Clinical and Experimental Dental Research最新文献

{"title":"Association Between Self-Reported Oral Health and Dental Fear Among Illicit Drug Users in Northern Finland","authors":"Raija Vainionpää,&nbsp;Antti Tiisanoja,&nbsp;Outi Kokkola,&nbsp;Pirkko Riipinen,&nbsp;Vuokko Anttonen","doi":"10.1002/cre2.70055","DOIUrl":"10.1002/cre2.70055","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>About 10% of adults in northern Finland have severe dental fear, but there is a lack of detailed knowledge about dental fear among illicit drug users. The aim of the study was to evaluate the prevalence of dental fear and its association with self-reported oral health and health behavior as well as background factors of the customers of substance abuse services living in the region of Oulu, Northern Ostrobothnia, Finland.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>One hundred seventeen volunteers, either active or former illicit drug users, were interviewed face-to-face about their background factors, health and health behaviors, and use of illicit drugs. The Modified Dental Anxiety Scale (MDAS) was used to assess a situation-specific level of dental anxiety. For analyses, Pearson's <i>χ</i>² test, Fisher's exact test, ANOVA, and logistic regression analysis were performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Three out of four participants had at least moderate dental fear (MDAS ≥ 10) and 24% had severe dental fear (MDAS ≥ 19), with the average MDAS being 14.0 (SD 5.7). Participants in drug rehabilitation reported significantly more dental fear than the rest of the participants. Severe dental fear was associated (adjusted) with previous painful experiences OR 10.8 (2.3–52.0) and poor behavior by dental personnel OR 4.1 (1.2–13.9).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Dental fear is common among illicit drug users, and it is, particularly, associated with previous painful experiences and poor behavior by dental personnel.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"10 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70055","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of a Quantitative Method for the Extraction of Nicotine and Cotinine in Gingival Tissue and Relationship Between Gingival Intoxication With Conventional Smoking Biomarkers: A Pilot Study","authors":"Leila Salhi,&nbsp;Samuel Hazout,&nbsp;Dorien Van hede,&nbsp;France Lambert,&nbsp;Corinne Charlier,&nbsp;Marine Deville","doi":"10.1002/cre2.70022","DOIUrl":"10.1002/cre2.70022","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Smoking is considered a major risk factor for periodontitis genesis and progression. In clinical studies, specific indicators have been used to characterize the smoking status of the patient as the number of cigarettes consumed (NCC), the pack-years (PY), or Fagerström Test for Nicotine Dependence (FTND). However, available literature is missing on the relationship between cotinine gingival intoxication and smoking indicators. First, the development of a quantitative method for the extraction of nicotine and cotinine in gingival tissue. Second, to investigate the relationship between gingival intoxication and conventional smoking biomarkers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Fourteen smoker patients were included in the study. After clinical data collection, salivary and gingival samples collection, toxicological analyses were performed using liquid extraction after enzymatic digestion (subtilisin) and ultra-performance liquid chromatography coupled to mass spectrometry (UPLC-MS/MS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Gingival cotinine quantification was successfully performed in 14 samples (100%) with a mean of 0.280 ng/mg (range = 0.094–0.505). Only FTND was statistically associated with gingival cotinine levels (<i>p</i> = 0.0072; <i>r</i>² = 0.60). Gingival nicotine quantification was achieved in 12 of the 14 gingival samples (86%) with a mean of 0.384 ± 1.00 ng/mg (range = 0.03–3.84). Gingival nicotine was statistically associated with NCC (<i>p</i> = 0.032; <i>r</i>² = 0.55), PY (<i>p</i> = 0.0011; <i>r</i>² = 0.76), and FTND (<i>p</i> = 0.016; <i>r</i>² = 0.60). Salivary nicotine and cotinine levels were statistically associated with, respectively, NCC (<i>p</i> = 0.030; <i>r</i>² = 0.34), and NCC (<i>p</i> = 0.0094; <i>r</i>² = 0.63) + PY (<i>p</i> = 0.0078; <i>r</i>² = 0.64).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This pilot study established a quantitative extraction method for nicotine and cotinine from human gingival samples. Additionally, FTND was associated with gingival cotinine. However, further large-scale studies are needed to confirm the relationship between nicotine dependence and gingival intoxication.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"10 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Implant Position Accuracy in Guided Implantology: The Role of Drill Play Under Lateral Forces","authors":"Vasilios Alevizakos,&nbsp;Yannick Stryga,&nbsp;Constantin von See","doi":"10.1002/cre2.70056","DOIUrl":"10.1002/cre2.70056","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study investigates the impact of drill play on the precision of implant positioning under lateral forces in guided implantology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>An in vitro experiment was conducted using artificial bone blocks and the SIC Invent-guided surgery implant system. Custom drill guides were designed, and 3D-printed, using three sleeve types: sleeveless, a big sleeve, and a small sleeve. Drillings were performed with varying lateral forces, and deviations in angle, depth, and position were measured.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sleeveless guides showed the highest variability in deviations, with a maximum deviation of 3.92 mm under extreme lateral forces. Big sleeve guides provided the most consistent precision, with deviations ranging from 0.42 to 1.33 mm. Small sleeve guides showed moderate precision, with deviations from 0.14 to 2.17 mm. Higher lateral forces generally increased deviations across all guide types.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Drill play significantly affects the precision of guided implant drilling, with lateral forces causing deviations from the planned implant position. Big sleeve guides offer better precision under lateral loads compared to sleeveless and small sleeve guides. Strict adherence to the drilling protocol is essential to minimize errors and ensure optimal implant positioning.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"10 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skeletal and Dental Effects of Forsus Fatigue Resistance Device Versus Twin Block Appliance for Class II Malocclusion Treatment in Growing Patients: A Systematic Review","authors":"Bahaa Aldeen Jeha,&nbsp;Rania Haddad","doi":"10.1002/cre2.70054","DOIUrl":"10.1002/cre2.70054","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study systematically searched the literature and assessed the available evidence to compare the efficacy of Forsus Fatigue Resistance Device (FRD) versus Twin Block Appliance (TBA) in treating class II malocclusion.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>The search for published literature was published up to May 28, 2024. The databases were included in the search: MEDLINE, PubMed, EMBASE, Cochrane Oral Trials Register, Tripe, Web of Science, and Scopus. Additionally, unpublished literature was searched on ClinicalTrials.gov, the National Research Register, and ProQuest Dissertations and Theses. All eligible studies were carefully reviewed and two reviewers independently extracted data. In cases of disagreement, an arbiter was consulted for resolution.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Two randomized controlled trials (RCTs) and five non-RCTs were included in this review. The total number of patients included in the studies examining SNA, SNB, and ANB was 254. The studies also looked at the variables Go-Gn, L1-ML, and U1-SN, with 279, 205, and 277 patients included for each variable, respectively. According to the evidence reported, TBA showed greater skeletal effects in terms of mandibular length and advancement. The pooled estimate revealed a statistically significant 1.3° increase in the SNB, and a decrease of −1.34° in the ANB angles for patients treated with TBA compared with those treated with FRD, with no statistically significant differences in the SNA angle. Most studies had a moderate risk of bias, while only two studies had a high risk of bias.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>FRD has been proven to be an effective treatment device for correcting ANB and restricting SNA angle, similar to TBA. However, TBA appears to offer better mandibular length and SNB outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"10 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11636309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular and Microbial Detections of Streptococcus mutans and Lactobacilli in Dental Caries: An Experimental Study on Iranian Children Aged 5–9","authors":"Marzieh Danaei,&nbsp;Milad Mollaali,&nbsp;Vida Fakharmohialdini,&nbsp;Hamidreza Poureslami,&nbsp;Fatemeh Sadat Sajadi,&nbsp;Elham Farokh Gisour,&nbsp;Fatemeh Jahanimoghadam,&nbsp;Aida Gholampour,&nbsp;Mehrnaz Foroudisefat,&nbsp;Arezoo Mirshekari,&nbsp;Raziyeh Shojaeipour","doi":"10.1002/cre2.70039","DOIUrl":"10.1002/cre2.70039","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Lactobacilli and <i>Streptococcus mutans</i> are stigmatized as cariogenic bacteria, but few studies have simultaneously examined the quantitative and qualitative aspects of lactobacilli and <i>S. mutans</i> in childhood dental caries. Therefore, this study aimed to detect the presence of <i>S. mutans</i> and lactobacilli in dental caries using Snyder's test, colony counting, and PCR in the primary teeth of Iranian children with dental caries.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>A cross-sectional study was conducted in Kerman, Iran, from March to Jun 2024. After dental examinations, 120 eligible children aged 5–9 were chosen using simple random sampling and classified into four groups based on their decayed, missing, and filled (primary) teeth (dmft) index: Group 1 (dmft = 0), Group 2 (dmft = 4–6), Group 3 (dmft = 7–9), and Group 4 (dmft = 10–13). The salivary levels of lactobacilli and <i>S. mutans</i> were calculated using colony counting (CFU/ml). Moreover, Snyder's test was applied to evaluate caries activity. PCR was also performed for molecular detection of lactobacilli (<i>16S rRNA</i> gene) and <i>S. mutans (gftB</i> gene). Lastly, the association between bacterial counting, molecular findings, and Snyder's test was estimated through statistical methods using SPSS 27.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significant differences were found between the age and the PCR results of lactobacilli and <i>S. mutans</i> among all dmft Groups (<i>p</i> &lt; 0.05). Moreover, positive significant correlations were observed between the counts of lactobacilli and <i>S. mutans</i> in dmft Group 1 compared to other dmft Groups (<i>p</i> &lt; 0.05). Furthermore, the counts of these two bacteria differed significantly in Snyder's test (<i>p</i> &lt; 0.05). However, Snyder's test differed significantly from the <i>S. mutans</i> PCR (<i>p</i> &lt; 0.05), but not from the lactobacilli PCR (<i>p</i> &gt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The results of the study could potentially be considered a promising and cost-effective screening program to identify children who are susceptible to dental caries.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"10 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11636308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontal Disease and Metabolic Syndrome in Women at Prior High Risk for Gestational Diabetes","authors":"Hanna Poulsen,&nbsp;Jukka H. Meurman,&nbsp;Hannu Kautiainen,&nbsp;Emilia Huvinen,&nbsp;Saila Koivusalo,&nbsp;Johan G. Eriksson","doi":"10.1002/cre2.70053","DOIUrl":"10.1002/cre2.70053","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to assess the association between periodontal disease and metabolic syndrome (MetS) among women at prior high risk for gestational diabetes with the hypothesis that women with MetS show more signs of periodontal disease than women without MetS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>A total of 112 women from an original study cohort of 348 women at high risk of gestational diabetes were examined 4–6 years postpartum. Diagnosis of MetS was based on the National Cholesterol Education Program Adult Treatment Panel III diagnostic criteria. Insulin resistance was approximated by the homeostatic model assessment for insulin resistance. Full-mouth examinations and panoramic radiographs provided the total dental index, number of teeth, and decayed, missing, and filled teeth index. Clinical examination assessed bleeding on probing, probing depth, visible plaque index, signs of infection, and clinical attachment levels. The periodontal inflammatory burden index (PIBI) was also calculated. Information on oral health habits, symptoms, and individual opinions on oral health was collected through questionnaires.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Five years after delivery, 21% of the women had MetS, and they had more gingivitis compared to those without MetS (bleeding on probing: 52% and 44%, <i>p</i> = 0.011). Women with MetS tended to have more periodontitis than those without (39% and 25%, <i>p</i> = 0.13). A high PIBI correlated with insulin resistance (partial correlation of PIBI and homeostatic model assessment for insulin resistance: 0.25 <i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Periodontal disease was associated with insulin resistance and MetS in women at prior high risk of developing gestational diabetes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"10 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11636310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Human and Porcine Natural Tooth Fluorescence—A Scoping Study to Inform Research on Dental Materials and Forensic Dentistry","authors":"Thomas Corfield,&nbsp;Denice Higgins","doi":"10.1002/cre2.70052","DOIUrl":"10.1002/cre2.70052","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Understanding human tooth structure fluorescence aids clinical and forensic dentistry, enabling tissue/material differentiation and the creation of esthetic restorative materials. Material manufacturers seek to replicate natural tooth fluorescence, necessitating the development of novel techniques to detect them. Procuring human teeth for research is challenging due to ethical and infection control standards, prompting a search for alternative models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>This study compares visible light-induced fluorescence of porcine and human teeth to assess the value of porcine teeth as human analogs. Using a pulsed laser, an optimal fluorescence-inducing wavelength was determined, followed by comparing fluorescence spectra between species.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Luminescence sensitivity and lifetimes were comparable between species, but spectral geometry differed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Porcine teeth, commonly used for dental material investigations, may not be suitable for dental fluorescence studies due to spectral differences. Accurately mimicking human tooth fluorescence remains complex. Further research is needed to develop reliable alternatives for dental fluorescence investigations that will advance clinical and forensic dentistry.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"10 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11636307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of 5 Nanosilica Concentrations and Humid Environments at 6 Different pH Levels on Fracture Toughness and Moisture Absorption of Dental Polymethyl Methacrylate Resin‎ Reinforced With Silica Nanoparticles: An Explorative Experimental Scanning Electron Microscopy Study","authors":"Mohammad Ali Golshokouh,&nbsp;Nima Refahati,&nbsp;Pouyan Roodgar Saffari","doi":"10.1002/cre2.70006","DOIUrl":"https://doi.org/10.1002/cre2.70006","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Introduction&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;No study has assessed the effects of nanosilica within polymethyl methacrylate (PMMA) resin and environmental pH on resin's fracture resistance and moisture absorption.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 90 specimens were divided into 30 subgroups of three, as per the ASTM D5045 standard: five groups of nanosilica percentages (0%/2%/5%/7%/10%), each ‎divided into six subgroups of pH levels (pH = 5/6/7/8/9, + “dry” control). The specimens were prepared by mixing silica nanoparticles with PMMA powder in a vacuum mixer. Then, the specimens were mixed with a diluent liquid (TEGDMA) according to the manufacturer's instructions. For each of the five weight percentages, 36 samples were produced. The 18 specimens in each group were randomly divided into six subgroups of pH levels. The specimens were kept in containers of liquid at different pH levels at room temperature for 1 week. Their before- and after-storage weights were recorded to calculate moisture absorption. The fracture resistance test was performed (ASTM D5045 standard) using the three-point bending method. Scanning electron microscopy was performed. Data were analyzed.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Both nanosilica extents and pH levels significantly affected the fracture toughness with a significant interaction (&lt;i&gt;p&lt;/i&gt; &lt; ‎‎0.00001). All post hoc comparisons of different pH levels (except pH= 5 vs. 6) were significant (&lt;i&gt;p&lt;/i&gt; &lt; ‎‎0.0001). All post hoc comparisons of different nanosilica concentrations were significant (&lt;i&gt;p&lt;/i&gt; &lt; ‎‎0.0001). Both nanosilica extents and pH levels significantly influenced the fracture toughness with a significant interaction (&lt;i&gt;p&lt;/i&gt; &lt; ‎‎0.00001). All post hoc comparisons of different pH levels and also between different nanosilica concentrations were significant (&lt;i&gt;p&lt;/i&gt; &lt; ‎‎0.0001). The correlation between moisture absorption and fracture toughness was significant (&lt;i&gt;R&lt;/i&gt; = −0.382, &lt;i&gt;p&lt;/i&gt; = 0.0009).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Fracture toughness decreases when placed in humid and acidic environments. Also, the samples that were placed in a humid environment suffered a brittle fracture. Increasing silica nanoparticles improved fracture toughness (becoming optimal at 5 wt% nanosilica).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective and Materials&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The objective of this study was to investigate the fracture toughness of dental samples made o","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"10 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Salivary Opiorphin in Burning Mouth Syndrome and Healthy Subjects and Its Correlation With Psychiatric Disorders","authors":"Zohreh Dalirsani,&nbsp;Maryam Amirchaghmaghi,&nbsp;Mahshid Malakuti Semnani,&nbsp;Mahdi Talebi,&nbsp;Seyed Isaac Hashemy,&nbsp;Mohammad Taghi Shakeri,&nbsp;Ava Taghizadeh","doi":"10.1002/cre2.934","DOIUrl":"https://doi.org/10.1002/cre2.934","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Burning mouth syndrome (BMS) is a chronic disease in which the patient experiences a burning sensation in the oral mucosa without any pathological cause. Opiorphin is a pentapeptide that prevents pain and can have an antidepressant effect. The aim of this study was to evaluate salivary opiorphin concentration in BMS and healthy subjects. In addition, opiorphin concentration in BMS patients before and after psychiatric treatment was compared and the association between burning severity and psychiatric scores with salivary opiorphin concentration was examined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This cross-sectional study included 28 BMS patients and 40 healthy individuals referred to the Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Mashhad, from September 2018 to August 2019. Patients with proven disease based on clinical and psychiatric examinations were included in the study. Unstimulated salivary opiorphin levels were assessed by ELISA. Statistical analysis was performed using SPSS version 24.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Salivary opiorphin levels were significantly higher in BMS patients (2.16 ± 0.30 ng/mL) than in healthy subjects (1.80 ± 0.36 ng/mL) (<i>p</i> &lt; 0.001). Opiorphin levels in BMS patients increased insignificantly after psychiatric therapy (<i>p</i> = 0.212). In addition, there was no significant association between opiorphin levels and age, gender, menopause, burning severity, anxiety, and depression status.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The opiorphin concentration in saliva is higher in BMS patients than in healthy subjects. Most BMS patients also suffer from anxiety and depression.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"10 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.934","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142758065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Local and Systemic Metronidazole as Adjunctive Treatment in Chronic Periodontitis Patients","authors":"Maryam Mehravani,&nbsp;Ehsan Houshyar,&nbsp;Sheida Jamalnia,&nbsp;Rasool Gharaaghaji","doi":"10.1002/cre2.70050","DOIUrl":"https://doi.org/10.1002/cre2.70050","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to compare the effects of local and systemic metronidazole in patients with chronic periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In this randomized clinical study, 30 patients (3 teeth per patient) were treated in three groups: scaling and root planing (SRP) treatment alone, metronidazole tablet as adjunctive treatment, and metronidazole gel as adjunctive treatment. BOP (bleeding on probing), PPD (pocket probing depth), and CAL (clinical attachment level) data were collected at the beginning and 3 months later. Collected data were tested by Wilcoxon and Kruskal–Wallis tests.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>BOP, CAL, and PPD levels were significantly different at the beginning of treatment and after 3 months, and this was true for all treatments. BOP, CAL, and PPD levels did not differ significantly between the three groups after the treatment (<i>p</i> &gt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The effectiveness of these methods was all equal and SRP is still considered as the gold standard in the treatment of periodontal diseases. Further studies are needed to confirm the findings. Chronic periodontitis is a progressive disease that can cause tooth loss. The accepted treatment is SRP. Antibiotics used systemically can penetrate the depth of the periodontal pockets but have several side effects. Hence, using a less complicated medicinal form as a topical gel as adjunctive therapy in treating chronic periodontitis can be more effective.</p>\u0000 \u0000 <p><b>Trial Registration</b>: Iranian clinical trial https://en.irct.ir/: IRCT20210408050898N1</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"10 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142758069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}