtasham,&nbsp;Farnaz Mohajertehran,&nbsp;Mohammad Taghi shakeri,&nbsp;Elahe Vazavandi","doi":"10.1002/cre2.70123","DOIUrl":"https://doi.org/10.1002/cre2.70123","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Survivin is used to determine the prognosis and clinical features of premalignant and malignant lesions. The aim of this study was to determine the correlation between the expression of survivin isoforms and clinical outcomes in oral lichen planus and oral squamous cell carcinoma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This cross-sectional study examined 119 cases, including oral squamous cell carcinoma (SCC), oral lichen planus (OLP), and healthy margins of lesions. For all lesions, survivin expression was assessed quantitatively and qualitatively using real-time polymerase chain reaction. The data were analyzed using SPSS 20.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The expression of survivin-∆EX3 and survivin-2B were quantitatively and qualitatively higher in SCC and OLP cases than in healthy mucosa (<i>p</i> &lt; 0.05). The mean expression of survivin-∆EX3 in erosive OLP (4.95 ± 4.41) was higher than that in nonerosive OLP (2.13 ± 3.32, <i>p</i> &lt; 0.05). Moreover, the mean expression of both genes was significantly higher in different grades of SCC compared to healthy mucosa (<i>p</i> &lt; 0.05). There was also a significant correlation between gene expressions (<i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The increased expression of survivin-∆EX3 and survivin-2B in OSCC correlates with tumor progression and advanced clinical stages, suggesting a potential prognostic role.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70123","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Dental Trauma in Spain: Systematic Review and Meta-Analysis","authors":"Elda Esther García Méndez,&nbsp;David Ribas-Pérez,&nbsp;Diego Rodríguez Menacho,&nbsp;Ignacio Barbero Navarro,&nbsp;Eva Rosel Gallardo,&nbsp;Antonio Castaño Séiquer","doi":"10.1002/cre2.70128","DOIUrl":"https://doi.org/10.1002/cre2.70128","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To estimate the prevalence of TDI in the Spanish population through a systematic review and meta-analysis, identifying differences by sex, age, and study setting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>An exhaustive search was conducted in databases such as PubMed, Scopus, Embase, Ovid Medline, and CINAHL, including gray literature and other alternative sources. Observational studies evaluating the prevalence of TDI in Spain, with a total of 8662 participants. The methodological quality of the studies was assessed using the JBI tool, and the PRISMA guidelines were followed to ensure transparency and reproducibility.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The estimated overall prevalence of TDI was 9.94% (95% CI: 5.98%–16.6%). The results showed a higher prevalence in males (10.5%) compared to females (5.7%), and in children (11.1%) compared to adolescents (6.1%). Fractures were the most common type of TDI (56.5%), followed by avulsion (4.0%). High heterogeneity was observed among the studies, suggesting variability in data collection methods and TDI classification.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study is the first to estimate the prevalence of TDI in Spain, which sheds light on the need for a standardized approach in future research. Although it presents significant methodological strengths, limitations such as high heterogeneity and lack of standardization should be considered when interpreting the results.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70128","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomics Analysis as a Tool in Periodontitis Diagnosis: A Systematic Review","authors":"Ana-Maria Condor,&nbsp;Andreea Iuliana Kui,&nbsp;Smaranda Dana Buduru,&nbsp;Marius Negucioiu,&nbsp;Daniela Cornelia Condor,&nbsp;Patricia-Ondine Lucaciu","doi":"10.1002/cre2.70095","DOIUrl":"https://doi.org/10.1002/cre2.70095","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aims to summarize recent studies available on untargeted metabolomics employed for periodontitis diagnosis, from saliva and gingival crevicular fluid samples, to identify recurring metabolites with biomarker-value potential. A secondary objective was to analysudurue the protocols of existing studies, to facilitate further research.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Three databases were electronically searched for relevant studies (PubMed, Web of Science, Scopus). Risk of bias assessment was performed using the Newcastle-Ottawa scale (NOS). Data was extracted from studies, regarding general characteristics and conclusions, population characteristics, periodontal protocols, and metabolomics protocols. Metabolic pathway analysis was performed for recurrent metabolites.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After screening 405 studies, 13 studies (10 using saliva samples, 3 using GCF samples) were included. 22 metabolites were identified in more than one study and included into the pathway analysis. Butyrate, lactate, isoleucine, glucose, pyruvate, isovalerate, hypoxanthine/xanthine, proline, valine, phenylalanine, and ethanol were most frequently encountered and were found upregulated in periodontitis patients compared to periodontally healthy patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Metabolomics could provide valuable opportunities in validating potential biomarkers or diagnosis panels, contributing to the screening, prognosis, progression and monitoring of periodontitis. Further studies on larger populations and using established protocols are needed. (PROSPERO CRD42023470339).</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of Editorial Bias: A Case Study of Factors Contributing to Review Time in a Leading Journal in Dentistry","authors":"Momen A. Atieh,&nbsp;Nabeel H. M. Alsabeeha","doi":"10.1002/cre2.70122","DOIUrl":"https://doi.org/10.1002/cre2.70122","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The aim of this study was to evaluate the risk of editorial bias in the field of Dentistry by examining surrogate measures which can be readily extracted from published randomized controlled trials (RCTs) in a journal of high impact factor.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>RCTs published between January 2019 and March 2023 were manually downloaded. Data related to author affiliation, dates of submission and first publication, study location, review time, compliance with Consolidated Standards for Reporting Trials (CONSORT) checklist, ethics approval number, clinical trial registration time, reported outcomes, and eligibility criteria in registries and sample size calculation were extracted.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 40 RCTs were included in this cross-sectional study. The mean review time was 165.38 ± 91.40 days with 55% of RCTs exceeding 120-day review time. A total of 23 RCTs (57.5%) were compliant with the CONSORT statement. The review time of RCTs with editorial co-authorship was significantly shorter than the review time of RCTs that had no authors from the editorial team (91.75 ± 42.03 vs. 239.00 ± 63.00 days; <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>RCTs with editorial co-authorship in the field of Dentistry were statistically favored in the initial screening or peer-review process having significantly short review time.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Practical Implications</h3>\u0000 \u0000 <p>Scientific journals should adopt a double-blind peer-review process that is thorough, fair, and transparent to improve the quality of published research. To address any concerns related to editorial co-authorship, editors should explicitly explain the peer-review process in a commentary added to the published paper.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70122","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IgG In Saliva, GCF, and Serum in Young Patients With Grade C Molar Incisor Pattern Periodontitis","authors":"Meaad M. Alamri,&nbsp;Gordon Proctor,&nbsp;Luigi Nibali","doi":"10.1002/cre2.70117","DOIUrl":"https://doi.org/10.1002/cre2.70117","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This cross-sectional study aimed to investigate immunoglobulin G levels in saliva, gingival crevicular fluid, and serum samples from young patients with grade C molar incisor pattern periodontitis (C/MIP) and age-matched periodontitis-free controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Saliva, gingival crevicular fluid, and blood samples were collected from 62 patients, divided into 31 cases and 31 periodontitis-free age-matched controls. Saliva and blood samples were centrifuged to extract supernatant and serum. Gingival crevicular fluid periopapers were eluted. Human total immunoglobulin G levels were assessed using an Enzyme-Linked Immunosorbent Assay.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After adjusting for covariates, cases had higher Immunoglobulin G levels in saliva (<i>p</i> = 0.005), gingival crevicular fluid (<i>p</i> &lt; 0.001) than controls; however, serum did not reach the significant threshold (<i>p</i> = 0.137). Among other factors contributing to immunoglobulin G levels, males had higher serum immunoglobulin G than females (<i>p</i> = 0.018), and serum immunoglobulin G levels increased with age (<i>p</i> = 0.033). Gender and ethnicity subgroup analyses revealed that C/MIP males had higher saliva IgG (<i>p</i> = 0.018) than control males, and both genders had higher GCF IgG than controls (<i>p</i> ≤ 0.001). C/MIP Caucasians had elevated saliva (<i>p</i> = 0.011) and GCF IgG p = (0.003) compared to the controls, and Asians had higher GCF IgG than the controls (<i>p</i> = 0.011).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study shows for the first time that C/MIP cases have higher Immunoglobulin G levels than controls in saliva and gingival crevicular fluid, confirming its association with C/MIP pathogenesis and suggesting that it could be a potential biomarker in grade C molar incisor pattern periodontitis. Further research on a larger sample size is needed.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Adhesive Retention and Denture Weight in Different Residual Ridge Morphologies: A Cross-Over Randomized-Controlled Trial","authors":"Naseer Ahmed,&nbsp;Maria Shakoor Abbasi,&nbsp;Asra Salahuddin,&nbsp;Lareb Tariq,&nbsp;Sarrah Siraj,&nbsp;Gotam Das,&nbsp;Ghazala Suleman,&nbsp;Fahim Vohra,&nbsp;Artak Heboyan","doi":"10.1002/cre2.70118","DOIUrl":"https://doi.org/10.1002/cre2.70118","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The aim of this study was to compare the retentive strengths of various forms of denture adhesives (paste, powder, and strips) on different types of mandibular residual alveolar ridges, considering their respective denture weights.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In this crossover randomized-controlled trial, the patients were randomly and equally divided into 3 groups based on clinical features and radiographic findings according to the Wical–Swoope classification. Three forms of denture adhesives were used, including powder, cream, and strips, for three residual ridge types. Quantification of retention without adhesive was carried out as a control. The retentive strength of adhesives was compared in each ridge pattern and correlated with the denture weight. The study was registered at https://clinicaltrials.gov (identifier number: NCT05063422).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean retentive strengths of dentures without adhesive (control) were relatively low across all ridge classifications, ranging from 0.27 to 0.69 lb. In contrast, the experimental groups utilizing Fittydent and Polygrip adhesive products showed significantly improved retentive strengths, with Fittydent cream and Polygrip cream showed the highest enhancement, ranging from 1.01 to 2.57 lb across different ridge types. Furthermore, significant mean differences were observed between ridge classes and the retentive strength of each adhesive product.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The study highlights the crucial role of tailored denture adhesive selection in optimizing retention for denture wearers. Polygrip cream demonstrated superior effectiveness across various ridge classifications compared to Fittydent cream, powder, and strips. These findings emphasize the importance of personalized treatment approaches based on ridge types and denture weight.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Bone Formation After Early and Late Secondary Alveolar Bone Grafting in Patients With Unilateral and Bilateral Cleft Lip and Palate","authors":"Aya Maeda-Iino,&nbsp;Shoko Nakagawa,&nbsp;Kanako Marutani,&nbsp;Yasuhiko Oga,&nbsp;Kotaro Tahakashi,&nbsp;Sayaka Hino,&nbsp;Mika Fukushima,&nbsp;Toshiro Kibe,&nbsp;Masahiro Tezuka,&nbsp;Norifumi Nakamura,&nbsp;Shouichi Miyawaki","doi":"10.1002/cre2.70116","DOIUrl":"https://doi.org/10.1002/cre2.70116","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Late-stage secondary alveolar bone grafting (SBG) has a poor prognosis; however, the case selection and timing of orthodontic treatment have not been thoroughly investigated. This study aimed to clarify the prognosis of early-SBG and late-SBG in patients with unilateral or bilateral cleft lip and palate.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Fifty-six patients underwent early-SBG performed before the eruption of the cleft-adjacent lateral incisors or canines (early-SBG group). Ten patients underwent late-SBG requiring significant tooth movement for gap closure; SBG was performed before phase II treatment for treatment efficiency, and tooth movement began approximately 3 months post-SBG (late-SBG group). Pre-SBG cleft width was measured; bone-bridge formation using the Chelsea scale and cleft gap closure post-SBG were evaluated. Types A and C bone bridges were considered adequate. These items were statistically compared between groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Cleft width in the early-SBG group was significantly smaller than that in the late-SBG group (<i>p</i> &lt; 0.001). There were no significant differences in the percentage of adequate bone-bridge formation (<i>p</i> = 0.055) and cleft-gap closure (<i>p</i> = 1.000) between groups. However, the ratio of type A bone bridges was significantly higher in the early-SBG group than in the late-SBG group (<i>p</i> = 0.035).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These results suggest that, even in late-SBG, early orthodontic tooth movement to the graft bone leads to the formation of an adequate bone bridge, similar to early-SBG. However, the maintenance of cervical grafted bone after late-SBG may be less than that after early-SBG.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased Serum and Salivary Levels of Aquaporin 5 in Oral Lichen Planus","authors":"Farzaneh Agha-Hosseini,&nbsp;Yalda Elham,&nbsp;Iraj Mirzaei-Dizgah,&nbsp;Mahdieh-Sadat Moosavi","doi":"10.1002/cre2.70107","DOIUrl":"https://doi.org/10.1002/cre2.70107","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Oral lichen planus (OLP) is an autoimmune disease with unknown etiology. Many OLP patients complain of xerostomia, and studies are still ongoing to find the reason for this manifestation. Aquaporin 5 has been expressed in salivary glands, and its physiological significance in transferring water as transcellular is properly identified. In this study, for the first time, we have investigated the serum and salivary levels of aquaporin 5 (as a salivary gland biomarker) in oral lichen planus patients with xerostomia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Thirty patients with OLP and xerostomia and 30 healthy individuals were chosen. The flow of stimulatory and non-stimulatory saliva was calculated, and the serums, in addition to salivary levels of aquaporin 5, were determined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The level of Aquaporin 5 in serum and its output in stimulatory, and non-stimulatory saliva were significantly decreased, the stimulatory and non-stimulatory saliva flow was reduced, and the degree of xerostomia was significantly higher in the OLP group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Aquaporin 5 is implicated in OLP patients in several ways such as impaired salivary functioning, xerostomia or dry mouth, diminished repair ability of the mucosal lesion, increased apoptosis, and probable carcinogenesis in this premalignant lesion.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}