Morgana Francisco Machado Guzzatti, Airam Barbosa de Moura, Ligia Milanez Venturini, Laura de Roch Casagrande, Igor Ramos Lima, Camila da Costa, Ellen de Pieri, Lariani Tamires Witt Tietbohl, Paulo Emilio Feuser, Ricardo Andrez Machado-de-Ávila, Yaodong Gu, Anand Thirupathi, Paulo Cesar Lock Silveira
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The first treatment session commenced 24 h after the injury and continued daily for 5 days. Twenty-four hours after the final treatment, the animals were euthanized, and the palatal mucosa tissue was collected for histological and biochemical analyses.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>AgNPs-Cur significantly reduced pro-inflammatory cytokines and oxidant markers, increased anti-inflammatory cytokines, the wound contraction rate, and the collagen area, and reduced the inflammatory infiltrate compared to the controls.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The therapies effectively aided inflammation resolution and accelerated tissue repair. 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引用次数: 0
摘要
目的本研究旨在比较姜黄素（Curcuma longa L.）或阿帕拉赛（Euterpe oleracea）合成的银纳米颗粒（AgNPs）与商业治疗和光生物调节对大鼠腭伤口的影响。方法采用体外细胞活力试验评价纳米颗粒的毒性。动物最初被麻醉，用直径为4毫米的穿孔器在腭黏膜上形成圆形病变。第一次治疗在伤后24小时开始，每天持续5天。最终处理24小时后，对动物实施安乐死，采集腭黏膜组织进行组织学和生化分析。结果与对照组相比，AgNPs-Cur显著降低了促炎细胞因子和氧化标志物，增加了抗炎细胞因子，增加了创面收缩率和胶原面积，减少了炎症浸润。结论治疗能有效缓解炎症，促进组织修复。这项研究强调了口腔和腭粘膜伤口愈合的潜在成本效益和有效的替代方案，改进了标准的商业治疗。
Biosynthesized Silver Nanoparticles Modulate Inflammation in a Palatine Wound Model
Objectives
This study aimed to compare the effects of silver nanoparticles (AgNPs) synthesized with Curcumin (Curcuma longa L.) or Açai (Euterpe oleracea) versus a commercial treatment and photobiomodulation in rat palatal wounds.
Methods
In vitro cell viability tests assessed nanoparticle toxicity. The animals were initially anesthetized, and circular lesions were created in the palatine mucosa using a 4 mm/diameter punch. The first treatment session commenced 24 h after the injury and continued daily for 5 days. Twenty-four hours after the final treatment, the animals were euthanized, and the palatal mucosa tissue was collected for histological and biochemical analyses.
Results
AgNPs-Cur significantly reduced pro-inflammatory cytokines and oxidant markers, increased anti-inflammatory cytokines, the wound contraction rate, and the collagen area, and reduced the inflammatory infiltrate compared to the controls.
Conclusion
The therapies effectively aided inflammation resolution and accelerated tissue repair. This study highlights potential cost-effective and efficient alternatives for oral and palatal mucosa wound healing, improving upon standard commercial treatments.
期刊介绍：
Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.
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